Survival analysis of cholangiocarcinoma:A 10-year experience in Malaysia

作     者：Ahmad Ramzi Yusoff Mohd Muzammil Abdul Razak Yoong Boon Koon R Vijeyasingam Siti Zuraidah Mahmud 

作者机构：Faculty of MedicineUniversiti Teknologi MARASg.Buloh Campus47000 Sg.BulohSelangorMalaysia Department of SurgeryUniversity Malaya Medical Centre59100 Kuala LumpurMalaysia Institute for Medical ResearchJalan Pahang50588 Kuala LumpurMalaysia 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2012年第18卷第5期

页      面：458-465页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Cholangiocarcinoma Bile duct tumor Sur-gery Malaysia 

摘      要：AIM:To investigate the clinical features and survival of patients treated for cholangiocarcinoma in our institution and to analyze the factors affecting their ***:This retrospective cohort study assessed patients diagnosed with cholangiocarcinoma between January 1997 and December 2007 at the University Malaya Medical Centre in *** clinical data and associated outcomes were collected using a structured ***:Of the 69 patients diagnosed with cholangiocarcinoma,38 (55%) were male;mean patient age was 61 *** patients (17%) had intrahepatic,38 (55%) had perihilar and 19 (28%) had distal *** 12 patients underwent curative surgery,including seven R0 *** one patient died within 30 d after *** overall median survival was 4 mo,whereas the median survival of R0 resected patients was 16 *** overall 1-,2-and 3-year cumulative survival rates were 67%,17% and 17%,*** rates were significantly associated with curative resection (P=0.002),intrahepatic tumor (P=0.003),negative margin status (P=0.013),early tumor stage (P=0.016),higher tumor differentiation (P=0.032) and absence of jaundice (P=0.038).Multivariate analysis showed that tumor location was a significant independent predictor of patient ***:Curative,margin-negative resection of early stage,well-differentiated intrahepatic tumors is associated with improved patient survival.