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Association between COX-2-1195G>A polymorphism and gastrointestinal cancer risk: A meta-analysis

World Journal of Gastroenterology 2017年第12期23卷 2234-2245页

作者： Xiao-wei Zhang Jun Li Yu-Xing Jiang Yu-Xiang chen Department of Gastrointestinal and Vascular Surgery Deyang People's Hospital Department of General Surgery and Center for Minimal Invasive Gastrointestinal Surgery Southwest Hospital Third Military Medical University

AIM To perform a meta-analysis to investigate the association between cyclooxygenase-2(COX-2)-1195G>A gene polymorphism and gastrointestinal cancers. METHODS Publications related to the COX-2-1195G>A gene polymorphism and gastrointestinal cancers published before July 2016 were retrieved from Pub Med, EMBASE, Web of Science, China Biological Medicine Database, China National Knowledge Infrastructure, and CQVIP Database. Meta-analysis was performed using Stata11.0 software. The strength of the association was evaluated by calculating the combined odds ratios(ORs) and the corresponding 95%CIs. The retrieved publications were excluded or included one by one for sensitivity analysis. In addition, the funnel plot, Begg's rank correlation test, and Egger's linear regression method were applied to analyse whether the included publications had publication bias. RESULTS A total of 24 publications related to the COX-2-1195G>A gene polymorphism were included, including 28 studies involving 11043 cases and 18008 controls. The meta-analysis results showed that the COX-2-1195G>A gene polymorphism significantly correlated with an increased risk of gastrointestinal cancers, particularly gastric cancer(A vs G: OR = 1.35; AA/AG vs GG: OR = 1.54; AA vs GG/AG: OR = 1.43; AA vs GG: OR = 1.80; AG vs GG: OR = 1.35). Compared to the Caucasian population in America and Europe, the COX-2-1195G>A gene polymorphism in the Asian population(A vs G: OR = 1.30; AA/AG vs GG: OR= 1.50; AA vs GG/AG: OR = 1.35; AA vs GG: OR = 1.71; AG vs GG: OR = 1.37) significantly increased gastrointestinal cancer risk. The sensitivity analysis(P sitive report probability(P siON The results showed that the COX-2-1195G>A gene polymorphism might be a potential risk factor for gastrointestinal cancers. Further validation by a large homogeneous study is warranted.

关键词： COX-2 -1195G>A Polymorphism Meta-analysis Gastrointestinal cancer

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Influence of modulation period for β-Cu2+xSe/siC nano-multilayer films on their thermoelectric properties

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Progress in Natural Science:Materials International 2022年第5期32卷 586-593页

作者： Guihong Song Yu chen Hao Du Xiaoyuan wei Guipeng Li Yusheng Wu Junhua You Fang Hu School of Materials Science and Technology Shenyang University of Technology Guangzhou Maritime University Institute of Corrosion Science and Technology

In this study, β-Cu2+xSe/siC nano-multilayer films with different modulation period were successfully deposited on siO2/si substrates by sputtering alternately using Cu–Se and siC targets. The deposited films were observed on both surface and cross-section, and the thermoelectric properties were studied. The results show that both carrier concentration and mobility at room temperature decreased with the reducing modulation period for the nanomultilayer films. The conductivity slightly decreased and Seebeck coefficient greatly increased with the reducing modulation period. As a result of competition, the power factor of the nano multilayer films increased with the reducing modulation period because the positive effect of the Seebeck coefficient exceeded the negative effect of the conductivity. In the case of β-Cu2+xxSe/siC nano multilayer film with the smallest modulation periods(210 nm), the power factor reached 0.39 mWm-1K-2and 0.59 mWm-1K-2at room temperature and 325°C,respectively. The enhanced power factor for nano multilayer films is attributed to the scattering process at theβ-Cu2+xSe/siC layer interface, which reduces the carrier concentration and the mobility. It is concluded that the thermoelectric properties of β-Cu2+xSe films can be effectively improved by designing nano multilayer structure.

