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Application of ultrasonography-elastography score to suspect porto-sinusoidal vascular disease in patients with portal vein thrombosis

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Hepatobiliary & Pancreatic diseases International 2024年第1期23卷 20-24页

作者： Stefania Gioia Adriano De Santis Giulia d’Amati silvia Nardelli Alessandra Spagnoli Arianna di Rocco Lorenzo Ridola Oliviero Riggio Department of Translational and Precision Medicine Sapienza University of RomeRomeItaly Department of Radiological Oncologicaland Pathological SciencesSapienza University of RomeRomeItaly Department of Public Health and Infectious diseases Sapienza University of RomeRomeItaly

Background:Porto-sinusoidal vascular disease(PSVD)and portal vein thrombosis(PVT)are causes of portal hypertension characterized respectively by an intrahepatic and a pre-hepatic obstacle to the flow in the portal *** PVT may be a consequence of PSVD,in PVT patients at presentation,a pre-existing PSVD should be *** these patients the identification of an underlying PSVD would have relevant implication regarding follow-up and therapeutic management,but it could be *** this setting ultrasonography may be valuable in differential *** aim of the study was to use ultrasonography to identify parameters to discriminate between PSVD and“pure”PVT and then to suspect PVT secondary to a pre-existing ***:Fifty-three patients with histologically proven PSVD and forty-eight patients affected by chronic PVT were enrolled and submitted to abdominal ultrasonography with elastography by acoustic radiation force impulse(ARFI).Results:ARFI was higher and superior mesenteric vein(SMV)diameter was wider in PSVD patients than in PVT ***,a prognostic score was obtained as linear combinations of the two parameters with a good discrimination capacity between PSVD and PVT(the area under the curve=0.780;95%confidence interval:0.690-0.869).Conclusions:A score based on ARFI and SMV diameter may be useful to suspect an underlying PSVD in patients with PVT and to identify a subgroup of patients to be submitted to liver biopsy.

关键词： Non-cirrhotic portal hypertension Porto-sinusoidal vascular disease Chronic portal vein thrombosis Liver stiffness Portal hypertension Acoustic radiation force impulse

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急性脑卒中患者溶栓治疗后神经功能无改善：预测指标及其与预后的关系

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美国医学会杂志（中文版） 2005年第5期24卷 271-276页

作者： Gustavo Saposnik Bryan Young Brian Silver silvia di legge Fiona Webster Vadim Beletsky Vivek Jain 孙伟平（译）黄一宁（校） Stroke Program Department of Clinical Neurological Sciences London Health Sciences Centre University of Western Ontario London Department of Neurology Henry Ford Hospital Detroit Mich 不详

背景：急性脑卒中溶栓治疗关注的焦点为3个月时神经功能的改善。很少研究分析24小时结局。早期准确预测不良预后可以影响临床治疗和出院计划。目的：评价重组人组织型纤溶酶原激活物（rt—PA）治疗后24小时神经功能无改善的预测指标及其... 详细信息

背景：急性脑卒中溶栓治疗关注的焦点为3个月时神经功能的改善。很少研究分析24小时结局。早期准确预测不良预后可以影响临床治疗和出院计划。目的：评价重组人组织型纤溶酶原激活物（rt—PA）治疗后24小时神经功能无改善的预测指标及其与3个月时不良预后的关系。设计、地点和参试者：对一所大学医院1999年1月至2003年3月连续收治的接受rt—PA治疗的急性脑卒中患者进行前瞻性队列研究。参试者来源于安大略省一个主要城市的2个学术中心和7个县的33家附属医院。主要观察指标：神经功能无改善定义为在24小时时国立卫生研究院卒中量表评分较基线水平改善≤3分。3个月时不良预后定义为改良Rankin量表评分3～5分或死亡。结果：216例接受rt—PA治疗的急性卒中患者中，111例（51．4％）在发病24小时神经功能无改善。在校正年龄、性别和卒中严重程度因素后，人院时基线血糖水平（血糖〉144mg／dL[8mmol／L]的优势比[OR]，2．89；95％CI，1．40～5．99）、皮层受累（OR，2．66；95％CI，1．36～5．20）以及治疗开始时间（治疗每延迟1分钟的OR，1．01；95％CI，1．0～1．02）是24小时神经功能无改善的独立预测指标。3个月时，43例患者（20．2％）死亡；在170例幸存者中，75例患者（44％）预后不良。在校正年龄、性别和卒中严重程度因素后，24小时神经功能无改善是不良预后（OR，12．9；95％CI，5．7—29．6）和死亡的独立预测指标（OR，7．5；95％C1，2．9～19．6）。24小时神经功能无改善的患者住院时间延长（14．5天比9．6天，P=0．02）。结论：对于接受溶栓治疗的急性脑卒中患者，24小时神经功能无改善与3个月时预后不良和死亡相关。高血糖、开始溶栓治疗时间和皮层受累是24小时神经功能无改善的预测指标。

