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Phytochrome B interacts with SWC6 and ARP6 to regulate H2A.Z deposition and photomorphogensis in Arabidopsis

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Journal of Integrative Plant Biology 2021年第6期63卷 1133-1146页

作者： Xuxu Wei Wanting Wang Peng Xu Wenxiu Wang Tongtong Guo shuang kou Minqing Liu Yake Niu Hong-Quan Yang Zhilei Mao Shanghai Key Laboratory of Plant Molecular Sciences College of Life SciencesShanghai Normal UniversityShanghai 200234China School of Life Sciences Fudan UniversityShanghai 200438China

Light serves as a crucial environmental cue which modulates plant growth and development, and which is controlled by multiple photoreceptors including the primary red light photoreceptor,phytochrome B(phyB). The signaling mechanism of phyB involves direct interactions with a group of basic helix-loop-helix(bHLH) transcription factors, PHYTOCHROME-INTERACTING FACTORS(PIFs), and the negative regulators of photomorphogenesis, COP1 and SPAs. H2 A.Z is an evolutionarily conserved H2 A variant which plays essential roles in transcriptional regulation. The replacement of H2 A with H2 A.Z is catalyzed by the SWR1 complex. Here, we show that the Pfr form of phyB physically interacts with the SWR1 complex subunits SWC6 and ARP6. phyB and ARP6 coregulate numerous genes in the same direction,some of which are associated with auxin biosynthesis and response including YUC9, which encodes a rate-limiting enzyme in the tryptophandependent auxin biosynthesis pathway. Moreover,phyB and HY5/HYH act to inhibit hypocotyl elongation partially through repression of auxin biosynthesis. Based on our findings and previous studies, we propose that phyB promotes H2 A.Z deposition at YUC9 to inhibit its expression through direct phyB-SWC6/ARP6 interactions,leading to repression of auxin biosynthesis, and thus inhibition of hypocotyl elongation in red light.

关键词： ARP6 H2A.Z hypocotyl elongation photomorphogenesis phytochrome B red light SWC6

Molecular characterization of avian influenza virus (H7N8) isolated from poultry in Central China in the mid-1980s

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Chinese Science Bulletin 2010年第16期55卷 1625-1630页

作者： YANG JiaLin XIA Han ZHAO JiuRu HE XiaoBin PAN LiMin TANG shuang ZHANG Zhong kou Zheng LI TianXian State Key Laboratory of Virology Wuhan Institute of Virology Chinese Academy of Sciences Wuhan 430071 China

The molecular and pathogenic properties of avian influenza virus (A/duck/Hubei/216/1985/H7N8) isolated from Hubei Province of China in 1985 were *** hemagglutinin gene (HA) of Dk/Hb/216/85/H7N8 had the multiple amino acid se-quences (-PEIPKGRG-) at the connecting peptide between HA1 and HA2, which is considered to be a distinguishing molecular characteristic of low *** key sites of host markers among the genes (M, NP, NS, PA and PB2) of Dk/Hb/ 216/85/H7N8 were similar to those of H5N1 *** analysis showed that the genes (M, NS and PB2) of Dk/Hb/ 216/85/H7N8 clustered closely with those of Gs/Guangdong/1996/H5N1 (Gs/GD/96), implying that three ancient genes of Gs/ GD/96-like viruses had been circulating in Central China during the *** experimental infection, Dk/Hb/216/85/H7N8 was lowly pathogenic to chickens and mice, consistent with the molecular feature of HA gene.

