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Changes in pulse pressure × heart rate, hs-CRP, and arterial stiffness progression in the Chinese general population: a cohort study involving 3978 employees of the Kailuan Company

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Journal of Geriatric Cardiology 2019年第9期16卷 710-716页

作者： Hao XUE Jun-Juan LI Jian-Li WANG shuo-hua chen Jing-Sheng GAO Yun-Dai chen Shou-Ling WU Department of Cardiology Chinese People’s Liberation Army General Hospital Beijing China Department of Cardiology Kailuan Hospital Hebei United University Tangshan China

Background Pulse wave velocity(PWV) is a marker of arterial stiffness, which represents sub-clinical atherosclerosis. Pulsatile stress and high-sensitivity C-reactive protein(hs-CRP) are associated with arteriosclerosis. However, there is no prospective data confirming whether changes in pulsatile stress and inflammatory markers affect the progression of arterial stiffness. The aim of this study was to investigate the relationships over time between the effects of changes in pulsatile stress and hs-CRP, and arterial stiffness progression during a 2-year follow-up. Methods We performed a longitudinal study involving 3978 participants. All participants underwent a physical examination in 2010–2011 and 2012–2013, during which we measured participants’ hs-CRP levels, brachial–ankle pulse wave velocity(ba PWV), and pulsatile stress. Results Baseline hs-CRP was correlated with ba PWV(r = 0.18, P = 0.000);however the correlation was weaker than that with systolic blood pressure(r = 0.65), pulsatile stress(r = 0.57), and rate-pressure product(r = 0.58). Multiple linear regression analysis demonstrated that changes in pulsatile stress, mean arterial pressure, and low-density lipoprotein-C(LDL-C) were positively correlated with changes in ba PWV, with correlation coefficients of 0.27, 0.25, and 0.07, respectively, but not with changes in hs-CRP. Moreover, each 100-a U increase in pulsatile stress, 1 mm Hg increase in mean blood pressure, and 1 mmol/L increase in LDL-C was associated with a 3 cm/s, 4.78 cm/s, and 17.37 cm/s increase in ba PWV, respectively. Conclusions Pulsatile stress increases are associated with arterial stiffness progression, but that changes in hs-CRP had no effect on arterial stiffness progression. Hs-CRP may simply be a marker of inflammation in arterial stiffness and has no association with arterial stiffness progression.

关键词： Atherosclerosis Blood vessels Brachial–ankle index C-reactive protein Pulse wave velocity

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Correlation of the history of stroke and the retinal artery occlusion: a nested case-control study

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International Journal of Ophthalmology(English edition) 2020年第3期13卷 431-437页

作者： Yue-Yan Xiao Wen-Bin Wei Ya-Xing Wang Ai-Dong Lu shuo-hua chen Lu Song Shou-Ling Wu Beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentBeijing Ophthalmology&Visual Sciences Key LabBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Ophthalmology Kailuan General HospitalTangshan 063000Hebei ProvinceChina Department of Cardiology Kailuan General HospitalTangshan 063000Hebei ProvinceChina

AIM:To analyze the systemic factors including stroke history related to the retinal artery occlusion(RAO).METHODS:Patients with an exact diagnosis of RAO in the medical database of the Kailuan Corporation were identified as the case *** patients without RAO were added for each case from the Kailuan Study and matched for sex and age(age±2)as the control *** Kailuan Study is a general population-based cohort study in northern China,in which a total of 101510 individuals(81110 men)aged 18-98 y were recruited to participate in the *** the participants were bi-annually *** database of both groups was from Kailuan study of 2010 *** the information,including the demographic characteristics,lifestyle behaviors,medical comorbidities,medical history,family medical history,drug usage,anthropometric measurements,blood pressure measurement,blood sample laboratory assessment,urine tests,and other physical examinations were all collected.A retrospective nested case-control method was used for this *** multivariate logistic regression was used to analyze the risk factors with SPSS 13.0 software and SAS 9.3 ***:A total of 45 patients were included as the case group,and the control group included 225 *** the case group,28 patients(62.2%)had a central retinal artery occlusion(CRAO),and 17 patients(37.8%)had a branch retinal artery occlusion(BRAO).A total of 18 patients(40.0%)had a stroke before the RAO(mean 4.04±3.88 y before the RAO),and 31 patients(81.6%)had infarctions or malacia identified by the cranial computed tomography(CT)*** basal ganglia and centrum semiovale were the most frequently involved *** in the common carotid artery were present in 32 patients(88.9%).Conditional multivariate logistic regression analysis showed that the RAO was found to be associated with the history of stroke(P=0.0023,OR=28.794;95%CI:3.322-249.586).CONCLUSION:A history of stroke can significantly increase the