关键词：独立预测指标脑卒中患者急性脑卒中神经功能不良预后溶栓治疗治疗后组织型纤溶酶原激活物前瞻性队列研究国立卫生研究院

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Artificial intelligence in detection of small bowel lesions and their bleeding risk:A new step forward

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World Journal of Gastroenterology 2024年第18期30卷 2482-2484页

作者： silvia Cocca Giuseppina Pontillo Giuseppe Grande Rita Conigliaro Gastroenterology and Endoscopy Unit Azienda Ospedaliero Universitaria Policlinico di ModenaModena 41121Italy Gastroenterology and Endoscopy Unit Presidio Ospedaliero San Giuseppe Moscati(AversaCE)-ASL CasertaCaserta 81100Italy Department of Gastroenterology and digestive Endoscopy Azienda Ospedaliero Universitaria di ModenaModena 41121Italy

The present letter to the editor is related to the study with the title“Automatic detection of small bowel(SB)lesions with different bleeding risk based on deep learning models”.Capsule endoscopy(CE)is the main tool to assess SB diseases but it is a time-consuming procedure with a significant error *** development of artificial intelligence(AI)in CE could simplify physicians’*** novel deep learning model by Zhang et al seems to be able to identify various SB lesions and their bleeding risk,and it could pave the way to next perspective studies to better enhance the diagnostic support of AI in the detection of different types of SB lesions in clinical practice.

关键词： Capsule endoscopy Small bowel Artificial intelligence Bleeding risk Vascular lesions

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Enhanced Solar Water Desalination by CuCo_(2)S_(4)-decorated Carbon Foam Derived from Waste Plastics

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Chemical Research in Chinese Universities 2024年第3期40卷 548-555页

作者： Muzammil HUSSAIN Tofik Ahmed SHIFA Pratik V.SHINDE Pankaj KUMAR Stefano CENTENARO silvia GROSS Elisa MORETTI Alberto VOMIERO Department of Molecular Sciences and Nanosystems Ca'Foscari University of VeniceVia Torino 15530172 VeniceItaly Department of Industrial Engineering University of PadovaVia Venezia 135131 PadovaItaly Department of Chemical Sciences University of PadovaVia Francesco Marzolo135131 PadovaItaly division of Materials Science Department of Engineering Sciences and MathematicsLulea University of Technology97187 LuleaSweden Center for Cultural Heritage Technologies(CCHT) Istituto Italiano di Tecnologia(IT)Via Torino 15530170 Venezia-MestreItaly

Interfacial solar desalination is an emerging technology for freshwater production,but the finding of novel solar evaporators is still *** the present research,graphitic carbon foam(CF)was synthesized from the upcycling of waste plastic polyethylene terephthalate(PET)waste bottles functionalized with carrollite CuCo_(2)S_(4) as a photothermal *** characterization[X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FTIR),and scanning electron microscopy-energy dispersive spectroscopy(SEM-EDS)]confirms the functionalization of carrollite CuCo_(2)S_(4) on graphitic carbon *** UV-Vis spectroscopy analysis showed an enhanced optical absorption in the UV-Vis-near IR region(>96%)for functionalized CuCo_(2)S_(4)-CF foam compared to carbon foam(67%).The interfacial solar desalination experiment presented a significantly enhanced evaporation rate of 2.4 kg·m^(−2)·h^(−1) for CuCo_(2)S_(4)-CF compared to that of CF(1.60 kg·m^(−2)·h^(−1))and that of CuCo_(2)S_(4)(1.60 kg·m^(−2)·h^(−1)).The obtained results proved that the newly synthesized CuCo_(2)S_(4)-CF from the upcycled plastic into new material for the photothermal desalination process can enhance the practice of a circular economy to produce fresh water.

