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Piper sarmentosum as an antioxidant on oxidative stress in human umbilical vein endothelial cells induced by hydrogen peroxide

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第5期11卷 357-365页

作者： Abdul Hamid HAFIZAH Zakaria ZAITON Amom ZULKHAIRI Adenan mohd ILHAM Megat mohd nordin nor ANITA Abdullah Mahdy ZALEHA Department of Physiology Universiti Kebangsaan Malaysia Medical CentreJalan Raja Muda Aziz50300 Kuala LumpurMalaysia Department of Human Anatomy Division of PhysiologyFaculty of Medicine and Health SciencesUniversiti Putra Malaysia Forest Research Institute of Malaysia Department of Obstetrics and Gynecology Universiti Kebangsaan Malaysia Medical Centre

Endothelial cell death due to increased reactive oxygen species(ROS) may contribute to the initial endothelial injury,which promotes atherosclerotic lesion *** sarmentosum(PS),a natural product,has been shown to have an antioxidant property,which is hypothesized to inhibit production of ROS and prevent cell ***,the present study was designed to determine the effects of PS on the hydrogen peroxide(H2O2)-induced oxidative cell damage in cultured human umbilical vein endothelial cells(HUVECs).In this experiment,HUVECs were obtained by collagenase perfusion of the large vein in the umbilical cord and cultured in medium M200 supplemented with low serum growth supplementation(LSGS).HUVECs were treated with various concentrations of H2O2(0-1000 μmol/L) and it was observed that 180 μmol/L H2O2 reduced cell viability by 50% as denoted by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) *** the above concentration as the positive control,the H2O2-induced HUVECs were concomitantly treated with various concentrations(100,150,250 and 300 μg/ml) of three different extracts(aqueous,methanol and hexane) of ***(MDA),superoxide dismutase(SOD),catalase(CAT) and glutathione peroxidase(GPX) levels showed a significant increase(P<0.05) in HUVECs compared to the negative ***,PS extracts showed a protective effect on HUVECs from H2O2-induced cell apoptosis with a significant reduction in MDA,SOD,CAT and GPX levels(P<0.05).Furthermore,PS had exhibited ferric reducing antioxidant power with its high phenolic ***,it was concluded that PS plays a beneficial role in reducing oxidative stress in H2O2-induced HUVECs.

关键词： Piper sarmentosum Human umbilical vein endothelial cells(HUVECs) Malondialdehyde Oxidative stress Antioxidant enzymes

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Copper oxide nanoparticles-loaded zeolite and its characteristics and antibacterial activities

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Journal of Materials Science & Technology 2017年第8期33卷 889-896页

作者： Abdullah A.Alswat Mansor Bin Ahmad mohd Zobir Hussein nor Azowa Ibrahim Tawfik A.Saleh Department of Chemistry Faculty of ScienceUniversiti Putra MalaysiaSelangor 43400Malaysia Department of Chemistry Sana'a UniversityYemen Department of Chemistry King Fahcl University of Petroleum&MineralsDhahran 31261Saudi Arabia

In the present work, a simple and green co-precipitation method was used to prepare copper oxide-zeolite nanocomposites（CuO-zeolite NCs）. The weight ratio（1, 3, 5, 8 and 10 wt%） of CuO nanoparticles（NPs）loaded into zeolite was investigated to obtain the optimum CuO distribution for antibacterial *** prepared CuO-zeolite NCs were characterized by ultraviolet-visible（UV–vis） spectroscopy, Fourier transform infrared（FT-IR） spectroscopy, powder X-ray diffraction（XRD）, and energy dispersive X-ray fluorescence spectrometry（EDXRF）. The transmission electron microscopy（TEM） and field emission scanning electron microscopy（FE-SEM） revealed a uniform surface morphology of the CuO-zeolite *** UV–vis spectrum of NCs showed absorption peaks between 230 and 280 nm for nano-CuO in the XRD patterns, and new peaks appeared between（36.56？–38.83？） related to the CuO. At weight ratio less than 10 wt%, the CuO nanoparticles loaded to the zeolite exhibited spherical shapes with average particle diameter of 6.5 nm measured by TEM and XRD. Antibacterial activities were tested against Gram-negative and Gram-positive bacteria. The obtained results showed that, CuO-zeolite NCs with 8 wt% CuO nanoparticles had the highest antibacterial activities against Bacillus Subtilis B29 and Salmonella Choleraesuis ATCC10708, which can be attributed to the good dispersion of CuO NPs on the zeolite surface.

