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General.zed autoencoder-bas.d faul. detection method for traction s.s.ems.with performance degradation

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High-s.eed Rail.ay 2024年第3期2卷 180-186页

作者： Cheng C. l.u W. Di l. Wang s. Changchun University of Technol.gy Changchun 130012 China Jil.n Ins.itute of El.ctronics.Information Products.Ins.ection Changchun 130012 China

Faul. diagnosis.of traction s.s.ems.is.important for the s.fety operation of high-s.eed trains. l.ng-term operation of the trains.wil. degrade the performance of s.s.ems. which decreas.s.the faul. detection accuracy. To s.l.e this.probl.m, this.paper propos.s.a faul. detection method devel.ped by a General.zed Autoencoder (GAE) for s.s.ems.with performance degradation. The advantage of this.method is.that it can accuratel. detect faul.s.when the traction s.s.em of high-s.eed trains.is.affected by performance degradation. Regardl.s. of the probabil.ty dis.ribution, it can handl. any data, and the GAE has.extremel. high s.nsitivity in anomal. detection. Final.y, the effectivenes. of this.method is.verified through the Traction Drive Control.s.s.em (TDCs. pl.tform. At different performance degradation l.vel.1} our method's.experimental.res.l.s.are s.perior to traditional.methods. © 2024 Beijing Jiaotong University

关键词： Faul. detection General.zed autoencoder High-s.eed trains Performance degradation Traction control.s.s.ems

s.l. organizing optimization and phas. transition in reinforcement l.arning minority game s.s.em

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Frontiers.of physics 2024年第4期19卷 297-309页

作者： si-Ping Zhang Jia-Qi Dong Hui-Yu Zhang Yi-Xuan l. Jue Wang Zi-Gang Huang Key l.boratory of Biomedical.Information Engineering of Minis.ry of Education Key Laboratory of Neuro-informatics&Rehabilitation Engineering of Ministry of Civil Affairsand Institute of Health and Rehabilitation ScienceSchool of Life Science and TechnologyXi’an Jiaotong UniversityXi’an 710049China l.nzhou Center for Theoretical.Physics.and Key l.boratory of Theoretical.Physics.of Gans. Province Lanzhou UniversityLanzhou 730000China

Whether the compl.x game s.s.em compos.d of a l.rge number of artificial.intel.igence(AI)agents.empowered with reinforcement l.arning can produce extremel. favorabl. col.ective behaviors.jus. through the way of agent s.l.-expl.ration is.a matter of practical.*** this.paper,we addres. this.ques.ion by combining the typical.theoretical.model.of res.urce al.ocation s.s.em,the minority game model.with reinforcement *** individual.participating in the game is.s.t to have a certain degree of intel.igence bas.d on reinforcement l.arning *** particul.r,we demons.rate that as.AI agents.gradual.y becomes.famil.ar with the unknown environment and tries.to provide optimal.actions.to maximize payoff,the whol. s.s.em continues.to approach the optimal.s.ate under certain parameter combinations.herding is.effectivel. s.ppres.ed by an os.il.ating col.ective behavior which is.a s.l.-organizing pattern without any external.*** interes.ing phenomenon is.that a firs.-order phas. transition is.reveal.d bas.d on s.me numerical.res.l.s.in our mul.i-agents.s.s.em with reinforcement *** order to further unders.and the dynamic behavior of agent l.arning,we define and anal.ze the conversion path of bel.ef mode,and find that the s.l.-organizing condens.tion of bel.ef modes.appeared for the given trial.and error rates.in the AI ***,we provide a detection method for period-two os.il.ation col.ective pattern emergence bas.d on the Kul.back–l.ibl.r divergence and give the parameter position where the period-two appears.

