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Engineering a cationic supramolecular charge switch for facile amino acids enantiodiscrimination based on extended-gate field effect transistors

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Chinese Chemical Letters 2022年第8期33卷 3873-3878页

作者： jing-jing zhang Si-Ying Wang Pan zhang shu-Chen Fan Hai-Tao Dai Yin Xiao Yong Wang School of Science Tianjin Key Laboratory of Molecular Optoelectronic ScienceDepartment of ChemistryCollaborative Innovation Center of Chemical Science and EngineeringTianjin UniversityTianjin 300072China Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparing TechnologyDepartment of PhysicsSchool of ScienceTianjin 300072China School of Chemical Engineering and Technology Tianjin Engineering Research Center of Functional Fine ChemicalsTianjin UniversityTianjin 300072China

Chiral recognition of essential amino acids(EAAs)is a huge challenge that keeps plaguing analytical scientists due to their cryptochirality and limited steric interaction *** by the superior enantioselectivity of functional supramolecular cyclodextrins(CDs)and strong signal amplification ability of field effect transistors(FETs),this work firstly reports a cationic supramolecular charge switch for facile enantiodiscrimination of EAAs based on extended-gate organic FET(EG-OFET).The cationic phenylcarbamoylated-CD single isomer acts as a charge switch via interacting with different enantiomers and the weak stereo-differentiation intermolecular interaction signals between the cationic perphenylcarbamoylated CDs and EAAs on the EG can be strongly and rapidly amplified through an *** chiral differentiation of six EAAs,including phenylalanine,tryptophan,leucine,isoleucine,lysine and valine,are successfully achieved without any derivation process and the detection limit for D-phenylalanine is down to 10^(-13)mol/*** believe that this study provides a new and facile sensing perspective for natural amino acids and may afford deeper understanding of molecular chirality.

关键词： Enantiodiscrimination EG-OFET Cyclodextrins Chirality amplification Amino acids

Highly efficient generation of blastocyst-like structures from spliceosomes-repressed mouse totipotent blastomere-like cells

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Science China(Life Sciences) 2023年第3期66卷 423-435页

作者： Pengfei zhang Xuzhao Zhai Boyan Huang shu Sun Wen jing Wang Man zhang GMU-GIBH Joint School of Life Sciences The Guangdong-Hong Kong-Macao Joint Laboratory for Cell Fate Regulation and DiseasesThe Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhou LaboratoryGuangzhou Medical UniversityGuangzhou 510005China Center for Cell Lineage and Atlas(CCLA) Bioland LaboratoryGuangzhou Regenerative Medicine and Health Guangdong LaboratoryGuangzhou 510005China

Mammalian embryogenesis begins with a totipotent ***-like structures can be captured by aggregated cells with extended pluripotent properties in a three-dimensional(3D)culture ***,the efficiency of generating blastoids is low,and it remains unclear whether other reported totipotent-like stem cells retain a similar *** this study,we demonstrated that spliceosomal repression-induced totipotent blastomere-like cells(TBLCs)form blastocyst-like structures within around 80%of all *** addition,we generated blastoids initiating from a single ***-blastoids express specific markers of constituent cell lineages of a blastocyst and resemble blastocyst in cell-lineage ***,singlecell RNA sequencing revealed that TBLC-blastoids share a similar transcriptional profile to natural embryos,albeit composed of fewer primitive endoderm-like ***,TBLC-blastoids can develop beyond the implantation stage in vitro and induce decidualization in *** summary,our findings provided an alternative cell type to efficiently generate blastoids for the study of early mouse embryogenesis.

关键词： blastoids TBLCs early embryogenesis totipotent

“In front of patients,I will always be a pupil.”*** zhang:the founder of the modern Chinese gastroenterology

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Protein & Cell 2019年第1期10卷 1-4页

作者： Lu Wang Xudong Liu Wenli Duan shu-yang zhang Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

*** zhang(张教骞,Hsiao-Chien Chang)was an outstanding clinician,therapist and medical educator,a member of the Academic Divisions of the Chinese Academy of Sciences,he is considered to be the founder of the modern Chinese gastroenterology(PUMCH,1988).As a doctor,he made a systemic and deep research on human blood volume,gastric secretion function,peptic ulcer disease,gastric ulcer and gastric cancer,celiac tuberculosis,amoebic dysentery,ulcerative colitis and so *** diagnosed and treated multiple intractable *** an educator,he emphasized the training of clinical basic skills,urged students to grasp the utilization of science in study and *** trained a large number of talents for Chinese medicine.

