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Neural Regeneration Research 2021年第12期16卷 2353-2358页

作者： Lidia Ciccone Susanna Nencetti simone Socci Elisabetta Orlandini Department of Pharmacy University of PisaPisaItaly Department of Earth Sciences University of PisaPisaItaly Research Center“E.Piaggio ”University of PisaPisaItaly

Neuroglobin(Ngb)is a 17 kDa monomeric hexa-coordinated heme protein belonging to the globin *** is mainly expressed in neurons of the central and peripheral nervous system,although moderate levels of Ngb have been detected in non-nervous *** the past decade,Ngb has been studied for its neuroprotective role in a large number of neurological disorders such as Alzheimer’s disease,Huntington’s disease,brain ischemia and *** review discusses and summarizes the natural compounds and the small synthetic molecules capable of modulating Ngb expression that exhibits a protective role against various neurodegenerative diseases.

关键词： Neuroglobin neuroglobin pharmacological induction neuroprotection neurodegenerative diseases natural compounds synthetic small molecules Alzheimer’s disease Huntington’s disease

Robustifying Dynamic Positioning of Crane Vessels for Heavy Lifting Operation

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IEEE/CAA Journal of Automatica Sinica 2021年第4期8卷 753-765页

作者： Jun Ye Spandan Roy Milinko Godjevac Vasso Reppa simone Baldi Department of Maritime and Transport Technology Delft University of TechnologyDelft 2628 CDThe Netherlands Robotics Research Center International Institute of Information Technology HyderabadHyderabad-500032India Future Proof Shipping Delft 3013 ALThe Netherlands School of Mathematics and School of Cyber Science and Engineering Southeast UniversityNanjing 210096China the Delft Center for System and Control Delft University of TechnologyDelft 2600 AA

Construction crane vessels make use of dynamic positioning(DP)systems during the installation and removal of offshore structures to maintain the vessel’s *** have reported cases of instability of DP systems during offshore operation caused by uncertainties,such as mooring ***"robustification"for heavy lift operations,i.e.,handling such uncertainties systematically and with stability guarantees,is a long-standing challenge in DP design.A new DP method,composed by an observer and a controller,is proposed to address this challenge,with stability guarantees in the presence of *** test the proposed method on an integrated cranevessel simulation environment,where the integration of several subsystems(winch dynamics,crane forces,thruster dynamics,fuel injection system etc.)allow a realistic validation under a wide set of uncertainties.

关键词： Construction crane vessels dynamic positioning system offshore robust control uncertainty

Parallel Molecular Dynamics with Irregular Domain Decomposition

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Communications in Computational Physics 2011年第9期10卷 1071-1088页

作者： Mauro Bisson Massimo Bernaschi simone Melchionna Department of Computer Science University of Rome"Sapienza"Italy Istituto Applicazioni Calcolo Consiglio Nazionale delle RicercheRomeItaly Institute of Material Sciences and Engineering ´Ecole Polytechnique F´ed´erale de LausanneSwitzerland CNR-IPCF Istituto Processi Chimico-FisiciConsiglio Nazionale delle RicercheRomeItaly

The spatial domain of Molecular Dynamics simulations is usually a regular box that can be easily divided in subdomains for parallel *** efforts aimed at simulating complex biological systems,like the blood flow inside arteries,require the execution of Parallel Molecular Dynamics(PMD)in vessels that have,by nature,an irregular *** those cases,the geometry of the domain becomes an additional input parameter that directly influences the outcome of the *** this paper we discuss the problems due to the parallelization of MD in complex geometries and show an efficient and general method to perform MD in irregular domains.

关键词： Molecular dynamics irregular domain decomposition parallel algorithms hemodynamics

Frailty in patients admitted to hospital for acute coronary syndrome: when, how and why?

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Journal of Geriatric Cardiology 2019年第2期16卷 129-137页

作者： Elisabetta Tonet Rita Pavasini simone Biscaglia Gianluca Campo Cardiovascular Institute Azienda Ospedaliero-Universitaria di FerraraConaItaly Maria Cecilia Hospital GVM Care&ResearchCotignolaItaly

Frailty is an issue of paramount importance for cardiologists,because of the aging of patients admitted to hospital for acute coronary syndrome(ACS)and the straight relationship between aging and *** tools have been provided in this setting,in order to objectively assess frailty status,but important questions are still *** are conflicting data about a unique definition of frailty in subjects with cardiovascular diseases,the timing to perform a frailty evaluation in the context of an acute myocardial infarction,the mean to assess frailty in these patients and the usefulness of the information derived from the frailty *** results from the analysis of several items and a multidomain evaluation including laboratory values,clinical data and physical performance assessment is required for a comprehensive frailty ***,regardless of the frailty tool,the prevalence of frailty in older ACS patients is high and it could add important information to the decision-making process about invasive strategy,the multivessel disease management,dual antiplatelet therapy and secondary prevention *** present overview tries to summarize the current knowledge about the definition and prevalence of frailty in older adults admitted to hospital for ACS,suggesting how frailty assessment may improve the management of older ACS patients.

