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概率语言分布视角下的最小调整二分类大群体共识决策方法

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系统科学与数学 2024年第7期44卷 2045-2059页

作者：李胜利舒婷魏翠萍曲国华太原师范学院数学与统计学院晋中030619 太原师范学院智能优化计算与区块链技术山西省重点实验室晋中030619 扬州大学数学科学学院扬州225002 山西财经大学管理科学与工程学院太原030006

针对考虑实际分类需求的大群体决策问题,文章从偏好信息的概率分布和最小调整视角研究二分类大群体共识决策模型.首先,基于PROMETHEE II方法,通过将数据的概率分布向量与优势度相结合,提出了一种备选方案的初排序方法;其次,根据分类需要... 详细信息

针对考虑实际分类需求的大群体决策问题,文章从偏好信息的概率分布和最小调整视角研究二分类大群体共识决策模型.首先,基于PROMETHEE II方法,通过将数据的概率分布向量与优势度相结合,提出了一种备选方案的初排序方法;其次,根据分类需要,建立二分类选择过程,接着构建了基于最小调整的二分类共识决策优化模型,该模型能够在获取群体共识方案分类需求的同时,最小化决策者的共识调整量;最后,通过一个算例来验证方法的有效性和可行性.

关键词：概率分布优势度二分类最小调整群体共识

5S-Heudelotinone alleviates experimental colitis by shaping the immune system and enhancing the intestinal barrier in a gut microbiota-dependent manner

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2153-2176页

作者： Qing Meng Jianshuang Guo Ke Lv Yang liu Jin Zhang Mingyue li Xirui Cheng Shenghua Chen Xiaoguang Huo Quan Zhang Yue Chen Jing li State Key Laboratory of Medicinal Chemical Biology College of PharmacyNankai UniversityTianjin 300353China College of Chemistry and Frontiers Science Center for New Organic Matter Haihe Laboratory of Sustainable Chemical TransformationsNankai UniversityTianjin 300071China Accendatech Company Ltd.Tianjin 300193China

Aberrant changes in the gut microbiota are implicated in many diseases,including inflammatory bowel disease(IBD).Gut microbes produce diverse metabolites that can shape the immune system and impact the intestinal barrier integrity,indicating that microbe-mediated modulation may be a promising strategy for preventing and treating *** fecal microbiota transplantation and probiotic supplementation are well-established IBD therapies,novel chemical agents that are safe and exert strong effects on the gut microbiota are urgently ***,we report the total synthesis of heudelotinone and the discovery of 5S-heudelotinone(an enantiomer)as a potent agent against experimental colitis that acts by modulating the gut microbiota.5S-Heudelotinone alters the diversity and composition of the gut microbiota and increases the concentration of short-chain fatty acids(SCFAs);thus,it regulates the intestinal immune system by reducing proinflammatory immune cell numbers,and maintains intestinal mucosal integrity by modulating tight junctions(TJs).Moreover,5S-heudelotinone(2)ameliorates colitis-associated colorectal cancer(CAC)in an azoxymethane(AOM)/dextran sulfate sodium(DSS)-induced in situ carcinoma ***,these findings reveal the potential of a novel natural product,namely,5S-heudelotinone,to control intestinal inflammation and highlight that this product is a safe and effective candidate for the treatment of IBD and CAC.

关键词： 5S-heudelotinone Total synthesis Inflammatory bowel disease Gut microbiota Short-chain fatty acids Immune system Intestinal barrier Drug discovery

Effect of Deposition Temperature on Optical Properties of Porous Amorphous SiC Film

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Journal of Wuhan University of Technology(Materials Science) 2024年第4期39卷 839-844页

作者：徐吉祥 TAO Weijie liU Canhui XU Haoyao li lixuan 贺振华 School of Information Engineering Wuhan University of TechnologyWuhan 430070China

To study the effect of different deposition temperatures on the optical properties of porous SiC films,single crystal Si was used as the substrate,a layer of anodic aluminum oxide(AAO)film was transferred on the Si substrate by chemical method,and then a layer of SiC was deposited on anodic aluminum oxide(AAO)template to prepare porous fluorescent SiC film by magnetron *** deposition temperature was ranged from 373 to 873 *** thickness of the porous SiC film coated on the AAO surface was around 283 *** is found that the porous SiC with the deposition temperature of 873 K has the strongest photoluminescence(PL)intensity excited by 375 nm *** time-resolved PL spectra prove that the PL is mainly from intrinsic light emitting of *** the optimized process,porous amorphous SiC film may have potential applications in the field of warm white LEDs.

