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自然科学史研究 2024年第3期43卷 364-376页

作者：李斌郭帅中国科学院大学人文学院北京100049

从普里斯特利的著作出发,本文深入考察普里斯特利发明苏打水以及后续技术改进和工业应用的过程,从而揭示出通俗化的科学写作方式和巡回讲座推动了苏打水知识广泛迅速的扩散,反映出18世纪下半叶工业启蒙背景下科学知识传播具有显著的应... 详细信息

从普里斯特利的著作出发,本文深入考察普里斯特利发明苏打水以及后续技术改进和工业应用的过程,从而揭示出通俗化的科学写作方式和巡回讲座推动了苏打水知识广泛迅速的扩散,反映出18世纪下半叶工业启蒙背景下科学知识传播具有显著的应用导向。

关键词：普里斯特利苏打水科学传播应用导向

Recent advances in biomimetic aggregation-induced emission photosensitizers for photodynamic therapy and immunotherapy

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BMEMat(BioMedical Engineering Materials) 2024年第3期2卷 74-91页

作者： shuai guo Hui Tang Yahui Zhang Zhouyu Wang Swee Ching Tan Department of Materials Science and Engineering National University of SingaporeSingapore Department of Chemistry School of ScienceXihua UniversityChengduChina

The development of novel photosensitizers(PSs)with aggregation-induced emission(AIE)properties has emerged as a crucial advancement in the field of photodynamic therapy(PDT).However,the versatile applications of AIE PSs are limited by low encapsulation efficiency and inadequate target tissue *** technology stands out as a promising strategy to overcome these challenges,aiming to enhance AIE PSs tumor penetration efficacy,and their association with antitumor immune *** this review,recent advancements in biomimetic AIE PSs for PDT and immunotherapy are *** start with introducing strategies involving biomimetic AIE PSs based on cell membranes and extracellular vesicles for the combined application of PDT and *** then discuss the preparation of biomimetic AIE PSs ***,we briefly outline the challenges and prospects associated with biomimetic AIE PSs.

关键词： aggregation induced emission biomimetic immunotherapy photodynamic therapy photosensitizers

次流通道对双喉道气动矢量喷管的性能影响研究

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推进技术 2014年第9期35卷 1174-1180页

作者：范志鹏徐惊雷郭帅江苏省航空动力系统重点实验室南京航空航天大学能源与动力学院江苏南京210016

为了进一步了解次流通道对双喉道气动矢量喷管(Dual Throat Nozzle,DTN)气动矢量性能的影响,基于二维DTN喷管构型进行了详细的数值模拟研究。结果表明:收扩的次流通道相对于平直的次流通道不会改善DTN喷管的推力矢量性能;随着次流流量增... 详细信息

为了进一步了解次流通道对双喉道气动矢量喷管(Dual Throat Nozzle,DTN)气动矢量性能的影响,基于二维DTN喷管构型进行了详细的数值模拟研究。结果表明:收扩的次流通道相对于平直的次流通道不会改善DTN喷管的推力矢量性能;随着次流流量增加,DTN的推力矢量角存在一个最大值,超过该值各推力矢量性能均会降低;次流通道宽度对DTN喷管推力矢量性能影响显著:(1)次流宽度不影响所能达到的最大推力矢量角;(2)小的次流宽度在进口总压较高的条件下具有更高的推力矢量角;(3)增大次流宽度能降低次流总压,但达到的矢量角会有所减小。

关键词：双喉道气动矢量喷管次流管道次流百分比推力矢量性能数值模拟

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丰台西站运输组织现状与分析

铁道运输与经济 2010年第7期32卷 33-36页

作者：郭彦郭帅军事交通学院基础部天津300161 北京铁路局丰台西站北京100070

针对石太客运专线的开通运营和运行图的大幅调整,对丰台西站运输组织现状及存在问题进行分析,从改进站场设备能力和加强运输作业组织两个方面采取相应措施,以保证车站运输生产的安全畅通。尤其是2011年京石、石武客运专线开通运营后,京... 详细信息

针对石太客运专线的开通运营和运行图的大幅调整,对丰台西站运输组织现状及存在问题进行分析,从改进站场设备能力和加强运输作业组织两个方面采取相应措施,以保证车站运输生产的安全畅通。尤其是2011年京石、石武客运专线开通运营后,京广铁路运输通道将实现客货分线运输,建议主要通过运输组织优化措施来解决现有能力不足等问题。

