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Journal of Integrative Plant Biology 2006年第9期48卷 1108-1114页

作者： so-young park Wi-young Lee youngki park Jin-Kwon Ahn Biotechnology Division Korea Forest Research Institute Suwon 441-350 Korea

Changes in cellular isoflavone （daidzein and genistein） contents were monitored in root cultures of Albizzia kalkora （Roxb.） Prain after feeding different ratios of NH4^＋/NO3^- and treatment with a biotic elicitor （three strains of Rhizobium sp.）. The NH4^＋/NO3^- ratio appears to be positively correlated with daidzein content in the roots and shows a negative correlation with genistein. Among the three different strains of Rhizobium used, the strain ATCC 15834 caused a 35% increase in daidzein production by infection. In the case of genistein, maximum production （94%） was obtained when cultures were treated on Day 6 by the strains ATCC 15834 and KCTC 1541. The biosynthetic pathway of the two isoflavones apparently reacts differently to the same culture conditions and the same strains of Rhizobium. Therefore, the present data suggest that the production of daidzein and genistein could be modulated by changing the NH4^＋/NO3^- ratio and the application of Rhizobium.

关键词： Albizzia kalkora infection isoflavone nitrogen root culture

Reciprocal inhibition of expression between RAV1 and BES1 modulates plant growth and development in Arabidopsis

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Journal of Integrative Plant Biology 2023年第5期65卷 1226-1240页

作者： Dami Yang Hyun-young Shin Hyun Kyung Kang Yun Shang so young park Dong-Hoon Jeong Kyoung Hee Nam Department of Biological Sciences Sookmyung Women's UniversitySeoul 04310Republic of Korea Research Institute for Women's HealthSookmyung Women's UniversitySeoul 04310Republic of Korea Department of Life Science and Multidisciplinary Genome Institute Hallym UniversityChuncheon 24252Republic of Korea Present Address:Peking University Institute of Advanced Agricultural ScienceWeifang 261325China

RAV1(Related to ABI3/VP1)is a plant-specific B3 and AP2 domain-containing transcription factor that acts as a negative regulator of growth in many plant *** expression of RAV1 is downregulated by brassinosteroids(BRs);large-scale transcriptome analyses have shown that the expression of RAV1 was previously targeted by BRI1-EMS-SUPPREsoR1(BES1)and BRASSINAZOLE-RESISTANT1(BZR1),which are critical transcription factors for the BR-signaling *** RAV1-overexpressing transgenic plants,we showed that RAV1 overexpression reduced the BR signaling capacity,resulting in the downregulation of BR biosynthetic genes and BES1 ***,we demonstrated that BES1,not BZR1,is directly bound to the RAV1 promoter and repressed RAV1 expression,and vice versa;RAV1 is also bound to the BES1 promoter and repressed BES1 *** mutual inhibition was specific to RAV1 and BES1 because RAV1 exhibited binding activity to the BZR1 promoter but did not repress BZR1 *** observed that constitutively activated BR signaling phenotypes in bes1-D were attenuated by the repression of endogenous BES1 expression in transgenic bes1-D plants overexpressing ***-sequencing analysis of RAV1-overexpressing transgenic plants and bes1-D mutant plants revealed differentially expressed genes by RAV1 and BES1 and genes that were oppositely co-regulated by RAV1 and ***1 and BES1 regulated different transcriptomes but co-regulated a specific set of genes responsible for the balance between growth and *** results suggested that the mutual inhibitory transcriptional activities of RAV1 and BES1 provide fine regulatory mechanisms for plant growth and development.

关键词： BES1 growth modulation RAV1 transcriptional regulation

Lentinula edodes extract inhibits matrix metalloproteinase expression and increases typeⅠprocollagen expression via the p38 MAPK/c-Fos signaling pathway in ultraviolet A and B-irradiated HaCaT keratinocytes

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Asian Pacific Journal of Tropical Biomedicine 2021年第4期11卷 164-173页

作者： Jung Im Lee Jung Hwan Oh Fatih Karadeniz so young park Hye Ran Kim Hyun Jin Jo Kyung Im Jung Byung-Jin Jeon Chang-Suk Kong Marine Biotechnology Center for Pharmaceuticals and Foods Silla UniversityBusan 46958Korea Department of Food and Nutrition College of Medical and Life SciencesSilla UniversityBusan 46958Korea Ocean Fisheries and Bio Center Busan technoparkBusan 46048Korea

