A bioactive compliant vascular graft modulates macrophage polarization and maintains patency with robust vascular remodeling

作     者：Alexander Stahl Dake Hao Janos Barrera Dominic Henn Sien Lin Seyedsina Moeinzadeh Sungwoo Kim William Maloney Geoffrey Gurtner Aijun Wang Yunzhi Peter Yang 

作者机构：Department of Orthopaedic SurgeryStanford University240 Pasteur DriveStanfordCA94304USA Department of ChemistryStanford University121 Mudd BuildingStanfordCA94305USA Department of SurgerySchool of MedicineUniversity of California DavisSacramentoCA95817USA Institute for Pediatric Regenerative MedicineShriners Hospitals for ChildrenSacramentoCA95817USA Department of SurgeryStanford University300 Pasteur DriveStanfordCA94305USA Department of Biomedical EngineeringUniversity of California DavisDavisCA95616USA Department of Materials Science and EngineeringStanford University496 Lomita MallStanfordCA94305USA Department of BioengineeringStanford University443 Via OrtegaStanfordCA4305USA 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2023年第19卷第1期

页      面：167-178页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0836[工学-生物工程] 

基　　金：support from NIH grants R01AR057837 U01AR069395 R01AR072613 R01AR074458 from NIAMS and DoD grant W81XWH-20-1-0343 the Stanford Woods Institute for the Environment and the Tad and Diane Taube Family Foundation 

主　　题：Vascular graft Vascular compliance Pore size Macrophage polarization Vascular remodeling 

摘      要：Conventional synthetic vascular grafts are associated with significant failure rates due to their mismatched mechanical properties with the native vessel and poor regenerative *** different tissue engineering approaches have been used to improve the biocompatibility of synthetic vascular grafts,it is still crucial to develop a new generation of synthetic grafts that can match the dynamics of native vessel and direct the host response to achieve robust vascular *** size of pores within implanted biomaterials has shown significant effects on macrophage polarization,which has been further confirmed as necessary for efficient vascular formation and ***,we developed biodegradable,autoclavable synthetic vascular grafts from a new polyurethane elastomer and tailored the grafts’interconnected pore sizes to promote macrophage populations with a pro-regenerative phenotype and improve vascular regeneration and patency *** synthetic vascular grafts showed similar mechanical properties to native blood vessels,encouraged macrophage populations with varying M2 to M1 phenotypic expression,and maintained patency and vascular regeneration in a one-month rat carotid interposition model and in a four-month rat aortic interposition *** innovative bioactive synthetic vascular graft holds promise to treat clinical vascular diseases.