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Latent tuberculosis infection among medical students in Malaysia

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Asian Pacific Journal of Tropical Medicine 2019年第4期12卷 181-184页

作者： Maha abdullah Ummi Nadira Daut siti Aishah Daud nor Afifi Mohd Romli Marsitah Abdul Jalil Noorelina Muhammad Safarina Mohammad Ismuddin Masriana Hassan Department of Pathology Faculty of Medicine and Health Sciences Universiti Putra Malaysia

Objective: This study aimed to determine prevalence of latent tuberculosis infection among medical students and tuberculosis exposure at the health facilities. Methods: A cross-section of study year 1(n=68) and year 5(n=75) medical students in a local university were recruited for latent tuberculosis infection testing using QuantiFERON-TB Gold Plus and a questionnaire analyzed for multivariate risk. Results: The majority of the study were vaccinated with BCG. None of year 1 medical students were positive for latent tuberculosis infection, however, six(8.0%) year 5 students were tested positive for latent tuberculosis infection. A higher incidence of year 5 medical students claimed to be exposed to tuberculosis at health facility(65.3% vs. 4.4%) and a higher percentage reported contact with tuberculosis case over the preceding year compared to year 1 students(30.7% vs. 8.8%). Conclusion: We observed a higher incidence of latent tuberculosis infection and higher exposure to tuberculosis in health facilities among year 5 medical students. Baseline screening and monitoring for progression to tuberculosis infection may benefit tuberculosis management programs.

关键词： Latent tuberculosis infection Medical students Interferon-gamma release assay

A Preliminary Genetic Investigation of Rastrelliger Kanagurta Based on Random Amplified Polymorphic DNA and Mitochondrial ND2 Gene

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湿地科学 2008年第4期6卷 518-525页

作者： siti Azizah Mohd nor Abu Talib A Mohd Ghows M A Samsudin B Aquaculture Research Group School of Biological Sciences University Sains Malaysia 11800 Minden Penang Malaysia Fisheries Research Institute 11900 Batu Maung Penang Malaysia

In a preliminary investigation, Random Amplified Polymorphic DNA (RAPD) analysis and partial mitochondrial ND2 gene sequencing were conducted to study the genetic variation of the Indian mackerel, Rastrelliger kanagurta along a 450 km stretch of its distribution on the west coast of Peninsular Malaysia. A total of 53 individuals from 6 populations were analyzed using 4 RAPD primers and a sub-sample of 15 individuals was chosen for sequencing of partial ND2 gene. Comparison between the 2 markers revealed genetic structuring in the RAPD results but genetic homogeneity for ND2 gene. Based on the former there may be at least 2 genetically differentiated groups of Rastrelliger kanagurta along this stretch.

关键词：基因 DNA分析分析方法生物技术水生生物

Development and characterization of food packaging bioplastic film from cocoa pod husk cellulose incorporated with sugarcane bagasse fibre

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Journal of Bioresources and Bioproducts 2020年第4期5卷 248-255页

作者： siti Nuurul Hud Mohammad Azmin Najah Aliah binti Mohd Hayat Mohd Shukri Mat nor Faculty of Agro-Based Industry Universiti Malaysia Kelantan Jeli CampusLocked Bag 10017600 Jeli KelantanMalaysia Department of Research and Development Jeli Agricultural TechnologyPT7458 Kampung Gemang Baru17700 Ayer LanasJeli KelantanMalaysia

Agricultural wastes,including cocoa pod husk(waste from the chocolate industry)and sugarcane bagasse(waste from the sugar industry),are increasing day by *** development of food packaging biofilms from these two wastes could be beneficial to the environment and ***,this study was conducted to develop biodegradable plastic films by using cocoa pod husk and sugarcane *** and fibre were extracted from cocoa pod husk and sugar-cane bagasse,*** developed bioplastic films were divided into several concentration ratios of cellulose and fibre which are 100꞉0(100%cellulose),75꞉25(cellulose꞉fibre),50꞉50(cel-lulose꞉fibre),25꞉75(cellulose꞉fibre),and 0꞉100(100%fibre).The physicochemical properties for all bioplastic concentration ratios were determined in terms of sensory evaluation,drying time,moisture content,water absorption and water vapor *** the observation and anal-ysis of the physicochemical properties of bioplastic,we found that the most suitable bioplastic film for food packaging goes to the combination of 75%cellulose and 25%fibre bioplastic,as it demonstrated the lowest water absorption percentage and water vapor permeability.