Objective:To determine the effect of Lentinula edodes extract on ultraviolet(UV)A and UVB-induced changes in matrix metalloproteinase(MMP)and type I procollagen expression using human immortalized HaCaT ***:Lentinula edodes ethanol extract(LEE)was obtained by extraction with 80%ethanol for 4 h at 80℃.Effect of LEE on UVinduced alteration on the expression and production of MMPs and type I procollagen in keratinocytes was investigated using ELISA,RT-PCR,and Western blotting *** determine the underlying mechanism of LEE-mediated effects,mitogen-activated protein kinase(MAPK)and activator protein 1 signaling pathways were analysed by Western blotting ***:LEE significantly inhibited the expression of MMP-1 and MMP-9 and increased the expression of type I procollagen in UVA and UVB-irradiated HaCaT *** phosphorylation levels of p38 were significantly inhibited by LEE whereas it did not affect c-Jun N-terminal kinase and extracellular signal-regulated kinase *** of p38 phosphorylation was also accompanied by downregulation of UVA and UVB-induced increase in ***:LEE effectively inhibits the expression of MMP-1 and MMP-9 and increases type I procollagen production through the p38 MAPK/c-Fos signaling pathway in UVA and UVB-irradiated HaCaT *** findings suggest that Lentinula edodes may be developed as a cosmetic material to suppress UV exposuremediated skin aging.

关键词： Lentinula edodes Ultraviolet Matrix metalloproteinases TypeⅠprocollagen Ha Ca T

Glucose-mediated mitochondrial reprogramming by cholesterol export at TM4SF5-enriched mitochondria-lysosome contact sites

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Cancer Communications 2024年第1期44卷 47-75页

作者： Ji Eon Kim so-young park Chulhwan Kwak Yoonji Lee Dae-Geun song Jae Woo Jung Haesong Lee Eun-Ae Shin Yangie Pinanga Kyung-hee Pyo Eun Hae Lee Wonsik Kim soyeon Kim Chang-Duck Jun Jeanho Yun Sun Choi Hyun-Woo Rhee Kwang-Hyeon Liu Jung Weon Lee Department of Pharmacy College of PharmacySeoul National UniversitySeoulRepublic of Korea Research Institute of Pharmaceutical Sciences College of PharmacySeoul National UniversitySeoulRepublic of Korea BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit College of Pharmacy and Research Institute of Pharmaceutical SciencesKyungpook National UniversityDaeguRepublic of Korea Department of Chemistry Seoul National UniversitySeoulRepublic of Korea College of Pharmacy Chung-Ang UniversitySeoulRepublic of Korea Natural Product Informatics Research Center Korea Institute of Science and Technology(KIST)Gangneung-siGangwon-doRepublic of Korea School of Life Sciences Gwangju Institute of Science and Technology(GIST)GwangjuRepublic of Korea Department of Biochemistry College of MedicineDong-A UniversityBusanRepublic of Korea Global AI Drug Discovery Center College of Pharmacy and Graduate School of Pharmaceutical SciencesEwha Womans UniversitySeoulRepublic of Korea Interdisciplinary Program in Genetic Engineering Seoul National UniversitySeoulRepublic of Korea

Background:Transmembrane 4 L six family member 5(TM4SF5)translocates subcellularly and functions metabolically,although it is unclear how intracellu-lar TM4SF5 translocation is linked to metabolic *** is thus of interests to understand how the traffic dynamics of TM4SF5 to subcellular endosomal membranes are correlated to regulatory roles of ***:Here,we explored the metabolic significance of TM4SF5 localization at mitochondria-lysosome contact sites(MLCSs),using in vitro cells and in vivo animal systems,via approaches by immunofluorescence,proximity labelling based proteomics analysis,organelle reconstitution ***:Upon extracellular glucose repletion following depletion,TM4SF5 became enriched at MLCSs via an interaction between mitochondrial FK506-binding protein 8(FKBP8)and lysosomal *** labeling showed molecular clustering of phospho-dynamic-related protein I(DRP1)and certain mitophagy receptors at TM4SF5-enriched MLCSs,leading to mitochondrial fis-sion and ***4SF5 bound NPC intracellular cholesterol transporter 1(NPC1)and free cholesterol,and mediated export of lysosomal cholesterol to mitochondria,leading to impaired oxidative phosphorylation but intact tri-carboxylic acid(TCA)cycle andβ-*** mouse models,hepatocyte Tm4sf5 promoted mitophagy and cholesterol transport to mitochondria,both with positive relations to liver ***:Our findings suggested that TM4SF5-enriched MLCSs regu-late glucose catabolism by facilitating cholesterol export for mitochondrial reprogramming,presumably while hepatocellular carcinogenesis,recapitulating aspects for hepatocellular carcinoma metabolism with mitochondrial repro-gramming to support biomolecule synthesis in addition to glycolytic energetics.