关键词： retinal artery occlusion stroke risk factor embolic source carotid plaque

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Deep eutectic solvents for separation and purification applications in critical metal metallurgy:Recent advances and perspectives

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 1-19页

作者： shuo chen Shengpeng Su Yanfang huang Bingbing Liu Hu Sun Shuzhen Yang Guihong Han School of Chemical Engineering Zhengzhou UniversityZhengzhou 450001China Zhongyuan Critical Metals Laboratory Henan ProvinceZhengzhou 450001China

Solvent extraction,a separation and purification technology,is crucial in critical metal *** solvents commonly used in solvent extraction exhibit disadvantages,such as high volatility,high toxicity,and flammability,causing a spectrum of hazards to human health and environmental *** solvents have been recognized as potential alternatives to these harmful organic *** the past two decades,several neoteric solvents have been proposed,including ionic liquids(ILs)and deep eutectic solvents(DESs).DESs have gradually become the focus of green solvents owing to several advantages,namely,low toxicity,degradability,and low *** this critical review,their classification,formation mechanisms,preparation methods,characterization technologies,and special physicochemical properties based on the most recent advancements in research have been systematically ***,the major separation and purification applications of DESs in critical metal metallurgy were comprehensively ***,future opportunities and challenges of DESs were explored in the current research *** conclusion,this review provides valuable insights for improving our overall understanding of DESs,and it holds important potential for expanding separation and purification applications in critical metal metallurgy.

关键词： deep eutectic solvents preparations properties separation and purification critical metal metallurgy

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Retinal nerve fiber layer defects and chronic kidney disease:the Kailuan Eye Study

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1696-1706页

作者： Qian-Qian Wan Jin-Qiong Zhou Li-Jian Fang Ya-Xing Wang Ye-Nan Wang Qian Wang Yan-Ni Yan Xuan Yang Shou-Ling Wu shuo-hua chen Jost B Jonas Wen-Bin Wei Beijing Tongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and TreatmentBeijing Ophthalmology&Visual Sciences Key LabMedical Artificial Intelligence Research and Verification Key Laboratory of the Ministry of Industry and Information TechnologyBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Ophthalmology the Second Hospital of Anhui Medical UniversityHefei 230000Anhui ProvinceChina Department of Ophthalmology Beijing Liangxiang HospitalCapital Medical UniversityBeijing 102400China Beijing Institute of Ophthalmology Beijing Key Laboratory of Ophthalmology and Visual SciencesBeijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Ophthalmology Xuanwu HospitalCapital Medical UniversityBeijing 100730China Department of Cardiology Kailuan General HospitalTangshan 063000Hebei ProvinceChina Health Care Center Kailuan GroupTangshan 063000Hebei ProvinceChina Department of Ophthalmology Medical Faculty Mannheim of the Ruprecht-Karls-University of HeidelbergHeidelberg 69117Germany

AIM:To investigate whether retinal nerve fiber layer defects(RNFLDs)is a potential risk factor for chronic kidney disease(CKD)in Chinese ***:The Kailuan Eye Study was a populationbased study that included 14440 *** participants underwent detailed assessments,RNFLDs were diagnosed using color fundus ***:Overall,12507 participants[8533 males(68.23%)]had complete systemic examination data and at least one evaluable fundus *** were found in 621 participants[5.0%;95%confidence interval(CI):4.6%-5.34%],and 70 cases of multiple RNFLDs were found(11.27%).After adjusting multiple factors,RNFLDs was significantly associated with CKD severity,the ORs of CKD stage 3,stage 4 and stage 5 were 1.698,4.167,and 9.512,*** RNFLDs were also associated with CKD severity after adjusting multiple factors,the ORs of CKD stage 3 and stage 5 were 4.465 and 11.833 ***,2294 participants had CKD(18.34%,95%CI:17.68%-18.99%).After adjusting for other factors,CKD presence was significantly correlated with the presence of ***:The strongest risk factors for RNFLDs are CKD and ***,RNFLDs can be an ocular feature in patients with *** can help detect systemic diseases,and assessment for RNFLDs should be considered in CKD patients.