关键词： Agricultural waste Cocoa pod husk Sugarcane bagasse Bioplastic film Water absorption Moisture content

mRNA transcriptome profiling of human hepatocellular carcinoma cells HepG2 treated with Catharanthus roseus-silver nanoparticles

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World Journal of Hepatology 2023年第3期15卷 393-409页

作者： Nur Asna Azhar siti Aishah Abu Bakar Marimuthu Citartan nor Hazwani Ahmad Department of Biomedical Science Advanced Medical and Dental InstituteUniversiti Sains MalaysiaKepala Batas 13200Pulau PinangMalaysia Liver Malignancies Research Program Advanced Medical and Dental InstituteUniversiti Sains MalaysiaKepala Batas 13200Pulau PinangMalaysia Faculty of Bioresources and Food Industry Universiti Sultan Zainal AbidinBesut CampusBesut 22200TerengganuMalaysia

BACKGROUND The demand for the development of cancer nanomedicine has increased due to its great therapeutic value that can overcome the limitations of conventional cancer ***,the presence of various bioactive compounds in crude plant extracts used for the synthesis of silver nanoparticles(AgNPs)makes its precise mechanisms of action *** To assessed the mRNA transcriptome profiling of human HepG2 cells exposed to Catharanthus roseus ***(***)-*** The proliferative activity of hepatocellular carcinoma(HepG2)and normal human liver(THLE3)cells treated with *** were measured using MTT *** RNA samples were extracted and sequenced using BGIseq500 *** is followed by data filtering,mapping,gene expression analysis,differentially expression genes analysis,Gene Ontology analysis,and pathway *** The mean IC 50 values of *** on HepG2 was 4.38±1.59μg/mL while on THLE3 cells was 800±1.55μg/*** profiling revealed an alteration of 296 *** induced the expression of stress-associated genes such as MT,HSP and *** signalling pathways were potentially activated through MAPK,TNF and TGF pathways that are responsible for apoptosis and cell cycle *** alteration of ARF6,EHD2,FGFR3,RhoA,EEA1,VPS28,VPS25,and TSG101 indicated the uptake of ***-AgNPs via both clathrin-dependent and clathrinindependent *** This study provides new insights into gene expression study of biosynthesised AgNPs on cancer *** cytotoxicity effect is mediated by the aberrant gene alteration,and more interestingly the unique selective antiproliferative properties indicate the *** as an ideal anticancer candidate.

关键词： Catharanthus roseus HepG2 Silver nanoparticles Transcriptome oxidative stress Apoptosis Cell cycle

Motivation in Information Searching Through ＂Mobile News＂ by Malaysian Youth

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Journalism and Mass Communication 2015年第6期5卷 263-269页

作者： akmar Hayati Ahmad Ghazali siti Zobidah Omar Universiti Putra Malaysia Serdang Selangor Malaysia

The rapid development of communication technology, have changed the landscape of information searching especially among youth. Youth are increasingly inclined to seek information using the new media such as mobile news. Nevertheless, the massive information flows have caused difficulties in finding quality, relevance and credibility of information. Hence, this study was undertaken to identify the problems encountered by the youth when searching for information through mobile news; to recognize the motivational factors in searching information through mobile news; and to find out the acceptance factor in searching information through mobile news. The underlying theory in this research is using Diffusion of Innovation Theory （DOI）. Employing a quantitative approach, a total of 400 respondents from higher learning institutes were selected to be the respondents of this study. The data were analyzed using Statistical Package for Social Science （SPSS） version 21.0. Results of the study show that the problems faced when seeking information through mobile news is information disorder. Further, motivational factors that encourage information seeking through mobile news by youth are related to advantage and observability. At the same time, seeking information through mobile news is accepted by the youth due to their perceived ease of use. In conclusion, it is hoped that the mobile news could be one of the leading learning medium among the youth in the future.