关键词： porous SiC film fluorescent SiC anodic aluminum oxide magnetron sputtering time-resolved spectrum

660 MW高水分褐煤机组等离子体点火技术应用

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洁净煤技术 2024年第9期30卷 52-59页

作者：李明邹鹏李冰冰蔡巍程中杰刘欣烟台龙源电力技术股份有限公司山东烟台264006

等离子体点火技术变负载灵活性高,点火启动时间短,有害气体排放低,经济效益好,在煤电机组深度调峰改造中应用广泛,是电站锅炉实现低负荷稳燃的主要措施之一。近年来,中速磨煤机在燃用高水分褐煤机组中的推广为高水分褐煤等离子体无油点... 详细信息

等离子体点火技术变负载灵活性高,点火启动时间短,有害气体排放低,经济效益好,在煤电机组深度调峰改造中应用广泛,是电站锅炉实现低负荷稳燃的主要措施之一。近年来,中速磨煤机在燃用高水分褐煤机组中的推广为高水分褐煤等离子体无油点火技术的应用提供了便利条件。然而,传统等离子体点火技术多适配于烟煤等优质煤种,对于燃用高水分低热值褐煤存在点火能量不足、需油枪辅助点火、燃油经济性差等问题。为此,开发了偏置浓缩狭缝式进粉多级筒结构等离子体点火煤粉燃烧器,在某入炉原煤全水分35%~40%的660 MW褐煤基建机组锅炉上开展变工况等离子体无油点火试验,分析了入炉煤质及机组操作参数对高水分褐煤无油点火特性的影响。基于点火试验结果,提出了等离子体燃烧器改进方案,在基准工况下,对高水分褐煤等离子体燃烧器进行数值模拟,对比讨论了燃烧器改造效果。点火试验结果表明,新型等离子体点火系统可点燃发热量10900~13400 kJ/kg的高水分褐煤,并实现机组无燃油启动,点火能力较强;燃烧器对煤质适应范围较小,点火能量过大,燃烧器中心筒与二级筒间隙较小,冷却效果较差,二级筒易超温,造成等离子体燃烧器二级筒结焦烧损;机组稳燃时,燃用胜利褐煤并投运等离子体发生器对锅炉NO_(x)排放基本没有影响。数值模拟结果表明,点火试验所用燃烧器由于一级燃烧筒内煤粉吸收等离子体热量过于集中而提前燃烧,燃烧筒壁面超温,导致内壁结焦;改进后燃烧器一、二级燃烧筒内中心火焰温度显著降低,在三级燃烧筒末端火焰温度趋近一致,燃烧器壁面最高温度为376℃,较改进前降低约74℃;改进方案减少了浓煤粉对一级燃烧筒入口端面的冲刷,提高了一级燃烧筒内煤粉量,优化了点火过程。因此,开发并优化新型等离子体燃烧器可实现宽煤质范围高水分褐煤机组稳定高效点火,为建成国内首座高水分褐煤无油电厂提供技术支撑。

关键词：高水分褐煤燃烧器等离子体数值模拟无油点火

Ganoderma lucidum spore oil enhances the effect of paclitaxel,improves the tolerance to paclitaxel and prolongs the survival in Lewis tumor-bearing mice

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Cancer Advances 2024年第12期7卷 1-6页

作者： Hong-Fei cai Zhao-Jian Jiang Cheng Yuan lin Cao Qin Wang Ya-Ming Han Qin Zhang Jing li Wen-Dong Xu Ju-Yan liu Guangzhou HanFang Pharmaceutical Company limited National Engineering Research Center of Pharmaceutical Processing Technology of Traditional Chinese Medicine and Drug InnovationGuangdong Provincial Key Laboratory of Medicinal LipidsGuangzhou 510240China Nanchang Research Institute Sun Yat-Sen UniversityNanchang 330096China Guangzhou Pharmaceutical Holdings limited Guangzhou 510130China

Purpose:This study aims to investigate whether Ganoderma lucidum spore oil(GLSO)could enhance the effect of paclitaxel(PTX),improve the tolerance to PTX and prolong the overall survival of Lewis tumor-bearing mice,which has never been reported ***:The tumor,spleen,and thymus were weighed at the end of the *** blood was collected for hematological index analysis,and the intact femur was removed to determine the bone marrow nucleated cell count(BMN).The percentage of lymphocytes in the spleen of mice was detected by flow cytometry,the activity of NK cells was detected by LDH assay,and the proliferation index of lymphocytes was determined by CCK-8 *** overall and mean survival time and life extension rate were calculated using SPSS ***:Our data showed that GLSO could enhance the anti-tumor effect of PTX and prolong the survival of *** underlying mechanisms of the above effects might be related to the toxic reduction effect of GLSO by relieving hematotoxicity,myelosuppression and ***,GLSO could increase the number of blood cells and bone marrow cells,alleviate the thymic index,and elevate the number and activity of NK cells in mice treated with ***:GLSO may enhance the efficacy of PTX by boosting the activity of immune NK cells and prolong survival by counteracting PTX-induced bone marrow alterations and improving *** findings suggested the promising role of GLSO in combination with PTX to extend the survival and increase the tolerance of patients in clinical chemotherapy of lung cancer.