关键词： be multiple doctor basic grasp he

3D characterization of porosity and minerals of low-permeability uranium-bearing sandstone based on multi-resolution image fusion

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Nuclear Science and Techniques 2020年第10期31卷 115-134页

作者： Bing Sun Shan-Shan Hou Sheng Zeng Xin Bai shu-Wen zhang jing zhang School of Civil Engineering University of South ChinaHengyang 421001China School of Resource Environment and Safety Engineering University of South ChinaHengyang 421001China School of Resources and Safety Engineering Central South UniversityChangsha 410083China

In the process of in situ leaching of uranium,the microstructure controls and influences the flow distribution,percolation characteristics,and reaction mechanism of lixivium in the pores of reservoir rocks and directly affects the leaching of useful *** this study,the pore throat,pore size distribution,and mineral composition of low-permeability uranium-bearing sandstone were quantitatively analyzed by high pressure mercury injection,nuclear magnetic resonance,X-ray diffraction,and wavelength-dispersive X-ray *** distribution characteristics of pores and minerals in the samples were qualitatively analyzed using energy-dispersive scanning electron microscopy and multi-resolution CT *** registration with the landmarks algorithm provided by FEI Avizo was used to accurately match the CT images with different *** multi-scale and multi-mineral digital core model of low-permeability uranium-bearing sandstone is reconstructed through pore segmentation and mineral segmentation of fusion core scanning *** results show that the pore structure of low-permeability uranium-bearing sandstone is complex and has multi-scale and multi-crossing *** intergranular pores determine the main seepage channel in the pore space,and the secondary pores have poor connectivity with other *** and coffinite are isolated from the connected pores and surrounded by a large number of clay minerals and ankerite cements,which increases the difficulty of uranium *** and a large amount of ankerite cement are filled in the primary and secondary pores and pore throats of the low-permeability uraniumbearing sandstone,which significantly reduces the porosity of the movable fluid and results in low overall permeability of the *** multi-scale and multi-mineral digital core proposed in this study provides a basis for characterizing macroscopic and microscopic pore-throat structures and mineral distributions of low-permea

关键词： Low-permeability uranium-bearing sandstone Digital core Micro-CT SEM–EDS Image fusion

NiCu bimetallic catalysts derived from layered double hydroxides for hydroconversion of n-heptane

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Chinese Chemical Letters 2022年第4期33卷 2069-2072页

作者： Yanru Zhu Minghuan Yang Zhen zhang Zhe An Jian zhang Xin shu jing He State Key Laboratory of Chemical Resource Engineering Beijing Advanced Innovation Center for Soft Matter Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China

Supported NiCu bimetallic catalysts have been produced in-situ on commercial Al_(2)O_(3)by using layered double hydroxides as precursors. The resulting catalysts show a uniform Ni and Cu distribution, thus providing good activity and selectivity in the reforming reaction of n-heptane. The catalytic performance has been found to depend on the Cu/Ni ratio, revealing the synergic catalysis between homogeneously dispersed Ni and Cu sites. The good catalysis of Ni Cu bimetallic catalysts makes it possible to partly or even completely replace Pt with NiCu bimetallic catalysts.

关键词： n-Heptane reforming NiCu bimetallic catalysts Synergic catalysis Uniform distribution Layered double hydroxides

Indoleamine 2,3-dioxygenase adjusts neutrophils recruitment and chemotaxis in Aspergillus fumigatus keratitis

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International Journal of Ophthalmology(English edition) 2022年第3期15卷 380-387页

作者： shu-Xuan Guo Nan Jiang Li zhang Wei Jiang jing-jing Ma Qingdao University Qingdao 266003Shandong ProvinceChina