关键词： cholesterol fluorescent imaging glucose catabolism hepatocellular carcinogenesis mem-brane contact sites mitochondria function mitophagy oxidative phosphorylation protein-protein interaction tetraspanin

Context Awareness by Noise-Pattern Analysis of a Smart Factory

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Computers, Materials & Continua 2023年第8期76卷 1497-1514页

作者： so-Yeon Lee Jihoon park Dae-young Kim Department of software Convergence Soonchunhyang UniversityAsan31538Korea Department of Computer software Engineering Soonchunhyang UniversityAsan31538Korea

Recently,to build a smart factory,research has been conducted to perform fault diagnosis and defect detection based on vibration and noise signals generated when a mechanical system is driven using deep-learning technology,a field of artificial *** of the related studies apply various audio-feature extraction techniques to one-dimensional raw data to extract sound-specific features and then classify the sound by using the derived spectral image as a training ***,compared to numerical raw data,learning based on image data has the disadvantage that creating a training dataset is very ***,we devised a two-step data preprocessing method that efficiently detects machine anomalies in numerical raw *** the first preprocessing process,sound signal information is analyzed to extract features,and in the second preprocessing process,data filtering is performed by applying the proposed *** efficient dataset was built formodel learning through a total of two steps of data *** addition,both showed excellent performance in the training accuracy of the model that entered each dataset,but it can be seen that the time required to build the dataset was 203 s compared to 39 s,which is about 5.2 times than when building the image dataset.

关键词： Noise-pattern recognition context awareness deep learning fault detection smart factory

Electrochemically Deposited CZTSSe Thin Films for Monolithic Perovskite Tandem solar Cells with Efficiencies Over 17%

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Energy & Environmental Materials 2024年第1期7卷 147-152页

作者： Sun Kyung Hwang Ik Jae park Se Won Seo Jae Hyun park so Jeong park Jin young Kim Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Korea Department of Applied Physics Sookmyung Women's UniversitySeoul 04310Korea Research Institute of Advanced Materials and Systems Sookmyung Women's UniversitySeoul 04310Korea Research Institute of Advanced Materials(RIAM) Seoul National UniversitySeoul 08826Korea

In spite of the high potential economic feasibility of the tandem solar cells consisting of the halide perovskite and the kesterite Cu2ZnSn(S,Se)4(CZTSSe),they have rarely been demonstrated due to the difficulty in implementing solution-processed perovskite top cell on the rough surface of the bottom ***,we firstly demonstrate an efficient monolithic two-terminal perovskite/CZTSSe tandem solar cell by significantly reducing the surface roughness of the electrochemically deposited CZTSSe bottom *** surface roughness(R_(rms))of the CZTSSe thin film could be reduced from 424 to 86 nm by using the potentiostatic mode rather than using the conventional galvanostatic mode,which can be further reduced to 22 nm after the subsequent ion-milling *** perovskite top cell with a bandgap of 1.65 eV could be prepared using a solution process on the flattened CZTSSe bottom cell,resulting in the efficient perovskite/CZTSSe tandem solar *** the current matching between two subcells involving the thickness control of the perovskite layer,the best performing tandem device exhibited a high conversion efficiency of 17.5%without the hysteresis effect.

关键词： CZTSSe monolithic tandem solar cells perovskite solution process surface roughness control

Calcium-dependent proteasome activation is required for axonal neurofilament degradation

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Neural Regeneration Research 2013年第36期8卷 3401-3409页

作者： Joo Youn park so young Jang Yoon Kyung Shin Duk Joon Suh Hwan Tae park Department of Physiology Mitochondria Hub Regulation Center College of Medicine Dong-A University

Even though many studies have identified roles of proteasomes in axonal degeneration, the mo- lecular mechanisms by which axonal injury regulates proteasome activity are still unclear. In the present study, we found evidence indicating that extracellular calcium influx is an upstream regulator of proteasome activity during axonal degeneration in injured peripheral nerves. In degenerating axons, the increase in proteasome activity and the degradation of ubiquitinated proteins were sig- nificantly suppressed by extracellular calcium chelation. In addition, electron microscopic findings revealed selective inhibition of neurofilament degradation, but not microtubule depolymerization or mitochondrial swelling, by the inhibition of calpain and proteasomes. Taken together, our findings suggest that calcium increase and subsequent proteasome activation are an essential initiator of neurofilament degradation in Wallerian degeneration.

