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基于分布重心的分拣码垛桁架机械手系统货位分配优化

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包装工程 2024年第11期45卷 198-203页

作者：崔维华尹书磊庄庆胥李明中铁十四局集团兖州国际陆港物流有限公司山东济宁272112 山东建筑大学信息与电气工程学院济南250101

目的提高大规模定制化按单生产应用场景下桁架机械手分拣码垛下线成品的作业效率。方法提出一种基于分布重心法的播种区货位分配法,针对分拣码垛桁架机械手系统的工作特点,建立设备分拣任务总时间数学模型,将其归结为以最小桁架机械手... 详细信息

目的提高大规模定制化按单生产应用场景下桁架机械手分拣码垛下线成品的作业效率。方法提出一种基于分布重心法的播种区货位分配法,针对分拣码垛桁架机械手系统的工作特点,建立设备分拣任务总时间数学模型,将其归结为以最小桁架机械手带载水平移动总时间为目标的播种区货位分配问题。根据待拣订单货品的初始数量和位置,构建订单–货品分布重心矩阵。在此基础上,依据分布重心系数由大到小的顺序对播种区内的货位进行订单分配。结果与货位随机分配法相比,采用分布重心法可以将桁架机械手带载水平移动时间平均缩短约28.14%,分拣任务总时间平均缩短约5.78%。结论通过货位分配的优化,有效缩短了桁架机械手完成分拣任务的时间,提高了系统分拣效率。

关键词：桁架机械手大规模定制分拣码垛货位分配

CD24 aggravates acute liver injury in autoimmune hepatitis by promoting IFN-γ production by CD4^(+) T cells

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Cellular & Molecular Immunology 2018年第3期15卷 260-271页

作者： Chenhong Zheng shulei yin Yang Yang Yizhi Yu Xiaohua Xie Department of Comprehensive Surgery Clinical Division of South BuildingChinese PLA General HospitalBeijing100853China National Key Laboratory of Medical Immunology and Institute of Immunology Second Military Medical UniversityShanghai200433China

The T-cell-mediated immune response is implicated in many clinical hepatic injuries, such as autoimmune hepatitis and acute virus hepatitis. CD24 is widely expressed by different immune cells and plays an important role in the pathogenesis of many autoimmune diseases. However, the role of CD24 in T-cell-mediated liver injury has not been elucidated until now. Here we showed that CD24 deficiency protects mice from concanavalin A (ConA)-induced fulminant liver injury by reducing serum interferon-γ (IFN-γ) levels. CD24 expression by hepatic T cells was markedly increased following ConA challenge. Moreover, decreased IFN-γ production by hepatic CD4^(+) T cells in CD24-deficient mice was detected, which was correlated with downregulated phosphorylation of STAT1 in hepatic tissue. In vitro experiments also supported the conclusion that CD24 deficiency impaired IFN-γ production by CD4^(+) T cells following ConA, CD3/CD28 and phorbol myristate acetate/ionomycin stimulation. Our study suggests that CD24 deficiency confers hepatoprotection by decreasing CD4^(+) T-cell-dependent IFN-γ production in vivo, which suggests that CD24 might be a potential target molecule for reducing clinical hepatitis.

关键词： CD24 CD4^(+)T cells concanavalin A(ConA) heat-stable antigen hepatitis interferon-γ liver injury

茶树病害病原菌Botryosphaeria dothidea生物学特性研究

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农业技术与装备 2024年第3期 186-188页

作者：王谦尹舒蕾尹慧存占欣如苗方愉赵丹信阳学院理工学院河南信阳464000

采用皿内测定方法,研究了河南省信阳市茶树叶部病害病原菌Botryosphaeria dothidea生物学特性。实验结果表明:Botryosphaeria dothidea能正常生长于PDA、OA和MEA培养基上,在MEA培养基上的生长速率较前两者略慢,产孢情况于OA培养基上相... 详细信息

采用皿内测定方法,研究了河南省信阳市茶树叶部病害病原菌Botryosphaeria dothidea生物学特性。实验结果表明:Botryosphaeria dothidea能正常生长于PDA、OA和MEA培养基上,在MEA培养基上的生长速率较前两者略慢,产孢情况于OA培养基上相对较好。在不同营养因子影响下,病原菌的生长速度不相同,在以葡萄糖为碳素的培养基上菌株生长速度最快,以蛋氨酸作为氮素的培养基中生长速度最快。菌株生长的最适温度为25℃。菌株在液体培养基中可正常生长,菌落呈球形,并伴随新菌落的产生。最适pH值为6,能够适宜微酸环境,当pH值为8时菌株几近停止生长。