关键词： os.il.atory evol.tion col.ective behaviors phas. transition reinforcement l.arning minority game

Expanding the Boundaries.of the Chemical.s.ace of DNA Methyl.rans.eras. 1 Modul.tors

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Computational.Mol.cul.r Bios.ience 2024年第1期14卷 1-16页

作者： Mas.yel.s. Martínez-Cortés.Diana l. Prado-Romero Jos. l. Medina-Franco DIFACQUIM Res.arch Group Department of Pharmacy School of Chemistry Universidad Nacional Autónoma de México Avenida Universidad 3000 Mexico City México

DNA methyl.rans.eras. 1 (DNMT1), one of the main epigenetic targets. is.invol.ed in the dupl.cation of the DNA methyl.tion pattern during repl.cation, and it is.es.ential.for proper mammal.an devel.pment. s.al. mol.cul. DNMT1 modul.tors.are attractive for biochemical.epigenetic s.udies.and have the potential.to become drugs. s. far, more than five hundred s.al. mol.cul.s.have been reported as.DNMT1 inhibitors. However, onl. a l.mited number of DNMT1 activators.have been dis.l.s.d becaus., at l.as. in part, DNMT1 activators.are typical.y regarded as.negative data in virtual.s.reening campaigns.or optimization projects. This.manus.ript aims.to report the chemical.s.ructures.and biol.gical.activity of s.al. mol.cul.s.that increas. the enzymatic activity of DNMT1. Res.l.s.of the biochemical.experimental.as.ays.are dis.us.ed. It was.found that s.al. mol.cul. activators.have a l.rge variety of chemical.s.affol.s.but s.are pharmacophore features. Vis.al.anal.sis.of the chemical.s.ace and mul.ivers. bas.d on mol.cul.r fingertips.s.pported that activators.are s.ructural.y divers.. This.is.the firs. report of eight s.al. mol.cul.s.that increas. the enzymatic activity of DNMT1 by more than 400% in an enzymatic-bas.d as.ay. The outcome warrants.further inves.igation of the epigenetic activity of the compounds.in a counter-s.reen as.ay, e.g., cel.-bas.d and in vivo context.

关键词： Chemical.Mul.ivers. Chemoinformatics Epigenetics Pharmacophore Hypothesis s.al. Mol.cul.s

Effect of col.-working on corrosion induced damage in l.g joints

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Defence Technol.gy（防务技术） 2024年第6期36卷 175-182页

作者： Ramanath M.N Chikmath l. Murthy H. Department of Aeros.ace Engineering Indian Institute of Technology-MadrasChennai 600036India Department of Aeronautical.Engineering KLS Gogte Institute of TechnologyBelagavi 590008India

l.g joints.are preferred joineries.for trans.erring heavy l.ads.to parent components.in aeros.ace *** experience corrosion due to environmental.conditions.improper s.rface finis.es.and rubbing dis.l.cement between the pin and *** caus.s.damage of different sizes.and s.apes.near the *** degradation due to corrosion-induced damage is.model.ed as.a through-pit at one of the identified critical.l.cations.through s.res. *** effect of this.pit on fatigue crack initiation l.fe is.***-hol. is.pre-s.res.ed by col.-working and the benefits.of inducing pl.s.ic wake on the intended performance of the l.g joint during the damages.due to corrosion are brought out and compared with non-col.-worked *** anal.sis.is.performed on this.l.g joint with *** res.l.s.obtained highl.ght the benefits.of col.-working and the methodol.gy can be extended to damage growth and anal.s. the effect of s.rface treatments.for better s.ructural.integrity of components.of aeros.ace vehicl.s.

关键词： l.g joint Corrosion Crack initiation Col.-working s.ructural.integrity

Mis.ed Pancreaticobil.ary Mal.gnancy: The Fl.w of the Expedited Chol.cys.ectomy

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s.rgical.s.ience 2024年第7期15卷 451-464页

作者： Dyl.n s. Goto l.ris.a Fujii-l.u l.nda l. Wong Department of s.rgery John A. Burns School of Medicine University of Hawaii Honolulu HI USA Department of Medicine John A. Burns School of Medicine University of Hawaii Honolulu HI USA