关键词：禽流感病毒分子特性中国年代血凝素基因孤立中期家禽

Arabidopsis cryptochrome 1 promotes stomatal development through repression of AGB1 inhibition of SPEECHLESS DNA-binding activity

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Journal of Integrative Plant Biology 2021年第11期63卷 1967-1981页

作者： Xiaoli Cao Pengbo Xu Yao Liu Guangqiong Yang Minqing Liu Li Chen Yingyu Cheng Peng Xu Langxi Miao Zhilei Mao Wenxiu Wang shuang kou Tongtong Guo Hong‐Quan Yang State Key Laboratory of Genetic Engineering Institute of Plant BiologySchool of Life SciencesFudan UniversityShanghai 200438China Department of Plant Sciences School of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240China Shanghai Key Laboratory of Plant Molecular Sciences College of Life SciencesShanghai Normal UniversityShanghai 200234China

Cryptochromes are blue light photoreceptors that mediate various light responses in plants and mammals. The heterotrimeric G-protein is known to regulate various physiological processes in plants and mammals. In Arabidopsis, cryptochrome 1(CRY1) and the G-protein β subunit AGB1 act antagonistically to regulate stomatal *** molecular mechanism by which CRY1 and AGB1 regulate this process remains ***, we show that Arabidopsis CRY1 acts partially through AGB1, and AGB1 acts through SPEECHLESS(SPCH), a master transcription factor that drives stomatal initiation and proliferation, to regulate stomatal development. We demonstrate that AGB1 physically interacts with SPCH to block the b HLH DNA-binding domain of SPCH and inhibit its DNA-binding activity. Moreover, we demonstrate that photoexcited CRY1 represses the interaction of AGB1 with SPCH to release AGB1 inhibition of SPCH DNA-binding activity, leading to the expression of SPCH-target genes promoting stomatal development. Taken together, our results suggest that the mechanism by which CRY1 promotes stomatal development involves positive regulation of the DNA-binding activity of SPCH mediated by CRY1 inhibition of the AGB1-SPCH interaction. We propose that the antagonistic regulation of SPCH DNA-binding activity by CRY1 and AGB1 may allow plants to balance light and G-protein signaling and optimize stomatal density and pattern.

关键词： cryptochrome 1(CRY1) heterotrimeric G-proteinβ-subunit AGB1 SPEECHLESS DNA-binding activity stomatal development

Amyloid precursor protein and growth-associated protein 43 expression in brain white matter and spinal cord tissues in a rat model of experimental autoimmune encephalomyelitis

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Neural Regeneration Research 2011年第2期6卷 101-106页

作者： Yizhou Wang shuang kou Jingcheng Tang Ping Zhang Qiuxia Zhang Yan Liu Qi Zheng Hui Zhao Lei Wang School of Traditional Chinese Medicine Capital Medical University Beijing 100069 China School of Chemical Biology and Pharmaceutical Sciences CapitalMedical University Beijing 100069 China Pathologic Department Wang Jing Hospital China Academy of Chinese Medical Sciences Beijing 100102 China

Studies have demonstrated that amyloid precursor protein （APP） expression increases in multiple sclerosis tissues during acutely and chronically active stages. To determine the relationship between axonal injury and regeneration in multiple sclerosis, an animal model of experimental autoimmune encephalomyelitis was induced using different doses of myelin basic protein peptide. APP and growth-associated protein 43 （GAP-43）, which is considered a specific marker of neural regeneration, were assessed by western blot analysis. Expression of APP and GAP-43, as well as the correlation between these two proteins, in brain white matter and spinal cord tissues of experimental autoimmune encephalomyelitis rats at different pathological stages was analyzed. Results showed that APP and GAP-43 expression increased during the acute stage and decreased during remission, with a positive correlation between APP and GAP-43 expression in brain white matter and spinal cord tissues. These results suggest that APP and GAP-43 could provide nutritional and protective effects on damaged neurons.

关键词： amyloid precursor protein axonal regeneration central nervous system experimental autoimmune encephalomyelitis growth-associated protein 43

面向大学新生阅读推广策略研究——基于美国“新生共同阅读计划”

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图书馆工作与研究 2019年第1期 100-105页

作者：寇爽杜坤廊坊卫生职业学院图书馆河北水利电力学院图书馆

"新生共同阅读计划"是美国高校重要的阅读推广模式。本文对"新生共同阅读计划"的目的、实现途径进行了介绍,在借鉴美国经验的基础上,指出了我国高校图书馆可以从成立专门的新生阅读推广机构、拓展新生阅读推广主体、建立新生阅读推广长... 详细信息

