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Imaging of the pediatric thymus:Clinicoradiologic approach

World Journal of Clinical Pediatrics 2017年第1期6卷 10-23页

作者： smita manchanda Ashu S Bhalla Manisha Jana Arun K Gupta Department of Radiodiagnosis All India Institute of Medical Sciences

The thymus is a lymphatic organ that undergoes dynamic changes with age and *** is important to be familiar with these physiological changes in the thymus gland to be able to identify pathology and make an accurate *** thymus may be involved in multisystem disorders or show focal isolated *** aim of this article is to review the radiological anatomy of the thymus,normal variants,and pathology including hyperplasia and benign/malignant lesions involving the thymus gland in the pediatric age *** also propose an algorithmic approach for imaging evaluation of a suspected thymic mass on the basis of morphologic features.

关键词： Thymus Pediatric Thymus hyperplasia Thymus neoplasms Mediastinum

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Characterization of tumors of jaw:Additive value of contrast enhancement and dual-energy computed tomography

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World Journal of Radiology 2024年第4期16卷 82-93页

作者： Deepak Justine Viswanathan Ashu Seith Bhalla smita manchanda Ajoy Roychoudhury Deepika Mishra Asit Ranjan Mridha Department of Radiodiagnosis and Interventional Radiology All India Institute of Medical SciencesNew Delhi 110029India Department of Oral and Maxillofacial Surgery All India Institute of Medical SciencesNew Delhi 110029India Department of Oral Pathology and Microbiology All India Institute of Medical SciencesNew Delhi 110029India Department of Pathology All India Institute of Medical SciencesAnsari NagarNew Delhi 110029India

BACKGROUND Currently,the differentiation of jaw tumors is mainly based on the lesion’s morphology rather than the enhancement characteristics,which are important in the differentiation of neoplasms across the *** is a paucity of literature on the enhancement characteristics of jaw *** is mainly because,even though computed tomography(CT)is used to evaluate these lesions,they are often imaged without intravenous *** study hypothesised that the enhancement characteristics of the solid component of jaw tumors can aid in the differentiation of these lesions in addition to their morphology by dual-energy CT,therefore improving the ability to differentiate between various *** To evaluate the role of contrast enhancement and dual-energy quantitative parameters in CT in the differentiation of jaw *** Fifty-seven patients with jaw tumors underwent contrast-enhanced dual-energy *** analysis of the tumor,including the enhancing solid component,was done,followed by quantitative analysis of iodine concentration(IC),water concentration(WC),HU,and normalized *** study population was divided into four subgroups based on histopathological analysis-central giant cell granuloma(CGCG),ameloblastoma,odontogenic keratocyst(OKC),and other jaw tumors.A one-way ANOVA test for parametric variables and the Kruskal-Wallis test for nonparametric variables were *** significant differences were found,a series of independent t-tests or Mann-Whitney U tests were *** Ameloblastoma was the most common pathology(n=20),followed by CGCG(n=11)and *** showed a higher mean concentration of all quantitative parameters than ameloblastomas(P<0.05).An IC threshold of 31.35×100μg/cm^(3) had the maximum sensitivity(81.8%)and specificity(65%).Between ameloblastomas and OKC,the former showed a higher mean concentration of all quantitative parameters(P<0.001),however when comparing unilocular ameloblastomas with OKCs,the latter showed

关键词： Jaw neoplasms Ameloblastomas Dual-energy computed tomography Iodine quantification Mandibular neoplasms Maxillary neoplasms

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Contrast-enhanced multidetector computed tomography features and histogram analysis can differentiate ameloblastomas from central giant cell granulomas

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World Journal of Radiology 2022年第9期14卷 329-341页

作者： Adarsh Ghosh Meyyappan Lakshmanan smita manchanda Ashu Seith Bhalla Prem Kumar Ongkila Bhutia Asit Ranjan Mridha Department of Radiology Children's Hospital of PhiladelphiaPhiladelphiaPA 19104United States Department of Radiology All India Institute of Medical SciencesNew Delhi 110029India Department of Radiodiagnosis All India Institute of Medical SciencesNew Delhi 110029India Department of Oral&Maxillofacial Surgery All India Institute of Medical SciencesNew Delhi 110029India Department of Pathology All India Institute of Medical SciencesAnsari NagarNew Delhi 110029India

BACKGROUND No qualitative or quantitative analysis of contrast-enhanced computed tomography(CT)images has been reported for the differentiation between ameloblastomas and central giant cell granulomas(CGCGs).AIM To describe differentiating multidetector CT(MDCT)features in CGCGs and ameloblastomas and to compare differences in enhancement of these lesions qualitatively and using histogram *** MDCT of CGCGs and ameloblastomas was retrospectively reviewed to evaluate qualitative imaging *** analysis was used to compare the extent of enhancement of the soft ***’s exact tests and Mann–Whitney U test were used for statistical analysis(P49.05 HU in the tumour providing 100%sensitivity and 85%specificity in identifying a *** A multilocular,lytic sclerotic lesion with significant hyperenhancement in soft tissue,which spares the angle of the mandible and has matrix mineralization,should indicate prospective diagnosis of CGCG.

关键词： Ameloblastoma Granuloma Giant cell Multidetector CT

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