关键词：客运专线运输组织车站能力

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压电发电技术研究综述

压电与声光 2011年第3期33卷 394-398页

作者：王剑郭吉丰郭帅浙江大学电气工程学院浙江杭州310027

面对21世纪能源短缺的挑战,努力寻找更可持续性和更环保的新型能源无疑成为解决问题的关键。从环境中采集能量转换为电能的技术也越来越受到重视。该文在对比此类新型发电方式的基础上,认为利用压电发电技术采集环境能量具有独特的优势... 详细信息

面对21世纪能源短缺的挑战,努力寻找更可持续性和更环保的新型能源无疑成为解决问题的关键。从环境中采集能量转换为电能的技术也越来越受到重视。该文在对比此类新型发电方式的基础上,认为利用压电发电技术采集环境能量具有独特的优势。分析了振动式压电发电技术在国内外的研究进展,并以大功率的道路压电发电为重点,阐述了其原理、结构和应用领域,总结了今后的发展方向和热点问题。

关键词：新能源压电陶瓷发电道路

Design of a novel hybrid quantum deep neural network in INEQR images classification

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Chinese Physics B 2024年第6期33卷 230-238页

作者：王爽王柯涵程涛赵润盛马鸿洋郭帅 School of Information and Control Engineering Qingdao University of TechnologyQingdao 266033China School of Sciences Qingdao University of TechnologyQingdao 266033China

We redesign the parameterized quantum circuit in the quantum deep neural network, construct a three-layer structure as the hidden layer, and then use classical optimization algorithms to train the parameterized quantum circuit, thereby propose a novel hybrid quantum deep neural network(HQDNN) used for image classification. After bilinear interpolation reduces the original image to a suitable size, an improved novel enhanced quantum representation(INEQR) is used to encode it into quantum states as the input of the HQDNN. Multi-layer parameterized quantum circuits are used as the main structure to implement feature extraction and classification. The output results of parameterized quantum circuits are converted into classical data through quantum measurements and then optimized on a classical computer. To verify the performance of the HQDNN, we conduct binary classification and three classification experiments on the MNIST(Modified National Institute of Standards and Technology) data set. In the first binary classification, the accuracy of 0 and 4 exceeds98%. Then we compare the performance of three classification with other algorithms, the results on two datasets show that the classification accuracy is higher than that of quantum deep neural network and general quantum convolutional neural network.

关键词： quantum computing image classification quantum–classical hybrid neural network quantum image representation interpolation

非酒精性脂肪性肝病中微小RNA调控肝脂肪变性机制的研究进展

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中国药学杂志 2022年第2期57卷 90-95页

作者：郭帅帅马艺溢肇丽梅中国医科大学附属盛京医院药学部沈阳110004

非酒精性脂肪性肝病(non-alcoholic fatty liver disease, NAFLD)与机体细胞内脂质代谢的紊乱有关,即肝细胞中脂质获取与去除之间的不平衡导致细胞质中甘油三酯(triglyceride, TG)的聚积。微小RNA(miRNA)是1类长度约为22个核苷酸片段的... 详细信息

非酒精性脂肪性肝病(non-alcoholic fatty liver disease, NAFLD)与机体细胞内脂质代谢的紊乱有关,即肝细胞中脂质获取与去除之间的不平衡导致细胞质中甘油三酯(triglyceride, TG)的聚积。微小RNA(miRNA)是1类长度约为22个核苷酸片段的非编码小分子RNA,在转录后水平通过翻译抑制或降解/裂解mRNA两种方式来调控基因的表达。越来越多的证据表明,miRNAs与NAFLD的发生、发展密切相关,并且miRNAs广泛参与调控脂质合成、代谢相关靶基因表达的过程。笔者从miRNAs调控脂质代谢通路的角度总结了有关NAFLD中miRNAs调控肝脂肪变性的机制,并简要分析了miRNAs作为NAFLD的生物标志物和/或治疗靶点的潜在用途。

关键词：非酒精性脂肪性肝病微小RNA 脂质代谢

A chromosome-level genome assembly of anesthetic drug–producing Anisodus acutangulus provides insights into its evolution and the biosynthesis of tropane alkaloids

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Plant Communications 2024年第1期5卷 231-244页

