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A Potential Anti-cancer Compound Separated from the Chloroform Extract of the Chinese Medicine Formula Shenqi San

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Current Medical Science 2020年第1期40卷 138-144页

作者： Lu SHI Yi-jun TU si-qi ye Yu XIA Chao-zhi MA Xiao-zhi PENG Yan-wen LIU Zhong-zhu AI Peng-tao YOU Department of Pharmacy Medical CollegeJianghan UniversityWuhan 430056China Hubei Key Laboratory of Resources and Chemistry of Chinese Medicine Hubei University of Chinese MedicineWuhan 430065China Department of Dermatology The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510220China

This study examined anti-cancer compounds present in the chloroform extract of the Chinese medicine formula Shenqi San(CE-SS).silica gel column chromatography,Sephadex LH-20,octadecylsilyl(ODS)column chromatography,and high performance liquid chromatography(HPLC)were used to separate the compounds from *** structural formulas of the separated compounds were determined using ID1H and 13C experiments as well as high resolution electrospray ionization mass spectroscopy(HREsiMS).The corresponding results were compared with the reported literature data.A total of six compounds were separated and their structures were identified on the basis of corresponding spectroscopic and physico-chemical *** were Saikogenin F(Ⅰ),Prosaikogenin D(Ⅱ),Prosaikogenin F(Ⅲ),p-sitosterol(Ⅳ),3β,16β,23-trihydroxy-13,28-epoxyurs-11-ene-3-O-β-D-glucopyranoside(V),and methyl ursolic acid(VI).The separated compounds were evaluated in vitro for their inhibitory ability against the proliferation of A549 cells via MTT *** was investigated using Annexin V-FITC/propidium iodide(PI)by flow ***-associated proteins were examined by Western *** the compounds were observed to have inhibitory activities against the proliferation of A549 cells to different *** cytometry showed that compound V increased the proportion of apoptotic A549 cells in a dose-dependent *** blotting showed that compound V increased the expression of Bax,cleaved-caspase-3,cleaved-caspase-9 and cleaved-poly ADP-ribose polymerase(PARP),and decreased the expression of *** results indicated that compound V featured a significant inhibitory effect on A549 cells when compared with other compounds,and it may be considered a potential drug against cancers.

关键词： Shenqi San separation identification A549 apoptosis

中国乡镇教育行政机构发展历程、运行模式及变革走向

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北京教育学院学报 2025年第1期39卷 1-8页

作者：司洪昌韩烨国家教育行政学院科研处北京102617 国家教育行政学院教育行政教研部北京102617

自新中国成立以来,乡镇教育行政机构经历了从隶属于乡镇政府到隶属于县教育局的转变。2002年起,乡镇教育行政机构归属于县教育局垂直管理,这一体制运行至今,各地乡镇教育行政机构名称复杂而多元,且存在多样化的模式。乡镇教育行政机构... 详细信息

自新中国成立以来,乡镇教育行政机构经历了从隶属于乡镇政府到隶属于县教育局的转变。2002年起,乡镇教育行政机构归属于县教育局垂直管理,这一体制运行至今,各地乡镇教育行政机构名称复杂而多元,且存在多样化的模式。乡镇教育行政机构的地方属性,给乡镇教育管理预留了政策空间。当前乡镇教育行政机构重构的窗口期已开启,各地根据区域方位、县域及乡镇面积大小与人口多少、居民点分布及经济发展水平等做出适应地方实际的动态调整,成为未来十年的一个重要趋势。

关键词：乡镇教育教育行政机构乡镇中心校

Angiogenesis and immune checkpoint dual blockade:Opportunities and challenges for hepatocellular carcinoma therapy

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World Journal of Gastroenterology 2022年第42期28卷 6034-6044页

作者： si-qi Li Yang Yang Lin-Sen ye Department of Hepatic Surgery and Liver Transplantation Center The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina

The disease burden related to hepatocellular carcinoma(HCC) is increasing. Most HCC patients are diagnosed at the advanced stage and multikinase inhibitors have been the only treatment choice for them. Recently, the approval of immune checkpoint inhibitors(ICIs) has provided a new therapeutic strategy for HCC. It is noteworthy that the positive outcomes of the phase Ⅲ clinical trial IMBrave150 [atezolizumab(anti-programmed cell death ligand 1 antibody) combined with bevacizumab(anti-vascular endothelial growth factor monoclonal antibody)],showed that overall survival and progression-free survival were significantly better with sorafenib. This combination therapy has become the new standard therapy for advanced HCC and has also attracted more attention in the treatment of HCC with anti-angiogenesis-immune combination therapy. Currently, the synergistic antitumor efficacy of this combination has been shown in many preclinical and clinical studies. In this review, we discuss the mechanism and clinical application of anti-angiogenics and immunotherapy in HCC, outline the relevant mechanism and rationality of the combined application of antiangiogenics and ICIs, and point out the existing challenges of the combination therapy.