关键词： Photothermal desalination Cobalt Copper Chalcogenide Waste upcycling Circular economy

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Enhancing sensitivity of triple-negative breast cancer to DNA-damaging therapy through chemical inhibition of the m6A methyltransferase METTL3

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Cancer Communications 2024年第2期44卷 282-286页

作者： Bianca Cesaro Alessia Iaiza Fabio Piscopo Marco Tarullo Eleonora Cesari Dante Rotili Antonello Mai Alberto diana Michela Londero Luca Del Giacco Riccardo Masetti Alba di Leone Chiara Naro silvia Masciarelli Giulia Fontemaggi Claudio Sette Francesco Fazi Alessandro Fatica Department of Anatomical HistologicalForensic&Orthopedic SciencesSection of Histology&Medical EmbryologySapienza University of RomeRomeItaly Department of Biology and Biotechnologies“Charles Darwin” Sapienza University of RomeRomeItaly GSTeP Organoids Research Core Facility Fondazione Policlinico A.Gemelli Istituto di Ricovero e Cura a Carattere Scientifico(IRCCS)RomeItaly Department of Drug Chemistry and Technologies Sapienza University of RomeRomeItaly Pasteur Institute Cenci-Bolognetti FoundationSapienza University of RomeRomeItaly Department of BioSciences University of MilanMilanItaly Multidisciplinary Breast Center Dipartimento Scienze della Salute della Donna e del Bambino e di SanitàPubblicaCatholic University of the Sacred HeartRomeItaly Department of Neuroscience Section of Human AnatomyCatholic University of the Sacred HeartRomeItaly Oncogenomic and Epigenetic Unit IRCCS Regina Elena National Cancer InstituteRomeItaly

Dear Editor,N 6-methyladenosine(m^(6)A)is a critical mRNA modi-fication catalyzed by the enzyme methyltransferase-like 3(METTL3),with implications in RNA ***3 upregulation is associated with cancer progres-sion,metast... 详细信息

关键词： cancer methyltransferase metastasis

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Geophysical evidence of large-scale silica-rich fluid flow above the continental subduction interface

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Science China Earth Sciences 2024年第9期67卷 2796-2809页

作者： Yuantong MAO Liang ZHAO Marco G.MALUSA Stefano SOLARINO silvia PONDRELLI Baolu SUN Coralie AUBERT Simone SALIMBENI Elena EVA Stéphane GUILLOT State Key Laboratory of Lithospheric and Environmental Coevolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China Department of Earth and Environmental Sciences University of Milano-BicoccaMilan 20126Italy Istituto Nazionale di Geofisica e Vulcanologia Osservatorio Nazionale TerremotiGenova 16145Italy Istituto Nazionale di Geofisica e Vulcanologia Sezione di BolognaBologna 40127Italy Université Grenoble Alpes Université Savoie Mont BlancCNRSIRDUGEISTerreGrenoble 38000France

Fluids in subduction zones can have major effects on subduction ***,geophysical constraints on the scale and impact of fluid flow during continental subduction are still *** we analyze the VP/VS ratios in the Western Alpine region,hosting one of the best-preserved fossil continental subduction zones worldwide,to investigate the impact of fluid flow during continental *** found a belt of high VP/VS ratios>1.9 on the upper-plate side of the subduction zone,consistent with a partially serpentinized upper-plate mantle,and a belt of unusually low VP/VS ratiosdicating past fluid flow along the continental subduction *** results suggest that past fluid flow may have reduced the effective stress along the subduction interface thus favoring continental subduction.

关键词： Western Alps Crustal structure Receiver function Vp/Vs ratio Silica enrichment

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Device-assisted enteroscopy: Are we ready to dismiss the spiral?

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World Journal of Gastroenterology 2024年第26期30卷 3185-3192页

作者： Alessandro Mussetto Elettra Merola Cesare Casadei Daniele Salvi Fabiola Fornaroli silvia Cocca Margherita Trebbi Armando Gabbrielli Cristiano Spada Andrea Michielan Department of Gastroenterology S Maria della Croci HospRavenna 48121Italy Department of Gastroenterology Unit G.B.Grassi Hospital(ASL Roma 3)Roma 00122Italy Section of digestive Endoscopy and Gastroenterology Fondazione PoliambulanzaBrescia 25124Italy Gastroenterology and Endoscopy Unit Department of Medicine and SurgeryUniversity of ParmaParma 43125Italy Gastroenterology and Endoscopy Unit Azienda Ospedaliero Universitaria Policlinico di ModenaModena 41121Italy Center for Medical Sciences(CISMed) University of TrentoTrento 38122Italy Gastroenterology and digestive Endoscopy Unit Santa Chiara HospitalAzienda Provinciale per i Servizi SanitariTrento 38122Italy digestive Endoscopy Unit Fondazione Policlinico Universitario A.Gemelli IRCSSRoma 00168Italy

