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Genes & Diseases 2024年第1期11卷 64-66页

作者： Ying Li lingli Ding Yage Zhang Bingyu Zhou Gene Chi Wai Man Min Wang Jinglan Li Yamei Liu Weiping lin Haibin Wang sien lin Liangliang Xu Key Laboratory of Orthopaedics&Traumatology Lingnan Medical Research CenterThe First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou University of Chinese MedicineGuangzhouGuangdong 510000China Department of Orthopaedics&Traumatology Faculty of MedicineThe Chinese University of Hong KongPrince of Wales HospitalShatinHong Kong SAR 999077China Departments of Diagnostics of Traditional Chinese Medicine Guangzhou University of Chinese MedicineGuangzhouGuangdong 510000China Orthopaedic Research Lab Affiliated Hospital of Guangdong Medical UniversityGuangdong Medical UniversityZhanjiangGuangdong 524001China

Fractures have an extraordinarily negative impact on individuals'quality of life and functional *** or disability of fracture is a major health issue with important clinical,social,and economic implications.1 Mesenchymal stem cells(MSCs)play an indispensable role in the initiation of the fracture repair process including the formation of a callus which is replaced by new *** use of MSCs in the treatment of fractures is very attractive as they can reduce the time of healing and occurrence of nonunion.

关键词： PI3K/Akt HIF1α healing

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T细胞免疫在骨重建和骨再生中的研究进展

浙江大学学报（医学版） 2024年第4期53卷 450-459页

作者：胡文慧邓金霞苏展鹏王海兴林思恩广东医科大学附属医院骨科中心广东湛江524000 香港中文大学医学院威尔斯亲王医院矫形外科及创伤学系中国香港999077

骨重建和骨再生对于保持骨骼完整性和维持矿物质稳态至关重要。T淋巴细胞为适应性免疫的关键成员,通过产生一系列细胞因子和生长因子,在骨重建和骨再生过程中起着举足轻重的作用。在生理状态下,T淋巴细胞通过与间充质干细胞、成骨细胞... 详细信息

骨重建和骨再生对于保持骨骼完整性和维持矿物质稳态至关重要。T淋巴细胞为适应性免疫的关键成员,通过产生一系列细胞因子和生长因子,在骨重建和骨再生过程中起着举足轻重的作用。在生理状态下,T淋巴细胞通过与间充质干细胞、成骨细胞、破骨细胞的交互作用参与骨稳态的维持;在病理状态下,T淋巴细胞通过与雌激素、糖皮质激素、甲状旁腺激素的协作参与不同类型骨质疏松的病理过程;在损伤后修复的骨折愈合过程中,T淋巴细胞在炎症血肿期、骨痂形成期和骨重建期发挥了不同的作用。因此,靶向T淋巴细胞成为调节骨稳态的潜在策略。本文综述了T细胞免疫参与骨重建和骨再生的研究进展及相关机制,以期为靶向T淋巴细胞调控骨重建和骨再生提供科学依据。

关键词：骨免疫学 T淋巴细胞适应性免疫骨重建骨再生骨质疏松骨折愈合综述

Analysis and Prediction of Team Performance based on Interaction Networks

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Analysis and Prediction of Team Performance based on Interac...

Surface decoration of development-inspired synthetic N-cadherin motif via Ac-BP promotes osseointegration of metal implants

第36届中国控制会议

作者： Sa Liu lin Wang sien lin Zhi Yang Xiaofan Wang Department of Automation Shanghai Jiao Tong Universityand Key Laboratory of System Control and Information ProcessingMinistry of Education of China

ISBN: (纸本)9781538629185

Quantifying team dynamics and predicting team performance in social physics have become increasingly important research *** this paper,the multi-model dataset of interaction networks about cooperating teams is collected through wearable sensing technologies,that allows gathering information on team performance and *** on this dataset,the predictive power of team discussion dynamics is evaluated by using automatically extracted features,including team members’ aural cues,face-to-face interaction between team members and the internal dynamics of the *** factors affecting the team performance are identified and the prediction is achieved by support vector ***,the factors associated with the team performance are simplified by RReliefF algorithm to improve the efficiency of prediction.

