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Genome editing in grass plants

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aBIOTECH 2020年第1期1卷 41-57页

作者： si nian char Bing Yang Division of Plant Sciences University of MissouriColumbiaMO 65211USA Donald Danforth Plant Science Center St.LouisMO 63132USA

Cereal crops including maize,rice,wheat,sorghum,barley,millet,oats and rye are the major calorie sources in our daily life and also important bioenergy sources of the *** rapidly advancing and state-of-the-art genome-editing tools such as zinc finger nucleases,TAL effector nucleases,and clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated systems(CRISPR-Cas9-,CRISPR-Cas12a-and CRISPR/Cas-derived base editors)have accelerated the functional genomics and have promising potential for precision breeding of grass *** the availability of annotated genomes of the major cereal crops,application of these established genome-editing toolkits to grass plants holds promise to increase the nutritional value and ***,these easy-to-use and robust genome-editing toolkits have advanced the reverse genetics for discovery of novel gene functions in crop *** this review,we document some of important progress in development and utilization of genome-editing tool sets in grass *** also highlight present and future uses of genome-editing toolkits that can sustain and improve the quality of cereal grain for food consumption.

关键词： Genome editing Cereal crops ZFNs TALENs CRISPR/Cas9 CRISPR/Cas12a Base editor

TRIPLET combined with microwave ablation:A novel treatment for advanced hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 10-12页

作者： Fei-Yu Zhao Guo-Wei si nian-Song Qian Department of Thoracic Oncology Respiratory and Critical Care MedicineThe Eighth Medical Center of People’s Liberation Army General HospitalBeijing 100853China Department of Gastroenterology Fourth Medical CentreGeneral Hospital of the People's Liberation ArmyBeijing 100142China Senior Department of Thoracic Oncology Respiratory and Critical Care MedicineThe Eighth Medical Center of People’s Liberation Army General HospitalBeijing 100091China

This editorial comments on a study by Zuo et *** focus is on the efficacy of he-patic arterial infusion chemotherapy combined with camrelizumab and apatinib(the TRIPLET regimen),alongside microwave ablation therapy,in treating advanced hepatocellular carcinoma(HCC).The potential application of this combination therapy for patients with advanced HCC is evaluated.

关键词： Microwave ablation Hepatic arterial infusion chemotherapy Apatinib Camrelizumab Hepatocellular carcinoma

Protective Effects of Anthocyanins Extracted from Vaccinium Uliginosum on 661W Cells Against Microwave-Induced Retinal Damage

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Chinese Journal of Integrative Medicine 2022年第7期28卷 620-626页

作者： YIN Lan FAN si-jun ZHANG Mao-nian Department of Ophthalmology Chinese PLA General HospitalBeijing 100853China Department of Ophthalmology PLA Rocket Characteristic Medical CenterBeijing 100853China

Objective: To study the protective effect of anthocyanins extracted from Vaccinium Uliginosum(VU)on retinal 661W cells against microwave radiation induced retinal injury. Methods: 661W cells were divided into 6 groups, including control, model [661W cells radiated by microwave(30 mW/cm2, 1 h)] and VU groups [661W cells pretreated with anthocyanins extracted from VU(25, 50, 100 and 200 μg/mL, respectively) for 48 h, and radiated by microwave 30 mW/cm2, 1 h]. After treatment with different interventions, the cell apoptosis index(AI)was determined using Heochst staining;contents of malonaldehyde(MDA), glutataione(GSH), and activity of superoxide dismutase(SOD) were measured. mRNA expressions of nuclear factor erythroid 2-related factor 2(Nrf2) and heme oxygenase 1(HO-1) were detected by real time quantitative polymerase chain reaction, and the expression of HO-1 protein was examined by Western blot analysis. Nucleus and cytoplasm were separated and Nrf2 protein expression was further verified by Western blot analysis. Results: There was significant difference in AI among the groups(F=322.83, Psignificantly higher in the model group and was lower in 4 VU-pretreated groups(Psion analysis showed the decline of AI was in a dose-dependent manner with VU treatment(r=0.8419, Psignificantly lower than the model group(Psignificantly higher(all Psions were slightly increased after irradiation, and obviously increased in 100 μg/mL VU-treated group. After irradiation, the relative expressions of HO-1 and Nrf2 proteins in nucleus were slightly increased(Pchanges in cytoplasm were not obvious,whereas it was significantly increased in both nucleus and cytoplasm in the VU treatment group

