检索结果-南通市图书馆

XPC Lys939Gln polymorphism, smoking and risk of sporadic colorectal cancer among Malaysians

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第23期19卷 3623-3628页

作者： Abdul Aziz Ahmad Aizat Mohd Shahpudin siti Nurfatimah Mustapha Mohd Aminudin Ravindran Ankathil Human Genome Centre School of Medical SciencesUniversiti Sains Malaysia Health Campus16150 Kubang Kerian Kelantan Malaysia

AIM: To investigate the risk association of xeroderma pigmentosum group C (XPC ) Lys939Gln polymorphism alone and in combination with cigarette smoking on colorectal cancer (CRC) predisposition. METHODS: Peripheral blood samples of 510 study subjects (255 CRC patients, 255 controls)were collected. DNA was extracted and genotyping was performed using polymerase chain reaction-restriction fragment length polymorphism. The association between polymorphic genotype and CRC predisposition was determined using the OR and 95%CI. RESULTS: The frequency of the homozygous variant (Gln/Gln) genotype was significantly higher in cases compared with controls (16.0% vs 10.2%, P = 0.049). The Gln/Gln genotype of XPC showed a significantly higher association with the risk of CRC (OR = 1.884; 95%CI: 1.082-3.277; P = 0.025). In the case of allele frequencies, variant allele C was associated with a significantly increased risk of CRC (OR = 1.375; 95%CI: 1.050-1.802; P = 0.020). Moreover, the risk was markedly higher for those who were carriers of the Gln/Gln variant genotype and were also cigarette smokers (OR = 3.409; 95%CI: 1.061-10.949; P = 0.032). CONCLUSION: The XPC Gln/Gln genotype alone and in combination with smoking increases the risk of CRC among Malaysians.

关键词： DNA repair Xeroderma pigmentosum group C Lys939Gln polymorphism Cigarette smoking Colorectal cancer Susceptibility risk

Virtual reality research and development in NTU

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Virtual Reality & Intelligent Hardware 2020年第5期2卷 394-408页

作者： Lihui HUANG siti Faatihah Binte Mohd TAIB Ryan Aung BA Zhe An GOH Mengshan XU Nanyang Technological University 639798Singapore

In 1981,Nanyang Technological Institute was established in Singapore to train engineers and accountants to keep up with the fast-growing economy of the *** 1991,the institute was upgraded to Nanyang Technological University(NTU).NTU holds the rank for world's top young university for six consecutive years according to the Quacquarelli Symonds(QS)world university *** Reality(VR)research began in NTU in the late ***'s colleges,schools,institutes,and centers have contributed toward the excellence of VR *** article briefly describes the VR research directions and activities in NTU.

关键词： Virtual reality Research and development Nanyang Technological University Singapore

Dual-specificity phosphatase 6(DUSP6): a review of its molecular characteristics and clinical relevance in cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Biology & Medicine 2018年第1期15卷 14-28页

作者： Muhammad Khairi Ahmad Nur Ainina Abdollah Nurul Husna Shafie Narazah Mohd Yusof siti Razila Abdul Razak Oncological and Radiological Sciences Cluster Advanced Medical and Dental Institute Universiti Sains Malaysia Department of Nutrition and Dietetics Faculty of Medicine and Health SciencesUniversiti Putra Malaysia Regenerative Medicine Cluster Advanced Medical and Dental Institute Universiti Sains Malaysia

Mitogen-activated protein kinases(MAPKs) are the main regulators of cellular proliferation, growth, and survival in physiological or pathological conditions. Aberrant MAPK signaling plays a pivotal role in carcinogenesis, which leads to development and progression of human cancer. Dual-specificity phosphatase 6(DUSP6), a member of the MAPK phosphatase family, interacts with specifically targeted extracellular signal-regulated kinase 1/2 via negative feedback regulation in the MAPK pathway of mammalian cells. This phosphatase functions in a dual manner, pro-oncogenic or tumor-suppressive, depending on the type of cancer. To date, the tumor-suppressive role of DUSP6 has been demonstrated in pancreatic cancer, non-small cell lung cancer, esophageal squamous cell and nasopharyngeal carcinoma, and ovarian cancer. Its pro-oncogenic role has been observed in human glioblastoma, thyroid carcinoma, breast cancer, and acute myeloid carcinoma. Both roles of DUSP6 have been documented in malignant melanoma depending on the histological subtype of the cancer. Loss-or gain-of-function effects of DUSP6 in these cancers highlights the significance of this phosphatase in carcinogenesis. Development of methods that use the DUSP6 gene as a therapeutic target for cancer treatment or as a prognostic factor for diagnosis and evaluation of cancer treatment outcome has great potential. This review focuses on molecular characteristics of the DUSP6 gene and its role in cancers in the purview of development, progression, and cancer treatment outcome.