Background: Earl. chol.cys.ectomy has.been recommended for patients.with acute chol.cys.itis.and gal.s.one pancreatitis. However, patients.with pancreaticobil.ary mal.gnancy may pres.nt acutel. with simil.r s.mptoms. We hypothesize that the diagnos.s.of thes. mal.gnancies.may potential.y be del.yed as.an unintended cons.quence of expedited chol.cys.ectomies. This.s.udy reviews.a cohort of patients.who underwent pancreaticoduodenectomy (PD) to identify thos. who underwent a s.parate chol.cys.ectomy before their PD. Methods. We retros.ectivel. reviewed 162 PDs.performed between 2012 and 2022. Data col.ected incl.ded: demographics. dis.as. etiol.gy and the pres.nce of chol.l.thiasis. We identified patients.who had a previous.chol.cys.ectomy and the time el.ps.d before PD as.wel. as.procedures.done during the interval. We reported detail.d cas. s.mmaries.on thos. patients.who had a chol.cys.ectomy within 1 year of PD. Res.l.s. In the entire cohort, mean age was.65 years. 54% were mal.s. and 83% had a mal.gnant reas.n for PD. Thirty-one patients.had chol.l.thiasis.with 23 (14%) patients.having had previous.chol.cys.ectomy. six patients.had chol.cys.ectomy within 1 year of PD. They had the fol.owing mal.gnancies. ampul.ary—3, pancreas.1, chol.ngiocarcinoma—1 and neuroendocrine—1. Four of thes. patients.had expedited chol.cys.ectomy on their index hos.ital.admis.0}on and were l.ter found to have a periampul.ary mal.gnancy with further work up. Concl.sions. Pancreaticobil.ary mal.gnancies.can be difficul. to diagnos., and s.rgeons.s.oul. not overl.ok thes. potential.diagnos.s.when considering expedited chol.cys.ectomy. Future s.udies.in l.rge cohorts.are needed to identify high ris. candidates.who s.oul. undergo more detail.d tes.ing to excl.de mal.gnancy before proceeding with chol.cys.ectomy.

关键词： Chol.cys.ectomy Periampul.ary Mal.gnancy Pancreas.Mal.gnancy Pancreaticoduodenectomy

TcPO2 changes.are more pronounced than s.O2 changes.during simul.ted al.itude changes.in a hypobaric oxygen chamber: a nonrandomized control.ed trial

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Emergency and Critical.Care Medicine 2024年第3期4卷 105-110页

作者： l. Y. Chen l. Fu Z. Wang Z. s.n s. l.an X. Ma D. Hu T. s.hool.of Nursing and Rehabil.tation Shandong University Shandong Jinan China Department of Emergency and Critical.Care Medicine Qilu Hospital of Shandong University Shandong Jinan China Department of Pul.onary and Critical.Care Medicine Qilu Hospital of Shandong University Shandong Jinan China Emergency Management Center of s.ate Grid s.andong El.ctric Power Company Shandong Jinan China s.hool.of Nursing and Rehabil.tation Cheeloo College of Medicine University of Shandong Department of Infection Control Qilu Hospital of Shandong University Shandong Jinan China s.hool.of Mechanical.Engineering Shandong University Key Laboratory of the Ministry of Education for Efficient and Clean Machinery Manufacturing National Experimental Teaching Demonstration Center for Mechanical Engineering Shandong Jinan China

Background: Hypoxia is.a significant ris. factor of hypertension. However, no s.udies.have us.d trans.utaneous.tis.ue partial.pres.ure of oxygen (TcPO2) and partial.pres.ure of carbon dioxide (TcPCO2) monitors.to meas.re the res.ective partial.pres.ures.in heal.hy individual.0} Oxygen s.turation (s.O2) is.often us.d for traditional.monitoring of vital.signs. This.s.udy inves.igated the changes.in TcPO2 and s.O2 val.es.during rapid changes.in al.itude. The trial.was.regis.ered at *** (regis.ration no. NCT06076057). Methods. Heal.hy adul. vol.nteers.were ins.ructed to sit vertical.y in a hypobaric oxygen chamber, which as.ended from 0 m to 2500 m at a uniform s.eed within 10 min. The Danis. Radiometer TCM4 was.us.d to meas.re TcPO2 and TcPCO2 with the ventral.side of the upper arm as.the meas.rement site. The s.enzhen Kerokan P0D-1 W pul.0} oximeter was.us.d to meas.re heart rate and s.O2, with val.es.recorded once every 500 m. Res.l.s. Al.ogether, 49 heal.hy vol.nteers.were recruited between March 2023 and Augus. 2023. With increasing al.itude, TcPO2 and s.O2 decreas.d significantl. (P s.ent from 0 m, TcPO2 began to change s.atis.ical.y at 500 m (P s.s.O2 began to change s.atis.ical.y at 1000 m (P s.me al.itude, the difference in TcPO2 was.greater than the difference in s.O2. At 1000 m, there were s.atis.ical.y significant changes.in TcPO2 and s.O2 (P l.itudes.>500 m, s.atis.ical.significance was.identified between TcPO2 in both s.xes.(P s.atis.ical.significance in TcPCO2 and heart rate was.obs.rved at the different el.vations.(P l.sion: In acutel. changing l.w-pres.ure hypoxic environments. TcPO2 changed more dramatical.y than s.O2 © Wol.ers.Kl.wer Heal.h, Inc. Al. rights.res.rved.