关键词： Vaccinium Uliginosum anthocyaninsm photoreceptor microwave apoptosis nuclear factor erythroid 2-related factor 2/heme oxygenase 1

characterizing a lubricant additive for 1,3,4-tri-(2-octyldodecyl) cyclopentane: Computational study and experimental verification

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Friction 2016年第3期4卷 257-265页

作者： Jingyan nian Yifan si Zhiguang GUO Ping GAO Weimin LIU State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics Chinese Academy of Sciences Lanzhou 730000 China State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics Chinese Academy of Sciences Lanzhou 730000 ChinaHubei Collaborative Innovation Centre for Advanced Organic Chemical Materials and Ministry of Education Key Laboratory for the Green Preparation and Application of Functional Materials Hubei University Wuhan 430062 China

In order to increase the life of spacecraft, it is important to improve the comprehensive lubrication performance. Multiple alkylated cyclopentane (MAC) lubricants are presently gaining wide acceptance for actual space applications; adding extreme pressure additive is a strategy to improve lubrication performance. In this study, taking 1,3,4-tri-(2-octyldodecyl) cyclopentane as base oil, tricresol phosphate (traditional additive) and tri-(2-octyldodecyl) phosphate (developmental additive) have been screened computationally for compatibility, shear film forming and energy dissipation. Theoretical results indicate that (a) tricresol phosphate additive is not suited for addition to 1,3,4-tri-(2-octyldodecyl) cyclopentane lubricant due to limited compatibility; (b) tri-(2-octyldodecyl) phosphate is an excellent lubricant additive due to its perfect compatibility, ease of forming a shear film on the surface of friction pairs, higher strength, and low energy dissipation; and (c) lubrication occurs through the solid-liquid composite lubrication mechanism. These theoretical results were confirmed experimentally.

关键词： 1,3,4-tri-(2-octyldodecyl) cyclopentane lubricant additive computational screening lubrication mechanism experimental verification

Experimental studies of H_(2)/Ar plasma in a cylindrical inductive discharge with an expansion region

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Chinese Physics B 2024年第10期33卷 321-330页

作者： Shi-Bo Li si-Yu Xing Fei Gao You-nian Wang Key Laboratory of Materials Modification by Laser Ionand Electron Beams(Ministry of Education)School of PhysicsDalian University of TechnologyDalian 116024China

The electrical parameters of H_(2)/Ar plasma in a cylindrical inductive discharge with an expansion region are investigated by a Langmuir probe,where Ar fractions range from 0%to 100%.The influence of gas composition and pressure on electron density,the effective electron temperature and the electron energy probability functions(EEPFs)at different spatial positions are *** driver region,with the introduction of a small amount of Ar at 0.3 Pa,there is a rapid increase in electron density accompanied by a decrease in the effective electron ***,the shape of the EEPF transitions from a three-temperature distribution to a bi-Maxwellian distribution due to an increase in electron-electron ***,this phenomenon resulting from the changes in gas composition vanishes at 5 Pa due to the prior depletion of energetic electrons caused by the increase in pressure during hydrogen *** EEPFs for the total energy in expansion region is coincident to these in the driver region at 0.3 Pa,as do the patterns of electron density variation between these two regions for differing Ar *** 5 Pa,as the discharge transitions from H_(2)to Ar,the EEPFs evolved from a bi-Maxwellian distribution with pronounced low energy electrons to a Maxwellian distribution in expansion *** evolve may be attributed to a reduction in molecular vibrational excitation reactions of electrons during transport and the transition from localized electron dynamics in hydrogen discharge to non-localized electron dynamics in argon *** order to validate the experimental results,we use the COMSOL simulation software to calculate electrical parameters under the same *** evolution and spatial distribution of the electrical parameters of the simulation results agree well with the trend of the experimental results.

关键词： inductively coupled plasma transmission and distribution energy distribution functions

A Theoretical Distinction Between Time-Resolved Resonance Raman andResonance Fluorescence

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Chinese Physics Letters 2000年第4期17卷 272-274页

作者： LU Jing DU si-De FAN Kang-nian Lee Soo-Ying Department of Chemistry Fudan UniversityShanghai 200433 Department of Physics Fudan UniversityShanghai 200433 Department of Chemistry National University of SingaporeSingapore 119260Singapore

Based on the time-dependent theory, an analysis of the distinction between resonance Raman (RR) and resonance fluorescence (RF) with pulse excitation was presented. The real population of the intermediate state gives two optical components-the independent time evolution of intermediate ket and bra states generates RR while RF originates from the phase coherent between ket and bra states. In cw limit, the transition probability of spontaneous emission with pulse excitation can be reduced to the classical theory.