关键词： team cooperation dataset team performance prediction SVR SVM RReliefF

来源： cnki会议评论

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Bioactive Materials 2021年第5期6卷 1353-1364页

作者： Meiling Zhu Kunyu Zhang Lu Feng sien lin Qi Pan Liming Bian Gang Li Department of Orthopaedics&Traumatology Faculty of MedicineThe Chinese University of Hong KongPrince of Wales HospitalShatinHong KongSARPR China Stem Cells and Regenerative Medicine Laboratory Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongPrince of Wales HospitalShatinSARHong KongPR China The Eighth Affiliated Hospital Sun Yat-Sen UniversityShenzhenPR China Department of Biomedical Engineering The Chinese University of Hong KongHong KongSARPR China Shenzhen Research Institute The Chinese University of Hong KongShenzhenPR China Centre of Novel Biomaterials The Chinese University of Hong KongHong KongSARPR China

Research works on the synergistic effect of surface modified bioactive molecules and bone metal implants have been highlighted.N-cadherin is regarded as a key factor in directing cell-cell interactions during the mesenchymal condensation preceding the osteogenesis in the musculoskeletal *** this study,the N-cadherin mimetic peptide(Cad)was biofunctionalized on the titanium metal surface via the acryloyl bisphosphonate(Ac-BP).To learn the synergistic effect of N-cadherin mimetic peptide,when tethered with titanium substrates,on promoting osteogenic differentiation of the seeded human mesenchymal stem cells(hMSCs)and the osseointegration at the bone-implant *** show that the conjugation of N-cadherin mimetic peptide with Ac-BP promoted the osteogenic gene markers expression in the *** biofunctionalized biomaterial surfaces promote the expression of the Wnt/β-catenin downstream axis in the attached hMSCs,and then enhance the in-situ bone formation and osseointegration at the bone-implant *** conclude that this N-cadherin mimetic peptide tethered on Ti surface promote osteogenic differentiation of hMSCs and osseointegration of biomaterial implants in vitro and in *** findings demonstrate the importance of the development-inspired surface bioactivation of metal implants and shed light on the possible cellular mechanisms of the enhanced osseointegration.

关键词： N-cadherin mimetic peptide Mesenchymal condensation Osseointegration Wnt/β-catenin signaling Titanium dioxide(TiO2)

Hallmarks of peripheral nerve function in bone regeneration

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Bone Research 2023年第1期11卷 47-64页

作者： Ranyang Tao Bobin Mi Yiqiang Hu sien lin Yuan Xiong Xuan Lu Adriana C.Panayi Gang Li Guohui Liu Department of Orthopaedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022P.R.China Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration Wuhan430022P.R.China Department of Orthopaedics&Traumatology Stem Cells and Regenerative Medicine LaboratoryLi Ka Shing Institute of Health SciencesThe Chinese University of Hong KongPrince of Wales HospitalShatinHong KongSAR999077P.R.China Division of Plastic Surgery Brigham and Women’s HospitalHarvard Medical SchoolBoston02215MAUSA

Skeletal tissue is highly *** different types of nerves have been recently identified in the bone,the crosstalk between bone and nerves remains *** this review,we outline the role of the peripheral nervous system(PNS)in bone regeneration following *** first introduce the conserved role of nerves in tissue regeneration in species ranging from amphibians to *** then present the distribution of the PNS in the skeletal system under physiological conditions,fractures,or ***,we summarize the ways in which the PNS communicates with bone-lineage cells,the vasculature,and immune cells in the bone *** on this comprehensive and timely review,we conclude that the PNS regulates bone regeneration through neuropeptides or neurotransmitters and cells in the peripheral *** in-depth understanding of the roles of peripheral nerves in bone regeneration will inform the development of new strategies based on bone-nerve crosstalk in promoting bone repair and regeneration.

关键词： nerves regeneration function

A bioactive compliant vascular graft modulates macrophage polarization and maintains patency with robust vascular remodeling

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Bioactive Materials 2023年第1期19卷 167-178页

作者： Alexander Stahl Dake Hao Janos Barrera Dominic Henn sien lin Seyedsina Moeinzadeh Sungwoo Kim William Maloney Geoffrey Gurtner Aijun Wang Yunzhi Peter Yang Department of Orthopaedic Surgery Stanford University240 Pasteur DriveStanfordCA94304USA Department of Chemistry Stanford University121 Mudd BuildingStanfordCA94305USA Department of Surgery School of MedicineUniversity of California DavisSacramentoCA95817USA Institute for Pediatric Regenerative Medicine Shriners Hospitals for ChildrenSacramentoCA95817USA Department of Surgery Stanford University300 Pasteur DriveStanfordCA94305USA Department of Biomedical Engineering University of California DavisDavisCA95616USA Department of Materials Science and Engineering Stanford University496 Lomita MallStanfordCA94305USA Department of Bioengineering Stanford University443 Via OrtegaStanfordCA4305USA

Conventional synthetic vascular grafts are associated with significant failure rates due to their mismatched mechanical properties with the native vessel and poor regenerative *** different tissue engineering approaches have been used to improve the biocompatibility of synthetic vascular grafts,it is still crucial to develop a new generation of synthetic grafts that can match the dynamics of native vessel and direct the host response to achieve robust vascular *** size of pores within implanted biomaterials has shown significant effects on macrophage polarization,which has been further confirmed as necessary for efficient vascular formation and ***,we developed biodegradable,autoclavable synthetic vascular grafts from a new polyurethane elastomer and tailored the grafts’interconnected pore sizes to promote macrophage populations with a pro-regenerative phenotype and improve vascular regeneration and patency *** synthetic vascular grafts showed similar mechanical properties to native blood vessels,encouraged macrophage populations with varying M2 to M1 phenotypic expression,and maintained patency and vascular regeneration in a one-month rat carotid interposition model and in a four-month rat aortic interposition *** innovative bioactive synthetic vascular graft holds promise to treat clinical vascular diseases.

