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Building Simulation 2023年第12期16卷 2307-2331页

作者： simon Pommerencke Melgaard Ivan Titov Nikolaisson Chen Zhang Hicham Johra Olena Kalyanova Larsen department of the Built Environment Aalborg UniversityDenmarkThomas Manns Vej 239220 AalborgDenmark

dynamic simulation of a double-skin façade(dSF)with computational fluid dynamics(CFd)can be challenging due to the lack of validated models and benchmarking ***,there is a lack of consensus in the scientific community on what constitutes a successfully validated dSF *** present review study identifies simulation trends and research gaps for dSFs simulated with ***,this article presents a series of CFd simulations in which key aspects of the dSF modelling are varied:2d or 3d modelling approaches,turbulence viscosity models(TVMs),radiation models,and wall *** simulation results are compared to the empirical data(both temperature and velocity fields)of a benchmark test with laboratory-controlled boundary *** analysis shows that using the k-εRNG model with enhanced wall treatment and surface-to-surface(S2S)radiation model yields the best results for the 2d case of natural convection ***,it is shown that accounting for the velocity field in the validation process is essential to ensure the suitability of a ***,the authors advocate for the use of selected dimensionless numbers to improve the comparability of the different dSF scientific *** would also help to identify relevant experimental datasets for validation and suitable CFd simulation settings for specific dSF cases.

关键词： double-skin facade ventilated cavity computational fluid dynamics empirical validation modelling parameters dimensionless numbers convection

Association between genome-wide epigenetic and genetic alterations in breast cancer tissue and response to HER2-targeted therapies in HER2- positive breast cancer patients: new findings and a systematic review

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Cancer drug Resistance 2022年第4期5卷 995-1015页

作者： daniela Furrer dzevka dragic Sue-Ling Chang Frédéric Fournier Arnaud droit simon Jacob Caroline diorio Centre de Recherche sur le cancer de l’UniversitéLaval 1050 Avenue de la MédecineQuébecQC G1V 0A6Canada Axe Oncologie Centre de Recherche du CHU de Québec-UniversitéLavalQuébecQC G1S 4L8Canada département de médecine sociale et préventive Facultéde MédecineUniversitéLavalQuébecQC G1V 0A6Canada UniversitéParis-Saclay UVSQInsermCESP U1018Exposome and Heredity TeamGustave RoussyVillejuif 94807France département de médecine moléculaire Facultéde MédecineUniversitéLavalQuébecQC G1V 0A6Canada département de biologie moléculaire de biochimie médicale et de pathologieFacultéde MédecineUniversitéLavalQuébecQC G1V 0A6Canada Centre des Maladies du Sein Hôpital du Saint-SacrementQuébecQC G1S 4L8Canada

Recent evidence suggests that genetic and epigenetic mechanisms might be associated with acquired resistance to cancer *** aim of this study was to assess the association of genome-wide genetic and epigenetic alterations with the response to anti-HER2 agents in HER2-positive breast cancer *** was screened for articles published until March 2021 on observational studies investigating the association of genome-wide genetic and epigenetic alterations,measured in breast cancer tissues or blood,with the response to targeted treatment in HER2-positive breast cancer *** studies were included in the review along with ours,in which we compared the genome-wide dNA methylation pattern in breast tumor tissues of patients who acquired resistance to treatment (case group, n = 6) to that of patients who did not develop resistance (control group, n =6). Among genes identified as differentially methylated between the breast cancer tissue of cases and controls, oneof them, PRKACA, was also reported as differentially expressed in two studies included in the review. Althoughincluded studies were heterogeneous in terms of methodology and study population, our review suggests thatgenes of the PI3K pathway may play an important role in developing resistance to anti-HER2 agents in breastcancer patients. Genome-wide genetic and epigenetic alterations measured in breast cancer tissue or blood mightbe promising markers of resistance to anti-HER2 agents in HER2-positive breast cancer patients. Further studiesare needed to confirm these data.

关键词： Breast neoplasms epigenetics genetics HER2 inhibitors treatment response biomarkers

Searching novel complex solid solution electrocatalysts in unconventional element combinations

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Nano Research 2022年第6期15卷 4780-4784页