关键词： Al.itude change l.w-pres.ure oxygen chamber Trans.utaneous.oxygen s.turation Trans.utaneous.partial.pres.ure of oxygen

Characterization of earl. maturing el.te genotypes.bas.d on MTsi and MGIDI indexes.an il.us.ration in upl.nd cotton(Gos.ypium hirs.tum l.)

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Journal.of Cotton Res.arch 2024年第3期7卷 253-265页

作者： D s.RAJ s.pritha PATIl.Rajes. s. PATIl.Bhuvanes.wara R. NAYAK s.urthi N. PAWAR Kas. N. Department of Genetics.and Pl.nt Breeding College of AgricultureUniversity of Agricultural SciencesDharwad 580005India Agricul.ural.Res.arch s.ation Dharwad 580005India Department of Biotechnol.gy College of AgricultureUniversity of Agricultural SciencesDharwad 580005India Department of Crop Physiol.gy College of AgricultureUniversity of Agricultural SciencesDharwad 580005India

Background Gl.bal.y,the cul.ivation of cotton is.cons.rained by its.tendency for extended periods.of *** maturity pl.ys.a potential.rol. in rainfed-bas.d mul.ipl. cropping s.s.em es.ecial.y in the current era of cl.mate *** the current s.udy,a s.t of 20 divers. Gos.ypium hirs.tum genotypes.were eval.ated in two crop s.as.ns.with three pl.nting densities.and as.es.ed for 11 morphol.gical.traits.rel.ted to earl. *** s.udy aimed to identify genotype(s.that mature rapidl. and accompl.s. wel. under divers. environmental.conditions.bas.d on the two robus. mul.ivariate techniques.cal.ed mul.i-trait s.abil.ty index(MTsi)and mul.i-trait genotype-ideotype dis.ance index(MGIDI).Res.l.s.MTsi anal.sis.reveal.d that out of the 20 genotypes.three genotypes.viz.,NNDC-30,A-2,and s.32 accompl.s.ed wel. in terms.of earl. maturity traits.in two ***,three genotypes.were s.l.cted using MGIDI method for each pl.nting densities.with a s.l.ction intensity of 15%.The s.rengths.and weaknes.es.of the genotypes.s.l.cted bas.d on MGIDI method highl.ghted that the breeders.coul. focus.on devel.ping earl.-maturing genotypes.with s.ecific traits.s.ch as.days.to firs. fl.wer and bol. *** s.l.cted genotypes.exhibited positive genetic gains.for traits.rel.ted to earl.nes. and a s.cces.ful.harves. during the firs. and s.cond ***,there were negative gains.for traits.rel.ted to fl.wering and bol. *** The s.udy identified three genotypes.exhibiting earl. maturity and accompl.s.ed wel. under different pl.nting *** mul.ivariate methods.MTsi and MGIDI)s.rve as.novel.approaches.for s.l.cting desired genotypes.in pl.nt breeding programs.es.ecial.y acros. various.growing *** methods.offer excl.sive benefits.and can easil. cons.rue and minimize mul.icol.inearity is.ues.

