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Non-alcoholic fatty liver degree and long-term risk of incident inflammatory bowel disease: A large-scale prospective cohort study

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中华医学杂志(英文版) 2024年第14期137卷 1705-1714页

作者： zhang Qian Liu Si Wu Jing Zhu Shengtao Wu Yongdong Wu Shanshan zhang shutian Department of Gastroenterology Beijing Friendship Hospital Capital Medical University National Clinical Research Center for Digestive Disease Beijing Digestive Disease Center Beijing Key Laboratory for Precancerous Lesion of Digestive Disease Beijing China

Background: Non-alcoholic fatty liver disease (NAFLD) and inflammatory bowel disease (IBD) have shown similar worsening epidemic patterns globally and shared various overlapping pathophysiological mechanisms. However, evidence on the relationship between NAFLD and IBD risk is lacking. We aimed to investigate the associations between long-term risk of incident IBD and NAFLD in a large prospective ***: Participants from the United Kingdom Biobank cohort (https://***/) who were free of IBD and alcoholic liver disease at baseline were enrolled. Baseline non-alcoholic fatty liver degree was measured by the well-established fatty liver index (FLI). The outcomes of interest included incident IBD, ulcerative colitis (UC), and Crohn’s disease (CD). Multivariable Cox proportional hazard regression was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs).Results: Among 418,721 participants (mean FLI: 48.11 ± 30.11), 160,807 (38.40%) participants were diagnosed as NAFLD at baseline. During a median of 12.4 years’ follow-up, 2346 incident IBD cases (1545 UC, 653 CD, and 148 IBD-unclassified) were identified. Due to limited events, those IBD-unclassified were combined in UC or CD when examining the associated risk of UC or CD, separately. Compared with the lowest quartile of FLI, the highest quartile showed a separately 36.00%, 25.00%, and 58.00% higher risk of incident IBD (HRQ4vs. Q1 =1.36, 95% CI: 1.19-1.55,Ptrend <0.001), UC (HRQ4vs. Q1 =1.25, 95% CI: 1.07-1.46,Ptrend=0.047), and CD (HRQ4vs. Q1 =1.58, 95% CI: 1.26-1.97,Ptrend <0.001) after multivariable adjustment. Compared with non-NAFLD, NAFLD participants had a significantly higher risk of incident IBD (HR=1.13, 95% CI: 1.04-1.24) and CD (HR =1.36, 95% CI: 1.17-1.58).Conclusions: Higher degree of non-alcoholic fatty liver is associated with increased risk of incident IBD. Interventions aimed at improving NAFLD may be a potential targeted strategy for the detection and treatm

关键词： Non-alcoholic fatty liver disease Inflammatory bowel disease Ulcerative colitis Crohn’s disease Cohort study

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Modifiable risk factors for esophageal cancer in endoscopic screening population:A modeling study

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Chinese Medical Journal 2024年第3期137卷 350-352页

作者： Qian zhang Fan Wang Hao Feng Jie Xing Shengtao Zhu Hao zhang Yang Li Wenqiang Wei shutian zhang Department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityNational Clinical Research Center for Digestive DiseaseBeijing Digestive Disease CenterBeijing Key Laboratory for Precancerous Lesion of Digestive DiseaseBeijing 100050China Center for Applied Statistics and School of Statistics Renmin University of ChinaBeijing 100872China Statistical Consulting Center Renmin University of ChinaBeijing 100872China National Cancer Center National Clinical Research Center for CancerCancer InstituteChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Gastroenterology Jizhong Energy Fengfeng Group HospitalHandanHebei 056000China RSS and China-Re Life Joint Lab on Public Health and Risk Management Renmin University of ChinaBeijing 100872China

