Sulforaphane as a Promising Natural Molecule for Cancer Prevention and Treatment
作者机构：McGill Craniofacial Tissue Engineering and Stem Cells LaboratoryFaculty of DentistryMcGill UniversityMontreal H3A 0G4Canada Department of Oral PathologyFaculty of DentistryMansoura UniversityMansoura 35516Egypt
出 版 物：《Current Medical Science》 (当代医学科学（英文）)
年 卷 期：2021年第41卷第2期
页 面：250-269页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：sulforaphane isothiocyanates cancer chemoprevention antineoplastic agent
摘 要：Tumorigenicity-inhibiting compounds have been identifled in our daily *** example,isothiocyanates(ITCs)found in cruciferous vegetables were reported to have potent cancer=prevention *** best characterized ITC is sulforaphane(SF).SF can simultaneously modulate multiple cellular targets involved in carcinogenesis,including(1)modulating carcinogen-metabolizing enzymes and blocking the action of mutagens;(2)inhibition of cell proliferation and induction of apoptosis;and(3)inhibition of neo-angiogenesis and *** targets cancer stem cells through modulation of nuclear factor kappa B(NF-κB),Sonic hedgehog(SHH),epithelial-mesenchymal transition,and Wnt/βcatenin *** chemotherapy/SF combination was tested in several studies and resulted in favorable *** its favorable toxicological profile,SF is a promising agent in cancer prevention and/or *** this article,we discuss the human metabolism of SF and its effects on cancer prevention,treatment,and targeting cancer stem cells,as well as providing a brief review of recent human clinical trials on SF.
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