关键词： Ganoderma lucidum spore oil Traditional Chinese Medicine lung cancer paclitaxel tolerance survival

Asymmetry in circulation system and cardiovascular diseases

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Medicine in Novel Technology and Devices 2024年第1期21卷 1-9页

作者： Chang liu Sheng Xie Yangchen li Da Zhang Deyu li Chi Zhang Key Laboratory of Biomechanics and Mechanobiology Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing100191China Department of Radiology China-Japan Friendship HospitalBeijing100029China Children’s Hospital Capital Institute of Pediatrics Beijing100020China Department of Physics Sichuan Cancer HospitalChengdu610041China State Key Laboratory of Virtual Reality Technology and Systems Beihang UniversityBeijing100191China

Asymmetries in the human vascular system and cardiovascular disease are *** physiological asymmetry can manifest in the morphological structure and blood flow state,whereas pathological asymmetry can reflect differences in the occurrence and cure of bilateral vascular *** causes associated with these asymmetrical differences may be demand-driven or due to vascular grading or asymmetries in other physiological *** article aims to review the asymmetry of several typical arteries,including cerebral,cervical,and limb arteries,and lists possible causes to emphasize the necessity of considering asymmetric factors in the prevention,treatment,and rehabilitation of vascular *** research on asymmetries in the vascular system may improve the risk assessment and personalized treatment of vascular diseases.

关键词： Vascular morphology Hemodynamics Cardiovasculardiseases Asymmetry

Oxidation damage and interfacial failure of dissimilar metal welds containing ferritic heat resistant steels

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Journal of Iron and Steel Research International 2021年第11期28卷 1439-1450页

作者： Xiao-gang li Zhi-peng cai Xin Chen shu-qing Dong Wen-he cai Yu Zhang Shan-lin li Ke-jian li Shao-shi Rui Ji-luan Pan Department of Mechanical Engineering Tsinghua UniversityBeijing 100084China Key Laboratory for Advanced Materials Processing Technology Ministry of EducationBeijing 100084China State Key Laboratory of Tribology Tsinghua UniversityBeijing 100084China Collaborative Innovation Center of Advanced Nuclear Energy Technology Tsinghua UniversityBeijing 100084China China Datang Corporation Science and Technological Research Institute Thermal Power Technology Research InstituteBeijing 100040China

The ex-service steam tubes containing dissimilar metal weld(DMW)between high Cr ferritic steel T91 and austenitic stainless steel TP347H and the ex-service steam tubes containing DMW between low Cr ferritic steel G102 and austenitic stainless steel TP347H were obtained from coal-fired thermal power plants in China,and their microstructures at the nickel-based weld metal(WM)/ferritic steel interfaces and oxidation characteristics were *** operating for 15,000 h at steam temperature of 541 C and steam pressure of 17.5 MPa,a G102/TP347H DMW failed along the WM/G102 steel interface,which was a dangerous premature failure mode without obvious plastic *** interfacial failure was attributed to the interaction between oxidation and cracking along the interface,where fracture appeared to be related with the strain concentration at the *** notch along the WM/G102 steel interface was the precursor of premature interfacial failure of DMW involving *** the DMW involving high Cr ferritic steel T91,ferritic steel side could form a Cr-rich passive film during service and thus would not be further oxidized after operating for 67,000 h at steam temperature of 541 C and steam pressure of 3.5 *** was concluded that oxidation played a more important role in failure of these DMWs,and retarding the development of oxidation and avoiding the interfacial oxide notch would dramatically improve the service performance of steam tubes containing DMWs.