关键词： Dual-specificity phosphatase 6 MAPK signaling cancer chemoresponsiveness chemoresistance

A Preliminary Genetic Investigation of Rastrelliger Kanagurta Based on Random Amplified Polymorphic DNA and Mitochondrial ND2 Gene

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

湿地科学 2008年第4期6卷 518-525页

作者： siti Azizah Mohd Nor Abu Talib A Mohd Ghows M A Samsudin B Aquaculture Research Group School of Biological Sciences University Sains Malaysia 11800 Minden Penang Malaysia Fisheries Research Institute 11900 Batu Maung Penang Malaysia

In a preliminary investigation, Random Amplified Polymorphic DNA (RAPD) analysis and partial mitochondrial ND2 gene sequencing were conducted to study the genetic variation of the Indian mackerel, Rastrelliger kanagurta along a 450 km stretch of its distribution on the west coast of Peninsular Malaysia. A total of 53 individuals from 6 populations were analyzed using 4 RAPD primers and a sub-sample of 15 individuals was chosen for sequencing of partial ND2 gene. Comparison between the 2 markers revealed genetic structuring in the RAPD results but genetic homogeneity for ND2 gene. Based on the former there may be at least 2 genetically differentiated groups of Rastrelliger kanagurta along this stretch.

关键词：基因 DNA分析分析方法生物技术水生生物

Antimicrobial activity and essential oils of Curcuma aeruginosa,Curcuma mangga,and Zingiber cassumunar from Malaysia

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2012年第3期5卷 202-209页

作者： Tg siti Amirah Tg Kamazeri Othman Abd Samah Muhammad Taher Deny Susanti Haitham Qaralleh Department of Biomedical Science Kulliyyah of ScienceInternational Islamic University MalaysiaJalan IstanaBandar Indera Mahkota25200 KuantanPahangMalaysia Kulliyyah of Pharmacy International Islamic University MalaysiaJalan IstanaBandar Indera Mahkota25200 KuantanPahangMalaysia

Objective:To analyze the chemical composition of the essential oils of Curcuma aeruginosa (***),Curcuma mangga(***),and Zingiber cassumunar(***). and study their antimicrobial ***:Essential oils obtained by steam distillation were analyzed by gas chromatography-mass speclrometry(GC-MS).The antimicrobial activity of the essential oils was evaluated against four bacteria:Bacillus cereus(***).Staphylococcus aureus(***).Escherichia coli(***).and Pseudomonas aeruginosa(***);and two fungi:Candida albicans(***) and Cyptococcus neoformans(***),using disc-diffusion and broth microdilution ***:Cycloisolongifolene,8.9-dehydro-9- formyl(35.29%) and dihydrocoslunolide(22.51%) were the major compounds in *** oil; whereas caryophyllene oxide(18.71%) and caryophyllene(12.69%) were the major compounds in *** oil:and 2,6.9,9-tetramethyl-2.6.10-cycloundecatrien-1-one(60.77%) andα-caryophyllene(23.92%) were abundant in *** *** essential oils displayed varying degrees of antimicrobial activity against all lested *** oil had the highest and most broad-spectrum activity by inhibiting all microorganisms tested,with *** being the most sensitive microorganism by having the lowest minimum inhibitory concentration(MIC) and minimum fungicidal concentration(MFC) values of 0.1μL/mL. *** oil showed mild antimicrobial activity,whereas *** had very low or weak activity against the tested ***:The preliminary results suggest promising antimicrobial properties of *** and ***,which may be useful for food preservation,pharmaceutical treatment and natural therapies.

关键词： Antimicrobial Gas chromatography-mass spectrometry Essential oil Curcuma aeruginosa Curcuma mangga Zingiber cassumunar

Efficacy and safety of latanoprost/timolol fixed combination dosed twice daily compared to once daily in patients with primary open angle glaucoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2023年第8期16卷 1243-1249页

作者： Anis Baidura Azal siti Husna Hussein Seng Fai Tang Othmaliza Othman Norshamsiah Md Din Department of Ophthalmology Faculty of MedicineUniversiti Kebangsaan Malaysia(UKM)Kuala Lumpur 56000Malaysia

AIM:To evaluate whether latanoprost/timolol fixed combination(LTFC)dosed twice daily may provide further intraocular pressure(IOP)reduction and evaluate the safety profile at this ***:This is an open-labeled,randomized,prospective crossover study on fourty primary open angle glaucoma *** weeks of washout period were followed by randomization to either once daily(OD,group A)or twice daily dosing(BD,group B)of LTFC for *** another 2-week washout period,the patients’treatment dose was crossed-over for another *** reduction alongside ocular and systemic side effects were ***:Mean baseline IOP was 18.57±2.93 and 17.8±3.01 mm Hg before OD and BD dose respectively,(P=0.27).Mean IOP after BD dose was statistically lower(12.49±1.59 mm Hg)compared to OD(13.48±1.81 mm Hg,P=0.017).Although IOP reduction after BD dose was more(5.32±3.24 mm Hg,29.89%)than after OD dosing(5.04 mm Hg,27.14%),it did not reach statistical significance(P=0.68).Patients switched from OD to BD(group A)showed mean IOP reduction by 0.69 mm Hg[95%confidence interval(CI):-0.09 to 1.48 mm Hg,P=0.078];but patients switched from BD to OD(group B)had significantly higher mean IOP by 1.25 mm Hg(95%CI:-2.04 to-0.46 mm Hg,P=0.006).BD dose had more ocular side effects albeit ***:Mean IOP after LTFC dosed twice daily is statistically lower,with additional mild side effects.