Motorized spiral enteroscopy(MSE)is the latest advance in device-assisted *** events related to MSE were discussed in a recent large systematic review and meta-analysis and were directly compared with those of balloon enteroscopy in a case-matched study and a randomized controlled *** the real-life application of MSE,an unexpected safety issue emerged regarding esophageal injury and the technique has been withdrawn from the global market,despite encouraging results in terms of diagnostic and therapeutic *** conducted an Italian multicenter real-life prospective study,which was prematurely terminated after the withdrawal of MSE from the *** primary goals were the evaluation of MSE performance(both diagnostic and therapeutic)and its safety in routine endoscopic practice,particularly in the early phase of introduction in the endoscopic unit.A subanalysis,which involved patients who underwent MSE after unsuccessful balloon enteroscopy,demonstrated,for the first time,the promising performance of MSE as a rescue *** its remarkable performance in clinical practice and its potential role as a backup technique following a previously failed enteroscopy,it may be more appropriate to refine and enhance MSE in the future rather than completely abandoning it.

关键词： Motorized spiral enteroscopy Rescue enteroscopy diagnostic yield Adverse events AGREE classification

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diversity-oriented synthesis of blue emissive nitrogen heterocycles and their conjugation with carbon nano-onions

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Frontiers of Chemical Science and Engineering 2020年第1期14卷 76-89页

作者： Viviana Maffeis Lisa Moni Daniele di Stefano silvia Giordani Renata Riva Nano Carbon Materials Istituto Italiano di Tecnologia(IIT)10144 TorinoItaly Department of Chemistry and Industrial Chemistry University of Genova16146 GenovaItaly School of Chemical Sciences Dublin City UniversityDublin 9Ireland Department of Pharmacy University of Genova16147 GenovaItaly

The search for new fluorescent molecules for possible applications as functional p-electron systems and their conjugation with different nanomaterials is nowadays of paramount importance to broaden the availability of materials with different *** we present a diversity-oriented approach to heterocyclic luminophores based on a multicomponent Ugi reaction followed by a Pd-mediated cascade *** new molecules are coupled to carbon nano-onions,and hybrid systems represent the first example of blue emitters conjugated with these carbon nanoparticles.

关键词： carbon nano-onions multicomponent reactions blue emitters fluorescence isoquinolines

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Exploring building's envelope thermal behavior of the neo-vernacular residential architecture in a hot and dry climate region of Algeria

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Building Simulation 2021年第5期14卷 1567-1584页

作者： Khaoula Amraoui Leila Sriti silvia di Turi Francesco Ruggiero Ahmed Kaihoul Department of Architecture LACOMOFA LaboratoryMohamed khider University of BiskraAlgeria Energy Efficiency Unit Department(DUEE) Italian National Agency for New TechnologiesEnergy and Sustainable Economic Development(ENEA)RomeItaly Department of Civil Engineering and Architecture Sciences(diCAR) Polytechnic University of BariItaly Department of Architecture Larbi Ben M'hidi University of Oum El-BouaghiAlgeria

It is well known that the passive strategies applying in traditional buildings respond satisfactory to climatic requirements and succeed to provide maximum indoor comfort with minimum energy *** this point of view,it is interesting to quantitatively assess the effectiveness of the vernacular strategies to improve the environmental performance of the building's envelope under desert climate *** research tries to address this issue and was undertaken in southern Algeria where a very hot and arid climate *** effect of some selected passive cooling strategies on enhancing the building's envelope climate performance was *** strategies are inspired from the local vernacular architecture,and they are expected to provide satisfactory indoor thermal comfort for users and to reduce the energy cooling demand from residential *** field and computational investigations,two existing residential buildings were tested:a typical residential unit and a contemporary vernacular(neo-vernacular)*** the latter,climate responsive strategies inspired from vernacular architecture were applied.A comparison based on site measurements was carried out on the two selected buildings which differ from their envelope design properties and components.

关键词： architectural envelope neo-vernacular architecture cooling passive strategies thermal comfort in hot dry climate computer simulation residential sector

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Stem cell-based 3D brain organoids for mimicking, investigating, and challenging Alzheimer's diseases

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Neural Regeneration Research 2022年第2期17卷 330-332页

作者： Federica Cordella Carlo Brighi Alessandro Soloperto silvia di Angelantonio Center for Life Nanoscience Istituto Italiano di TecnologiaRomeItaly Department of Physiology and Pharmacology Sapienza UniversityRomeItaly

Alzheimer's disease(AD) is a progressive and irreversible neurodegene rative disorder that causes a decline of cognitive functions and a deterioration of behavioral and social performances. According to current estima... 详细信息

关键词： Alzheimer diseases irreversible

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