关键词：茶树叶部病害 Botryosphaeria dothidea 生物学特性

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Immune responsive gene 1 broadly promotes viral entry by production of itaconate

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Seasonal compensation implied no weakening of the land carbon sink in the Northern Hemisphere under the 2015/2016 El Niño

第十三届全国免疫学学术大会

作者： shulei yin Yijie Tao Yizhi Yu National Key Laboratory of Medical Immunology & Institute of Immunology Second Military Medical University

Immune responsive gene 1(IRG-1) high expresses in inflammatory state such as stimulation by TLR ligands, bacterial infection and viral ***-1 converts cis-aconitate to itaconate in ***, an endogenous metabolite of tricarboxylic acid(TCA) cycle, is a well-known anti-inflammatory agent that also has antibacterial ***, the definite function of IRG-1 in viral infection is not adequately *** this study, we identified IRG-1 as a broad-spectrum enhancing factor of *** results showed that deficiency of IRG-1 broadly inhibited replication of enveloped viruses including VSV, HSV and Sev but not uncoated *** animal models, IRG-1-deficient mice were tolerant to VSV *** treatment in cultured cells enhanced growth of VSV by assisting viral ***, transcriptome suggested that IRG-1 deficiency caused some viral receptors expression and metabolic pathway ***, our study demonstrates a new mechanism by which viruses utilize itaconate to change the constituents of cytomembrane to assist them in entering host cells and IRG-1 can be targeted by antiviral drugs.

关键词： IRG-1 itaconate viral entry

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Science China Earth Sciences 2024年第1期67卷 281-294页

作者： Fangzhong SHI Xiuchen WU Xiaoyan LI Philippe CIAIS Hongyan LIU Chao YUE Yuting YANG shulei ZHANG Shushi PENG Yi yin Benjamin POULTER Deliang CHEN State Key Laboratory of Earth Surface Processes and Resource Ecology Beijing Normal UniversityBeijing 100875China Faculty of Geographical Science Beijing Normal UniversityBeijing 100875China Key Laboratory of Tibetan Plateau Land Surface Processes and Ecological Conservation Qinghai Normal UniversityXining 810016China Research and Development Center for Watershed Environmental Eco-Engineering Beijing Normal University(Zhuhai)Zhuhai 519085China Laboratoire des Sciences du Climat et de l’Environnement(LSCE) CEA-CNRS-UVSQUMR821291191Gif-sur-YvetteFrance College of Urban and Environmental Science MOE Laboratory for Earth Surface ProcessesPeking UniversityBeijing 100871China State Key Laboratory of Hydroscience and Engineering Department of Hydraulic EngineeringTsinghua UniversityBeijing 100084China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) School of Atmospheric SciencesSun Yat-sen UniversityGuangzhou 510275China California Institute of Technology PasadenaCA 91125USA Biospheric Sciences Laboratory NASA Goddard Space Flight CenterGreenbeltMaryland 20771USA Regional Climate Group Department of Earth SciencesUniversity of GothenburgGothenburg SE-40530Sweden

The recurrent extreme El Niño events are commonly linked to reduced vegetation growth and the land carbon sink over many but discrete regions of the Northern Hemisphere(NH).However,we reported here a pervasive and continuous vegetation greening and no weakened land carbon sink in the maturation phase of the 2015/2016 El Niño event over the NH(mainly in the extra-tropics),based on multiple evidences from remote sensing observations,global ecosystem model simulations and atmospheric CO_(2)*** discovered a significant compensation effect of the enhanced vegetation growth in spring on subsequent summer/autumn vegetation growth that sustained vegetation greening and led to a slight increase in the land carbon sink over the spring and summer of 2015(average increases of 23.34%and 0.63%in net ecosystem exchange from two independent datasets relative to a 5-years average before the El Niño event,respectively)and spring of 2016(6.82%),especially in the extra-tropics of the NH,where the water supply during the pre-growing-season(November of the previous year to March of the current year)had a positive *** seasonal compensation effect was much stronger than that in 1997 and 1998 and significantly alleviated the adverse impacts of the 2015/2016 El Niño event on vegetation growth during its maturation *** legacy effect of water supply during the pre-growing-season on subsequent vegetation growth lasted up to approximately six *** findings highlight the role of seasonal compensation effects on mediating the land carbon sink in response to episodic extreme El Niño events.