关键词： neural regeneration peripheral nerve injury neurofilament degradation sciatic nerve calcium calpain mitochondria microtubule depolymerization axon axon degeneration neuroregeneration

Distribution of dinoflagellate cysts in Yellow Sea sediments

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Acta Oceanologica Sinica 2013年第9期32卷 91-98页

作者： SHIN Hyeon Ho LIM Dhongil park soung-Yun HEO Seung KIM so-young Library of Marine Samples Korea Institute of Ocean Science and Technology West Sea Fisheries Research Institute National Fisheries Research&Development Institute Division of Polar Climate Research Korea Polar Research Institute

To investigate the distribution, abundance, and species composition of dinoflagellate cysts in the Yellow Sea, surface sediment samples were collected at 37 sites, including the Korean dump site. Twenty-one di- noflagellate cyst taxa were identified, with the assemblages dominated mainly by Spiniferites bulloideus, Operculodinium centrocarpum, and cyst of Alexandrium catenella/tarnarense type. A high frequency of O. centrocarpum in the Yellow Sea was observed for the first time, and it is likely that this can be attributed to the dynamics of the Yellow Sea Cold Water Mass and the Changjiang （Yangtze） River runoff. Total cyst concentrations ranged from 23 to 48 442 cysts/g dry weight, and high cyst concentrations were recorded adjacent to the dumping site. This result suggests that anthropogenic activities such as ocean dumping s- timulate the growth of dinoflagellates in the Yellow Sea, which in turn leads to high levels of dinoflagellate cyst production.

关键词： Yellow Sea dumping site dinoflagellate cyst Alexandrium catenella/tamarense type Operculo- dinium centrocarpum

Standard vs magnifying narrow-band imaging endoscopy for diagnosis of Helicobacter pylori infection and gastric precancerous conditions

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World Journal of Gastroenterology 2021年第18期27卷 2238-2250页

作者： Jun-Hyung Cho Seong Ran Jeon so-young Jin Suyeon park Digestive Disease Center Soonchunhyang University HospitalSeoul 04401South Korea Department of PathologySoonchunhyang University HospitalSeoul 04401South Korea Department of Pathology Soonchunhyang University HospitalSeoul 04401South Korea Department of Medical Biostatistics Soonchunhyang University HospitalSeoul 04401South Korea

BACKGROUND Advances in endoscopic imaging enable the identification of patients at high risk of gastric ***,there are no comparative data on the utility of standard and magnifying narrow-band imaging(M-NBI)endoscopy for diagnosing Helicobacter pylori(***)infection,gastric atrophy,and intestinal *** To compare the diagnostic performance of standard and M-NBI endoscopy for *** gastritis and precancerous *** In 254 patients,standard endoscopy findings were classified into mosaic-like appearance(type A),diffuse homogenous redness(type B),and irregular redness with groove(type C).Gastric mucosal patterns visualized by M-NBI were classified as regular round pits with polygonal sulci(type Z-1),more dilated and linear pits without sulci(type Z-2),and loss of gastric pits with coiled vessels(type Z-3).RESULTS The diagnostic accuracy of standard and M-NBI endoscopy for *** gastritis was 93.3%and 96.1%,*** gastric precancerous conditions,the accuracy of standard and M-NBI endoscopy was 72.0%vs 72.6%for moderate to severe atrophy,and 61.7%vs.61.1%for intestinal metaplasia in the corpus,*** to type A and Z-1,types B+C and Z-2+Z-3 were significantly associated with moderate to severe atrophy[odds ratio(OR)=5.56 and 8.67]and serum pepsinogen I/II ratio of≤3(OR=4.48 and 5.69).CONCLUSION Close observation of the gastric mucosa by standard and M-NBI endoscopy is useful for the diagnosis of *** gastritis and precancerous conditions.

关键词： Endoscopy Magnifying narrow-band imaging Helicobacter pylori Gastric atrophy Intestinal metaplasia Pepsinogen

Short-term interval combined chemoembolization and radiofrequency ablation for hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第35期20卷 12588-12594页

作者： Won Hyeok Choe young Jun Kim Hee Sun park Sang Woo park Jeong Han Kim so young Kwon Department of Internal Medicine Konkuk University School of Medicine Department of Radiology Konkuk University School of Medicine

AIM: To investigate hepatic function after combined transcatheter arterial chemoembolization (TACE) and radiofrequency ablation (RFA) with a short-term interval (0-2 d).

关键词： Child-Pugh score Liver cirrhosis Hepatocellular carcinoma Transcatheter arterial chemoembolization Radiofrequency ablation