AIM: To explore the effect of indoleamine 2,3-dioxygenase(IDO) on recruitment and chemotaxis function of neutrophils in Aspergillus fumigatus(***) ***: C57BL/6 mice models of *** keratitis were established by inoculating hyphae of *** evenly on the *** clinical scores and inflammatory cytokines expression were measured respectively on the 1^(st), 3^(th), 5^(th) day after *** 1-MT(1 mg/m L) was administered by gavage to exert an inhibitory effect on IDO during *** mice were divided into control group, 1-MT group, ***(A.F.) group, and 1-MT+*** corneas were monitored by slit lamp microscopy, and recorded disease scores in 3 d after ***(MPO) assay was done to evaluate the neutrophils *** staining was used to detect the recruitment of neutrophils in murine *** m RNA of inflammatory cytokines was measured with reverse transcription-polymerase chain reaction(RT-PCR).RESULTS: The corneal inflammation and the clinical score reached the peak on the 3;day after the corneal *** m RNA of inflammatory cytokines of the *** reached the highest on the 3;day after the infection ***, the results of slit light photography indicated that inhibitors of IDO made inflammation more serious contrasted with the *** on the 3;***, imunofluorescence staining and MPO indicated that 1-MT enhanced the recruitment, infiltration and chemotaxis of neutrophils obviously in contrast to the ***-PCR indicated that 1-MT increased the expression of CXCL-1, ICAM-1, IL-1β, and IL-8 ***: IDO participates in the pathogenesis of *** keratitis and plays an important role in inducing immune protection by inhibiting neutrophils-related inflammatory reaction and suppressing recruitment and chemotaxis of the neutrophils.

关键词： indoleamine 2 3-dioxygenase keratitis neutrophils Aspergillus fumigatus innate immune

Field-Free Molecular Orientation with a Few Half-Cycle Pulses in the Terahertz Region

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Chinese Physics Letters 2011年第10期28卷 74-76页

作者： YU Jie zhang Wei YANG jing CONG shu-Lin School of Physics and Optoelectronic Technology Dalian University of TechnologyDalian 116024

A theoretical scenario used for achieving efficient field-free molecular orientation with a few half-cycle pulses (HCPs) is proposed, with the LiH molecule as an example. Compared with a single HCP, three HCPs can excite more rovibrational transitions and enhance the degree of molecular orientation. By optimizing the laser parameters, a maximum value of 0.798 for the degree of molecular orientation is obtained.

关键词： Pulse Molecular value

Nanocrystalline Ni(OH)_2 Preparation by Electrolysis in an Aqueous Solution of Nickel Nitrate

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Chemical Research in Chinese Universities 2002年第3期18卷 334-336页

作者： zhang Heng bin LI Xue yin CAO Xue jing LI shu jia College of Chemistry Jilin UniversityChangchun 130023P.R.China

Nanocrystalline Ni(OH) 2 was prepared by cathode deposition in an aqueous solution of nickel nitrate. The structure and the morphology were characterized by means of XRD and TEM. The electrode performances were exami... 详细信息

关键词： Nanocrystal Nickel hydroxide Electrolysis

Electronic Effect of Carbon Support on Pt Catalyst Supported on Graphite Intercalation Compound

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Chemical Research in Chinese Universities 2010年第3期26卷 465-471页

作者： WEI Ang WANG Qing-jing ZHAO Xiao-hui zhang shu-yong Key Lab of Colloid and Interface Chemistry Ministry of Education School of Chemistry and Chemical Engineering Shandong University Jinan 250100 P. R. China

Graphite intercalation compounds（GIC） were tested as an experimental model for studying the electronic effect of carbon support on the catalytic activity and poisoning tolerance of Pt catalyst for direct methanol fuel cells. The GIC samples with different intercalation degrees were prepared by electrolyzing graphite flake in H2SO4 for varying the periods of time. The GIC-supported Pt catalyst was deposited electrochemically. The catalytic activity and poisoning tolerance of the GIC-supported Pt catalysts were evaluated. It was found that GIC with sulfate anion as intercalate was able to catalyze methanol electrooxidation, which could be related to the positive charges generated on the graphite layer upon intercalation. As intercalation degree increased, the catalytic activity of the GIC-supported Pt catalyst decreased while the poisoning tolerance improved. This suggests that electron donation from support to catalyst had great effect on both catalytic activity and poisoning tolerance of Pt catalyst. And intercalation can be adopted as another important way to make modification on carboneous catalyst support.

关键词： Catalyst support Electronic effect Graphite intercalation compound Catalytic activity Poisoning tolerance