Engineering a cationic supramolecular charge switch for facile amino acids enantiodiscrimination based on extended-gate field effect transistors

作     者：Jing-Jing Zhang Si-Ying Wang Pan Zhang Shu-Chen Fan Hai-Tao Dai Yin Xiao Yong Wang Jing-Jing Zhang;Si-Ying Wang;Pan Zhang;Shu-Chen Fan;Hai-Tao Dai;Yin Xiao;Yong Wang

作者机构：School of ScienceTianjin Key Laboratory of Molecular Optoelectronic ScienceDepartment of ChemistryCollaborative Innovation Center of Chemical Science and EngineeringTianjin UniversityTianjin 300072China Tianjin Key Laboratory of Low Dimensional MaterialsPhysics and Preparing TechnologyDepartment of PhysicsSchool of ScienceTianjin 300072China School of Chemical Engineering and TechnologyTianjin Engineering Research Center of Functional Fine ChemicalsTianjin UniversityTianjin 300072China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2022年第33卷第8期

页      面：3873-3878页

核心收录：

学科分类：081702[工学-化学工艺] 08[工学] 0817[工学-化学工程与技术] 

基　　金：financially funded by the National Key R&D Program of China(No.2019YFC1905500) the National Natural Science Foundation of China(Nos.21922409,21976131) Tianjin Research Program of Application Foundation and Advanced Technology(No.18JCZDJC37500) 

主　　题：Enantiodiscrimination EG-OFET Cyclodextrins Chirality amplification Amino acids 

摘      要：Chiral recognition of essential amino acids(EAAs)is a huge challenge that keeps plaguing analytical scientists due to their cryptochirality and limited steric interaction *** by the superior enantioselectivity of functional supramolecular cyclodextrins(CDs)and strong signal amplification ability of field effect transistors(FETs),this work firstly reports a cationic supramolecular charge switch for facile enantiodiscrimination of EAAs based on extended-gate organic FET(EG-OFET).The cationic phenylcarbamoylated-CD single isomer acts as a charge switch via interacting with different enantiomers and the weak stereo-differentiation intermolecular interaction signals between the cationic perphenylcarbamoylated CDs and EAAs on the EG can be strongly and rapidly amplified through an *** chiral differentiation of six EAAs,including phenylalanine,tryptophan,leucine,isoleucine,lysine and valine,are successfully achieved without any derivation process and the detection limit for D-phenylalanine is down to 10^(-13)mol/*** believe that this study provides a new and facile sensing perspective for natural amino acids and may afford deeper understanding of molecular chirality.