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Pro-resolving lipid mediator reduces amyloid-β42–induced gene expression in human monocyte–derived microglia

Neural Regeneration Research 2025年第3期20卷 873-886页

作者： Ying Wang Xiang Zhang Henrik Biverstål Nicolas GBazan shuai tan Nailin Li Makiko Ohshima Marianne Schultzberg Xiaofei Li Department of Neurobiology Care Sciences&SocietyDivision of NeurogeriatricsKarolinska InstitutetStockholmSweden Department of Neurology Neuroscience CenterThe First Hospital of Jilin UniversityChangchunJilin ProvinceChina Department of Physiology and Pharmacology Karolinska InstitutetStockholmSweden Department of Biosciences and Nutrition Karolinska InstitutetHuddingeSweden Neuroscience Center of Excellence Louisiana State UniversityNew OrleansLAUSA Department of Medicine SolnaClinical Pharmacology GroupKarolinska University HospitalStockholmSweden

Specialized pro-resolving lipid mediators including maresin 1 mediate resolution but the levels of these are reduced in Alzheimer's disease brain, suggesting that they constitute a novel target for the treatment of Alzheimer's disease to prevent/stop inflammation and combat disease pathology. Therefore, it is important to clarify whether they counteract the expression of genes and proteins induced by amyloid-β. With this objective, we analyzed the relevance of human monocyte–derived microglia for in vitro modeling of neuroinflammation and its resolution in the context of Alzheimer's disease and investigated the pro-resolving bioactivity of maresin 1 on amyloid-β42–induced Alzheimer's disease–like inflammation. Analysis of RNA-sequencing data and secreted proteins in supernatants from the monocyte-derived microglia showed that the monocyte-derived microglia resembled Alzheimer's disease–like neuroinflammation in human brain microglia after incubation with amyloid-β42. Maresin 1 restored homeostasis by down-regulating inflammatory pathway related gene expression induced by amyloid-β42 in monocyte-derived microglia, protection of maresin 1 against the effects of amyloid-β42 is mediated by a re-balancing of inflammatory transcriptional networks in which modulation of gene transcription in the nuclear factor-kappa B pathway plays a major part. We pinpointed molecular targets that are associated with both neuroinflammation in Alzheimer's disease and therapeutic targets by maresin 1. In conclusion, monocyte-derived microglia represent a relevant in vitro microglial model for studies on Alzheimer's disease-like inflammation and drug response for individual patients. Maresin 1 ameliorates amyloid-β42–induced changes in several genes of importance in Alzheimer's disease, highlighting its potential as a therapeutic target for Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β maresin microglia monocyte neuroinflammation resolution RNA-sequencing specialized pro-resolving lipid mediator

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INVESTIGATION OF FRACTURE DESIGN FOR MEDIUM CARBON STEEL UNDER EXTRA-LOW CYCLIC FATIGUE IN AXIAL LOADING

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Acta Mechanica Solida Sinica 2008年第4期21卷 375-382页

作者： Youtang Li shuai tan Hongyan Duan Key Laboratory of Digital Manufacturing Technology and Application Ministry of Education Lanzhou University of Technology Lanzhou 730050 China College of Mechano-Electronic Engineering Lanzhou University of Technology Lanzhou 730050 China

The extra-low cyclic fracture problem of medium carbon steel under axial fatigue loading was investigated. Several problems, such as the relations of the cycle times to the depth and tip radius of the notch, loading frequency, loading range and the parameters of fracture design for medium carbon steel on condition of extra-low axial fatigue loading were discussed based on the experiments. Experimental results indicated that the tension-pressure fatigue loading mode was suitable for extra-low cyclic fatigue fracture design of medium carbon steel and it resulted in low energy consumption, fracture surface with high quality, low cycle times, and high efficiency. The appropriate parameters were as follows： loading frequency 3-5 Hz, notch tip radius r = （0.2-0.3） mm, opening angle α = 60°, and notch depth t = （0.14-0.17）D.