关键词： Thermoelectric materials β-Cu 2-x Se/siC multilayer Films Seebeck coefficient Layer interface scattering Modulation period

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基于混合Logit模型的网约车选择行为研究

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交通运输系统工程与信息 2018年第1期18卷 108-114页

作者：唐立邹彤罗霞陈思为西华大学汽车与交通学院成都610039 上海市政工程设计研究总院(集团)有限公司成都分公司成都610000 西南交通大学交通运输与物流学院成都610031

近年来,网约车发展迅速,而现有研究较少从市场角度理解用户对网约车的选择偏好.本文构建了基于混合Logit选择模型,选取网约车依赖性、出行目的等出行相关属性,年龄等个人社会经济属性为效用函数特征变量,假设到达时间、在车时间和费用... 详细信息

近年来,网约车发展迅速,而现有研究较少从市场角度理解用户对网约车的选择偏好.本文构建了基于混合Logit选择模型,选取网约车依赖性、出行目的等出行相关属性,年龄等个人社会经济属性为效用函数特征变量,假设到达时间、在车时间和费用为随机变量并服从对数正态分布.使用D-efficient效率设计法生成问卷,在成都市开展网约车使用特征与选择偏好的实证调查.基于观察数据标定模型,参数显著性及符号解释了城市综合交通背景下出行方式选择的关键因素.对出租车和网约车费用进行边际效应分析,明确了价格变化对出行结构的影响.

关键词：城市交通出行方式选择混合Logit模型网约车出行行为分析

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Uneven deposition on the Al electrode under tension strain

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Journal of Energy Chemistry 2022年第8期31卷 98-103,I0004页

作者： Jie He Le Yang Na Li wei-Li Song Shuqiang Jiao Hao-Sen chen Daining Fang Institute of Advanced Structure Technology Beijing Institute of TechnologyBeijing 100081China Beijing Key Laboratory of Lightweight Multi-functional Composite Materials and Structures Beijing Institute of TechnologyBeijing 100081China State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

Structural deformation and dendrite formation, which would impact the electrochemical processes of rechargeable metal batteries, are usually observed in the high-energy density metal electrodes. Herein,we design an in-situ optical mechano-electrochemical system to study Al deposition on the Al electrode in non-aqueous Al batteries under non-uniform strain. Inhomogeneous distribution of applied strain is realized by creating an oval hole in the Al electrode. The results of the in-situ experiments suggest that the dense Al deposition, which is related to the evolution of surface morphology and increasing reactive sites, is achieved in the regions of stress concentration. The evolution of surface morphology is monitored by the in-situ tension experiments using scanning electron microscope and atomic force ***, a qualitative mathematical model is employed to analyze the changes of the local reaction rate owing to the changed surface morphology and the cracks of oxide film under tensile stress. The results are useful to understand the Al deposition when the mechanical force is applied to the metal electrode.

关键词： Metal electrode In-situ devices Al deposition Surface morphology Tensile strain

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High-resolution and large-size stretchable electrodes based on patterned silver nanowires composites

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Nano Research 2022年第5期15卷 4590-4598页

作者： Yong Lin Qingsong Li chen Ding Jiayi Wang wei Yuan Zhiyuan Liu Wenming Su Zheng Cui Printable Electronics Research Centre Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China CAS Key Laboratory of Human-Machine Intelligence-Synergy Systems Shenzhen Institute of Advanced TechnologyChinese Academy of Sciences(CAS)Shenzhen 518055China School of Nano-Tech and Nano-Bionics University of Science and Technology of ChinaHefei 230026China

Electrodes based on composites of silver nanowires(AgNWs)and elastic polymers have been widely studied and applied in various stretchable electronic ***,due to the high aspect ratio of nanowires,the patterning of AgNW-based composite electrodes remains a huge challenge,especially for high-resolution complex circuit wiring on large-size elastic *** this paper,we propose a method for preparing large-size stretchable circuit boards with high-resolution electrodes by the combination of screen printing and vacuum filtration of AgNWs/polydimethylsiloxane(PDMS)*** as-prepared stretchable electrodes have smooth edges with patterning resolution up to-50 μ*** conductivity of the composite electrode can be precisely controlled by varying deposition densities of AgNWs and have reached to 1.07 x 10^(4) S/cm when the deposition density was 2.0 mg/cm^(2).In addition,the uniformity of conductivity and the resistance-strain characteristics of composite electrodes were systematically evaluated with different AgNWs deposition *** composite electrodes have been successfully employed to construct a large-size programmable display system and an 18-channel surface electromyography(EMG)recording,showing great potentials for some strain-insensitive stretchable circuits in wearable and health-related electronic applications.