关键词： Vascular graft Vascular compliance Pore size Macrophage polarization Vascular remodeling

Enhancing cartilage repair with optimized supramolecular hydrogel-based scaffold and pulsed electromagnetic field

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Bioactive Materials 2023年第4期22卷 312-324页

作者： Yucong Li linlong Li Ye Li Lu Feng Bin Wang Ming Wang Haixing Wang Meiling Zhu Yongkang Yang Erik IWaldorff Nianli Zhang Ingmar Viohl sien lin Liming Bian Wayne Yuk-Wai Lee Gang Li Department of Orthopaedics&Traumatology Stem Cells and Regenerative Medicine LaboratoryLi Ka Shing Institute of Health SciencesThe Chinese University of Hong KongPrince of Wales HospitalShatinHong Kong Special Administrative Region Research&Clinical Affairs Orthofix Medical Inc.LewisvilleTXUSA Department of Rehabilitation Sciences Hong Kong Polytechnic UniversityHong Kong Special Administrative Region Innovation Centre for Advanced Interdisciplinary Medicine Key Laboratory of Biological Targeting DiagnosisTherapy and Rehabilitation of Guangdong Higher Education InstitutesThe Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina The Eighth Affiliated Hospital Sun Yat-Sen UniversityShenzhenPR China School of Biomedical Sciences and Engineering National Engineering Research Center for Tissue Restoration and ReconstructionKey Laboratory of Biomedical Materials and Engineering of the Ministry of EducationSouth China University of TechnologyGuangzhouPR China Department of Orthopaedics and Traumatology SH Ho Scoliosis Research LaboratoryJoint Scoliosis Research Center of the Chinese University of Hong Kong and Nanjing UniversityThe Chinese University of Hong KongHong Kong Special Administrative Region

Functional tissue engineering strategies provide innovative approach for the repair and regeneration of damaged *** is widely used because it could provide rapid defect filling and proper structure support,and is biocompatible for cell aggregation and matrix *** have been made to seek suitable scaffolds for cartilage tissue *** Alg-DA/Ac-β-CD/gelatin hydrogel was designed with the features of physical and chemical multiple crosslinking and self-healing *** time,swelling ratio,biodegradability and biocompatibility of the hydrogels were systematically characterized,and the injectable self-healing adhesive hydrogel were demonstrated to exhibit ideal properties for cartilage ***,the new hydrogel design introduces a pre-gel state before photo-crosslinking,where increased viscosity and decreased fluidity allow the gel to remain in a semi-solid *** granted multiple administration routes to the hydrogels,which brings hydrogels the ability to adapt to complex clinical *** electromagnetic fields(PEMF)have been recognized as a promising solution to various health problems owing to their noninvasive properties and therapeutic *** treatment offers a better clinical outcome with fewer,if any,side effects,and wildly used in musculoskeletal tissue *** we propose PEMF as an effective biophysical stimulation to be 4th key element in cartilage tissue *** this study,the as-prepared Alg-DA/Ac-β-CD/gelatin hydrogels were utilized in the rat osteochondral defect model,and the potential application of PEMF in cartilage tissue engineering were *** treatment were proven to enhance the quality of engineered chondrogenic constructs in vitro,and facilitate chondrogenesis and cartilage repair in *** of the results suggested that with the injectable self-healing adhesive hydrogel and PEMF treatment,this newly proposed tissue engineering strategy r

关键词： Supramolecular hydrogels Pulsed electromagnetic field Cartilage tissue engineering Mesenchymal stem cells Chondrogenesis

脂肪来源的干细胞复合壳聚糖支架促进大鼠颅骨缺损修复的实验研究

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重庆医科大学学报 2020年第2期45卷 161-166页

作者：黄健萍林思恩兰青广东医科大学附属医院口腔科湛江524001 广东医科大学附属医院骨科中心湛江524001

目的:探讨以脂肪来源的干细胞(adipose-derived stem cells,ADSCs)为基础构建组织工程生物材料修复大鼠颅骨缺损的效果。方法:分离、培养ADSCs,并进行成骨、成脂、成软骨三系分化。制备壳聚糖多孔支架,扫描电镜观察接种ADSCs前后的微结... 详细信息