关键词： extra-low cyclic fatigue fracture design medium carbon steel crack technique

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Orthogonal nonnegative matrix factorization based local hidden Markov model for multimode process monitoring

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Chinese Journal of Chemical Engineering 2016年第7期24卷 856-860页

作者： Fan Wang Honglin Zhu shuai tan Hongbo Shi Key Laboratory of Advanced Control and Optimization for Chemical Processes of Ministry of Education East China University of Science and Technology

Traditional data driven fault detection methods assume that the process operates in a single mode so that they cannot perform well in processes with multiple operating modes. To monitor multimode processes effectively,this paper proposes a novel process monitoring scheme based on orthogonal nonnegative matrix factorization(ONMF) and hidden Markov model(HMM). The new clustering technique ONMF is employed to separate data from different process modes. The multiple HMMs for various operating modes lead to higher modeling *** proposed approach does not presume the distribution of data in each mode because the process uncertainty and dynamics can be well interpreted through the hidden Markov estimation. The HMM-based monitoring indication named negative log likelihood probability is utilized for fault detection. In order to assess the proposed monitoring strategy, a numerical example and the Tennessee Eastman process are used. The results demonstrate that this method provides efficient fault detection performance.

关键词： Multimode processFault detectionHidden Markov modelOrthogonal nonnegative matrix factorization

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Synthesis and properties of novel N,C,N terdentate skeleton based on 1,3-di(pyridin-2-yl)benzene moiety-new tricks for old dogs

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Chinese Chemical Letters 2019年第11期30卷 1951-1954页

作者： shuai tan Xiugang Wu Yanqiong Zheng Yafei Wang a Jiangsu Engineering Laboratory of Light-Electricity-Heat Energy-Converting Materials and Applications Jiangsu Key Laboratory of Environmentally Friendly Polymeric MaterialsJiangsu Collaboration Innovation Center of Photovoltaic Science and EngineeringSchool of Materials Science&EngineeringChangzhou UniversityChangzhou 213164China b College of Chemistry Key Lab of Environment-Friendly Chemistry and Application of the Ministry of EducationXiangtan UniversityXiangtan 411105China c Key Laboratory of Advanced Display and System Applications of Ministry of Education Shanghai UniversityShanghai 200072China

Utilization of intermolecular Friedel-Crafts and intramolecular condensation reaction,novel 1,3-di-(pyridine-2-yl)benzene(N,C,N terdentate)skeleton with electro-withdrawing group in 6'position of pyridyl and a cyclization between 6'position of pyridyl and 6 position of benzyl ring were firstly designed and *** structures of these novel N,C,N terdentate were confirmed by NMR,MS and X-ray single *** photophysical properties of these compounds were briefly explored.

关键词： 1,3-Di(pyridin-2-yl)benzene skeleton Platinum complex Synthesis Intramolecular cyclization

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A DEVELOPED FULL-FIELD FEM ANALYSIS COMBINED WITH ESPI FOR THE INVESTIGATION OF DEFECT EVOLUTION IN POLYMER FILMS

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Chinese Journal of Polymer Science 2013年第7期31卷 1022-1028页

作者： Xiao-fang Liu shuai-xia tan Xiao-li Zhang 赵宁徐坚 Beijing National Laboratory of Molecular Science Laboratory of Polymer Physics and ChemistryInstitute of ChemistryChinese Academy of Sciences Graduate University of the Chinese Academy of Sciences

A full-field finite element method （FEM） analysis combined with electronic speckle pattern interferometry （ESPI） measurement was developed to investigate defect evolution in polymer films. Different from the previous reports, which only compare the ESPI experimental and FEM simulated results at several points or lines, herein the full-field FEM results were exported, subtracted with a continuous distribution. By choosing proper parameters and number of substeps, the simulated and experimental results showed excellent correspondence. Furthermore, the displacement fields vertical to the tensional direction were also presented, and the strain field was preliminarily evaluated. The current method of combination of ESPI and FEM allows for capturing the experimental fringe maps to validate and optimize FEM results simulated, and would give a higher security to structural and mechanical analysis of polymeric materials.

关键词： Electronic speckle pattern interferometry Finite element method Defect In-plane displacement Polymer film.

