Relationship of sleep duration and annual changes in sleep duration with the incidence of gastrointestinal cancers:a prospective cohort study

作     者：Yu-Heng Chen Zhang-Yan Lyu Gang Wang Xiao-Shuang Feng Shuang-Hua Xie Shuo-Hua Chen Jian Yin Jian-Song Ren Zi-Han Mi Shen Wang Shou-Ling Wu Ni Li Min Dai Yu-Heng Chen;Zhang-Yan Lyu;Gang Wang;Xiao-Shuang Feng;Shuang-Hua Xie;Shuo-Hua Chen;Jian Yin;Jian-Song Ren;Zi-Han Mi;Shen Wang;Shou-Ling Wu;Ni Li;Min Dai

作者机构：Cancer Foundation of ChinaNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Office of Cancer ScreeningNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of OncologyKailuan General HospitalTangshanHebei 063000China Health Department of Kailuan(Group)TangshanHebei 063000China Jiangsu Key Lab of Cancer BiomarkersPrevention and TreatmentCollaborative Innovation Center for Personalized Cancer MedicineNanjing Medical UniversityNanjingJiangsu 211166China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2021年第134卷第24期

页      面：2976-2984页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：funded by grants from the National Key R&D Program of China(Nos.2018YFC1315000,2018YFC1315001,2016YFC1302500,and 2016YFC1302503) the CAMS Innovation Fund for Medical Sciences(Nos.2019-I2M-2-002 and 2017-I2M-1-006) the Training Programme Foundation for the Talents in Beijing City(No.2017000021223TD05) the National Natural Science Foundation of China(No.81673265) 

主　　题：Gastrointestinal cancer Sleep duration Annual changes Prospective cohort Cancer risk 

摘      要：Background:Prospective analyses have yet to identify a consistent relationship between sleep duration and the incidence of gastrointestinal(GI)*** effect of changes in sleep duration on GI cancer incidence has scarcely been ***,we aimed to examine the association between baseline sleep duration and annual changes in sleep duration and GI cancer risk in a large population-based cohort ***:A total of 123,495 participants with baseline information and 83,511 participants with annual changes in sleep duration information were prospectively observed from 2006 to 2015 for cancer *** proportional-hazards models were used to calculate hazard ratios(HRs)and their confidence intervals(CIs)for GI cancers according to sleep duration and annual changes in sleep ***:In baseline sleep duration analyses,short sleep duration(≤5 h)was significantly associated with a lower risk of GI cancer in females(HR:0.31,95%CI:0.10-0.90),and a linear relationship between baseline sleep duration and GI cancer was observed(P=0.010),especially in males and in the50-year-old *** the annual changes in sleep duration analyses,with stable category(0 to-15 min/year)as the control group,decreased sleep duration(≤-15 min/year)was significantly associated with the development of GI cancer(HR:1.29;95%CI:1.04-1.61),especially in the50-year-old group(HR:1.32;95%CI:1.01-1.71),and increased sleep duration(0 min/year)was significantly associated with GI cancer in females(HR:2.89;95%CI:1.14-7.30).Conclusions:Both sleep duration and annual changes in sleep duration were associated with the incidence of GI cancer.