目的:探讨以脂肪来源的干细胞(adipose-derived stem cells,ADSCs)为基础构建组织工程生物材料修复大鼠颅骨缺损的效果。方法:分离、培养ADSCs,并进行成骨、成脂、成软骨三系分化。制备壳聚糖多孔支架,扫描电镜观察接种ADSCs前后的微结构变化,以细胞活力试剂盒测试ADSCs接种于壳聚糖多孔支架后的细胞活力。取15只雄性Sprague Dawley(SD)大鼠予手术制备颅骨缺损模型,将缺损留空或植入壳聚糖支架,壳聚糖支架表面预先种植低密度(2.5×10~5)或高密度(1×10~6)ADSCs。术后8周收集样品用于微型计算机断层扫描分析,随后脱钙,石蜡包埋切片后行苏木素-伊红染色和免疫组化染色观察成骨指标骨涎蛋白。结果:ADSCs可以成功诱导成骨、成软骨和成脂肪分化;扫描电镜和细胞活力测试结果提示壳聚糖支架呈现多孔结构,ADSCs可黏附于支架并增殖,增殖效果与普通培养板相比无统计学差异。在大鼠颅骨缺损模型中,高密度ADSCs/壳聚糖支架组骨组织体积百分数分别比空白对照组和低密度ADSCs/壳聚糖支架组升高140.8%(P=0.014)和37.4%(P=0.036)。与空白缺损对照组相比,低密度ADSCs/壳聚糖支架组和高密度ADSCs/壳聚糖支架组骨密度分别升高29.4%(P=0.123)和64.1%(P=0.022)。组织学结果表明,骨缺损区新生骨组织的分布和数量与微型计算机断层扫描分析结果一致。成骨分化指标骨涎蛋白在高密度组表达有增高趋势。结论:高密度ADSCs复合壳聚糖支架可有效修复大鼠的颅骨缺损。

关键词：脂肪间充质干细胞组织工程学壳聚糖支架颅骨缺损

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糖代谢对骨骼细胞的影响

中国骨质疏松杂志 2022年第11期28卷 1625-1628页

作者：王振虎崔燎林思恩魏波广东医科大学附属医院骨科中心广东湛江524001 广东天然药物研究与开发重点实验室药理教研室广东湛江524023

骨骼细胞之间的相互平衡是维持骨骼健康的重要因素之一,骨骼细胞之间失衡容易造成骨质疏松等骨骼疾病。很多研究表明,糖代谢异常会打破骨形成和骨吸收的平衡,从而引起骨量减少和骨质疏松性骨折等疾病。笔者对成骨细胞、破骨细胞以及骨... 详细信息

骨骼细胞之间的相互平衡是维持骨骼健康的重要因素之一,骨骼细胞之间失衡容易造成骨质疏松等骨骼疾病。很多研究表明,糖代谢异常会打破骨形成和骨吸收的平衡,从而引起骨量减少和骨质疏松性骨折等疾病。笔者对成骨细胞、破骨细胞以及骨细胞相关的糖代谢的最新研究进展进行总结,系统剖析糖代谢对成骨细胞、破骨细胞以及骨细胞分化和功能的关键调控作用,为骨质疏松等骨疾病的治疗提供理论指导。

关键词：成骨细胞破骨细胞骨细胞糖代谢

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神经人因学:培训效果评估新方法

中国人力资源开发 2017年第8期34卷 99-107页

作者：王桢杨志林思恩李旭培郭晶中国人民大学劳动人事学院中国科学院心理研究所探客柏瑞科技(北京)有限公司中国科学院心理研究所组织与员工促进中心

神经人因学通过将认知神经科学的理论和技术应用于人因工效学,测量和分析人在工作中大脑的反应,客观、准确、实时了解工作绩效和心理状态。虽然神经人因学在营销领域得到了一定应用,但是神经人因学在人力资源管理领域的应用仍非常初步... 详细信息

神经人因学通过将认知神经科学的理论和技术应用于人因工效学,测量和分析人在工作中大脑的反应,客观、准确、实时了解工作绩效和心理状态。虽然神经人因学在营销领域得到了一定应用,但是神经人因学在人力资源管理领域的应用仍非常初步。本文首先阐述人力资源管理领域的重要方面——培训效果评估的现状和问题,然后介绍神经人因学相关的理论和方法,提出神经人因学可以应用在培训评估中。接着,通过某公司的培训案例具体探讨了将神经人因学技术运用于培训评估的方法和评估效果,并介绍了适用条件和支撑保障要素。研究结果表明神经人因学在人力资源管理领域具有较大的应用价值,能够帮助企业管理者和人力资源部门更好地实现人力资源开发。

关键词：神经人因学培训评估认知神经科学