关键词： Anti-angiogenesis Immunotherapy Combination therapy Vascular endothelial growth factor Immune checkpoint blockade Hepatocellular carcinoma

Solution-phase Synthesis of One-dimensional Semiconductor Nanostructures

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Journal of Materials Science & Technology 2008年第4期24卷 529-540页

作者： Jianfeng ye Limin qi Beijing National Laboratory for Molecular Sciences （BNLMS） State Key Laboratory for Structural Chemistry of Unstable and Stable Species College of Chemistry Peking University Beijing 100871 China

The synthesis of one-dimensional （1D） semiconductor nanostructures has been studied intensively for a wide range of materials due to their unique structural and physical properties and promising potential for future technological applications. Among various strategies for synthesizing 1D semiconductor nanostructures, solution-phase synthetic routes are advantageous in terms of cost, throughput, modulation of composition, and the potential for large-scale and environmentally benign production. This article gives a concise review on the recent developments in the solution-phase synthesis of ID semiconductor nanostructures of different compositions, sizes, shapes, and architectures. We first introduce several typical solution-phase synthetic routes based on controlled precipitation from homogeneous solutions, including hydrothermal/solvothermal process, solution-liquid-solid （SLS） process, high-temperature organic-solution process, and low-temperature aqueous-solution process. Subsequently, we discuss two solution-phase synthetic strategies involving solid tem- plates or substrates, such as the chemical transformation of 1D sacrificial templates and the oriented growth of 1D nanostructure arrays on solid substrates. Finally, prospects of the solution-phase approaches to 1D semiconductor nanostructures will be briefly discussed.

关键词： Solution-phase synthesis One-dimensional Nanostructures Semiconductor

Using an image segmentation and support vector machine method for identifying two locust species and instars

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Journal of Integrative Agriculture 2020年第5期19卷 1301-1313页

作者： Shuhan LU ye si-jing Department of Computer and Information Science College of Art and ScienceOhio State UniversityColumbusOH 43210USA State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal UniversityBeijing 100875P.R.China Center for Geodata and Analysis Beijing Normal UniversityBeijing 100875P.R.China

Locusts are agricultural pests around the world. To cognize how locust distribution density and community structure are related to the hydrothermal and vegetation growth conditions of their habitats and thereby providing rapid and accurate warning of locust invasions, it is important to develop efficient and accurate techniques for acquiring locust information. In this paper, by analyzing the differences between the morphological features of Locusta migratoria manilensis and Oedaleus decorus asiaticus, we proposed a semi-automatic locust species and instar information detection model based on locust image segmentation, locust feature variable extraction and support vector machine(SVM) classification. And we subsequently examined its applicability and accuracy based on sample image data acquired in the field. Locust image segmentation experiment showed that the proposed GrabCut-based interactive segmentation method can be used to rapidly extract images of various locust body parts and exhibits excellent operability. In a locust feature variable extraction experiment, the textural, color and morphological features of various locust body parts were calculated. Based on the results, eight feature variables were selected to identify locust species and instars using outlier detection, variable function calculation and principal component analysis. An SVM-based locust classification experiment achieved a semi-automatic detection accuracy of 96.16% when a polynomial kernel function with a penalty factor parameter c of 2 040 and a gamma parameter g of 0.5 was used. The proposed detection model exhibits advantages such as high applicability and accuracy when it is used to identify locust instars of L. migratoria manilensis and O. decorus asiaticus, and it can also be used to identify other species of locusts.

