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Samarium Diiodide-Induced Reductive Cleavage of Se-St Bond in Arylselenotrimethylsilane Leading to the Formation of Samarium Arylselenolate: Synthesis of β-Arylseleno Estsrs and β-Arylseleno Nitriles

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Chinese Chemical Letters 1998年第10期9卷 885-887页

作者： Song Lin ZHANG and Yong Min ZHANG(department of Chemistry, hangzhou Univer{2.ty, hangzhou, 31002.) department of Chemistry Hangzhou University Hangzhou 310028 China

The Se-St bond in arylselenotrimethylsilane was reduced by samarium diiodide to produce samarium arylselenolate, which reacted with a,β-unsaturated esters or α,β-unsaturated nitriles to give β-selenoesters and β-... 详细信息

关键词： samarium diiodide arylselenotrimethylsilane arylseleno esters arylseleno nitriles

Orthopedic revolution:The emerging role of nanotechnology

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World Journal of Orthopedics 2024年第10期15卷 932-938页

作者： Wen-Jie Ruan si-si Xu Dong-Hui Xu Zhi-Peng Li department of Sports Medicine Zhejiang Provincial People's Hospital(The Affiliated People's Hospital)Hangzhou 310000Zhejiang ProvinceChina School of Medicine Taizhou UniversityTaizhou 318000Zhejiang ProvinceChina The Second department of Orthopedics The Fifth Affiliated Hospital of Zhengzhou UniversityZhengzhou 450015Henan ProvinceChina

This review summarizes the latest progress in orthopedic nanotechnology,ex-plores innovative applications of nanofibers in tendon repair,and evaluates the potential of selenium and cerium oxide nanoparticles in osteoarthritis and osteo-blast *** review also describes the emerging applications of inje-ctable hydrogels in cartilage engineering,emphasizing the critical role of inter-disciplinary research and highlighting the challenges and future prospects of in-tegrating nanotechnology into orthopedic clinical *** comprehensive approach provides a holistic perspective on the transformative impact of nanote-chnology in orthopedics,offering valuable insights for future research and clinical applications.

关键词： Cerium oxide nanoparticles Injectable hydrogels Interdisciplinary research Orthopedic nanotechnology Selenium nanoparticles

Noise‐tolerant matched filter scheme supplemented with neural dynamics algorithm for sea island extraction

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CAAI Transactions on Intelligence Technology 2024年第4期9卷 996-1013页

作者： Yiyu Chen Dongyang Fu Difeng Wang Haoen Huang Yang si Shangfeng Du School of Electronics and Information Engineering Guangdong Ocean UniversityZhanjiangChina State Key Laboratory of Satellite Ocean Environment Dynamics Second Institute of OceanographyMinistry of Natural ResourcesHangzhouChina School of Artificial Intelligence and Automation Huazhong University of Science and TechnologyWuhanChina

Achieving high‐precision extraction of sea islands from high‐resolution satellite remote sensing images is crucial for effective resource development and sustainable ***,achieving such accuracy for sea island extraction presents significant challenges due to the presence of extensive background interference.A more widely applicable noise‐tolerant matched filter(NTMF)scheme is proposed for sea island extraction based on the MF *** NTMF scheme effectively suppresses the background interference,leading to more accurate and robust sea island *** further enhance the accuracy and robustness of the NTMF scheme,a neural dynamics algorithm is supplemented that adds an error integration feedback term to counter noise interference during internal computer operations in practical *** comparative experiments were conducted on various remote sensing images of sea islands under different noisy working conditions to demonstrate the superiority of the proposed neural dynamics algorithm‐assisted NTMF *** experiments confirm the ad-vantages of using the NTMF scheme for sea island extraction with the assistance of neural dynamics algorithm.

关键词： edge detection image classification image recognition shape extraction

Quality of life in patients with liver cancer after operation:a 2.year follow-up study

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Hepatobiliary & Pancreatic Diseases International 2004年第4期3卷 530-533页

作者： Li Chen, Yong Liu, Guo-Gang Li, si-Feng Tao, Yuan Xu and Hua Tian hangzhou, {2. : department of Surgery, Second Affiliated Hospital, Zhejiang University School of Medicine, hangzhou 310009 , {2. department of Surgery Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310009 China. chenli@***