To the Editor:Esophageal cancer,one of the most common cancer types in China,with an estimated 346,633 new cases and 323,600 deaths in 2022,is becoming an increasingly serious clinical and public health problem.^([1])The successful promotion of the self-management strategy has indicated that lifestyle modifications can be valuable in the primary prevention of cancer *** a healthy lifestyle has become a novel strategy for primary prevention and risk reduction in high-risk *** epidemiological studies have identified several lifestyle-related risk factors for esophageal cancer,including smoking and diet.^([2])Each factor can typically explain a modest proportion of cancer ***,when combined,these known risk factors may substantially affect the risk of esophageal ***,some risk factors for esophageal cancer are non-modifiable,including age,low socioeconomic status,and family *** and how these non-modifiable risk factors affect primary cancer prevention by intervening with modifiable risk factors remain unclear.

关键词： esophageal prevention promotion

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基于因果正则化极限学习机的风电功率短期预测方法

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电力系统保护与控制 2024年第11期52卷 127-136页

作者：杨茂张书天王勃现代电力系统仿真控制与绿色电能新技术教育部重点实验室(东北电力大学) 吉林吉林132012 新能源与储能运行控制国家重点实验室(中国电力科学研究院有限公司) 北京100192

随着风电并网比例的逐年提高,电力系统对风电功率预测的准确性和稳定性提出了更高要求。对于同一风电场而言,为了避免不同特征选择方法所选择的风电场特征子集不同,从因果关系的角度出发,提出了一种基于因果正则化极限学习机(causal reg... 详细信息

随着风电并网比例的逐年提高,电力系统对风电功率预测的准确性和稳定性提出了更高要求。对于同一风电场而言,为了避免不同特征选择方法所选择的风电场特征子集不同,从因果关系的角度出发,提出了一种基于因果正则化极限学习机(causal regularized extreme learning machine, CRELM)的风电功率短期预测方法。首先将极限学习机(extreme learning machine, ELM)建模为结构因果模型(structural causal model, SCM),在此基础上计算隐藏层神经元与输出层神经元之间的平均因果效应向量。然后将该平均因果效应向量与输出层权重相结合构成因果正则化项,在最小化训练误差的同时最大化网络的因果关系,以进一步提升模型的预测准确性和预测稳定性。最后,以国内蒙西某风电场数据为例,与采用特征选择或不采用特征选择的预测模型相对比,验证了所提方法的有效性和适用性。

关键词：特征选择因果正则化结构因果模型平均因果效应向量极限学习机

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Nonlinear interaction of head-on solitary waves in integrable and nonintegrable systems

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Chinese Physics B 2024年第5期33卷 480-487页

作者：张树甜刘世鲲矫滕菲孙敏胡凤兰黄德财 Department of Applied Physics Nanjing University of Science and TechnologyNanjing 210094China

This study numerically investigates the nonlinear interaction of head-on solitary waves in a granular chain(a nonintegrable system)and compares the simulation results with the theoretical results in fluid(an integrable system).Three stages(the pre-in-phase traveling stage,the central-collision stage,and the post-in-phase traveling stage)are identified to describe the nonlinear interaction processes in the granular *** nonlinear scattering effect occurs in the central-collision stage,which decreases the amplitude of the incident solitary *** with the leading-time phase in the incident and separation collision processes,the lagging-time phase in the separation collision process is *** asymmetrical nonlinear collision results in an occurrence of leading phase shifts of time and space in the post-in-phase traveling *** next find that the solitary wave amplitude does not influence the immediate space-phase shift in the granular *** space-phase shift of the post-in-phase traveling stage is only determined by the measurement position rather than the wave *** results are reversed in the *** increase in solitary wave amplitude leads to decreased attachment,detachment,and residence times for granular chains and *** the immediate time-phase shift,leading and lagging phenomena appear in the granular chain and the fluid,*** results offer new knowledge for designing mechanical metamaterials and energy-mitigating systems.