关键词： locust identification machine learning support vector machine L.migratoria manilensis O.decorus asiaticus

Multiplicity of Periodic Bouncing Solutions for Sublinear Damped Variation Systems via Nonsmooth Variational Methods

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Acta Mathematica sinica,English Series 2023年第7期39卷 1332-1350页

作者： si qi WANG Fei GUO School of Mathematics Tianjin UniversityTianjin 300354China Tianjin Key Laboratory of Brain-Inspired Intelligence Technology Tianjin 300354China

Two results about the multiplicity of nontrivial periodic bouncing solutions for sublinear damped vibration systems-x=g(t)x+f(t,x) are obtained via the Generalized Nonsmooth Saddle Point Theorem and a technique established by Wu Xian and Wang *** of them imply the condition "f≥0" required in some previous papers can be weakened,furthermore,one of them also implies the condition about ■F(t,x)/■t required in some previous papers,such as "|■F(t,x)/■t|=σ_(0)F(t,x)" and "|■F(t,x)/■t|≤C(1+F(t,x))", is unnecessary,where F(t,x):=∫_(0)~xf(t,x)ds,and σ_(0),C are positive constants.

关键词： Damped vibration systems generalized Nonsmooth Saddle Point Theorem sublinear conditions periodic bouncing solutions multiplicity

Recent advances in fabrication of monolayer colloidal crystals and their inverse replicas

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Science China Chemistry 2014年第1期57卷 58-69页

作者： ye XiaoZhou qi LiMin Beijing National Laboratory for Molecular Sciences State Key Laboratory for Structural Chemistry of Unstable and Stable Species College of Chemistry Peking University

Monolayer colloidal crystals(MCCs)are two-dimensional(2D)colloidal crystals consisting of a monolayer of monodisperse colloidal particles arrayed with a 2D periodic *** recent years,MCCs have attracted intensive interest because they can act as 2D photonic crystals and be used as versatile templates for fabrication of various 2D nanostructure *** this review,we provide an overview of the recent progress in the controllable fabrication of MCCs and their inverse ***,some newly-developed methods for the self-assembly of MCCs based on different strategies including interfacial assembly and convective assembly are ***,some representative novel methods regarding the fabrication of various functional2D inverse replicas of MCCs,such as 2D arrays of nanobowls,nanocaps,and hollow spheres,as well as 2D monolayer inverse opals(MIOs),are *** addition,the potential applications of MCCs and their inverse replicas are discussed.

关键词： monolayer colloidal crystals,2D inverse replica,nanosphere lithography,self-assembly,replication,fabrication method

Tribological properties of cobalt-based alloy coating with different cobalt contents by electro-spark deposition

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Rare Metals 2013年第1期32卷 40-46页

作者： qi-Feng Jing ye-Fa Tan Engineering Institute of Engineering Corps PLA University of Science & Technology Unit 78649 of PLA

The cobalt-based alloy coating with different Co contents was deposited on 45 steel by electro-spark deposition with the self-made electrode. The coating has a compact and uniform microstructure with low porosity and no visible microcracks. When Co content increases grad- ually, oxygen content of coating samples 1-5 decreases first and then increases in the range of 2.52 wt%-3.05 wt%; sample 3 has the lowest oxygen content of 2.52 %. Mi- crohardness of the coating is improved remarkably com- pared with the substrate （HV 230.18）. With Co content increasing, microhardness of the coating samples 1-5 first rises slightly and then declines rapidly in the range of HV 580.61-1052.33. Sample 3 gets the maximum of HV 1052.33, which is about 4.6 times that of the substrate. The coating presents excellent wear resistance, which first increases and then decreases when Co content increases. Sample 3 shows the best wear resistance of about 6.4 times that of the substrate. Main wear mechanism of the coating is abrasive wear and fatigue wear, along with oxidation wear under high speed or heavy load conditions.

关键词： Electro-spark deposition Cobalt Content Microstructure Wear resistance Wear mechanism

N-soliton solutions for the nonlocal two-wave interaction system via the Riemann–Hilbert method

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Chinese Physics B 2018年第12期27卷 157-163页

作者： si-qi Xu Xian-Guo Geng School of Mathematics and Statistics Zhengzhou UniversityZhengzhou 450001China College of Civil Engineering Xinyang Normal UniversityXinyang 464000China

In this paper, a nonlocal two-wave interaction system from the Manakov hierarchy is investigated via the Riemann–Hilbert approach. Based on the spectral analysis of the Lax pair, a Riemann–Hilbert problem for the nonlocal two-wave interaction system is constructed. By discussing the solutions of this Riemann–Hilbert problem in both the regular and nonregular cases, we explicitly present the N-soliton solution formula of the nonlocal two-wave interaction system. Moreover,the dynamical behaviour of the single-soliton solution is shown graphically.

关键词： nonlocal two-wave interaction system Riemann–Hilbert problem N-soliton solutions