关键词： M-news information youth needs motives

Extraction and Characterization of Litopenaeus vannamei’s Shell as Potential Sources of Chitosan Biopolymers

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Journal of Renewable Materials 2023年第3期11卷 1181-1197页

作者： Che Engku noramalina Che Engku Chik Amyra Suryatie Kamaruzzan Ahmad Ideris Abdul Rahim Fathurrahman Lananan Azizah Endut siti Aslamyah nor Azman Kasan Higher Institution Centre of Excellence(HICoE) Institute of Tropical Aquaculture and Fisheries(AKUATROP)Universiti MalaysiaTerengganuMalaysia East Coast Environmental Research Institute(ESERI) Universiti Sultan Zainal Abidin(UniSZA)Terengganu Darul ImanMalaysia Faculty of Bioresources and Food Industry Universiti Sultan Zainal Abidin(UniSZA)Terengganu Darul ImanMalaysia Faculty of Innovative Design and Technology Universiti Sultan Zainal AbidinTerengganu Darul ImanMalaysia Faculty of Marine Science and Fisheries Hasanuddin UniversityMakassarIndonesia

Chitin is the second most abundant polysaccharide,produced mainly as an industrial waste stream during crustacean *** can be derived into chitosan through the deacetylation *** of shrimp waste into chitosan via the deacetylation process could be considered a practical approach for shell waste *** this study,chitosan’s physicochemical characteristics extracted from two types of Pacific white leg shrimp,***’s shell(i.e.,rough and smooth),were compared with commercial *** yield,moisture,ash,solubility,water and fat binding capacity were *** degree of deacetylation(DDA)was calculated using FTIR,and their chemical Structure was confirmed using XRD and *** extracted chitosan showed no significant difference in yield,moisture,ash,solubility and water binding capacity but showed a significant difference with commercial ***,the fat binding capacity of commercial chitosan showed the lowest percentage(408.34±0.83%)as compared to extracted chitosan(smooth shell 549.59±12.48%;rough shell 500.55±12.10%).The DDA indicated that extracted chitosan from the smooth and rough shell was considered good chitosan as compared to commercial chitosan with 84.08±1.27%,80.78±0.79%and 74.99±1.48%,***,the presence of hydroxyl and amino groups from FTIR and a good crystallinity index was recorded using XRD of extracted *** on observed characteristics,shrimp shell waste from *** can achieve chitosan standard quality as a biopolymer and highly potential to be applied in various industrial applications.

关键词： Chitin chitosan degree of deacetylation L.vannamei shrimp shell surface morphology

Association of vitamin D and magnesium with insulin sensitivity and their influence on glycemic control

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World Journal of Diabetes 2023年第1期14卷 26-34页

作者： Wan nor Fazila Hafizan Wan Nik Hani Ajrina Zulkeflee siti Nadirah Ab Rahim Tuan Salwani Tuan Ismail Department of Chemical Pathology School of Medical SciencesUniversiti Sains MalaysiaKota Bharu 16150KelantanMalaysia Faculty of Medicine and Health Sciences Universiti Sains Islam MalaysiaBandar Baru NilaiNilai 71800Negeri SembilanMalaysia Pathology Unit Faculty of Medicine and Defence HealthNational Defence University of MalaysiaKem Perdana Sungai Besi 57000Kuala LumpurMalaysia

Insulin resistance increases the risk of developing diabetes,and the degree of resistance influences the glycemic control of patients with *** researchers have focused on improving insulin sensitivity in order to prevent diabetes-related complications and other chronic *** studies have also linked vitamin D levels to insulin secretion and resistance,given that both vitamin D and its receptor complex play important roles in regulating pancreaticβ-*** has been suggested that vitamin D supplementation improves vitamin D levels,but further research is needed to confirm this as neither insulin function nor glycemic control improves when vitamin D levels *** is a cofactor for many *** the role of magnesium in the management of diabetes has long been evaluated,it has not yet been determined whether magnesium supplements improve insulin ***,several researchers have found that patients with good glycemic control have high magnesium *** is closely related to vitamin D and is necessary for the transport and activation of vitamin D in *** supplementation with vitamin D and magnesium improves glycemic control in patients with diabetes.