作者： Olga A.Krysiak simon Schumacher Alan Savan Wolfgang Schuhmann Alfred Ludwig Corina Andronescu Analytical Chemistry-Center for Electrochemical Sciences(CES) Faculty of Chemistry and BiochemistryRuhr University BochumUniversitätsstr.150D-44780 BochumGermany Chemical Technology Ⅲ Faculty of ChemistryCarl-Benz-Straße 199D-47057 DuisburgGermany CENIdE-Center for Nanointegration University duisburg Essen Carl-Benz-Straße 199D-47057 DuisburgGermany Chair for Materials discovery and Interfaces Institute for MaterialsFaculty of Mechanical EngineeringRuhr University BochumUniversitätsstr.150D-44780 BochumGermany ZGH Ruhr University BochumUniversitätsstr.150D-44780 BochumGermany

despite outstanding accomplishments in catalyst discovery,finding new,more efficient,environmentally neutral,and noble metalfree catalysts remains challenging and ***,complex solid solutions consisting of at least five different elements and often named as high-entropy alloys have emerged as a new class of electrocatalysts for a variety of *** multicomponent combinations of elements facilitate tuning of active sites and catalytic *** optimal catalyst composition remains difficult,making testing of a very high number of them *** present the high-throughput screening of the electrochemical activity of thin film material libraries prepared by combinatorial co-sputtering of metals which are commonly used in catalysis(Pd,Cu,Ni)combined with metals which are not commonly used in catalysis(Ti,Hf,Zr).Introducing unusual elements in the search space allows discovery of catalytic activity for hitherto unknown *** libraries with very similar composition spreads can show different activities *** trends for different *** order to address the inherent challenge of the huge combinatorial material space and the inability to predict active electrocatalyst compositions,we developed a high-throughput process based on co-sputtered material libraries,and performed high-throughput characterization using energy dispersive X-ray spectroscopy(EdS),scanning transmission electron microscopy(SEM),X-ray diffraction(XRd)and conductivity measurements followed by electrochemical screening by means of a scanning droplet *** results show surprising material compositions with increased activity for the oxygen reduction reaction and the hydrogen evolution *** data are important input data for future data-driven materials prediction.

关键词： high-entropy alloys electrocatalysis high-throughput screening thin films hydrogen evolution reaction oxygen reduction reaction

Sulforaphane as a Promising Natural Molecule for Cancer Prevention and Treatment

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Current Medical Science 2021年第2期41卷 250-269页

作者： Osama A.Elkashty simon d.Tran McGill Craniofacial Tissue Engineering and Stem Cells Laboratory Faculty of DentistryMcGill UniversityMontreal H3A 0G4Canada department of Oral Pathology Faculty of DentistryMansoura UniversityMansoura 35516Egypt

Tumorigenicity-inhibiting compounds have been identifled in our daily *** example,isothiocyanates(ITCs)found in cruciferous vegetables were reported to have potent cancer=prevention *** best characterized ITC is sulforaphane(SF).SF can simultaneously modulate multiple cellular targets involved in carcinogenesis,including(1)modulating carcinogen-metabolizing enzymes and blocking the action of mutagens;(2)inhibition of cell proliferation and induction of apoptosis;and(3)inhibition of neo-angiogenesis and *** targets cancer stem cells through modulation of nuclear factor kappa B(NF-κB),Sonic hedgehog(SHH),epithelial-mesenchymal transition,and Wnt/βcatenin *** chemotherapy/SF combination was tested in several studies and resulted in favorable *** its favorable toxicological profile,SF is a promising agent in cancer prevention and/or *** this article,we discuss the human metabolism of SF and its effects on cancer prevention,treatment,and targeting cancer stem cells,as well as providing a brief review of recent human clinical trials on SF.

关键词： sulforaphane isothiocyanates cancer chemoprevention antineoplastic agent

Catalysts for the hydrogen evolution reaction in alkaline medium:Configuring a cooperative mechanism at the Ag-Ag_(2)S-MoS_(2) interface

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Journal of Energy Chemistry 2022年第11期31卷 481-488,I0013页

作者： Avraham Bar-Hen simon Hettler Ashwin Ramasubramaniam Raul Arenal Ronen Bar-Ziv Maya Bar Sadan department of Chemistry Ben-Gurion University of the NegevBeer-Sheva 8410501Israel department of Chemistry Nuclear Research Center NegevP.O.Box 9001Beer-Sheva 84190Israel Laboratorio de Microscopías Avanzadas Universidad de Zaragoza50018 ZaragozaSpain Instituto de Nanociencia y Materiales de Aragon CSIC-U.de ZaragozaCalle Pedro Cerbuna 1250009 ZaragozaSpain department of Mechanical and Industrial Engineering University of MassachusettsAmherstMA 01003United States ARAId Foundation 50018 ZaragozaSpain

designing electrocatalysts for HER in alkaline conditions to overcome the sluggish kinetics associated with the additional water dissociation step is a recognized challenge in promoting the hydrogen *** this end,delicately tuning the atomic-scale structure and surface composition of nanoparticles is a common strategy and,specifically,making use of hybrid structures,can produce synergistic effects that lead to highly active ***,we present a core-shell catalyst of Ag@MoS_(2)that shows promising results towards the hydrogen evolution reaction(HER)in both 0.5 M H_(2)SO_(4)and 0.5 M *** this hybrid structure,the MoS_(2)shell is strained and defective,and charge transfer occurs between the conductive core and the shell,contributing to the electrocatalytic *** shelling process results in a large fraction of Ag_(2)S in the cores,and adjusting the relative fractions of Ag,Ag_(2)S,and MoS_(2)leads to improved catalytic activity and fast charge-transfer *** suggest that the enhancement of alkaline HER is associated with a cooperative effect of the interfaces,where the Ag(Ⅰ)sites in Ag_(2)S drive the water dissociation step,and the formed hydrogen subsequently recombines on the defective MoS_(2)*** study demonstrates the benefits of hybrid structures as functional nanomaterials and provides a scheme to activate MoS_(2)for HER in alkaline conditions.