关键词： integrable system nonintegrable system granular chain solitary wave

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重视全链条理念规范消化道早期癌诊治

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中华消化内镜杂志 2024年第7期41卷 505-508页

作者：刘揆亮李鹏张澍田首都医科大学附属北京友谊医院消化内科、国家消化系统疾病临床医学研究中心、北京市消化疾病中心、消化健康全国重点实验室北京100050

规范的内镜筛查和治疗是降低消化系统癌症发病率和死亡率的关键,我国的消化道早期癌诊治亟待整体水平的提升和规范。消化道早期癌的规范诊治涵盖多个学科,涉及多个环节,需树立全链条的理念。只有各环节密切配合,通力合作,才能保证消化... 详细信息

规范的内镜筛查和治疗是降低消化系统癌症发病率和死亡率的关键,我国的消化道早期癌诊治亟待整体水平的提升和规范。消化道早期癌的规范诊治涵盖多个学科,涉及多个环节,需树立全链条的理念。只有各环节密切配合,通力合作,才能保证消化道早期癌诊治全链条运转顺畅,不断提高消化道早期癌的检出率和治愈率,降低死亡率,改善消化道癌的预后。

关键词：消化道肿瘤早期癌全链条

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新型农村集体经济对农户收入差距的影响研究

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农林经济管理学报 2024年第3期23卷 273-282页

作者：王永平张舒甜贵州财经大学经济学院贵州贵阳550025

基于2020年中国乡村振兴综合调查数据库(CRRS)的数据,在采用再中心化影响函数(RIF)测算农户收入差距的基础上,运用精确断点回归(RDD)方法检验新型农村集体经济对农户收入差距的影响。结果表明:发展新型农村集体经济有助于缩小农户收入差... 详细信息

基于2020年中国乡村振兴综合调查数据库(CRRS)的数据,在采用再中心化影响函数(RIF)测算农户收入差距的基础上,运用精确断点回归(RDD)方法检验新型农村集体经济对农户收入差距的影响。结果表明:发展新型农村集体经济有助于缩小农户收入差距,这种影响有赖于新型农村集体经济整体实力水平,具体体现为发展实力较强的新型农村集体经济有助于缩小农户收入差距,而实力较弱的新型农村集体经济对农户收入差距不具有稳健影响。机制分析与异质性分析发现,促进公共资源分配公平与农户发展机会公平是新型农村集体经济缩小农户收入差距的重要途径;在脱贫地区与数字治理水平较高的地区,新型农村集体经济更有助于缩小农户收入差距。据此,建议持续推进农村集体产权制度改革,培育“有能集体”,构建巩固拓展脱贫攻坚成果同乡村振兴有效衔接机制,提升新型农村集体经济数字治理水平。

关键词：新型农村集体经济农户收入差距共同富裕效应回归分析(RDD)

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《中国肥胖症消化内镜治疗专家共识》解读

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中华消化内镜杂志 2024年第1期41卷 11-17页

作者：隗永秋程芮李鹏张澍田首都医科大学附属北京友谊医院消化内科北京100050

对《中国肥胖症消化内镜治疗专家共识》的出台背景以及需要关注的一些重点问题,如消化内镜减重手术的角色及指征界定、不同技术方案的选择及适用场景、围手术期的处理策略等进行解读。

关键词：肥胖内镜减重微创减重胃内球囊内镜下袖状胃成形术解读

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超声内镜引导下胆管引流对内镜逆行胰胆管造影失败的梗阻性黄疸患者的减黄效果评价

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中华内科杂志 2024年第10期63卷 975-981页

作者：张果赵桂平梁正张澍田首都医科大学附属北京友谊医院消化科北京

目的评估超声内镜引导下胆管引流(EUS-BD)对内镜逆行胰胆管造影(ERCP)失败的梗阻性黄疸患者的减黄效果。方法回顾性收集并分析2018年9月至2023年11月在北京友谊医院消化内镜中心因ERCP失败而行EUS-BD的梗阻性黄疸患者的临床资料, 分析EU... 详细信息

