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Unveiling the nanotoxicological aspects of Se nanomaterials differing in size and morphology

Bioactive Materials 2023年第2期20卷 489-500页

作者： Hana Stepankova Hana Michalkova Zbynek Splichal Lukas Richtera Pavel Svec Tomas Vaculovic Jan Pribyl Martin Kormunda simona rex Vojtech Adam Zbynek Heger Department of Chemistry and Biochemistry Mendel University in BrnoZemedelska 1BrnoCZ-61300Czech Republic Central European Institute of Technology Brno University of TechnologyPurkynova 123BrnoCZ-61200Czech Republic Department of Chemistry Masaryk UniversityKamenice 5BrnoCZ-62500Czech Republic Institute of Laboratory Research on Geomaterials Faculty of Natural SciencesComenius University in BratislavaMlynska dolinaIlkovicova 684215 BratislavaSlovak Republic Central European Institute of Technology Masaryk UniversityKamenice 5BrnoCZ-62500Czech Republic Department of Physics Faculty of ScienceJ.E.Purkyne UniversityPasteurova 1Usti nad LabemCZ-40096Czech Republic

Although the general concept of nanotechnology relies on exploitation of size-dependent properties of nanoscaled materials,the relation between the size/morphology of nanoparticles with their biological activity remains not well ***,we aimed at investigating the biological activity of Se nanoparticles,one of the most promising candidates of nanomaterials for biomedicine,possessing the same crystal structure,but differing in morphology(nanorods *** particles)and aspect ratios(AR,11.5 vs.22.3 vs.1.0)in human cells and BALB/c ***,we report that in case of nanorod-shaped Se nanomaterials,AR is a critical factor describing their cytotoxicity and ***,spherical nanoparticles(AR 1.0)do not fit this statement and exhibit markedly higher cytotoxicity than lower-AR Se *** of cytotoxicity,we also show that morphology and size substantially affect the uptake and intracellular fate of Se *** line with in vitro data,in vivo *** of Se nanomaterials revealed the highest toxicity for higher-AR nanorods followed by spherical nanoparticles and lower-AR ***,we revealed that Se nanomaterials are able to alter intracellular redox homeostasis,and affect the acidic intracellular vesicles and cytoskeletal architecture in a size-and morphology-dependent *** the tested nanoparticles were produced from the similar sources,their behavior differs markedly,since each type is promising for several various application scenarios,and the presented testing protocol could serve as a concept standardizing the biological relevance of the size and morphology of the various types of nanomaterials and nanoparticles.

关键词： Aspect ratio Biocompatibility Nanotoxicology Nanorods

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Molecular and phenotypic characterization of human amniotic fluid cells and their differentiation potential

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Cell Research 2006年第4期16卷 329-336页

作者： Patrizia Bossolasco Tiziana Montemurro Lidia Cova Stefano Zangrossi Cinzia Calzarossa simona Buiatiotis Davide Soligo Silvano Bosari Vincenzo Silani Giorgio Lambertenghi Deliliers PaoloRebulla LorenzaLazzari Fondazione Matarelli 20121 Milanltaly Cell Factory Centro di Medicina TrasfusionaleTerapia Cellulare e CriobiologiaFondazione IRCCS Ospedale Maggiore PoliclinicoMangiagalli e Regina Elena20122 Milan Italy Dipartimento Cell Factor Centro di Medicina TrasfusionaleTerapia Cellulare e CriobiologiaFondazione IRCCS Ospedale Maggiore PoliclinicoMangiagalli e Regina Elena20122 Milan Italy Dipartimento di Anatomia Patologica Ospedale San Paolo20142 MilanItaly Ematologia

The main goal of the study was to identify a novel source of human multipotent cells,overcoming ethical issues in-volved in embryonic stem cell research and the limited availability of most adult stem *** fluid cells(AFCs)are routinely obtained for prenatal diagnosis and can be expanded in vitro;nevertheless current knowledge about theirorigin and properties is *** samples of AFCs were exposed in culture to adipogenic,osteogenic,neurogenicand myogenic *** was evaluated using immunocytochemistry,RT-PCR and Western ***,AFCs showed heterogeneous *** were negative for MyoD,Myf-5,MRF4,Myogenin andDesmin but positive for osteocalcin,PPARgamma2,GAP43,NSE,Nestin,MAP2,GFAP and beta tubulin Ⅲ by *** cells expressed Oct-4,rex-1 and Runx-1,which characterize the undifferentiated stem cell *** immunocyto-chemistry they expressed neural-glial proteins,mesenchymal and epithelial *** culture,AFCs differentiatedinto adipocytes and osteoblasts when the predominant cellular component was *** and late neuronal an-tigens were still present after 2 week culture in neural specific media even if no neuronal morphologies were *** results provide evidence that human amniotic fluid contains progenitor cells with multi-lineage potential showingstem and tissue-specific gene/protein presence for several lineages.

关键词： amniotic fluid cells adult stem cells mesenchymal stem cells cellular differentiation plasticity

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