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“双碳”背景下热轧厂能源管理体系构建与实施

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能源与节能 2024年第1期 24-27,36页

作者：黄爽杨孝鹤高文刚银呈祥首钢京唐钢铁联合有限责任公司热轧作业部河北唐山063200

现阶段,中国能源体系和发展模式进入崭新阶段。热轧是钢铁企业的关键工序,热轧厂绿色、低碳、高效能源体系建设尤为重要。在“双碳”背景下,通过建立健全能源管理制度、构建“1+14”能源管理模式、建设多终端能源管理平台、产能提升助... 详细信息

现阶段,中国能源体系和发展模式进入崭新阶段。热轧是钢铁企业的关键工序,热轧厂绿色、低碳、高效能源体系建设尤为重要。在“双碳”背景下,通过建立健全能源管理制度、构建“1+14”能源管理模式、建设多终端能源管理平台、产能提升助力高效节能、推行节能技术革新、建立精细化多重预警机制、强化体制机制保障等多措并举,成功构建实施了绿色、低碳、高效热轧厂能源管理体系,创新了管理理念,优化了管理架构,创新了管控模式,热轧厂综合工序能耗降幅明显,取得了显著的经济效益。

关键词：热轧厂能源管理燃耗电耗

15例儿童非免疫缺陷原发中枢神经系统淋巴瘤的临床研究

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中华血液学杂志 2024年第2期45卷 190-194页

作者：高慧霞张宁宁周春菊金玲杨菁黄爽张梦李楠张永红段彦龙国家儿童医学中心首都医科大学附属北京儿童医院儿童肿瘤中心肿瘤内科儿童血液病与肿瘤分子分型北京市重点实验室儿童肿瘤国家临床重点专科儿科重大疾病研究教育部重点实验室北京100045 首都医科大学附属北京儿童医院影像中心北京100045 首都医科大学附属北京儿童医院病理科北京100045

回顾性分析首都医科大学附属北京儿童医院2013年5月至2023年5月收治年龄≤18岁的15例非免疫缺陷原发中枢神经系统淋巴瘤(PCNSL)患儿的临床资料,总结临床特点以及基于病理组织亚型的、以大剂量甲氨蝶呤(HD-MTX)为基础的化疗方案的治疗效... 详细信息

回顾性分析首都医科大学附属北京儿童医院2013年5月至2023年5月收治年龄≤18岁的15例非免疫缺陷原发中枢神经系统淋巴瘤(PCNSL)患儿的临床资料,总结临床特点以及基于病理组织亚型的、以大剂量甲氨蝶呤(HD-MTX)为基础的化疗方案的治疗效果。男女比例2.7∶1,中位确诊年龄7.2(2.3~16.4)岁,临床首发症状以颅高压伴颅神经受损为主,影像学以多发病灶为主。免疫功能正常的儿童PCNSL发病率极低,以HD-MTX为基础的化疗整体预后良好,部分病情评估稳定者可减量维持或不予维持治疗。初治以非HD-MTX为主的化疗,病情进展或复发患儿再次予HD-MTX为基础的化疗仍有效。

关键词：大剂量甲氨蝶呤非免疫缺陷预后良好多发病灶病情评估维持治疗颅高压病情进展

Complications and comorbidities associated with antineoplastic chemotherapy:Rethinking drug design and delivery for anticancer therapy

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2901-2926页

作者： Xiaoman Mao shuang Wu Dandan huang Chong Li College of Pharmaceutical Sciences Southwest UniversityChongqing 400715China Medical Research Institute Southwest UniversityChongqing 400715China School of Pharmaceutical Sciences Southern Medical UniversityGuangzhou 510515China

Despite the considerable advancements in chemotherapy as a cornerstone modality in cancer treatment,the prevalence of complications and pre-existing diseases is on the rise among cancer patients along with prolonged survival and aging *** relationships between these disorders and cancer are intricate,bearing significant influence on the survival and quality of life of individuals with cancer and presenting challenges for the prognosis and outcomes of ***,we review the prevailing complications and comorbidities that often accompany chemotherapy and summarize the lessons to learn from inadequate research and management of this scenario,with an emphasis on possible strategies for reducing potential complications and alleviating comorbidities,as well as an overview of current preclinical cancer models and practical advice for establishing bio-faithful preclinical models in such complex context.