关键词： theory. states. excitation

Synthesis and biological evaluation of substituted indazolyl amide derivatives as S-adenosyl-L-homocysteine hydrolase inhibitors

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Chinese Chemical Letters 2016年第6期27卷 984-988页

作者： Xiang-Duan Tan Li-Guang Mao Wei Wu si-Yun nian Guo-Ping Wang College of Pharmacy Guilin Medical University Department of Medicinal Chemistry and Pharmacognosy College of Pharmacy The Ohio State University Zhangjiang Institute China State Institute of Pharmaceutical Industry Shanghai Institute of Pharmaceutical Industry China State Institute of Pharmaceutical Industry

A series of novel amide derivatives bearing an indazole moiety were synthesized and evaluated for their in vitro S-adenosylL-homocysteine hydrolase（SAHase） inhibitory activity. Among these compounds, 8b,8m, 8r and 8w showed better or similar inhibitory effects compared to the positive control aristeromycin. These results provide a novel lead for the discovery of more potent non-adenosine analogs as SAHase inhibitors.

关键词： S-Adenosylhomocysteine hydrolase SAHase inhibitors Amide derivatives Indazole Synthesis

Edible agro-products quality and safety in China

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Journal of Integrative Agriculture 2015年第11期14卷 2166-2175页

作者： LI Zhe-min SU nian-si DONG Xiao-xia YANG Yan-tao WANG Yu-ting XIAO Hong-li Agricultural Information Institute Chinese Academy of Agricultural Sciences Key Laboratory of Digital Agricultural Early-Warning Technology Ministry of Agriculture Institute of Agricultural Economics and Development Chinese Academy of Agricultural Sciences Beijing Senior Expert Technology Center Chinese Academy of Sciences

Ensuring an acceptable level of edible agro-products quality and safety is necessary to provide adequate protection for con- sumers. It is the first time that we analyzed the edible agro-products quality and safety issues in the supply chain, including production, processing, circulation, and consumption. The results indicate that the agro-products quality and safety levels improves steadily, and the supervision system and standardization system are both enhanced significantly, however, certain challenges still remain in each stage of the supply chain and the entire supervision process. Finally, five recommendations regarding four aspects （production, processing, circulation, and consumption） are concluded.

关键词： edible agro-products quality and safety food safety supply chain supervision

Application of Endoscopic Vein Harvesting in Obese Patients Undergoing Coronary Artery Bypass Grafting

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Current Medical Science 2018年第4期38卷 691-696页

作者： Peng BAI Yi-xuan WANG si CHEN Jin-ping LIU nian-guo DONG Jun-wei LIU Department of Cardiovascular Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China

This study aims to evaluate the clinical outcomes of endoscopic vein harvesting （EVH） for coronary artery bypass grafting （CABG） in obese patients. Totally, 153 obese patients who underwent EVH （n=81） or standard bridging technique （SBT, n=72） in CABG surgery from May 2012 to October 2014 in our hospital were enrolled in this retrospective non-randomized controlled study. The general situation of operation, postoperative complications and short medium-term outcomes were analyzed. The baseline characteristics were similar between these two groups （P〉0.05）. There were no statistical differences in total operation time （226±28 min vs. 224±30 min, P〉0.05）, number of damaged vessels （0.12±0.05 vs. 0.16±0.06, P〉0.05） and short medium-term outcomes including revascularization rate （1.25% vs. 2.78%, P〉0.05）, vessel dysfunction rate （11.25% vs. 11.11%, P〉0.05） and mortality （0.00% vs. 0.00%, P〉0.05）. Use of EVH was associated with significant reduction of total harvesting time （41±6 min vs. 63±11 min, P〈0.05）, incision length （4.4±1.1 cm vs. 18.2±4.5 cm, P〈0.05） and postoperative lower extremity complications （P〈0.05）. EVH can reduce the risk of wound complications, whereas does not influence short- and medium-term outcomes in obese patients. It can be considered a reliable procedure of harvesting vessel conduits for obese patients undergoing CABG.

关键词： minimally invasive endoscopy saphenous vein harvesting obesity coronary artery bypass grafting