"新生共同阅读计划"是美国高校重要的阅读推广模式。本文对"新生共同阅读计划"的目的、实现途径进行了介绍,在借鉴美国经验的基础上,指出了我国高校图书馆可以从成立专门的新生阅读推广机构、拓展新生阅读推广主体、建立新生阅读推广长效机制、丰富新生阅读推广内容、鼓励新生积极参与五个方面开展面向大学新生的阅读推广活动。

关键词：高校图书馆阅读推广共同阅读美国大学新生 “新生共同阅读计划”

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立己·成事·达人:立人教育探微

中国教育学刊 2020年第4期 100-102页

作者：寇爽张晓阳郑州师范学院附属小学河南郑州450000 河南师范大学教育学部河南新乡453007

立德树人背景下,学校对于"目中无人"式教育应当时刻保持警惕。立人教育是郑州师范学院附属小学优秀办学经验在新时期的生动表达。作为一种办学理念,立人教育的内涵可以从三个维度进行界定:立己、成事与达人,具体而言即为师资队伍的"立己... 详细信息

立德树人背景下,学校对于"目中无人"式教育应当时刻保持警惕。立人教育是郑州师范学院附属小学优秀办学经验在新时期的生动表达。作为一种办学理念,立人教育的内涵可以从三个维度进行界定:立己、成事与达人,具体而言即为师资队伍的"立己"观、组织管理的"成事"观及五育并举的"达人"观。立人教育的实践探索主要从强化师资队伍、优化组织管理、构建学本课堂、丰富课程类型、美化校园环境五个方面展开。

关键词：立己成事达人立人教育

3种核桃青皮提取物对玉米螟中肠酯酶活性的影响

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北京农业（下旬刊） 2010年第11期 22-27页

作者：寇爽北京市通州区植物保护站北京101117

通过核桃青皮馏分3、6与核桃青皮萃取物青甲水对玉米螟幼虫进行了室内毒力测定,以及中肠酯酶离体活性测定,结果表明核桃青皮馏分6对玉米螟5龄幼虫有较强地抑制作用,青甲水对中肠酯酶的抑制作用不显著。

关键词：玉米螟中肠酯酶植物源杀虫剂

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辽宁省农业产业剩余劳动力转移研究

湖北农业科学 2021年第4期60卷 134-138页

作者：寇爽阜新市委党校辽宁阜新123000

对辽宁省农业产业结构调整背景下的剩余劳动力转移状况进行具体分析,阐释了产业结构和农业产业剩余劳动力的均衡性,并对辽宁省具体行业吸纳就业能力进行研究。结果表明,农业产业剩余劳动力正在向第二产业和第三产业转移,第三产业能够较... 详细信息

对辽宁省农业产业结构调整背景下的剩余劳动力转移状况进行具体分析,阐释了产业结构和农业产业剩余劳动力的均衡性,并对辽宁省具体行业吸纳就业能力进行研究。结果表明,农业产业剩余劳动力正在向第二产业和第三产业转移,第三产业能够较大程度带动农业产业剩余劳动力就业。同时,提出相应对策,包括大力发展第三产业、加强农村地区城镇化建设以及加强农业产业技能的培训等,以帮助农业产业剩余劳动力转移就业,有利于针对性地对农业产业剩余劳动力提出帮扶措施,以帮助其更好地实现就业。

关键词：农业产业剩余劳动力经济

政府购买公共文化服务的实践与思考——以廊坊市安次区为例

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内蒙古科技与经济 2020年第2期 11-13页

作者：寇爽廊坊卫生职业学院图书馆河北廊坊065000

政府购买公共文化服务有利于提高公共服务效率、优化政府职能、推动社会组织自身能力的发展,节约财政资金、进一步推进廉政建设。本文以廊坊市安次区为例,阐述了廊坊市安次区在政府购买公共文化服务方面实施的一些措施和取得的成效。

关键词：政府购买公共文化服务图书馆社会力量