关键词： Complications Comorbidities Chemotherapy Preclinical cancer models Drug design Drug delivery

Metabonomics delineates allergic reactions induced by shuang-huang-lian injection in rats using ultra performance liquid chromatography-mass spectrometry

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Chinese Journal of Natural Medicines 2018年第8期16卷 628-640页

作者： GU Yuan-Yuan SHI Lang ZHANG Dan-Dan huang Xin CHEN Da-Zhong Research Institute of Traditional Chinese Medicine Heilongjiang University of Chinese Medicine First Clinical Medical College Heilongjiang University of Chinese Medicine

shuang-huang-lian Injection(SHLI) is the first successfully developed drug from traditional Chinese medicine(TCM) powder for injection,since its use for the treatment of acute respiratory tract infection,pneumonia,influenza,*** the same time,its allergic reactions have also emerged,which limits clinical ***,few scholars pay attention to the mechanism of allergic *** this present study,metabonomics technology was used to explore the changes in endogenous metabolites in urine of the rat model of SHLI induced allergic reaction;we and analyzed the metabolites,metabolic pathway,and the mechanism which were closely related to the allergic *** levels of serum histamine and tryptase were examined and changes in histomorphology were also *** on the UPLC-Q-TOF/MS metabonomics,we carried out the pattern recognition analysis,selected potential biomarkers associated with allergic reactions,and explored the pathological mechanism for SHLI induced allergic reaction,which laid the foundation for the safety research of *** results showed that SHLI increased the levels of serum histamine and tryptase in rats with allergic reaction;we determined 15 biomarkers in rat allergic reaction model induced by SHLI and found multiple metabolic pathways involved,such as metabolism of linolenic acid,phenylalanine,amino acid,2-oxo acid,and purine and other metabolic pathways.

关键词： shuang-huang-lian injection Biomarker Metabonomics Allergic mechanism Metabolites

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脉冲式加热炉水梁结瘤的分析和预防

新疆钢铁 2024年第1期 92-94页

作者：赵鑫张国臣何志钢魏福顺黄爽首钢京唐公司热轧作业部1580作业区河北唐山063200

为了进一步降低加热炉的燃耗和烧损,加热炉的燃烧控制模式从蓄热式改进为脉冲式。此项改进后,步进梁上开始出现结瘤,板坯在炉内走斜,并导致板坯变形,使轧机无法进行轧制。为解决脉冲式加热炉水梁结瘤的问题,通过分析结瘤成分、探究结瘤... 详细信息

为了进一步降低加热炉的燃耗和烧损,加热炉的燃烧控制模式从蓄热式改进为脉冲式。此项改进后,步进梁上开始出现结瘤,板坯在炉内走斜,并导致板坯变形,使轧机无法进行轧制。为解决脉冲式加热炉水梁结瘤的问题,通过分析结瘤成分、探究结瘤产生机理,并采取了相应的预防措施,成功解决了结瘤问题。

关键词：脉冲式加热炉结瘤分析和预防

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苏里格区块储层解堵技术研究与应用

内蒙古石油化工 2024年第7期50卷 95-98页

作者：黄爽刘峰梁亚军刘天宇韩浩王晓东渤海钻探工程有限公司油气合作分公司天津300450

苏里格气田属于低压、低渗、致密砂岩气田,随开发不断深入,气井压力、产量逐渐降低,部分气井逐渐产水,地层中流体的流动由气体的单相渗流逐渐演变为气、水两相渗流,近井地带含水饱和度增加、造成储层水锁;同时苏里格区块目前气井主要排... 详细信息

苏里格气田属于低压、低渗、致密砂岩气田,随开发不断深入,气井压力、产量逐渐降低,部分气井逐渐产水,地层中流体的流动由气体的单相渗流逐渐演变为气、水两相渗流,近井地带含水饱和度增加、造成储层水锁;同时苏里格区块目前气井主要排液手段为间歇配合泡排生产,通过地层近井地带能量储集,利用高瞬流将井筒积液带出,而带来的后果则是储层中颗粒物等杂质不断向近井地带聚集,造成储层气道堵塞。为明确气在生产过程中出现水锁伤害和颗粒物堵塞特征及气井生产动态动态响应特征,选取研究区块120口低产低效井开展储层解堵工艺技术应用。

关键词：苏里格区块井筒积液产量递减储层堵塞解水锁工艺

Electron engineering of nickel phosphide for Ni^(δ+) in electrochemical nitrate reduction to ammonia

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Nano Research 2024年第6期17卷 4864-4871页

作者： Jie Hu Hao huang Miao Yu shuang Wang Jinping Li College of Environmental Science and Engineering Taiyuan University of TechnologyJinzhong 030600China School of Sustainable Energy Materials and Science Jinhua Advanced Research InstituteJinhua 321000China Shanxi Key Laboratory of Gas Energy Efficient and Clean Utilization Taiyuan University of TechnologyTaiyuan 030024China