关键词： chronic kidney disease retinal nerve fiber layer defects Kailuan Eye Study fundus examination

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Relationship of sleep duration and annual changes in sleep duration with the incidence of gastrointestinal cancers:a prospective cohort study

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Chinese Medical Journal 2021年第24期134卷 2976-2984页

作者： Yu-Heng chen Zhang-Yan Lyu Gang Wang Xiao-Shuang Feng Shuang-hua Xie shuo-hua chen Jian Yin Jian-Song Ren Zi-Han Mi Shen Wang Shou-Ling Wu Ni Li Min Dai Cancer Foundation of China National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Office of Cancer Screening National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Oncology Kailuan General HospitalTangshanHebei 063000China Health Department of Kailuan(Group) TangshanHebei 063000China Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Personalized Cancer MedicineNanjing Medical UniversityNanjingJiangsu 211166China

Background:Prospective analyses have yet to identify a consistent relationship between sleep duration and the incidence of gastrointestinal(GI)*** effect of changes in sleep duration on GI cancer incidence has scarcely been ***,we aimed to examine the association between baseline sleep duration and annual changes in sleep duration and GI cancer risk in a large population-based cohort ***:A total of 123,495 participants with baseline information and 83,511 participants with annual changes in sleep duration information were prospectively observed from 2006 to 2015 for cancer *** proportional-hazards models were used to calculate hazard ratios(HRs)and their confidence intervals(CIs)for GI cancers according to sleep duration and annual changes in sleep ***:In baseline sleep duration analyses,short sleep duration(≤5 h)was significantly associated with a lower risk of GI cancer in females(HR:0.31,95%CI:0.10-0.90),and a linear relationship between baseline sleep duration and GI cancer was observed(P=0.010),especially in males and in the>50-year-old *** the annual changes in sleep duration analyses,with stable category(0 to-15 min/year)as the control group,decreased sleep duration(≤-15 min/year)was significantly associated with the development of GI cancer(HR:1.29;95%CI:1.04-1.61),especially in the>50-year-old group(HR:1.32;95%CI:1.01-1.71),and increased sleep duration(>0 min/year)was significantly associated with GI cancer in females(HR:2.89;95%CI:1.14-7.30).Conclusions:Both sleep duration and annual changes in sleep duration were associated with the incidence of GI cancer.

关键词： Gastrointestinal cancer Sleep duration Annual changes Prospective cohort Cancer risk

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Interleukin-6 in epilepsy and its neuropsychiatric comorbidities: How to bridge the gap

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World Journal of Psychiatry 2025年第1期15卷 1-6页

作者： Xiao-Man chen shuo Zhang Shi-Qi Gao Michael Xu Department of Neurology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina Department of Rehabilitation Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110004Liaoning ProvinceChina International Education School China Medical UniversityShenyang 110004Liaoning ProvinceChina

There is growing evidence that interleukin(IL)-6 plays an important role in neurological and psychiatric *** editorial comments on the study published in the recent issue of the World Journal of Psychiatry,which employed Mendelian randomization to identify a causal relationship between IL-6 receptor blockade and decreased epilepsy *** purpose of this editorial is to highlight the dual effects of IL-6 in epilepsy and its related neuropsychiatric ***-6 plays a critical role in the facilitation of epileptogenesis and maintenance of epileptic seizures and is implicated in neuroinflammatory proce-sses associated with ***,IL-6 significantly influences mood regulation and cognitive dysfunction in patients with epilepsy,highlighting its involvement in neuropsychiatric *** summary,IL-6 is not only a pivotal factor in the pathogenesis of epilepsy but also significantly contributes to the emergence of epilepsy-related neuropsychiatric *** resear-ch should prioritize elucidating the specific mechanisms by which IL-6 operates across different subtypes,stages and neuropsychiatric comorbidities of epilepsy,with the aim of developing more precise and effective ***,the potential of IL-6 as a biomarker for the early diagnosis and prognosis of epile-psy warrants further investigation.

关键词： Epilepsy Interleukin-6 Neuropsychiatric comorbidities Depression Tocilizu-mab Neuroinflammation Interleukin-6 receptor blockade

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Asymptotic lower and upper bounds for linear elasticity eigenvalues

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Acta Mathematica Sinica,English Series 2025年

作者： Yifan YUE Hongtao chen shuo ZHANG School of Mathematical Sciences Xiamen University Fujian Provincial Key Laboratory of Mathematical Modeling and High-Performance Scientific Computing Xiamen University LSEC Institute of Computational Mathematics and Scientific/Engineering Computation Academy of Mathematics and System Science Chinese Academy of Sciences School of Mathematical Sciences University of Chinese Academy of Sciences

Lower and upper bounds for eigenvalues help estimate the location interval of eigenvalues,which is of practical meanings especially for those problems of which the eigenvalues cannot be exactly obtained. In this paper, we study the lower and upper bounds for linear elasticity eigenvalues by displacement-pressure mixed finite element schemes. By applying expansion identities for the error of eigenvalues, lower and upper numerically computable bounds for the eigenvalues are derived based on certain mathematical hypotheses. For the schemes studied here, roughly speaking, the accuracy loss of the local approximation of the discrete displacement may lead to lower bound and that of pressure to upper bound. By utilizing the min-max principle and perturbation theory for the solution operator,theoretical lower and upper bounds can be controlled by setting proper Lamé parameters.