关键词： El Niño Seasonal compensation effect Vegetation greening Land carbon sink Net ecosystem exchange Legacy effect

The zinc transporter SLC39A5 promotes chemotherapy resistance by regulating the stability of p53

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The zinc transporter SLC39A5 promotes chemotherapy resistanc...

基于诺贝尔奖案例的课程思政在医学免疫学教学中的探索与应用

第十四届全国免疫学学术大会

作者： shulei yin Yijie Tao Yudan Qiu Zui Zou Yizhi Yu National Key Laboratory of Medical Immunology &Institute of Immunology Naval Medical University Shanghai Jiao Tong University Department of Anesthesiology Changzheng Hospital

Chemotherapy is the most traditional and effective treatment of non-small cell lung cancer(NSCLC),and platinum-based drugs are the most widely ***,in the course of chemotherapy treatment,patients will develop drug resistance,which seriously hinders the efficacy of *** is an essential trace element for health,whose entry and exit mainly depend on the metal ion transcription families SLC39 and *** has been reported that zinc ions play a certain role in tumors,but whether different transporters have functions in chemotherapy resistance has not been clearly *** this study,we screened and found SL39 A5 was highly expressed in A549 cells after cisplatin *** searching the TCGA database we observed that SL39 A5 is highly expressed in NSCLC tissues and indicates poor prognosis of NSCLC *** results show that knocking out SL39 A5 broadly increases the sensitivity of lung cancer cell lines to cisplatin,including increased apoptosis,decreased clonal formation and splicing of ***,the signal pathway results show that knocking out SL39 A5 significantly increases the protein stability of ***,eliminating the expression of SLC39 A5 could make NSCLC cells more sensitive to the first-line antineoplastic cisplatin via modulating p53,which may be applied into clinical therapies for NSCLC care.

关键词： NSCLC cisplatin Zinc SLC39A5

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中国免疫学杂志 2023年第6期39卷 1139-1141,1145页

作者：殷书磊李天亮(指导) 海军军医大学基础医学院免疫学教研室上海200433

医学免疫学是重要的基础医学课程,课程思政融入理论课教学既能提高学生的学习兴趣,又能使医学免疫学课堂紧跟科学前沿。将免疫学相关的诺贝尔奖案例融入课堂的课程思政设计有效提高了学生的学习积极性,拓宽了学生的科研视野,培养了学生... 详细信息

医学免疫学是重要的基础医学课程,课程思政融入理论课教学既能提高学生的学习兴趣,又能使医学免疫学课堂紧跟科学前沿。将免疫学相关的诺贝尔奖案例融入课堂的课程思政设计有效提高了学生的学习积极性,拓宽了学生的科研视野,培养了学生的正确人生观和价值观,取得了良好的教学效果。

关键词：课程思政医学免疫学教学设计诺贝尔奖

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CAR-NK抗肿瘤研究的现状与发展趋势

中国肿瘤生物治疗杂志 2016年第1期23卷 1-10页

作者：殷书磊于益芝曹雪涛第二军医大学免疫学研究所暨医学免疫学国家重点实验室上海200433

作为固有免疫中重要的效应细胞,NK细胞具有强大的抗肿瘤功能,在肿瘤免疫治疗方面具有良好的应用前景。随着嵌合抗原受体(chimeric antigen receptor,CAR)修饰的T细胞(CAR-T)技术的兴起,NK细胞的CAR修饰潜力也受到了关注。CAR-NK的研发... 详细信息

作为固有免疫中重要的效应细胞,NK细胞具有强大的抗肿瘤功能,在肿瘤免疫治疗方面具有良好的应用前景。随着嵌合抗原受体(chimeric antigen receptor,CAR)修饰的T细胞(CAR-T)技术的兴起,NK细胞的CAR修饰潜力也受到了关注。CAR-NK的研发既传承了经典CAR-T研发的思路,也实现了诸多基于NK细胞生物特点的创新和发展。外周血NK细胞、NK细胞系和干细胞来源的NK细胞各具生物学特色,在CAR-NK研发中被广泛使用。已有靶向多种血液肿瘤和实体瘤抗原的CAR-NK在体外实验和动物模型中取得显著效果。虽然在临床暂未有数据支持CAR-NK的疗效且仍存在一些瓶颈问题需要攻克,但是CAR-NK有望在治疗实体瘤、简化免疫治疗等方面实现新的突破。

关键词：嵌合抗原受体 CAR-NK NK-92 血液肿瘤实体瘤肿瘤免疫治疗

Ephedrine hydrochloride offers mice protection from Staphylococcus aureus-induced peritonitis

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Ephedrine hydrochloride offers mice protection from Staphylo...