The electrochemical reduction of nitrate to ammonia(ENRA)provides an efficient approach to remove nitrate pollution and achieve ammonia production ***,inspired by bio-enzyme in denitrifying bacteria,a carbon-coated nickel phosphide(NiPC)nanosheet derived from metal-organic frameworks(MOFs)is proposed as an efficient catalyst for *** electron engineering,controllable Ni^(δ+)in nickel phosphide is achieved by regulating the degree of phosphating,which enhances its activity for the hydrogenation of *** the result,Niδ+becomes one of dominating factors determining the efficiency of the ENRA reaction in nickel *** optimal NiPC catalyst exhibits impressive property toward ENRA:NH_(4)^(+)Faraday efficiency of 96.68%,NH4+selectivity of 99.04%,and nitrate conversion rate of 90.43%under low nitrate concentration(200 mg·L^(−1)).This work opens a new avenue for the design of next-generation catalysts through electron engineering for ENRA.

关键词： electron engineering transition metal phosphide nitrate reduction ammonia production metal-organic frameworks

Degree of style coiling is associated with corolla-tube length in the nectarless flowers of Roscoea schneideriana

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Plant Diversity 2023年第6期45卷 748-751页

作者： Bo Wang Ze-Yu Tong Ying-Ze Xiong Xiao-Fan Wang W.Scott Armbruster shuang-Quan huang State Key Laboratory of Hybrid Rice College of Life SciencesWuhan UniversityWuhan 430072China Institute of Evolution and Ecology School of Life SciencesCentral China Normal UniversityWuhan 430079China School of Biological Sciences University of PortsmouthPortsmouth PO12DYUK Institute of Arctic Biology University of Alaska FairbanksFairbanksAK 99775USA

The plant-pollinator‘arms race’model posits that a major driver of the evolution of elongated corollas in flowers is reciprocal selection for‘morphological fit’between pollinator-tongue length and access distance to nectar(usually corolla-tube length).Evidence for the pollinator-mediated selection on tube length and evolution of multiple,correlated floral traits remains *** gain possible insights into the strength of stabilizing selection by assessing standing phenotypic variation,we measured a series of functionally important floral traits,including corolla tube length and‘effective’tube depth and degree of style *** then calculated coefficients of variation(CV)for these traits in three field populations of *** in most long-tubed flowers,the bottom part of the corolla tube is completely occupied by the style,with no room for *** length of this portion of the corolla tube was more variable(higher CV)than the upper part of the corolla tube,suggesting that functional tube depth was under stronger stabilizing *** degree of style coiling was negatively related to the corolla-tube length in all three populations of ***,suggesting that there may be conflicting selection acting on style length and corolla-tube length,which are otherwise usually tightly *** the lack of nectar in the flowers of this species,the long corolla tubes and long styles may represent morphological holdovers from ancestors that were pollinated by long-tongued pollinators,as is still seen in related species in the western Himalayas.

关键词： Coefficient of variation Coiled style Corolla-tube length Nectar depth Pollinator shift Trait covariation

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多因素作用下混凝土梁长期性能时变劣化规律

交通科学与工程 2024年第4期40卷 65-75页

作者：柏玉良金伟良张怡雪吴俊黄爽朱明江浙江大学建筑工程学院浙江杭州310058

为了探究混凝土梁在锈蚀、疲劳、徐变等多因素长期作用下的性能劣化规律,对21根试验梁开展了锈蚀、疲劳和徐变的正交分组试验,通过对钢筋锈蚀深度、梁的刚度和疲劳寿命的测量计算,研究了钢筋混凝土梁长期性能的时变劣化规律。研究结果表... 详细信息

为了探究混凝土梁在锈蚀、疲劳、徐变等多因素长期作用下的性能劣化规律,对21根试验梁开展了锈蚀、疲劳和徐变的正交分组试验,通过对钢筋锈蚀深度、梁的刚度和疲劳寿命的测量计算,研究了钢筋混凝土梁长期性能的时变劣化规律。研究结果表明:相较于无损梁,在2.5%、15.0%、60.0%疲劳寿命比和3、6个月持续荷载作用下,损伤混凝土梁的锈蚀深度扩大了1.337~1.934倍;随着钢筋锈蚀和疲劳损伤程度的加深,损伤梁的刚度下降了1.694 kN·m^(2),在持续荷载作用下,其刚度仅为无损梁的34.1%;在锈蚀和徐变相继作用后,损伤梁的疲劳寿命仅为无损梁的16.14%。根据试验研究结果,给出了损伤混凝土梁的临界锈蚀深度衰减系数、短期刚度降低系数、刚度退化系数和疲劳寿命衰减系数,以反映复杂荷载与环境作用对混凝土梁长期性能的影响,为混凝土结构的长期性能评估提供了科学依据。

关键词：多因素作用混凝土梁临界锈蚀深度短期刚度疲劳寿命长期性能