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Allolobophora caliginosa coelomic fluid ameliorates gentamicin-induced hepatorenal toxicity in rats

Asian Pacific Journal of Tropical Biomedicine 2020年第9期10卷 411-416页

作者： Saad Bin Dajem Sara Bayoumi Ali Omar Ghanem Abdelrady Nouraldin Mahmoud Salahaldin Ahmed Muhammed Soliman Yasmin Mohamed Kamal Ammar Yasser Abdelazim Aya Fadi Mohamed Kareem Morsy Ayman Saber Mohamed sohair ramadan fahmy Department of Biology College of ScienceKing Khalid UniversityAbhaSaudi Arabia Department of Zoology Faculty of ScienceCairo UniversityCairoEgypt

Objective:To explore the efficacy of earthworm’s coelomic fluid against gentamicin-induced hepatic and renal toxicity in ***:The animals were divided randomly into three groups(n=6 per group):control,gentamicin,and Allolobophora caliginosa coelomic fluid-treated *** was established after injection of gentamicin daily for 8 days at a dose of 100 mg/*** aminotransferase,alanine aminotransferase,alkaline phosphatase,total proteins,albumin,creatinine,urea,uric acid,malondialdehyde,glutathione,catalase and histopathology of tissues were investigated in the ***:Allolobophora caliginosa coelomic fluid significantly decreased urea,creatinine,uric acid,alanine aminotransferase,aspartate aminotransferase,alkaline phosphatase,and malondialdehyde levels while significantly increasing levels of total proteins,albumin,glutathione and *** histopathological investigation showed partial restoration of renal and hepatic ***:This study shows the potency of Allolobophora caliginosa coelomic fluid in improving the biochemical and histopathological changes induced by gentamicin in the liver and kidney of the rats.

关键词： Allolobophora caliginosa Coelomic fluid Gentamicin Hepatorenal toxicity Earthworm

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Effectiveness of Echinochrome on HFD‑Induced Hyperlipidemia in Rats

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Natural Products and Bioprospecting 2019年第5期9卷 337-344页

作者： sohair R.fahmy Nashwah Ismail Zaki Shaimaa Zakaria Eid Ayman Saber Mohamed Sarah S.Hassanein Zoology Department Faculty of ScienceCairo UniversityGiza 12613Egypt Physiology Department National Organization for Drug Control and ResearchCairoEgypt

Obesity has been identified with an expanded danger of a progression of illnesses that include different organ-frameworks of the *** the present examination,we evaluated the hypolipidemic properties of Echinochrome(Ech)pigment in a high-fat diet(HFD)induced hyperlipidemia in *** the hyperlipidemic model was set up,rats were haphazardly separated into five groups as follows:normal control group,HFD group,Atorvastatin(ATOR)group(80 mg/kg),Ech group(1 mg/kg)and combined group ATOR+*** outcomes demonstrated that Ech improves lipid profile,liver functions,kidney functions and antioxidant markers of obese *** findings of the present investigation indicated that the Ech possesses hypolipidemic potential in obese rats.

关键词： High-fat diet Atorvastatin Echinochrome Obesity Oxidative stress

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