关键词： Copper oxide-zeolite Nanocomposites Antibacterial

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The flow behavior of powder stearin-based methyl ester sulfonates and the effect of glidant

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Particuology 2023年第9期80卷 148-156页

作者： Zulina Abd Maurad Luqman Chuah Abdullah mohd Shamsul Anuar nor Nadiah Abdul Karim Shah Zainab Idris Malaysian Palm Oil Board 6Persiaran InstitusiBandar Baru Bangi43000SelangorMalaysia Department of Chemical and Environmental Engineering Faculty of EngineeringUniversiti Putra MalaysiaSerdangSelangor43400Malaysia Department of Process and Food Technology Faculty of EngineeringUniversiti Putra MalaysiaSerdangSelangor43400Malaysia

The preparation and behavior of powder stearin-based methyl ester sulfonates(MES)with the addition of builder as a glidant agent was *** is an anionic surfactant and its performance is equivalent to petroleum-based linear alkylbenzene sulfonates(LAS),the workhorses of the detergent *** the same time,zeolites or soda ash were the alternative builders for non-phosphate-based *** behavior of powder MES properties was measured in terms of morphology,particle size,cohesion,caking,and *** that,these palm stearin-based MES of carbon chain 16–18 with ratios of 98:2,80:20,and 60:40 in flakes were ground using a high shear mixer by 23,000 rpm to produce powder *** the particle size of MES powder can reduce the powder's cohesion,caking,and *** addition of zeolite or soda ash as a glidant in powdered MES can improve the caking *** high stearic in MES greatly influenced getting fine particle powders and required more glidant *** powder MES with excellent powder characteristics can perform well as a bio-based cleaning product.

关键词： Methyl ester sulfonates Caking Compaction Cohesion Glidant

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Calf Posture Recognition Using Convolutional Neural Network

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Computers, Materials & Continua 2023年第1期74卷 1493-1508页

作者： Tan Chen Tung Uswah Khairuddin mohd Ibrahim Shapiai norhariani Md nor Mark Wen Han Hiew Nurul Aisyah mohd Suhaimie Malaysia-Japan International Institute of Technology Universiti Teknologi MalaysiaKuala Lumpur54100Malaysia Faculty of Veterinary Medicine Universiti Putra MalaysiaSelangor43400Malaysia Faculty of Bioresources and Food Industry Besut22200Malaysia

Dairy farm management is crucial to maintain the longevity of the farm,and poor dairy youngstock or calf management could lead to gradually deteriorating calf health,which often causes premature *** was found to be the most neglected part among the management workflows in Malaysia and has caused continuous loss over the recent *** posture recognition is one of the effective methods to monitor calf behaviour and health state,which can be achieved by monitoring the calf behaviours of standing and lying where the former depicts active calf,and the latter,passive *** posture recognition module is an important component of some automated calf monitoring systems,as the system requires the calf to be in a standing posture before proceeding to the next stage of monitoring,or at the very least,to monitor the activeness of the *** posture such as standing or resting can easily be distinguished by human eye,however,to be recognized by a machine,it will require more complicated frameworks,particularly one that involves a deep learning neural networks *** number of highquality images are required to train a deep learning model for such *** this paper,multiple ConvolutionalNeuralNetwork(CNN)architectures were compared,and the residual network(ResNet)model(specifically,ResNet-50)was ultimately chosen due to its simplicity,great performance,and decent inference *** ResNet-50 models having the exact same architecture and configuration have been trained on two different image datasets respectively sourced by separate cameras placed at different *** were two camera placements to use for comparison because camera placements can significantly impact the quality of the images,which is highly correlated to the deep learning model *** model training,the performance for both CNN models were 99.7%and 99.99%accuracies,respectively,and is adequate for a real-time calf monitoring system.