BACKGROUND:Quality of life (QL) is a concept which reflects the physical, social, and emotional attitudes and behaviours of an individual. QL assessment is becoming in- creasingly recognised as an outcome and predictor for can- cer patients. Although hepatectomy has been widely ac- cepted as treatment of choice to offer a chance of cure for patients with liver cancer, little is known about the subjec- tive clinical results after this operation. This prospective study was designed to evaluate the Pre- and postoperative quality of life in patients with liver cancer. METHODS: The quality of life of 36 consecutive patients was measured using gastrointestinal quality of life index (GQLI) regularly 2.years after the operation, starting with a preoperative measurement. RESULTS: The score of mean preoperative GQLI was 106 ± 13 points, and it was reduced significantly 2.10 weeks after the operation (86-98) (P 2. points 4 months after operation and increased to the preo- perative level ( P > 0. 05 ). In the patients who survived more than 9 months, the GQLI score was higher than that before the operation. Major hepatectomy (lobectomy and combined segmentectomy) reduced the GQLI score more evidently than did minor hepatectomy (simple segmentec- tomy ) in 2.5 weeks after the operation (P siONS: The assessment of the quality of life is meaningful for patients with liver cancer. Tumor recur- rence, poor liver function and major operation are the most important factors for reducing the quality of life. He- patic resection is justified by its effects on the survival and the quality of life of the patients.

关键词： quality of life liver cancer operation

Delivery room resuscitation intensity and associated neonatal outcomes of 2.^(+0)-31^(+6) weeks'preterm infants in china:a retrospective cross-sectional study

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World Journal of Pediatrics 2024年第1期20卷 64-72页

作者： si-Lu Wang Chun Chen Xin-Yue Gu Zhao-Qing Yin Le Su si-Yuan Jiang Yun Cao Li-Zhong Du Jian-Hua Sun Jiang-Qin Liu Chuan-Zhong Yang department of Neonatology Shanghai Key Laboratory of Maternal Fetal MedicineShanghai Institute of Maternal-Fetal Medicine and Gynecologic OncologyShanghai First Maternity and Infant HospitalSchool of MedicineTongji UniversityNo.2699Gaoke Western RoadPudong DistrictShanghai 201204China department of Neonatology Affiliated Shenzhen Maternity and Child Healthcare HospitalSouthern Medical UniversityNo.2004Hongli RoadFutian DistrictShenzhen 518028China NHC Key Laboratory of Neonatal Diseases Fudan UniversityChildren's Hospital of Fudan UniversityShanghaiChina department of Neonatology People's Hospital of DehongKunming Medical UniversityDehongChina department of Neonatology Children's Hospital of Fudan UniversityShanghaiChina department of Neonatology Children's HospitalZhejiang University School of MedicineHangzhouChina department of Neonatology Shanghai Children's Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Background The aim of this study was to review current delivery room(DR)resuscitation intensity in Chinese tertiary neonatal intensive care units and to investigate the association between DR resuscitation intensity and short-term outcomes in preterm infants born at 2.+0_31+6 weeks gestation age(GA).Methods This was a retrospective cross-sectional *** source population was infants born at 2.+0_31+6 weeks'GA who were enrolled in the Chinese Neonatal Network 2.19 *** infants were categorized into five groups:(1)regular care;(2.oxygen supplementation and/or continuous positive airway pressure(O2.CPAP);(3)mask ventilation;(4)endotracheal intubation;and(5)cardiopulmonary resuscitation(CPR).The association between DR resuscitation and shortterm outcomes was evaluated by inverse propensity score-weighted logistic *** Of 7939 infants included in this cohort,2.19(30.5%)received regular care,1994(2..1%)received O,/CPAP,1436(18.1%)received mask ventilation,1769(2..3%)received endotracheal intubation,and 32.(4.0%)received CPR in the *** maternal age and maternal hypertension correlated with a higher need for resuscitation,and antenatal steroid use tended to be associated with a lower need for resuscitation(Psignificantly with increasing amounts of resuscitation in DR after adjusting for perinatal *** strategies vary widely between centers,with over 50%of preterm infants in eight centers requiring higher intensity *** Increased intensity of DR interventions was associated with increased mortality and morbidities in very preterm infants in *** is wide variation in resuscitative approaches across delivery centers,and ongoing quality improvement to standardize resuscitation practices is needed.

关键词： Cardiopulmonary resuscitation Delivery room Endotracheal intubation Neonatal resuscitation Preterm

The lower and upper bounds of the degree distribution of a graded algebra

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Science china mathematics 2013年第5期56卷 983-994页

作者： si junru department of mathematics Hangzhou Dianzi University

For a graded algebra,the minimal projective resolution often reveals amounts of *** generated degrees of modules in the minimal resolution of the trivial module form a sequence,which can be called the degree distribution of the *** try to find lower and upper bounds of the degree distribution,introduce the notion of(s,t)-(homogeneous) determined algebras and construct such algebras with the aid of algebras with pure *** some cases,the Ext-algebra of an(s,t)-(homogeneous) determined algebra is finitely generated.