作者： Wei Zhou Can Wang Xiaolong Hao Fei Chen Qikai Huang Tingyao Liu Jiang Xu shuai guo Baosheng Liao Zhixiang Liu Yue Feng Yao Wang Pan Liao Jiayu Xue Min Shi Itay Maoz guoyin Kai Zhejiang Provincial International S&T Cooperation Base for Active Ingredients of Medicinal and Edible Plants and Health Zhejiang Provincial Key TCM Laboratory for Chinese Resource Innovation and TransformationSchool of Pharmaceutical SciencesJinhua AcademyZhejiang Chinese Medical UniversityHangzhouZhejiang 310053China Sanya Nanfan Research Institute from Hainan University Hainan Yazhou Bay Seed LaboratorySanya 572025China Institute of Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China Department of Biology Hong Kong Baptist UniversityKowloon TongHong KongChina College of Horticulture Academy for Advanced Interdisciplinary StudiesNanjing Agricultural UniversityNanjing 210095China Department of Postharvest Science Agricultural Research OrganizationVolcani CenterP.O.Box 15159HaMaccabim Road 68Rishon LeZion 7505101Israel

Tropane alkaloids(TAs),which are anticholinergic agents,are an essential class of natural compounds,and there is a growing demand for TAs with anesthetic,analgesic,and spasmolytic *** acutan-gulus(Solanaceae)is a TA-producing plant that was used as an anesthetic in ancient *** this study,we assembled a high-quality,chromosome-scale genome of *** with a contig N50 of 7.4 Mb.A recent whole-genome duplication occurred in *** after its divergence from other Solanaceae species,which resulted in the duplication of ADC1 and UGT genes involved in TA *** catalytic activities of H6H enzymes were determined for three Solanaceae *** the basis of evolution and co-expressed genes,AaWRKY11 was selected for further analyses,which revealed that its encoded tran-scription factor promotes TA biosynthesis by activating AaH6H1 *** provide useful insights into genome evolution related to TA biosynthesis and have potential implications for genetic manipulation of TA-producing plants.

关键词： Anisodus acutangulus tropane alkaloid biosynthesis hyoscyamine 6 b-hydroxylase AaWRKY11

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高校图书馆社会化服务模式探索

图书情报工作 2014年第19期58卷 74-78页

作者：宫平郭帅沈阳师范大学图书馆信息咨询部南开大学商学院中国刑事警察学院 <中国刑事警察>编辑部

指出高校图书馆面向社会服务首先要充分考虑实际情况,以科学发展观为指导,遵循一定的原则,逐步扩展服务内容和范围。对高校图书馆社会化服务定位进行分析,认为其定位应为政府智囊团、企业情报源、社会教育中心和文化休闲中心。最后,基... 详细信息

指出高校图书馆面向社会服务首先要充分考虑实际情况,以科学发展观为指导,遵循一定的原则,逐步扩展服务内容和范围。对高校图书馆社会化服务定位进行分析,认为其定位应为政府智囊团、企业情报源、社会教育中心和文化休闲中心。最后,基于服务主体和服务内容探索多种模式并存的高校图书馆社会化服务模式。

关键词：高校图书馆社会化服务服务模式

Mapping prediction with recurrent neural networks for future LISP enabled networks

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Journal of Information and Intelligence 2023年第2期1卷 134-147页

作者： Yue Li shuai guo Qipeng Song Yao Wang Xiaomin Wei Jianfeng Ma School of Cyber Engineering Xidian UniversityXi'an 710071China

Locator/identifier separation paradigm(LISP)is an emerging Internet architecture evolution trend that decouples the identifier and location of an entity attached to the *** to its flexibility,LISP has seen its application in various fields such as mobile edge computing,and V2X ***,LISP relies on a DNS-like mapping system to associate identifiers and locations before connection *** a procedure incurs an extra latency overhead and thus hinders the adoption of LISP in delay-sensitive use *** this paper,we propose a novel RNN-based mapping prediction scheme to boost the performance of the LISP mapping resolution,by modeling the mapping procedure as a time series prediction *** key idea is to predict the mapping data regarding services to be utilized by users in edge networks administered by xTRs and proactively cache the mapping information within xTRs in *** compare our approach with several baseline methods,and the experiment results show a 30.02%performance gain in LISP cache hit ratio and 55.6%delay reduction compared with the case without mapping prediction *** work preliminarily proves the potential of the approach in promoting lowlatency LISP-based use cases.

关键词： LISP Future internet architecture Mapping prediction Recurrent neural network