关键词： AgNWs patterning silver nanowires AgNWs/PDMS composite stretchable circuit board high-density electrode array

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Human umbilical cord-derived mesenchymal stem cells promote repair of neonatal brain injury caused by hypoxia/ischemia in rats

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Neural Regeneration Research 2022年第11期17卷 2518-2525页

作者： Yang Jiao Yue-Tong Sun Nai-Fei chen Li-Na Zhou Xin Guan Jia-Yi Wang Wen-Juan wei Chao Han Xiao-Lei Jiang Ya-chen Wang wei Zou Jing Liu Stem Cell Clinical Research Center National Joint Engineering LaboratoryRegenerative Medicine CenterThe First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning ProvinceChina Dalian Innovation Institute of Stem Cells and Precision Medicine DalianLiaoning ProvinceChina Department of Neurology The First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning ProvinceChina College of Life Science Liaoning Normal UniversityDalianLiaoning ProvinceChina

Administration of human umbilical cord-derived mesenchymal stem cells(hUC-MSCs)is believed to be an effective method for treating neurodevelopmental disorde *** this study,we investigated the possibility of hUC-MSCs treatment of neonatal hypoxic/ischemic brain injury associated with maternal immune activation and the underlying *** established neonatal rat models of hypoxic/ischemic brain injury by exposing pregnant rats to lipopolysaccharide on day 16 or 17 of *** offspring were intranasally administe red hUC-MSCs on postnatal day *** found that polypyrimidine tract-binding protein-1(PTBP-1)participated in the regulation of lipopolysaccharide-induced maternal immune activation,which led to neonatal hypoxic/ischemic brain *** delive ry of hUC-MSCs inhibited PTBP-1 expression,alleviated neonatal brain injury-related inflammation,and regulated the number and function of glial fibrillary acidic protein-positive astrocytes,there by promoting plastic regeneration of neurons and im p roving brain *** findings suggest that hUC-MSCs can effectively promote the repair of neonatal hypoxic/ischemic brain injury related to maternal immune activation through inhibition of PTBP-1 expression and astrocyte activation.

关键词： developmental brain disease model disease-associated astrocytes intranasal administration lipopolysaccharide maternal immune activation neonatal brain injury neuroplasticity repair polypyrimidine tract-binding protein-1 stem cell therapy umbilical cord-derived mesenchymal stem cells

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Revealing unconventional host-guest complexation at nanostructured interface by surface-enhanced Raman spectroscopy

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Light(Science & Applications) 2021年第5期10卷 898-905页

作者： Gan-Yu chen Yi-Bin Sun Pei-chen Shi Tao Liu Zhi-Hao Li si-Heng Luo Xin-Chang Wang Xiao-Yu Cao Bin Ren Guo-Kun Liu Liu-Lin Yang Zhong-Qun Tian State Key Laboratory of Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materials(iChEM)College of Chemistry and Chemical EngineeringXiamen UniversityXiamen361005China State Key Laboratory of Marine Environmental Science Fujian Provincial Key Laboratory for Coastal Ecology and Environmental StudiesCenter for Marine Environmental Chemistry&ToxicologyCollege of the Environment and EcologyXiamen UniversityXiamen361102China School of Electronic Science and Engineering(National Model Microelectronics College) Xiamen UniversityXiamen361005China Key Laboratory of Chemical Biology of Fujian Province Xiamen UniversityXiamen361005China

Interfacial host–guest complexation offers a versatile way to functionalize ***,the complicated interfacial environment and trace amounts of components present at the interface make the study of interfacial complexation very ***,taking the advantages of near-single-molecule level sensitivity and molecular fingerprint of surface-enhanced Raman spectroscopy(SERS),we reveal that a cooperative effect between cucurbit[7]uril(CB[7])and methyl viologen(MV^(2+)2^(I−))in aggregating Au NPs originates from the cooperative adsorption of halide counter anions I^(−),MV^(2+),and CB[7]on Au NPs ***,similar SERS peak shifts in the control experiments using CB[n]s but with smaller cavity sizes suggested the occurrence of the same guest complexations among CB[5],CB[6],and CB[7]with MV2+.Hence,an unconventional exclusive complexation model is proposed between CB[7]and MV^(2+)on the surface of Au NPs,distinct from the well-known 1:1 inclusion complexation model in aqueous *** summary,new insights into the fundamental understanding of host–guest interactions at nanostructured interfaces were obtained by SERS,which might be useful for applications related to host–guest chemistry in engineered nanomaterials.