关键词： Water splitting Core-shell Catalytic mechanism Electrocatalysis 2d materials

Optimal harvesting for a single-species population governed by Gompertz law:Influence of environmental fluctuation and limited harvesting capacity

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International Journal of Biomathematics 2019年第2期12卷 115-142页

作者： P.d.N.Srinivasu simon d.Zawka Sri Sathya Sai University for Human Excellence Navanihala Village Okali PostKamalapur Taluk Gulbarga DistrictKarnataka 585313India department of Mathematics Andhra University Visakhapatnam 530003India department of Mathematics Ar ba Minch University Arba MinchEthiopia

This work presents an optimal harvesting problem associated with a single-species population governed by Gompertz law in a seasonally fluctuating *** influence of environmental fluctuation is accommodated by choosing the coefficients in the differential equation to be periodic functions with the same period and restriction on the harvesting effort is accommodated by considering binding constraints on the control ***,a linear optimal control problem has been considered where the state dynamics is governed by Gompertz equation and the control variable is subject to the binding *** the help of maximum principle and the concept of blocked intervals,an optimal periodic solution has been obtained which is followed by the construe tion of optimal solution using the theory of most rapid *** results of the study are demonstrated through numerical simulations.

关键词： Optimal harvesting Gompertz equation seasonality binding constraint blocked intervals

dissolution of WO_(3) modified with IrO_(x) overlayers during photoelectrochemical water splitting

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SusMat 2023年第1期3卷 128-136页

作者： Ken J.Jenewein Julius Knopel AndréHofer Attila Kormányos Britta Mayerhofer Florian d.Speck Markus Bierling simon Thiele Julien Bachmann Serhiy Cherevko Helmholtz Institute Erlangen-Nürnberg for Renewable Energy(IEK-11) Forschungszentrum Jülich GmbHErlangenGermany department of Chemical and Biological Engineering Friedrich-Alexander-Universität Erlangen-NürnbergErlangenGermany Chemistry of Thin Film Materials Department of Chemistry and PharmacyFriedrich-Alexander-Universität Erlangen-NürnbergErlangenGermany department of Physical Chemistry and Materials Science Interdisciplinary Excellence CentreUniversity of SzegedSzegedHungary

WO_(3),an abundant transition metal semiconductor,is one of the most discussed materials to be used as a photoanode in photoelectrochemical water-splitting *** photoelectrochemical properties,such as photoactivity and selectivity of WO_(3) in different electrolytes,are already well ***,the understanding of stability,one of the most important properties for utilization in a commercial device,is still in the early *** this work,a photoelectrochemical scanning flow cell coupled to an inductively coupled plasma mass spectrometer is applied to determine the influence of co-catalyst overlayers on photoanode ***-coatedWO_(3) photoanodes are used as a model *** is applied to the electrodes by atomic layer deposition in controlled layer thickness,as determined by ellipsometry and x-ray photoelectron *** of the iridium-modified WO_(3) photoanodes decreases with increasing iridium layer *** blocking of the WO_(3) surface by iridium is proposed as the main cause of the decreased photoelectrochemical *** the other hand,the stability of WO_(3) is notably increased even in the presence of the thinnest investigated iridium *** on our findings,we provide a set of strategies to synthesize nanocomposite photoelectrodes simultaneously possessing high photoelectrochemical activity and photostability.

关键词： dissolution in situ ICP-MS overlayers PEC-SFC photoelectrochemistry

Modified shear cell for characterization of the rheological behavior of particulate networks under compression

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Particuology 2020年第4期18卷 1-9页

作者： simon Hammerich Anthony d.Stickland Benjamin Radel Marco Gleiss Hermann Nirschl Institute of Mechanical Process Engineering and Mechanics Karlsruhe Institute for Technology(KIT)Strasse am Forum 876131 KarlsruheGermany Particulate Fluids Processing Centre Department of Chemical EngineeringThe University of Melbourne3010Australia

Knowledge of the rheological behavior of saturated particulate networks is crucial for every process in which a particulate network is built-up,dewatered,or transported,as in a decanter ***,difficulties arise as to how to characterize the material *** far,no standardized method or measurement device has *** this work,the requirements for a useful device are discussed,followed by the design of a modified shear cell for a Schulze ring shear tester *** and its measurement *** experiments under normal load with different sediments consisting of inorganic and organic particles whose material properties strongly affect the rheological behavior were *** results demonstrate the potential of the modified shear ***,current challenges in characterization are *** characterization possibilities of the developed shear cell are a further step toward understanding the theological behavior of liquid-saturated particulate networks.