关键词： Calf posture machine vision deep learning transfer learning

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Generating Type 2 Trapezoidal Fuzzy Membership Function Using Genetic Tuning

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Computers, Materials & Continua 2022年第4期71卷 717-734页

作者： siti Hajar Khairuddin mohd Hilmi Hasan Emilia Akashah P.Akhir Manzoor Ahmed Hashmani Centre for Research in Data Science Department of Computer and Information SciencesUniversiti Teknologi PETRONASPerakMalaysia

Fuzzy inference system(FIS)is a process of fuzzy logic reasoning to produce the output based on fuzzified *** system starts with identifying input from data,applying the fuzziness to input using membership functions(MF),generating fuzzy rules for the fuzzy sets and obtaining the *** are several types of input MFs which can be introduced in FIS,commonly chosen based on the type of real data,sensitivity of certain rule implied and computational *** paper focuses on the construction of interval type 2(IT2)trapezoidal shape MF from fuzzy C Means(FCM)that is used for fuzzification process of mamdani *** the process,upper MF(UMF)and lower MF(LMF)of the MF need to be identified to get the range of the footprint of uncertainty(FOU).This paper proposes Genetic tuning process,which is a part of genetic algorithm(GA),to adjust parameters in order to improve the behavior of existing system,especially to enhance the accuracy of the system *** novel process is a hybrid approach which produces Genetic Fuzzy System(GFS)that helps to enhance fuzzy classification problems and *** approach provides a new method for the construction and tuning process of the IT2 MF,based on the FCM *** result is compared to Gaussian shape IT2 MF and trapezoid IT2 MF generated by the classic GA *** is shown that the proposed approach is able to outperform the mentioned benchmarked *** work implies a wider range of IT2 MF types,constructed based on FCM outcomes,and an optimum generation of the FOU so that it can be implemented in practical applications such as prediction,analytics and rule-based solutions.

关键词： Fuzzy inference system membership function genetic tuning lateral adjustment trapezoidal MF fuzzy C means

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Relapse typhoid fever in north-eastern state in Malaysia

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Asian Pacific Journal of Tropical Medicine 2010年第1期3卷 48-50页

作者： Zakuan Zainy Deris siti Suraiya Md Noor nor Hashimah Abdullah Abdul Rahman Noor Department of Medical Microbiology and Parasitology Universiti Sains MalaysiaKubang KerianKelantanMalaysia Kelantan State Department of Public Health Kota BharuKelantanMalaysia Department of Pharmacology School of Medical SciencesUniversiti Sains MalaysiaKubang KerianKelantanMalaysia

Objective:To discuss the prevalence,clinical and laboratory presentations of relapse typhoid ***:All relapse cases were reviewed to identify the clinical and laboratory presentation of the relapse typhoid ***:Two hundred and forty six patients were admitted to a teaching tertiary hospital in north-eastern state of Malaysia and fourteen(5.69%) relapse cases were *** duration of relapse after the patient was discharged was(25.0±9.9) *** patients presented with fever,diarrhoea,headache,abdominal pain and constipation. The duration of fever before admission in the initial episode[(8.6±4.2) d]was significantly longer than the relapse episode[(5.0±2.5) d](P=0.019).Four patients have hepatomegaly in initial episode and ten in relapse episode(P=0.852).The defervescence days of initial episodes was (3.2±2.2) d,comparing to relapse episode[(2.0±1.8) d]which was statistically not significant (P=0.124).Conclusion:Assumption of the relapse typhoid fever is milder comparing to original episodes based on observation and is not supported by statistical analysis.