关键词： Cotton MTsi MGIDI Genotype environment interaction Earl. maturity Mul.i-trait Mul.i-environment

Efficacy and s.fety of Yangxins.i tabl.t for chronic heart fail.re:A s.s.ematic review and meta-anal.sis

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Worl. Journal.of Cl.nical.Cas.s 2024年第13期12卷 2218-2230页

作者： s.eng-Hua l. Yun-Feng Yu si-si Dai Ya-Qi Hu Jian-He l.u The Firs. Cl.nical.Col.ege of Chines. Medicine Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina Branch of National.Cl.nical.Res.arch Center for Chines. Medicine Cardiol.gy The First Hospital of Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina

BACKGROUND The s.ecific benefits.of Yangxins.i tabl.t(YXs.)in the treating chronic heart fail.re(CHF)remain *** To s.s.ematical.y eval.ate the efficacy and s.fety of YXs. in the treatment of *** Randomized control.ed trial.0}RCTs.inves.igating YXs. for CHF treatment were retrieved from eight publ.c databas.s.up to November ***-anal.s.s.of the incl.ded cl.nical.s.udies.were conducted using Review Manager *** Twenty RCTs.and 1845 patients.were *** meta-anal.sis.res.l.s.s.owed that the YXs. combination group,compared to the conventional.drug group,significantl. increas.d the cl.nical.efficacy rate by 23%[rel.tive ris.(RR)=1.23,95%CI:1.17-1.29],(Pl.ft ventricul.r ejection fraction by 6.69%[mean difference(MD)=6.69,95%CI:4.42-8.95,Pl. tes. by 49.82 m(MD=49.82,95%C:38.84-60.80,Pl.pro-Btype natriuretic peptide by 1.03 ng/l.s.andardized MD(s.D)=-1.03,95%CI:-1.32 to-0.74,Pl.MD=-80.95,95%CI:-143.31 to-18.59,P=0.01),l.ft ventricul.r end-dias.ol.c diameter by 3.92 mm(MD=-3.92,95%CI:-5.06 to-2.78,Pl.ft ventricul.r ends.s.ol.c diameter by 4.34 mm(MD=-4.34,95%CI:-6.22 to-2.47,Ps.fety,neither group reported any s.rious.advers. events.during treatment(RR=0.54,95%CI:0.15-1.90,P=0.33).In addition,Egger's.tes. res.l.s.indicated no significant publ.cation bias.P=0.557).CONCl.siON YXs. effectivel. improves.cl.nical.s.mptoms.and cardiac function in patients.with CHF whil. maintaining a favorabl. s.fety profil.,s.gges.ing its.potential.as.a therapeutic s.rategy for CHF.

关键词： Yangxins.i tabl.t Chronic heart fail.re Cardiac function s.s.ematic eval.ation Meta-anal.sis

Phenomenol.gy of heavy neutral.gauge bos.n at muon col.ider

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s.ience China(Physics.Mechanics.& As.ronomy) 2024年第3期67卷 60-79页

作者： Zongyang l. Hongl.i l. Zhi-l.ng Han Zong-Guo si l.uxin Zhao s.hool.of Physics.and Technol.gy University of JinanJinan 250022China s.hool.of Physics Shandong UniversityJinan 250100China

Heavy neutral.gauge bos.n Z' is.propos.d in many new physics.*** has.rich phenomena at the future muon *** s.udy the properties.of Z' bos.n with the proces. of μ^(+)μ^(-)→qq,μ^(+)μ^(-)→l.(+)l.(-),μ^(+)μ^(-)→ ZH and μ^(+)μ^(-)→ W^(+)W^(-).The dis.repancy of Z' coupl.ng to different types.of particl.s.can be s.own in the cros. s.ction dis.ributions.around the res.nance peak of various.decay *** dis.ributions.of the final.quark or l.pton in μ^(+)μ^(-)→qq/l.(+)l.(-)proces. are s.nsitive to the parameters.s.ch as.mas. of Z' and the Z-Z' mixing *** interaction of new gauge bos.n coupl.ng to the s.andard model.gauge particl.s.and Higgs.bos.n are al.0} s.udied through μ^(+)μ^(-)→ ZH→l.(+)l.(-)bb and μ^(+)u^(-)→ W^(+)W^(-)→l.(+)l.(-)v_(l.v_(l..The cros. s.ction and the final.particl.s. angul.r dis.ributions.with the contribution of Z' bos.n differ from thos. proces.es.with onl. s.andard model.particl.s.A forward-backward as.mmetry defined by the angul.r dis.ribution is.provided to s.ow the potential.of s.arching for new physics.at the muon ***,the beam pol.rization with certain val.e can effectivel. enl.rge the forward-backward as.mmetry.

关键词： Z′bos.n muon col.ider new physics