目的评估超声内镜引导下胆管引流(EUS-BD)对内镜逆行胰胆管造影(ERCP)失败的梗阻性黄疸患者的减黄效果。方法回顾性收集并分析2018年9月至2023年11月在北京友谊医院消化内镜中心因ERCP失败而行EUS-BD的梗阻性黄疸患者的临床资料, 分析EUS-BD的技术成功率、临床成功率以及不良事件发生情况。结果 39例患者共进行了43次EUS-BD术, 技术成功率为86.0%(37/43)。临床成功率为81.1%(30/37), 7例未有效实现胆管引流, 包括死亡病例2例和术后复发性胆管梗阻5例。不良事件发生率为21.6%(8/37), 包括术后胆汁渗漏性腹膜炎2例, 支架移位2例, 支架脱落1例, 穿孔1例, 死亡2例。结论 EUS-BD是相对安全、有效的胆管引流方式, 可以作为ERCP失败的梗阻性黄疸患者的可靠替代治疗方法。

关键词：超声检查, 介入性胰胆管造影术, 内窥镜逆行引流术黄疸

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Vonoprazan 10 mg or 20 mg *** 15 mg as maintenance therapy in Asian patients with healed erosive esophagitis:A randomized controlled trial

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Chinese Medical Journal 2024年第8期137卷 962-971页

作者： Yinglian Xiao Jiaming Qian shutian zhang Ning Dai Hoon Jai Chun Chengtang Chiu Chui Fung Chong Nobuo Funao Yuuichi Sakurai Jessica D.Eisner Li Xie Minhu Chen Department of Gastroenterology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510062China Department of Gastroenterology Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100006China Department of Gastroenterology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Gastroenterology Sir Run Run Shaw HospitalSchool of Medicine Zhejiang UniversityHangzhouZhejiang 310020China Department of Internal Medicine Korea University Anam HospitalKorea University College of Medicine73 Goryeodae-roSeongbuk-guSeoul 02841Republic of Korea Department of Gastroenterology&Hepatology Linkou Medical CenterChang Gung Memorial HospitalTaoyuanTaiwan 33353China College of Medicine Chang Gung UniversityTaoyuanTaiwan 33353China Takeda Development Center Asia Singapore 018981Singapore Takeda Pharmaceutical Company Chuo-kuOsaka 540-8645Japan Takeda Pharmaceuticals International Company CambridgeMA02142 USA China Medical Team Takeda ChinaBeijing 100027China Hoffmann-La Roche Basel4070 Switzerland Abbott Laboratories Lake ForestIL 60045USA

Background:Erosive esophagitis(EE)is a gastroesophageal reflux disease characterized by mucosal breaks in the *** pump inhibitors are widely used as maintenance therapy for EE,but many patients still *** this trial,we evaluated the noninferiority of vonoprazan *** as maintenance therapy in patients with healed ***:We performed a double-blind,double-dummy,multicenter,phase 3 clinical trial among non-Japanese Asian adults with endoscopically confirmed healed EE from April 2015 to February *** from China,South Korea,and Malaysia were randomized to vonoprazan 10 mg or 20 mg once daily or lansoprazole 15 mg once daily for 24 *** primary endpoint was endoscopically confirmed EE recurrence rate over 24 weeks with a noninferiority margin of 10%using a two-sided 95%confidence interval(CI).Treatment-emergent adverse events(TEAEs)were ***:Among 703 patients,EE recurrence was observed in 24/181(13.3%)and 21/171(12.3%)patients receiving vonoprazan 10 mg or 20 mg,respectively,and 47/184(25.5%)patients receiving lansoprazole(differences:-12.3%[95%CI,-20.3%to-4.3%]and-13.3%[95%CI,-21.3%to-5.3%],respectively),meeting the primary endpoint of noninferiority to lansoprazole in preventing EE recurrence at 24 *** of superiority(upper bound of 95%CI<0%)was also *** 12 weeks,endoscopically confirmed EE recurrence was observed in 5/18,2/20,and 7/20 of patients receiving vonoprazan 10 mg,vonoprazan 20 mg,and lansoprazole,*** were experienced by 66.8%(157/235),69.0%(156/226),and 65.3%(158/242)of patients receiving vonoprazan 10 mg,vonoprazan 20 mg,and lansoprazole,*** most common TEAE was upper respiratory tract infection in 12.8%(30/235)and 12.8%(29/226)patients in vonoprazan 10 mg and 20 mg groups,respectively and 8.7%(21/242)patients in lansoprazole ***:Vonoprazan maintenance therapy was well-tolerated and noninferior to lansoprazole for preventing EE recurrence i