关键词： Acute coronary syndrome Frailty The elderly

Gastrointestinal stromal tumors:Thirty years experience of an Institution

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World Journal of Gastroenterology 2011年第14期17卷 1836-1839页

作者： simone Arolfo Paolo Mello Teggia Mario Nano Department of Clinical and Biological Sciences San Luigi Gonzaga Teaching HospitalUniversity of Turin-Second School of MedicineReg. Gonzole 1010043 OrbassanoTurinItaly

AIM:To report our experience of gastrointestinal stromal tumors (GISTs) during the last 29 years. METHODS:Thirty two cases of GIST referred to our Institution from the 1st January 1981 to the 10th June 2010 were reviewed. Metastases,recurrence and survival data were collected in relation to age,history,clinical presentation,location,size,resection margins and cellular features. RESULTS:Mean age was 63.7 years (range,40-90) and incidence was slightly higher in males (56%). R0 resection was performed in 90.7% of cases,R1 in 6.2% (2 cases) and R2 in 3.1% (one case). Using Fletcher's classification 8/32 (25%) had high risk,9/32 (28%) intermediate and 15/32 (47%) low risk tumors. Follow-up varied from 1 mo to 29 years,with a median of 8 years; overall survival was 75% (24/32),disease-free survival was 72% and tumor-related mortality was 9.3%. Three patients with high risk GIST were treated with imatinib mesylate:one developed a recurrence after 36 mo,and 2 are free from disease at 41 mo. CONCLUSION:Surgical treatment remains the gold standard therapy for resectable GISTs. Pathological and biological features of the neoplasm represent the most important factors predicting the prognosis.

关键词： Gastrointestinal stromal tumors Fletcher’s classification Resection margins Recurrence

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对神的爱与不幸·续篇

上海文化 2024年第3期 97-106页

作者：西蒙娜·薇依张逸雯(译) 不详

《对神的爱与不幸》是薇依的名篇,收录于《在期待之中》。这里的“续篇”作为后来被发现的文稿,并不在《在期待之中》,而收录于全集中的《马赛文稿》一卷。薇依一贯质朴洗练的笔触下,续篇中思考的张力更为强烈。译者从日本的薇依的研究... 详细信息

《对神的爱与不幸》是薇依的名篇,收录于《在期待之中》。这里的“续篇”作为后来被发现的文稿,并不在《在期待之中》,而收录于全集中的《马赛文稿》一卷。薇依一贯质朴洗练的笔触下,续篇中思考的张力更为强烈。译者从日本的薇依的研究者今村纯子的译本译出。

关键词：文稿译出期待不幸

Insect-plant-pathogen interactions as shaped by future climate effects on biology, distribution, and implications for agriculture

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Insect Science 2017年第6期24卷 975-989页

作者： Piotr Trebicki Beatriz Dader simone Vassiliadis Alberto Fereres Biosciences Research Department of Economic Development Jobs Transport and Resources (DEDJTR) Horsham VIC Australia INRA UMR 385 BGPI (CIRAD-INRA-SupAgroM) Campus International de Baillarguet Montpellier France Biosciences Research DEDJTR La Trobe University AgriBio Centre 5 Ring Road Bundoora VIC Australia Institute of Agricultural Sciences-CSIC Madrid Spain

Carbon dioxide （CO2） is the main anthropogenic gas which has drastically increased since the industrial revolution, and current concentrations are projected to double by the end of this century. As a consequence, elevated CO2 is expected to alter the earths＇ climate, increase global temperatures and change weather patterns. This is likely to have both direct and indirect impacts on plants, insect pests, plant pathogens and their distribution, and is therefore problematic for the security of future food production. This review summarizes the latest findings and highlights current knowledge gaps regarding the influence of climate change on insect, plant and pathogen interactions with an emphasis on agriculture and food production. Direct effects of climate change, including increased CO2 concentration, temperature, patterns of rainfall and severe weather events that impact insects （namely vectors of plant pathogens） are discussed. Elevated CO2 and temperature, together with plant pathogen infection, can considerably change plant biochemistry and therefore plant defense responses. This can have substantial consequences on insect fecun- dity, feeding rates, survival, population size, and dispersal. Generally, changes in host plant quality due to elevated CO2 （e.g., carbon to nitrogen ratios in C3 plants） negatively affect insect pests. However, compensatory feeding, increased population size and distribution have also been reported for some agricultural insect pests. This underlines the importance of additional research on more targeted, individual insect-plant scenarios at specific locations to fully understand the impact of a changing climate on insect-plant-pathogen interactions.