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Property Prediction Using Hierarchical Regression Model Based on Calibration

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Journal of Iron and Steel Research International 2010年第8期17卷 30-35页

作者： tan shuai CHEN Wei-dong WANG Fu-li CHANG Yu-qing School of Information Science and Engineering Northeastern UniversityShenyang 110004LiaoningChina Baosteel Industry Inspection Co Shanghai 201900 China)

Redundant information and inaccurate model will greatly affect the precision of quality prediction.A multiphase orthogonal signal correction modeling and hierarchical statistical analysis strategy are developed for the improvement of process understanding and quality *** orthogonal signal correction is used to remove the structured noise in both X and Y,which does not contribute to prediction *** corresponding loading vectors provide good interpretation of the covariant part in X and *** to background,hierarchical PLS（Hi-PLS）is used to build regression model of process variables and property *** blocking leads to two model levels：the lower level shows the relationship of variables in each annealing furnace using hierarchical PLS based on bidirectional orthogonal signal correction,and the upper level reflects the relationship of annealing *** analysis of continuous annealing line data,the production precisions of hardness and elongation are improved by comparison of previous *** demonstrates the efficiency of the proposed algorithm for better process understanding X and property interpretation Y.

关键词： continuous annealing line property prediction hierarchical PLS orthogonal signal correction

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Quality Prediction of Strip Steel Based on Windows-Mean MPLS

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Journal of Iron and Steel Research International 2010年第7期17卷 28-33页

作者： CHANG Yu-qing WANG Jin-fen tan shuai WANG Fu-li CHEN Wei-dong School of Information Science and Engineering Northeastern University Shenyang 110819 Liaoning China Baosteel Industry Inspection Co Shanghai 201900 China

A windows-mean multi-way partial-least squares（MPLS）method was proposed to build the strip steel quality prediction model for continuous annealing *** proposed method can deal with the problem of large time lag in hardness measurement of the strip steel and the difficulties in building mechanism *** on the average trajectories of the process variable information,the proposed method was used to realize the strip steel quality *** with the traditional MPLS,the proposed method can eliminate the abundant and redundant process information and reduce the number of the model input ***,it can avoid the uneven-length modeling data problem of the traditional MPLS *** simulation result demonstrates the performance and advantages of the proposed method for predicting the strip steel hardness.

关键词： continuous annealing strip steel hardness quality prediction windows-mean MPLS

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Effects of process parameters on microstructure and mechanical properties of friction stir lap linear welded 6061 aluminum alloy to NZ30K magnesium alloy

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Journal of Magnesium and Alloys 2017年第1期5卷 56-63页

作者： shuai tan Feiyan Zheng Juan Chen Jingyu Han Yujuan Wu Liming Peng National Engineering Research Center of Light Alloy Net Forming State Key Laboratory of Metal Matrix CompositeShanghai Jiao Tong UniversityShanghai 200240China

The microstructures and lap-shear behaviors of friction stir lap linear welded as-extruded 6061 Al alloy to as-cast Mg–3.0Nd–0.2Zn–0.7Zr(wt.%)(NZ30K)alloy joints were *** tool rotation and travel speeds were adopted to prepare the *** analysis of temperature field indicates that the peak temperature for each sample can reach 450℃,which exceeds the eutectic reaction temperatures of 437℃ and 450℃ according to the binary phase diagram of Al–Mg *** fierce intermixing can be found at the interface between Al and Mg alloys,forming the intermetallic of Al_(3)Mg_(2).Welds with the rotation speed of 900 rpm and travel speed of 120 mm/min display the highest tensile shear failure load of about 2.24 *** value was increased by 13%after the sample was heat treated at 400℃ for 0.5 h.