关键词： Recurrence Typhoid fever Salmonella Typhi Malaysia

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Molecular epidemiology of piliated pneumococcal isolates at a major tertiary hospital in the Klang Valley,Malaysia

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Asian Pacific Journal of Tropical Medicine 2023年第2期16卷 80-88页

作者： Nurul Diana Dzaraly mohd Nasir mohd Desa AbdulRahman Muthanna siti norbaya Masri Niazlin mohd Taib Nurul Hana Zainal Baharin Nurshahira Sulaiman Nurul Asyikin Abdul Rahman Navindra Kumari Palanisamy Zarizal Suhaili Semiat Opeyemi Yusuff nor Iza A.Rahman Tuan Suhaila Tuan Soh Fatimah Haslina Abdullah Department of Biomedical Sciences Faculty of Medicine and Health SciencesUniversiti Putra MalaysiaUPM SerdangSelangorMalaysia Department of Medical Microbiology Faculty of Medicine and Health SciencesUniversiti Putra MalaysiaUPM SerdangSelangorMalaysia School of Biology Faculty of Applied SciencesUniversiti Teknologi MARA Negeri SembilanKuala Pilah BranchKuala PilahNegeri SembilanMalaysia Department of Medical Microbiology and Parasitology Faculty of MedicineUniversiti Teknologi MARASungai Buloh CampusJalan HospitalSungai BulohSelangorMalaysia School of Animal Science Aquatic Science and EnvironmentFaculty of Bioresources and Food IndustryUniversiti Sultan Zainal AbidinBesut CampusBesutTerengganuMalaysia Faculty of Medicine Universiti Sultan Zainal AbidinJalan Sultan MahmudKuala TerengganuTerengganuMalaysia Department of Pathology Sungai Buloh HospitalJalan HospitalSungai BulohSelangorMalaysia Department of Pathology Sultanah Nur Zahirah HospitalJalan Sultan MahmudKuala TerengganuTerengganuMalaysia

Objective:To characterise a collection of pili-carrying and none pili-carrying pneumococcal isolates of clinical origin for serotypes,antibiotic resistance and ***:In total,42 clinical isolates were collected between October 2017 and December *** isolates were analysed for antimicrobial susceptibility,serotype distribution,detection of pneumococcal virulence and pilus *** sequence typing was performed only for piliated isolates,followed by phylogenetic ***:The common isolation sites among the pneumococcal isolates were tracheal aspirate(28.6%),blood(26.2%),and sputum(23.8%).Fifty percent isolates were resistant to erythromycin,tetracycline(50.0%)and trimethoprim-sulfamethoxazole(43.0%).The most frequent were serotypes 19F(28.6%),6A/B(23.8%)and 19A(14.3%).Piliated isolates were detected in a small proportion(33.3%);64.3%were ***320 was the prevalent sequence type among the piliated isolates and genetically related to the Pneumococcal Molecular Epidemiology Network clones Taiwan19F-14(CC271).In the phylogenetic analysis,some piliated isolates showed a close association having similar ST320,carrying serotype 19A and both pilus genes indicating their clonal ***:Pneumococcal lineages of piliated isolates have been globally disseminated and pili could have played a role in the spread of antibiotic resistant clones.

关键词： Pneumococci Pili Genotype Malaysia

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A literature review on the improvement strategies of passive design for the roofing system of the modern house in a hot and humid climate region

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Frontiers of Architectural Research 2016年第1期5卷 126-133页

作者： O.airuniza Roslana siti Halipah Ibrahim Rohaida Affandi mohd Nasrun mohd Nawi Azhaili Baharun Faculty of Civil Engineering Universiti Malaysia Sarawak Sorawak 94300 Malaysia School of Technology Management and Logistics Universiti Utara Malaysia Kedah 06010 Malaysia

Increase of indoor temperature compared with outdoor temperature is a major concern in modern house design. Occupants suffer from this uncomfortable condition because of overheating indoor temperature. Poor passive design causes heat to be trapped, which influences the rise in indoor temperature. The upper part, which covers the area of the roof, is the most critical part of the house that is exposed to heat caused by high solar radiation and high emissivity levels. During daytime, the roof accumulates heat, which increases the indoor temperature and affects the comfort level of the occupants. To maintain the indoor temperature within the comfort level, most house designs usually depend on mechanical means by using fans or air conditioning systems. The dependence on a mechanical ventilation system could lead to additional costs for its installation, operation, and maintenance. Thus, this study concentrates on reviews on passive design and suggests recommendations for future developments. New proposals or strategies are proposed to improve the current passive design through ventilated and cool roof systems. It is possible to achieve the comfort level inside a house throughout the day by reducing the transmitted heat into the indoor environment and eliminating the internal hot air. These recommendations could become attractive strategies in providing a comfortable indoor temperature to the occupants as well as in minimizing energy consumption.