关键词： materials. surface. complexation

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AC vector magnetometer for space-based applications using low-resource magneto-impedance sensor

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Science China(Technological Sciences) 2023年第12期66卷 3663-3670页

作者： YU XiangQian HUANG Cong XIAO ChiJie LI Jiawei LIU si WANG JingDong LI YunPeng QU YaNan WANG YongFu chen HongFei ZOU Hong SHI weiHong ZONG QiuGang chen XiaoFei ZHANG XiaoXin ZONG weiGuo WANG JingSong School of Earth and Space Sciences Peking UniversityBeijing 100871China Key Laboratory of Space Weather National Satellite Meteorological Center(National Center for Space Weather)China Meteorological AdministrationBeijing 100081China Innovation Center for Feng-Yun Meteorological Satellite(FYsiC) Beijing 100081China School of Physics Peking UniversityBeijing 100871China School of Physics and Electronic Science Changsha University of Science&TechnologyChangsha 410114China Center for Space Science and Applied Research Chinese Academy of SciencesBeijing 100190China Institute of Shandong Aerospace Technology Yantai 264003China Shanghai Institute of Satellite Engineering(siSE) Shanghai 201108China

This study proposes a novel AC vector magnetometer developed using a low-resource magneto-impedance sensor for China’s Feng-Yun meteorological satellite(FY-3E).It was calibrated and characterized to determine its performance *** total weight of the AC vector magnetometer is 51 g(the aluminum box excluded),while the total power consumption is 310 m *** proposed AC vector magnetometer can detect magnetic field variations in the range of±1000 nT and noise power spectral density of≤50 pT/Hz^(1/2)@1 ***,the proposed device has a maximum nonlinearity of≤0.71‰over the entire range and a nonorthogonality error of 3.07 nT or 0.15%(root mean square).The total dose hardness of the sensor is≥30 krad(si).Furthermore,we propose the first survey results of a magnetometer equipped aboard a Chinese FY-3E satellite in a Sunsynchronous *** data revealed that the AC vector magnetometer can detect transient physical signals such as quasistatic field-aligned currents(~50 nT)and waves at the auroral *** features render the proposed AC vector magnetometer suitable for space-based applications,particularly those involving the study of geomagnetic activity.

关键词： AC vector magnetometer low-resource magneto-impedance sensor FY-3E satellite

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Optimal control based coordinated taxiing path planning and tracking for multiple carrier aircraft on flight deck

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Defence Technology（防务技术） 2022年第2期18卷 238-248页

作者： Xin-wei Wang Hai-jun Peng Jie Liu Xian-zhou Dong Xu-dong Zhao chen Lu Department of Engineering Mechanics State Key Laboratory of Structural Analysis for Industrial EquipmentDalian University of TechnologyDalianLiaoning116024China Faculty of Electronic Information and Electrical Engineering Dalian University of TechnologyDalianLiaoning116024China War Research Institute Academy of Military SciencesBeijing100850China School of Reliability and Systems Engineering Beihang UniversityXueyuan RoadHaidian DistrictBeijing100191China

Coordinated taxiing planning for multiple aircraft on flight deck is of vital importance which can dramatically improve the dispatching *** this paper,first,the coordinated taxiing path planning problem is transformed into a centralized optimal control problem where collision-free conditions and mechanical limits are *** the formulated optimal control problem is of large state space and highly nonlinear,an efficient hierarchical initialization technique based on the Dubins-curve method is ***,a model predictive controller is designed to track the obtained reference trajectory in the presence of initial state error and external *** experiments demonstrate that the proposed“offline planningþonline tracking”framework can achieve efficient and robust coordinated taxiing planning and tracking even in the presence of initial state error and continuous external disturbances.

关键词： Carrier aircraft Coordinated path planning Centralized optimal control Trajectory tracking Model predictive control

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Microstructures and properties of 6016 aluminum alloy with gradient composition

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Rare Metals 2021年第8期40卷 2154-2159页

作者： Xiang-Jie Wang wei Sun Jun-Fu chen Fu-Yue Wang Lei Li Jian-Zhong Cui Key Laboratory of Electromagnetic Processing of Materials Ministry of EducationNortheastern UniversityShenyang110819China

weight reduction plays an important role in reducing fuel and emissions,and the heat-treatable 6016 aluminum alloy exhibits excellent application prospect in automobile *** this paper,ingot with constant Mg/si ratio and decreased Mg and si contents was *** the microstructure and the texture of 6016 aluminum alloy plate designed with different alloy compositions at the top/bottom were systematically investigated by electron backscatter diffraction technology(EBSD)measurement,as well as the room-temperature mechanical properties at the different positions with composition *** results indicate that as Mg and si contents increase,the grain size decreases,improving the cube texture with recrystallization and weakening the S *** strength of 6016 aluminum alloy decreases with lower Mg and si contents.

关键词： 6016 Aluminum alloy plate Mg and si contents Mechanical properties

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