Modified Xiaoyao powder for postpartum depression:A systematic review and meta-analysis
作者机构：School of Traditional Chinese MedicineBeijing University of Chinese MedicineBeijing 102488China Centre for Evidence Based Chinese MedicineBeijing University of Chinese MedicineBeijing 100029China School of Chinese MedicineThe University of Hong KongHong KongChina
出 版 物：《Journal of Traditional Chinese Medical Sciences》 (中医科学杂志（英文）)
年 卷 期：2024年第11卷第1期
页 面：120-130页
学科分类：100506[医学-中医内科学] 1006[医学-中西医结合] 1005[医学-中医学] 10[医学] 100602[医学-中西医结合临床]
基 金：supported by the State Administration of Traditional Chinese Medicine High-level Key Discipline Construction Project of Traditional Chinese Medicine-Beijing University of Traditional Chinese Medicine Combined Fundamentals of Chinese and Western Medicine(Pharmacology Discipline Project No.zyyzdxk-2023256)
主 题：Postpartum depression Modified Xiaoyao Chinese medicine Systematic review Meta-analysis
摘 要：Objective:To evaluate the effectiveness and safety of modified Xiaoyao powder for postpartum depression(PPD)by conducting a systematic review of randomized controlled trials(RCTs).Methods:The Chinese National Knowledge Infrastructure Databases(CNKI),the Chinese Scientific Journals Database(VIP),Wanfang,Google Scholar,the SinoMed,Embase,Cochrane Library,and PubMed databases were searched from their inception to April 25,*** Cochrane Risk of Bias tool was used to assess the quality of the *** applied the risk ratio to present dichotomous data and the mean difference to present continuous *** with similar characteristics were pooled for meta-analysis and heterogeneity was assessed using ***:This review included 35 trials involving 2848 *** quality of the included studies was low(unclear randomization processes and insufficient reporting of blinding).Participants treated with modified Xiaoyao powder plus Western medicine showed lower Hamilton Depression Scale(HAMD)depression score than those who used Western medicine alone(mean difference=-2.15;95%confidence interval:-2.52 to 1.78;P.00001),and higher effective rate(relative risk=1.19;95%confidence interval:1.15 to 1.24;P.00001),When comparing modified Xiaoyao alone with Western medicine,the HAMD depression score remained low,however,the efficacy rate was higher in the modified Xiaoyao *** adverse events,the modified Xiaoyao group reported weight gain,nausea,and diarrhea,but no severe adverse events were ***:Modified Xiaoyao may help relieve depression in PPD when used alone or in combination with Western medicine,with minor side ***,future high-quality,large-sample size RCTs are warranted.
维普期刊数据库