关键词： Heat transfer Thermal comfort Passive design Cool roof Ventilated roof

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Disseminated strongyloidiasis in an immunocompromised host:A case report

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Asian Pacific Journal of Tropical Biomedicine 2017年第6期7卷 587-590页

作者： Nurul Suhaiza Hassanudin Zubaidah Abdul Wahab Khalid Ibrahim Fadzilah mohd nor Microbiology Unit Department of PathologyHospital Sg.Buloh Director Office Hospital Sg.Buloh Microbiology Discipline Faculty of MedicineUniversiti Teknologi MARASg.Buloh CampusJalan Hospital Integrative Pharmacogenomics Institute (iPROMISE) Level 7FF3Universiti Teknologi MARAPuncak Alam Campus

Infections caused by Strongyloides stercoralis(***) in human are generally asymptomatic,however in immunocompromised individual,hyperinfection may develop with dissemination of larvae to extra-intestinal *** diagnosis could be easily missed due to asymptomatic presentation and insufficient exposure towards the infection itself,which may lead to low index of suspicion as a *** this report,a case of a Malaysian male with underlying diabetes mellitus,hypertension,cerebrovascular accident,bullous pemphigus and syndrome of inappropriate antidiuretic hormone secretion who initially complained of generalized body weakness and poor appetite without any history suggestive of sepsis is ***,he developed septicemic shock later,and *** larvae was incidentally found in the tracheal aspirate that was sent to look for acid fast *** of aggressive resuscitation,the patient succumbed due to pulmonary hemorrhage and acute respiratory distress *** was revealed that the current case has alarmed us via incidental finding of *** larvae in the tracheal aspirate,indicating that the importance of the disease should be emphasized in certain parts of the world and population respectively.

关键词： Disseminated strongyloidiasis Immunocompromised host Hyperinfection Strongyloides stercoralis

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Effect of intermetallic compounds on the fracture behavior of dissimilar friction stir welding joints of Mg and Al alloys

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International Journal of Minerals,Metallurgy and Materials 2019年第10期26卷 1285-1298页

作者： Amir Hossein Baghdadi Zainuddin Sajuri nor Fazilah Mohamad Selamat mohd Zaidi Omar Yukio Miyashita Amir Hossein Kokabi Centre for Materials Engineering and Smart Manufacturing Faculty of Engineering and Built EnvironmentUniversiti Kebangsaan Malaysia43600 UKM BangiSelangor 43600Malaysia Department of Mechanical Engineering Nagaoka University of TechnologyNagaoka940-2188Japan Department of Materials Science and Engineering Sharif University of TechnologyTehran 11365-11155Iran

Joining Mg to Al is challenging because of the deterioration of mechanical properties caused by the formation of intermetallic compounds(IMCs) at the Mg/Al interface. This study aims to improve the mechanical properties of welded samples by preventing the fracture location at the Mg/Al interface. Friction stir welding was performed to join Mg to Al at different rotational and travel speeds. The microstructure of the welded samples showed the IMCs layers containing Al12Mg17(γ) and Al3Mg2(β) at the welding zone with a thickness(< 3.5 μm). Mechanical properties were mainly affected by the thickness of the IMCs, which was governed by welding parameters. The highest tensile strength was obtained at 600 r/min and 40 mm/min with a welding efficiency of 80%. The specimens could fracture along the boundary at the thermo-mechanically affected zone in the Mg side of the welded joint.

关键词： aluminum alloy magnesium alloy intermetallic compounds dissimilar welded joint friction stir welding

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