关键词： Erosive esophagitis Lansoprazole Maintenance therapy Potassium-competitive acid blockers Vonoprazan

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内镜下胃转流支架系统治疗肥胖的疗效和安全性分析

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中华消化内镜杂志 2024年第1期41卷 18-24页

作者：周艳华张倩张澍田李鹏首都医科大学附属北京友谊医院消化内科、国家消化系统疾病临床医学研究中心北京100050

目的评价内镜下胃转流支架系统对肥胖患者体重和肥胖相关代谢指标的疗效, 并评估设备的安全性。方法选取2021年3月至2022年10月全国多中心随机对照试验中于首都医科大学附属北京友谊医院行胃转流支架治疗的14例肥胖患者进行亚组分析。... 详细信息

目的评价内镜下胃转流支架系统对肥胖患者体重和肥胖相关代谢指标的疗效, 并评估设备的安全性。方法选取2021年3月至2022年10月全国多中心随机对照试验中于首都医科大学附属北京友谊医院行胃转流支架治疗的14例肥胖患者进行亚组分析。患者入组后行内镜下胃转流支架置入术, 12周后经内镜取出, 取出后继续随访至36周。主要评价入组12周、24周和36周患者的多余体重减少率、总体重减少率、胰岛素抵抗、转氨酶、血脂和尿酸的变化, 以及设备的安全性。结果 14例患者中男9例、女5例, 年龄(34.3±7.4)岁, 初始体重(104.8±13.9)kg。2例患者因不能耐受消化道不良反应提前取出支架, 其余12例患者完成了随访, 12周、24周和36周多余体重减少率分别为34.4%±25.5%、39.1%±37.5%和27.3%±40.8%;总体重减少率分别为8.7%±6.2%、10.1%±10.2%和8.3%±13.8%。胰岛素抵抗的稳态模型评估基线水平为7.03±3.59, 12周时为4.81±3.71(与基线相比P=0.022), 24周时为4.17±2.77(与基线相比P=0.002), 36周时为4.66±3.58(与基线相比P=0.016)。丙氨酸转氨酶(alanine aminotransferase, ALT)在基线、12周、24周和36周分别为48(21~124)U/L、39(14~96)U/L、27(10~86)U/L和32(16~113)U/L, ALT下降在24周、36周差异均有统计学意义(与基线相比P=0.009, P=0.026)。天冬氨酸转氨酶(aspartate aminotransferase, AST)在基线、12周、24周和36周分别为30(20~62)U/L、24(15~72)U/L、22(11~56)U/L和26(13~74)U/L, AST下降在24周差异有统计学意义(与基线相比P=0.018)。而血脂、尿酸的变化无统计学意义(P>0.05)。唯一的严重不良事件是在支架取出过程中发生1例食管黏膜撕裂, 经内镜下金属夹成功夹闭治疗。所有患者无器械移位、急性胰腺炎或肝脓肿等发生。结论胃转流支架系统短期内具有良好的减重效果, 且相对安全, 还可以改善胰岛素抵抗和肝酶。

关键词：肥胖胃转流支架系统多余体重减少率总体重减少率安全性

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