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Chinese Medical Journal 2018年第19期131卷 2357-2359页

作者： Yue-Yan Xiao Wen-Bin Wei Ya-Xing Wang Ai-Dong Lu shuo-hua chen Lu Song Shou-Ling Wu Beijing rongren Eye Center Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment Beijing Ophthalmology and Visual Sciences Key Laboratory Beijing Tongren Hospital Capital Medical University Beijing 100730 China Department of Ophthalmology Beijing Airport Hospital Beijing 101318 China Department of Ophthalmology Kailuan General Hospital Tangshan Hebei 063000 China Department of Cardiology Kailuan General Hospital Tangshan Hebei 063000 China Department of Respiratory Kailuan General Hospital Tangshan Hebei 063000 China

To the Editor： Nonarteritic anterior ischemic optic neuropathy （NAION） is an acute optic neuropathy disease that is common in the elderly. The incidence of NA1ON is approximately （2.3-10.2）/100,000, and both eyes are involved in many patients. Xu et al. reported that the incidence in the Chinese population was 1/16,000. Acute visual acuity （VA） damage without any pain and a poor prognosis are the main features of NAION. This study aimed to find the related risk factors for NAION in average individuals to promote the prevention or early diagnosis of NAION.

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Improved reference-frame-independent quantum key distribution with intensity fluctuations

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Chinese Physics B 2025年第2期34卷 48-52页

作者： Zi-Qi chen Hao-Bing Sun Ming-shuo Sun Qin Wang Institute of Quantum Information and Technology Nanjing University of Posts and TelecommunicationsNanjing 210003China Broadband Wireless Communication and Sensor Network Technology Key Laboratory of Ministry of EducationNanjing University of Posts and TelecommunicationsNanjing 210003China

Reference-frame-independent quantum key distribution(RFI-QKD) can avoid real-time calibration operation of reference frames and improve the efficiency of the communication process. However, due to imperfections of optical devices,there will inevitably exist intensity fluctuations in the source side of the QKD system, which will affect the final secure key rate. To reduce the influence of intensity fluctuations, an improved 3-intensity RFI-QKD scheme is proposed in this *** considering statistical fluctuations and implementing global parameter optimization, we conduct corresponding simulation analysis. The results show that our present work can present both higher key rate and a farther transmission distance than the standard method.

关键词： quantum key distribution intensity fluctuations decoy-state method

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New Potential Barite Reference Materials for LA-MC-ICP-MS Sulfur Isotope Analysis with Application to Hydrothermal Barite in the huayangchuan Deposit,Western China

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Journal of Earth Science 2025年第1期36卷 1-10页

作者： Jiali Fu Xinqian He Zhaochu Hu shuo Yin Jian Ma Kaiyun chen Wen Zhang National Key Laboratory of Uranium Resource Exploration-Mining andNuclear Remote Sensing East China UniversityofTechnologyNanchang 330013China State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China School of Earth Sciences East China University of TechnologyNanchang 330013China State Key Laboratory of Geological Processes and Mineral Resources China University of GeosciencesWuhan 430078China State Key Laboratory of Continental Dynamics Department of GeologyNorthwest UniversityXi'an 710069China

Sulfur isotopes of S-bearing materials are powerful tools to trace various geological processes and sulfur sources in earth sciences,especially in ore deposits where sulfide-sulfate pair coprecipitates ***,in-situ S isotope determination of barite is challenging without natural matrix-matched reference *** this study,we present two natural barite reference materials(1-YS and 294-YS)for in-situ sulfur isotopic *** LA-MC-ICP-MS laboratories were utilized to test theδ34S micron-scale homogeneity of 1-YS and 294-YS barites that have 2s repeatabilities of better than±0.45‰and±0.41‰,***,the in-situ analysis results are consistent with the results of the bulk analysis by GS-IRMS within *** grand meanδ~(34)S values of 1-YS(13.37‰±0.42‰,2s)and 294-YS(14.38‰±0.44‰,2s)are the final recommended values obtained from four independent *** the results confirm the suitability of 1-YS and 294-YS barite used as calibration materials with respect to in-situ S isotopic ***,the new developed barite reference materials were used as matrix-matched standard to calibrate the barite samples from the huayangchuan carbonatite-hosted U-polymetallic deposit(Qinling orogenic belt,western China)to obtainδ34S *** the temperaturedependentδ34S fractionation of barite-pyrite pair,we calculate the formation temperature of barite(i.e.,506 to 537°C)and theδ34S value of mineralizing fluid(i.e.,-7.11‰to-7.59‰)in the huayangchuan *** results indicate an involvement of sedimentary sulfur,presumably acting as a potential uranium source(e.g.,upper crustal materials)for the giant huayangchuan deposit.

关键词： LA-MC-ICP-MS S isotope reference material barite geothermometry

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