关键词： d-Koszul algebra spectral sequence regular normal extension

Structure of a histone hexamer bound by the chaperone domains of SPT16 and MCM2

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Science china(Life Sciences) 2024年第6期67卷 1305-1307页

作者： Songlin Gan Wen-si Yang Liting Wei Zhiguo Zhang Rui-Ming Xu Key Laboratory of Epigenetic Regulation and Intervention Institute of BiophysicsChinese Academy of SciencesBeijing 100101China School of Life Sciences University of Chinese Academy of SciencesBeijing 100049China Institute for Cancer Genetics Department of Pediatrics and Department of Genetics and DevelopmentColumbia University Irving Medical CenterNew York 10032USA School of Life Science Hangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China

Dear Editor,The passage of DNA replication forks during eukaryotic cell division disrupts the nucleosomes they encounter,and de novo assembly of nucleosomes onto replicated DNA must take place to restore chromatin ***... 详细信息

关键词： structure nucleosome passage

The 1:2.Complex of Piperazine with Some Phenols:Hydrogen Bonding Pattern Involved in Transition States in Solution

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Chinese Chemical Letters 2000年第2期11卷 105-106页

作者： Zhi Min JIN1 Yuan Jiang PAN1 si Hua SHANG2.Duan Jun XU1 Yuan Zhi XU1 (1 department of Chemistry, Zhejiang University, hangzhou 31002. 2.hejiang Entry-exit Inspection and Quarantine Bureau of the People’s Republic of china, hangzhou 310012. Zhejiang Univ Dept Chem Hangzhou 310027 Peoples R China Zhejiang Entry Exit Inspect & Quarantine Bur Hangzhou 310012 Peoples R China

A novel model for the 1: 2.complex of piperazine with some phenols in solution is established and verified. In CDCl3 solution, one piperazine molecule is tied to two phenol molecules by hydrogen bonds of O-H---N and N-H---O. And the protons of >NH and -OH groups exchange quickly and simultaneously between the atoms of phenol oxygen and piperazine nitrogen.

关键词： piperazine phenol hydrogen bond (HNMR)-H-1 Esi-MS

Multifunctional RGD coated a single-atom iron nanozyme:A highly selective approach to inducing ferroptosis and enhancing immunotherapy for pancreatic cancer

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Nano Research 2024年第6期17卷 5469-5478页

作者： Haoqi Pan Xu Chen Mingming Xiao He Xu Jiansheng Guo Zhiyi Lu Dong Cen Xianjun Yu si Shi department of Pancreatic Surgery Fudan University Shanghai Cancer CenterShanghai 200032China department of Oncology Shanghai Medical CollegeFudan UniversityShanghai 200032China Shanghai Pancreatic Cancer Institute Shanghai 200032China Pancreatic Cancer Institute Fudan UniversityShanghai 200032China Key Laboratory of Advanced Fuel Cells and Electrolyzers Technology of Zhejiang Province Qianwan Institute of CNITECHNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China department of Pathology of sir Run Run Shaw Hospital Zhejiang University School of MedicineHangzhou 310016China Key Laboratory of Laparoscopic Technology of Zhejiang Province Department of General SurgerySir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China

Nanozyme is a new promising approach to cancer therapy for its ability to induce ferroptosis by activating H_(2.O_(2.via a traditional radical pathway and enhance cancer ***,short half-life period of hydroxyl radical(·OH)results in unsatisfied ***,we synthesized a single-atom iron nanozyme(Fe-SAzyme),which can activate H_(2.O_(2.via a non-radical pathway to generate Fe-based reactive oxygen species(ROS)(O=FeO_(3)=O)for promoting the ferroptosis of pancreatic cancer *** Fe-SAzyme could be specifically phagocytosed by pancreatic cancer cells,increasing ROS levels and inhibiting glutathione(GSH)synthesis,which activates *** magnetic resonance imaging(MRI)showed decreased T2.signal after intravenous injection of RGD@Fe-AC(AC=activated carbon).Moreover,RGD@Fe-AC promoted dendritic cell(DC)maturation,overcame Treg-mediated immunosuppression,activated T cells to trigger adaptive immune responses,and enhanced the efficacy ofα-PD-L1 *** research demonstrated that RGD@Fe-AC provided a straightforward,easily implemented,and selective approach for pancreatic cancer treatment and immunotherapy.

关键词： single-atom iron nanozyme pancreatic cancer immunotherapy ferroptosis