关键词： Dissimilar metal weld Ferritic heat resistant steel Nickel-based weld metal Oxidation Interfacial failure High-temperature service

Modified Xiaoyao powder for postpartum depression:A systematic review and meta-analysis

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Journal of Traditional Chinese Medical Sciences 2024年第1期11卷 120-130页

作者： Mengyuan Hu Xiaowen Zhang Xuya Zhang Dan Cheng Yali Zhang Xinyu Zhang lingling li Xinjie li Xue li Yi Lu School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing 102488China Centre for Evidence Based Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China School of Chinese Medicine The University of Hong KongHong KongChina

Objective:To evaluate the effectiveness and safety of modified Xiaoyao powder for postpartum depression(PPD)by conducting a systematic review of randomized controlled trials(RCTs).Methods:The Chinese National Knowledge Infrastructure Databases(CNKI),the Chinese Scientific Journals Database(VIP),Wanfang,Google Scholar,the SinoMed,Embase,Cochrane library,and PubMed databases were searched from their inception to April 25,*** Cochrane Risk of Bias tool was used to assess the quality of the *** applied the risk ratio to present dichotomous data and the mean difference to present continuous *** with similar characteristics were pooled for meta-analysis and heterogeneity was assessed using ***:This review included 35 trials involving 2848 *** quality of the included studies was low(unclear randomization processes and insufficient reporting of blinding).Participants treated with modified Xiaoyao powder plus Western medicine showed lower Hamilton Depression Scale(HAMD)depression score than those who used Western medicine alone(mean difference=-2.15;95%confidence interval:-2.52 to 1.78;Plieve depression in PPD when used alone or in combination with Western medicine,with minor side ***,future high-quality,large-sample size RCTs are warranted.

关键词： Postpartum depression Modified Xiaoyao Chinese medicine Systematic review Meta-analysis

四逆散改善Mdr2^(-/-)小鼠胆汁淤积性肝纤维化作用

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药物评价研究 2024年第2期47卷 291-301页

作者：范桂芳蔡雅洁李方红李宇飞刘闰平北京中医药大学中药学院北京100029

目的研究四逆散对Mdr2(Abcb4)基因缺陷(Mdr2^(-/-))小鼠胆汁淤积性肝纤维化的缓解作用,并探究其作用机制。方法 C57BL/6J小鼠作为对照组;C57BL/6J背景的Mdr2^(-/-)小鼠作为模型小鼠,设模型组和四逆散低、高剂量(按生药量计为3.12、6.2... 详细信息

目的研究四逆散对Mdr2(Abcb4)基因缺陷(Mdr2^(-/-))小鼠胆汁淤积性肝纤维化的缓解作用,并探究其作用机制。方法 C57BL/6J小鼠作为对照组;C57BL/6J背景的Mdr2^(-/-)小鼠作为模型小鼠,设模型组和四逆散低、高剂量(按生药量计为3.12、6.24 g·kg^(-1))组。四逆散组连续3周ig给予四逆散水提物,每天1次,对照组给予纯水。试剂盒法检测血清丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、总胆汁酸水平;取肝脏、脾脏称质量,计算肝脏、脾脏系数;结合小鼠肝组织HE染色,Masson染色,纤连蛋白(Fibronectin)、细胞角蛋白19(CK19)的免疫组化染色,明确四逆散对Mdr2^(-/-)小鼠肝纤维化及胆汁淤积的影响。基于小鼠肝脏转录组学测序技术,挖掘四逆散改善Mdr2^(-/-)小鼠肝损伤的作用靶点,并通过实时荧光定量PCR(qRT-PCR)法检测肝纤维化[fibronectin(Fn1)、胶原蛋白1(Col1a1)、角蛋白19(krt19)]、炎症[白细胞介素-1β(Il1β)、Il6、肿瘤坏死因子-α(Tnfα)、一氧化氮合成酶(Inos)]、细胞焦亡[凋亡相关斑点样蛋白(Pycard)、Il18]、胆汁酸合成[细胞色素P450家族成员7A1(Cyp7a1)]及转运[胆盐输出泵(Abcb11)、ATP结合盒转运蛋白(Abcc3)、钠离子-牛磺胆酸共转运蛋白(Slc10a1)]相关基因的转录水平。结果与模型组比较,四逆散高剂量显著降低血清总胆汁酸的水平(P<0.05);明显缓解了Mdr2^(-/-)小鼠肝脏中央静脉及胆管周围炎性细胞的浸润和胶原纤维的沉积,并显著抑制胆管反应的发生。转录组学及qRT-PCR结果共同表明,四逆散下调Mdr2^(-/-)小鼠肝脏纤维化、炎症、细胞焦亡相关基因的转录(P<0.05);同时,四逆散下调胆汁酸合成关键限速酶调控基因Cyp7a1和调控胆汁酸向肝内转运的基因Slc10a1的转录,并上调调控胆汁酸外排的基因Abcb11、Abcc3的转录。结论四逆散能缓解Mdr2^(-/-)小鼠胆汁淤积性肝纤维化,机制可能与其调控炎症反应、细胞焦亡以及胆汁酸的合成和转运有关。

关键词：四逆散胆汁淤积性肝纤维化转录组学炎症细胞焦亡胆汁酸代谢