Molecular epidemiology of piliated pneumococcal isolates at a major tertiary hospital in the Klang Valley,Malaysia

作     者：Nurul Diana Dzaraly Mohd Nasir Mohd Desa AbdulRahman Muthanna Siti Norbaya Masri Niazlin Mohd Taib Nurul Hana Zainal Baharin Nurshahira Sulaiman Nurul Asyikin Abdul Rahman Navindra Kumari Palanisamy Zarizal Suhaili Semiat Opeyemi Yusuff Nor Iza A.Rahman Tuan Suhaila Tuan Soh Fatimah Haslina Abdullah Nurul Diana Dzaraly;Mohd Nasir Mohd Desa;AbdulRahman Muthanna;Siti Norbaya Masri;Niazlin Mohd Taib;Nurul Hana Zainal Baharin;Nurshahira Sulaiman;Nurul Asyikin Abdul Rahman;Navindra Kumari Palanisamy;Zarizal Suhaili;Semiat Opeyemi Yusuff;Nor Iza A.Rahman;Tuan Suhaila Tuan Soh;Fatimah Haslina Abdullah

作者机构：Department of Biomedical SciencesFaculty of Medicine and Health SciencesUniversiti Putra MalaysiaUPM SerdangSelangorMalaysia Department of Medical MicrobiologyFaculty of Medicine and Health SciencesUniversiti Putra MalaysiaUPM SerdangSelangorMalaysia School of BiologyFaculty of Applied SciencesUniversiti Teknologi MARA Negeri SembilanKuala Pilah BranchKuala PilahNegeri SembilanMalaysia Department of Medical Microbiology and ParasitologyFaculty of MedicineUniversiti Teknologi MARASungai Buloh CampusJalan HospitalSungai BulohSelangorMalaysia School of Animal ScienceAquatic Science and EnvironmentFaculty of Bioresources and Food IndustryUniversiti Sultan Zainal AbidinBesut CampusBesutTerengganuMalaysia Faculty of MedicineUniversiti Sultan Zainal AbidinJalan Sultan MahmudKuala TerengganuTerengganuMalaysia Department of PathologySungai Buloh HospitalJalan HospitalSungai BulohSelangorMalaysia Department of PathologySultanah Nur Zahirah HospitalJalan Sultan MahmudKuala TerengganuTerengganuMalaysia 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志(英文版))

年 卷 期：2023年第16卷第2期

页      面：80-88页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：supported by Fundamental Research Grant Scheme(FRGS/1/2020/SKK0/UPM/02/10)of the Ministry of Higher Education Malaysia 

主　　题：Pneumococci Pili Genotype Malaysia 

摘      要：Objective:To characterise a collection of pili-carrying and none pili-carrying pneumococcal isolates of clinical origin for serotypes,antibiotic resistance and ***:In total,42 clinical isolates were collected between October 2017 and December *** isolates were analysed for antimicrobial susceptibility,serotype distribution,detection of pneumococcal virulence and pilus *** sequence typing was performed only for piliated isolates,followed by phylogenetic ***:The common isolation sites among the pneumococcal isolates were tracheal aspirate(28.6%),blood(26.2%),and sputum(23.8%).Fifty percent isolates were resistant to erythromycin,tetracycline(50.0%)and trimethoprim-sulfamethoxazole(43.0%).The most frequent were serotypes 19F(28.6%),6A/B(23.8%)and 19A(14.3%).Piliated isolates were detected in a small proportion(33.3%);64.3%were ***320 was the prevalent sequence type among the piliated isolates and genetically related to the Pneumococcal Molecular Epidemiology Network clones Taiwan19F-14(CC271).In the phylogenetic analysis,some piliated isolates showed a close association having similar ST320,carrying serotype 19A and both pilus genes indicating their clonal ***:Pneumococcal lineages of piliated isolates have been globally disseminated and pili could have played a role in the spread of antibiotic resistant clones.