关键词： Friction stir lap linear welding(FSLW) Temperature field Tensile shear test Heat treatment

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Stimuli-responsive cyclometalated platinum complex bearing bent molecular geometry for highly efficient solution-processable OLEDs

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Chinese Chemical Letters 2021年第1期32卷 493-496页

作者： Zhenhua Wei Kai Zhang Chan Kyung Kim shuai tan Shaojie Wang Lin Wang Jun Li Yafei Wang National Experimental Demonstration Center for Materials Science and Engineering(Changzhou University) Jiangsu Collaborative Innovation Center of Photovoltaic Science and EngineeringJiangsu Engineering Laboratory of Light-Electricity-Heat Energy-Converting Materials and ApplicationsSchool of Materials Science&EngineeringChangzhou UniversityChangzhou 213164China Center for High Pressure Science(CHiPS) State Key Laboratory of Metastable Materials Science and TechnologyYanshan UniversityQinhuangdao 066004China Department of Chemistry and Chemical Engineering Inha UniversityIncheon 22212South Korea College of Chemistry Xiangtan UniversityXiangtan 411105China School of Chemical Engineering and Technology North University of ChinaTaiyuan 030051China Center for High Pressure Science and Technology Advanced Research Shanghai 201203China

Smart materials,such as stimuli-responsive luminescence,have attracted much attentions due to their potential application in semiconductor *** this context,platinum complexes of(dfppy-DC)Pt(acac) and(dfppy-O-DC)Pt(acac) were prepared and characterized,in which(2-(4',6'-difluorophenyl)pyridinato-N,C2')(2,4-pentanedionato-0,0)Pt(Ⅱ) was used as the planar emission core and 9-(4-(phenylsulfonyl)phenyl)-9 H-carbazole(DC) was regard as the bent *** platinum complexes showed bright emission in solution and solid state,concomitant with charming external-stimuli-responsive emission under mechanical grinding,organic solvent vapors and *** change emission color spanned from yellow to near-infrared *** the platinum complexes as the dopant,solution processable organic light-emitting diodes(OLEDs) were fabricated and a maximum external quantum efficiency of ~18% was achieved,which is the highest value among the reported solution-processable OLEDs based on externalstimuli-responsive *** research demonstrated that platinum complex can show promising stimuli responsive emission via ingenious molecular design,indicating a novel way for developing the smart materials in semiconductor filed.

关键词： Stimuli responsive emission Platinum complex Solution-processable OLEDs Synthesis and property

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Experimental study on surface-active polymer flooding for enhanced oil recovery: A case study of Daqing placanticline oilfield, NE China

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Petroleum Exploration and Development 2019年第6期46卷 1206-1217页

作者： YU Qiannan LIU Yikun LIANG Shuang tan shuai SUN Zhi YU Yang College of Mechanical and Electrical Engineering Guangdong University of Petrochemical TechnologyMaoming 525000China School of Petroleum Engineering Northeast Petroleum UniversityDaqing 163318China School of Chemical Engineering Sichuan UniversityChengdu 610065China PetroChina Daqing Oil Field Co.Ltd. Daqing 163002China

Experiments on surface-active polymer flooding for enhanced oil recovery were carried out by detection analysis and modern physical simulation technique based on reservoirs and fluids in Daqing placanticline *** experimental results show that the surface-active polymer is different from other common polymers and polymer-surfactant systems in molecular aggregation,viscosity and flow capacity,and it has larger molecular coil size,higher viscosity and viscosifying capacity,and poorer *** surface-active polymer solution has good performance of viscosity-increasing and viscosity retention,and has good performance of viscoelasticity and deformability to exert positive effects of viscosifying and viscoelastic ***-active polymer can change the chemical property of interface and reduce interfacial tension,making the reservoir rock turn water-wet,also it can emulsify the oil into relatively stable oil-in-water emulsion,and emulsification capacity is an important property to enhance oil washing efficiency under non-ultralow interfacial *** surface-active polymer flooding enlarges swept volume in two ways:Microscopically,the surface-active polymer has mobility control effect and can enter oil-bearing pores not swept by water to drive residual oil,and its mobility control effect has more contribution than oil washing capacity in enhancing oil ***,it has plugging capacity,and can emulsify and plug the dominant channels in layers with high permeability,forcing the injected fluid to enter the layer with medium or low permeability and low flow resistance,and thus enlarging swept volume.

关键词： high water-cut oilfield reservoir surface-active polymer oil-washing efficiency swept volume plug by emulsification enhanced oil recovery

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