关键词： Sediment rheology Saturated particulate network Shear cell Shear compression Rheological behavior

Collembola communities and soil conditions in forest plantations established in an intensively managed agricultural area

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Journal of Forestry Research 2021年第5期32卷 1819-1832页

作者： István Harta Barbara simon Szergej Vinogradov dániel Winkler Institute of Environmental Science Szent István UniversityGödöllőHungary Institute of Methodology Szent István UniversityGödöllőHungary Institute of Wildlife Management and Vertebrate Zoology University of SopronSopronHungary

The challenges of a changing climate have directed greater attention to afforestation,but the effects of afforestation on soil fertility and soil biota have not been fully *** explore changes in the soil conditions in two 20-year-old forest plantations established in formerly intensively fertilized plots of agricultural land,we focused on the current developmental state of the sites that received the most fertilizer and evaluated soil properties and Collembola(springtails)*** oak(Quercus petraea)and black locust(Robinia pseudoacacia)that had been planted in the afforestation sites were assessed for differences between plantations of native and invasive *** adjacent reference associations,including forests and open habitats,were also analyzed and *** showed that the soils in the two afforested sites were similar in their properties and Collembola communities to those of the control cultivated forests,but differed from each other in pH,calcium,phosphorus,and ammonium *** available potassium and phosphorus contents in the soil of the sessile oak plantation were still high,while the soil organic matter content was adequate(SOM>2.0%)in both *** richness of Collembola ranged from 18 in the cultivated arable land to 43 in the relict *** a few species typical for forests(e.g.,Neanura muscorum,Isotomiella minor,Entomobrya muscorum)were detected in the young plantations,while species characteristic of open habitats(e.g.,Protaphorura campata,Lepidocyrtus cyaneus)occurred as *** more individuals and species of Collembola were present in the soil of young plantations than in arable fields,their community diversities were significantly lower compared to the control forest *** community diversity differed significantly also between the two plantation types(with native and non-native tree species).Mean abundance in the afforested sites was about 2.5 times higher than in the cultiv

关键词： Afforestation diversity Fertilizers Soil fauna Soil properties Springtails

Nest predators, nest-site selection and nest success of the Emei Shan Liocichla(Liocichla omeiensis), a vulnerable babbler endemic to southwestern China

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Chinese Birds 2016年第3期7卷 161-166页

作者： Yiqiang Fu Benping Chen simon d.dowell Zhengwang Zhang Sichuan Institute Key Laboratory for Protecting Endangered Birds in the Southwest Mountains College of Life Sciences Leshan Normal University Laojunshan National Nature Reserve Administration North of England Zoological Society Chester Zoo Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering College of Life Sciences Beijing Normal University

Background: The Emei Shan Liocichla(Liocichla omeiensis) is a globally vulnerable babbler, endemic to southwestern China. We investigated its nest predators, nest-site selection and nest success at the Laojunshan National Nature Reserve in Sichuan, China in order to identify the precise nesting-habitat requirements of the species, and to test whether the nest-site-selection cues, preferred by the Emei Shan Liocichla, are positively associated with nest ***: We used infrared cameras to determine nest predators. We compared the microhabitat attributes between nest and random sites, as well as successful and failed nests. We used Binary Logistic Regression to determine the most important variables affecting nest-site selection of the Emei Shan Liocichla. We used the nest survival analysis in Program MARK to estimate daily nest survival rates(dSR). Nest success was calculated using the Mayfield ***: In total 56 nests were found. The dSR for all nests that contained at least one egg was 0.9564 ± 0.0091(95 % CI 0.9346–0.9711)(n = 40), while the total nest success was 27.5 %. We identified four categories of predators in 10 nest predation events, i.e. squirrels(n = 5), snakes(n = 3), raptors(n = 1) and wasps(n = 1). We found that:(1) nest predation was the primary reason for nest failure of the Emei Shan Liocichla,(2) tree cover, bamboo cover, liana abundance and distance to forest edge or gap were the most important variables affecting nest-site selection of this species, and(3) the nest-site-selection variables we measured appeared not to be positively associated with nest ***: Our findings suggest that the Emei Shan Liocichla tended to select nest sites near forest edges or gaps with good concealment and that nest-site selection by this species was nonrandom but not necessarily adaptive. Reducing forest-edge development and protecting bamboo stands should be effective for conservation of this species.

关键词： Nest predator Nest-site selection Nest success Liocichla omeiensis Laojunshan Nature Reserve