关键词： carbon dioxide climate change food security pests trophic interactions

SIRENE: A Spatial Data Infrastructure to Enhance Communities' Resilience to Disaster-Related Emergency

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International Journal of Disaster Risk Science 2018年第1期9卷 129-142页

作者： simone Sterlacchini Gloria Bordogna Giacomo Cappellini Debora Voltolina Institute for the Dynamics of Environmental Processes –National Research Council of Italy (CNR-IDPA) Institute for Electromagnetic Sensing of the Environment –National Research Council of Italy (CNR-IREA)

Planning in advance to prepare for and respond to a natural hazard-induced disaster-related emergency is a key action that allows decision makers to mitigate unexpected impacts and potential damage. To further this aim, a collaborative, modular, and information and communications technology-based Spatial Data Infrastructure(SDI)called SIRENE—Sistema Informativo per la Preparazione e la Risposta alle Emergenze(Information System for Emergency Preparedness and Response) is designed and implemented to access and share, over the Internet, relevant multisource and distributed geospatial data to support decision makers in reducing disaster risks. SIRENE flexibly searches and retrieves strategic information from local and/or remote repositories to cope with different emergency phases. The system collects, queries, and analyzes geographic information provided voluntarily by observers directly in the field(volunteered geographic information(VGI) reports) to identify potentially critical environmental conditions. SIRENE can visualize and cross-validate institutional and research-based data against VGI reports,as well as provide disaster managers with a decision support system able to suggest the mode and timing of intervention, before and in the aftermath of different types of emergencies, on the basis of the available information and in agreement with the laws in force at the national andregional levels. Testing installations of SIRENE have been deployed in 18 hilly or mountain municipalities(12 located in the Italian Central Alps of northern Italy, and six in the Umbria region of central Italy), which have been affected by natural hazard-induced disasters over the past years(landslides, debris flows, floods, and wildfire) and experienced significant social and economic losses.

关键词： Data retrieval Decision support system Disaster management Italy Spatial data infrastructure Susceptibility/hazard and risk maps Volunteered geographic information

Quantum point defects in 2D materials-the QPOD database

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npj Computational Materials 2022年第1期8卷 532-547页

作者： Fabian Bertoldo Sajid Ali simone Manti Kristian S.Thygesen CAMD Computational Atomic-Scale Materials DesignDepartment of PhysicsTechnical University of Denmark2800Kgs.LyngbyDenmark

Atomically thin two-dimensional(2D)materials are ideal host systems for quantum defects as they offer easier characterisation,manipulation and read-out of defect states as compared to bulk *** we introduce the Quantum Point Defect(QPOD)database with more than 1900 defect systems comprising various charge states of 503 intrinsic point defects(vacancies and antisites)in 82 different 2D semiconductors and *** Atomic Simulation Recipes(ASR)workflow framework was used to perform density functional theory(DFT)calculations of defect formation energies,charge transition levels,Fermi level positions,equilibrium defect and carrier concentrations,transition dipole moments,hyperfine coupling,and zero-field *** states and photoluminescence spectra were calculated for selected high-spin *** this paper we describe the calculations and workflow behind the QPOD database,present an overview of its content,and discuss some general trends and correlations in the *** analyse the degree of defect tolerance as well as intrinsic dopability of the host materials and identify promising defects for quantum technological *** database is freely available and can be browsed via a web-app interlinked with the Computational 2D Materials Database(C2DB).

关键词： database Quantum point

Comparison the effects of bioaugmentation versus biostimulation on marine microbial community by PCR–DGGE： A mesocosm scale

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Journal of Environmental Sciences 2016年第5期28卷 136-146页

作者： Mehdi Hassanshahian Zeynab Bayat simone Cappello Francesco Smedile Michail Yakimov Department of Biology Faculty of Sciences Shahid Bahonar University of Kerman Kerman Iran Istituto per l'Ambiente Marino Costiero (IAMC)--CNR of Messina Messina Italy

In order to better understand the effects of biostimulation and bioaugmentation processes on a marine microbial community, three different mesocosm experiments were planned. Natural seawater（10.000 L） was artificially polluted with crude oil（1 L） and（1） inorganic nutrients（Biostimulating Mesocosm, BM）,（2） inorganic nutrients and an inoculum of Alcanivorax borkumensis SK2（Single Bioaugmentation Mesocosm, SBM）,（3） inorganic nutrients and inoculums of A. borkumensis SK2 and Thalassolituus oleivorans MIL-1（Consortium Bioaugmentation Mesocosm, CBM）. During the experimental period（20 days）, samples were taken from each mesocosm and the community structure was analyzed by PCR–DGGE. The 16 S r RNA gene DGGE banding patterns and sequence analysis demonstrated that biostimulation had the lowest effect on microbial biodiversity in the mesocosms; however, the biodiversity of the marine microbial community dramatically decreased in the CBM（Shannon index was 0.6 in T3）. The community structures among the three mesocosms were also markedly different,and major bacteria derived from DGGE bands were related to uncultured Gamma Proteobacteria. The biodegradation results show that the Single Bioaugmentation Mesocosm（SBM） system had the highest percentage of degradation（95%） in comparison to the BM mesocosm（80%） and CBM（70%）.

关键词： Alcanivorax Crude oil DGGE Marine environment Mesocosm