关键词： Vitamin D Magnesium Diabetes Insulin sensitivity Insulin resistance Glycemic control

Sedimentology of the Redang Island Coral Reefs Environment

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Journal of Chemistry and Chemical Engineering 2010年第2期4卷 41-47页

作者： nor Antonina Binti abdullah Noor Azhar Mohd Shazili norhayati binti Mohd . Tahir siti Zauyah binti Darus Marine Science Department Faculty of Maritime Studies and Marine Science University Malaysia Terengganu MengabangTelipot Kuala Terengganu 21030 Malaysia Institute of Oceanography Universiti Malaysia Terengganu Mengabang Telipot Kuala Terengganu 21030 Malaysia Research and Management Centre Universiti l~l＇alaysia Terengganu Mengabang Telipot Kuala Terengganu 21030 Malaysia Land Management Department Faculty of Agriculture Universi~ Putra Malaysia Serdang Selangor 41300 Malaysia

A study on the sedimentology of the Redang Island coral reefs environment was conducted. Sediments were collected on board UNIPERTAMA VII during the pre and post monsoon seasons. Twenty and seven sediments samples were collected using a Smith McIntyre grab on board UNI PERTAMA VII and put in labelled plastic bags then brought back to the laboratory for analysis. The sediments were analyzed for their sedimentological characteristics （mean size, skewness, standard deviation and kurtosis） using dry sieving method. Results showed that the highest mean size value of the sediments during the pre and post monsoons seasons are 2.14 ~ and 2.37 O. respectively and the lowest are -0.40 q~ and -0.10 ~, respectively. Based on the results, sediments can be classified as medium sand （34%）, poorly sorted （67%）, strongly negative skewed （36%） and extremely leptokurtic （56%） during the pre monsoon season, while during the post monsoon season sediments can be classified as medium sand （38%）, poorly sorted （73%）, strongly negative skewed （41%） and very leptokurtic （62%）. Results revealed that the sediments in the whole study area are relatively coarse. No relationship was observed between mean size and other sedimentological characteristics （R2= 0.05 pre-monsoon. R2 =0.0017 post monsoon） with seasons.

关键词： Sedimentology redang island coral reefs sediment.

Descriptive assessment on diabetic retinopathy screening in an awareness programme in Malaysia

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International Journal of Ophthalmology(English edition) 2020年第11期13卷 1808-1813页

作者： nor Fariza Ngah nor Asiah Muhamad Zalifa Zakiah Asnir Roslin Azni Abdul Aziz Zaidah Mhad Kassim siti Aishah Sahar nor Azita Ahmad Tarmidzi Chan Li Yen Rosmawati Uthman Narjis Satar Noor Zahirah Husain Azian Adnan John Mathen Kayalakakathu Bariyah Kadas Noor Suriani Mohamad Shaiful Azlan Kassirn Department of Ophthalmology Shah Alam HospitalSelangor 40000Malaysia Sector for Evidence Based Healthcare National Institutes of HealthMinistry of HealthSelangor 40170Malaysia Institute for Public Health National Institutes of HealthMinistry of HealthSelangor 40170Malaysia Department of Ophthalmology Ampang HospitalSelangor 68000Malaysia Department of Ophthalmology Serdang HospitalSelangor 43000Malaysia Department of Ophthalmology Putrajaya HospitalFederal Territory 62250Malaysia Department of Ophthalmology Kuala Lumpur HospitalFederal Territory 50586Malaysia Department of Ophthalmology Tengku Ampuan Rahimah HospitalSelangor 41200Malaysia Department of Ophthalmology Selayang HospitalSelangor 68100Malaysia Department of Ophthalmology Sungai Buloh HospitalSelangor 47000Malaysia Selangor State Health Department Ministry of HealthSelangor 40100Malaysia

AIM:To determine the prevalence of diabetic retinopathy(DR)among diabetic patients at the primary health clinics in Selangor,***:All diabetic patients were screened in Retinal Disease Awareness Programme(RDAP)and those who had significant DR changes were referred to the hospital for further *** analyses were done to determine the prevalence of DR and sociodemographic characteristics among patients with *** and multivariable analysis using Logistic regression were performed to find association and predictor factors in this ***:A total of 3305 patients aged 40y and above were screened for *** patients screened,9%patients were found to have DR and other visual complication such as maculopathy(0.9%),cataract(4.8%)and glaucoma(0.4%).The mean age of patients without retinopathy was 57.82±8.470y and the mean age of patients with DR was 63.93±*** 61.5%of the patients screened were aged below 60y and 38.5%were aged 60y and *** of the patients screened were women 58.5%and Malay in the age group of 50-59y,while 27%were aged *** association were found between age,sex,race,visual loss and ***:Although the prevalence of DR among patients is not alarming,effective interventions need to be implemented soon to avert a large burden of visual loss from DR.

关键词： diabetic retinopathy retinal disease awareness programme eye screening Selangor