关键词： efficacy fixed combination latanoprost timolol primary open angle glaucoma safety

Estimating Loss Given Default Based on Beta Regression

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2021年第3期66卷 3329-3344页

作者： Jamil J.Jaber Noriszura Ismail siti Norafidah Mohd Ramli Baker Albadareen Nawaf N.Hamadneh Department of Risk Management and Insurance The University of JordanAqaba77111Jordan Universiti Kebangsaan Malaysia Department of Mathematical SciencesMalaysia Department of Basic Sciences College of Science and Theoretical StudiesSaudi Electronic UniversityRiyadh11673Saudi Arabia

Loss given default(LGD)is a key parameter in credit risk management to calculate the required regulatory minimum *** internal ratings-based(IRB)approach under the Basel II allows institutions to determine the loss given default(LGD)on their *** this study,we have estimated LGD for a credit portfolio data by using beta regression with precision parameter(∅)and mean parameter(μ).The credit portfolio data was obtained from a banking institution in Jordan;for the period of January 2010 untilDecember *** the first stage,we have used the“outstandingamount”and“amount of borrowing”to find LGD of each default borrower(494 out of 4393 borrower).In the second stage,we fit univariate parametric distributions to the LGD data to obtain the beta *** that,we have estimated the values of∅based on microeconomic variables(SPP,OE and LR).Moreover,we have estimated the values ofμbased on macroeconomic variables(GDP and Inflation rate).Finally,we have compared between six different link functions(Logit,loglog,probit,cloglog,cauchit,and log),which have used with∅andμ.The results show that Beta regression with probit link function has the highest R-squared with accepted measurements for logL,AIC and BIC.

关键词： Credit risk loss given default parametric distribution regression model

Development and characterization of food packaging bioplastic film from cocoa pod husk cellulose incorporated with sugarcane bagasse fibre

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Bioresources and Bioproducts 2020年第4期5卷 248-255页

作者： siti Nuurul Hud Mohammad Azmin Najah Aliah binti Mohd Hayat Mohd Shukri Mat Nor Faculty of Agro-Based Industry Universiti Malaysia Kelantan Jeli CampusLocked Bag 10017600 Jeli KelantanMalaysia Department of Research and Development Jeli Agricultural TechnologyPT7458 Kampung Gemang Baru17700 Ayer LanasJeli KelantanMalaysia

Agricultural wastes,including cocoa pod husk(waste from the chocolate industry)and sugarcane bagasse(waste from the sugar industry),are increasing day by *** development of food packaging biofilms from these two wastes could be beneficial to the environment and ***,this study was conducted to develop biodegradable plastic films by using cocoa pod husk and sugarcane *** and fibre were extracted from cocoa pod husk and sugar-cane bagasse,*** developed bioplastic films were divided into several concentration ratios of cellulose and fibre which are 100꞉0(100%cellulose),75꞉25(cellulose꞉fibre),50꞉50(cel-lulose꞉fibre),25꞉75(cellulose꞉fibre),and 0꞉100(100%fibre).The physicochemical properties for all bioplastic concentration ratios were determined in terms of sensory evaluation,drying time,moisture content,water absorption and water vapor *** the observation and anal-ysis of the physicochemical properties of bioplastic,we found that the most suitable bioplastic film for food packaging goes to the combination of 75%cellulose and 25%fibre bioplastic,as it demonstrated the lowest water absorption percentage and water vapor permeability.

关键词： Agricultural waste Cocoa pod husk Sugarcane bagasse Bioplastic film Water absorption Moisture content

Isolation of Kytococcus schroeteri from the brown rat Rattus norvegicus

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2021年第4期14卷 191-192页

作者： Shih Keng Loong Nurul Asma Anati Che-Mat-Seri Kim-Kee Tan Noor-Syahida Azizan siti Noraisah Ahmad-Nasrah siti Nursheena Mohd-Zain Sazaly AbuBakar Tropical Infectious Diseases Research&Education Centre High Impact Research BuildingUniversity of Malaya50603 Kuala LumpurMalaysia Department of Medical Microbiology Faculty of MedicineUniversity of Malaya50603 Kuala LumpurMalaysia Institute of Biological Sciences Faculty of ScienceUniversity of Malaya50603 Kuala LumpurMalaysia

Rodents such as Rattus rattus and Rattus norvegicus have adapted to living close to human settlements[1].This presents a public health challenge as these rodents are considered as pests that can transmit a number of zoonotic diseases to humans[1,2].A rodent surveillance programme was initiated between the years 2014 and 2015,focusing on rodents captured at wet markets where there is abundant food and considerable human *** present study was conducted in several wet markets in Kuala Terengganu,Malaysia(5.3333°N,103.1500°E).

关键词： Rattus initiated abundant