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Hydrophobic long-chain two-dimensional perovskite scintillators for underwater X-ray imaging

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Rare Metals 2024年第1期43卷 175-185页

作者： Jin-Xiao Zheng Zi-An zhou Tiao Feng Hui Li Cheng-Hua Sun NüWang Yang Tian Yong Zhao shu-yun zhou Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Laboratory of Bioinspired Smart Interfacial Science and Technology of the Ministry of Education Beijing Key Laboratory of Bioinspired Energy Materials and DevicesSchool of ChemistryBeijing Advanced Innovation Center for Biomedical EngineeringBeihang UniversityBeijing 100191China Department of Engineering Physics Tsinghua University and Key Laboratory of Particle and Radiation Imaging Ministry of EducationTsinghua UniversityBeijing 100084China e-mail:yangt@***

The underwater X-ray imaging technology development is significant to subaqueous target reconnaissance/detection/identification, subfluvial archaeology,submerged resource exploration, etc. As the core of X-ray imaging detection, the scintillator has been plagued by inherent moisture absorption and decomposition, and strict requirements for seamless packaging and ***, we designed a manganese-doped two-dimensional(2D) perovskite scintillator modified by hydrophobic longchain organic amine through the combination of component and doping engineering. The modified perovskites show high water repellency that can be used as an underwater X-ray scintillator. X-ray images of aquatic organisms or other objects with a high spatial resolution of10 lp·mm^(-1) at a big view field(32 mm × 32 mm) were obtained by scintillation screen. This hydrophobic perovskite scintillator based on molecular design is of great promise in underwater X-ray nondestructive testing technology development.

关键词： Two-dimensional perovskite Hydrophobic Scintillators Underwater X-ray imaging Underwater nondestructive testing technology

急性髓系白血病患者外周血细胞中FLT3基因表达与FLT3/ITD突变的关系及其意义

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癌症 2009年第6期28卷 632-636页

作者：徐兵史鹏程宋小燕唐家宏周淑芸南方医科大学南方医院血液科广东广州510515

背景与目的:研究表明FLT3/ITD突变的急性髓性白血病(acute myeloid leukemia,AML)患者预后差,但关于AML患者FLT3基因的表达水平在预后中的作用及其与FLT3/ITD突变关系的研究尚不充分。本研究探讨初治AML患者FLT3基因的表达水平与FLT3/IT... 详细信息

背景与目的:研究表明FLT3/ITD突变的急性髓性白血病(acute myeloid leukemia,AML)患者预后差,但关于AML患者FLT3基因的表达水平在预后中的作用及其与FLT3/ITD突变关系的研究尚不充分。本研究探讨初治AML患者FLT3基因的表达水平与FLT3/ITD突变的关系及其临床意义。方法:建立实时荧光定量PCR检测FLT3基因表达水平及PCR检测FLT3/ITD突变的方法,分析79例初治AML患者FLT3基因水平、FLT3/ITD突变及与预后的关系。结果:22.7%(18/79)的AML患者存在FLT3/ITD突变。92.4%(73/79)的患者标本中可检测到FLT3基因表达,FLT3基因表达水平为0～7320,中位数为312,正常对照组未检测到FLT3基因的表达。FLT3基因高表达及FLT3/ITD突变AML组的白细胞计数及骨髓白血病细胞均显著高于低表达和无突变AML组(P0.05),FLT3/ITD突变AML患者FLT3基因表达中位数与无突变组比较差异也无统计学意义。FLT3/ITD突变组的完全缓解率(58.8%)显著低于无FLT3/ITD突变组(82.1%)(P0.05),但无FLT3/ITD突变组中,FLT3基因高表达组完全缓解率(69.2%)显著低于低表达组(93.3%)(P<0.05)。结论:FLT3高表达与FLT3/ITD突变之间无明显相关性,FLT3高表达对于无FLT3/ITD突变AML患者可能是一个预后不良的指标。

关键词：白血病髓细胞急性 FLT3 FLT3/ITD突变实时定量PCR

Ginseng Total Saponins Enhance Neurogenesis after Focal Cerebral Ischemia

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Ginseng Total Saponins Enhance Neurogenesis after Focal Cere...

Effects of ultrasonic-assisted extraction on bioactive compounds,volatile flavors and antioxidant activities of vine tea water extracts

中华中医药学会第三次血栓病学术会议暨河南省中西医结合学会心血管病专业委员会、山东省中西医结合学会活血化瘀专业委员会年会、冠心病中医、中西医结合诊疗新进展学习班、全国心血管疾病中西医结合诊治新进展学习班

作者： Guo-qing Zheng,Wei Cheng,Yan Wang,Xiu-min Wang,shu-zhi Zhao,yun zhou,Shi-jue Liu,Xiao-tong Wang Center of Neurology and Rehabilitation,The Second Affiliated Hospital of Wenzhou Medical College,Wenzhou 325027,PR China

Background:Stroke is associated with high mortality and major disability burdens worldwide,but there are few effective and widely available *** is one of the most commonly used healing herbs for stroke and chronic debilitating conditions in *** are the main active principles of ginsengs efficacy,but the mechanisms have not been fully ***:To test the hypothesis that the administration of Ginseng Total Saponins(GTS) after focal cerebral ischemia may induce endogenous neural stem cells activation and adult central nervous system regeneration,and thereby improve neurological deficits. Methods:The rats were randomly divided into sham-operation(Sham) group,normal sodium(NS) group and GTS *** group and GTS group were further divided into four sub-groups according the time point 1d,3 d,7 d and 14 d with 8 rats per sub-group after the permanent middle cerebral artery occlusion(MCAO) insult. Rats in GTS groups received intraperitoneal injections of GTS dissolved at a dose of 25 mg·kg·*** in NS group were only received intraperitoneal injections of same amount *** injections of GTS or NS twice daily were start to perform 3 days before model establishment until the animals were *** sham animals received neither GTS nor *** neurological status of the awake rats was assessed blindly after model establishment at 1d,3d,7 d and 14 d, *** immunostaining and double staining were performed by following the 3-steps ***:A,GTS-treated rats have better neurological scores compared with those in normal saline(NS) group at 14 d time point(p<0.05);B, at 3d,7d and 14d time point,BrdU-positive cell numbers in GTS group were significantly higher than those in NS group in the ipsilateral subventricular zone(SVZ) after middle cerebral artery occlusion(MCAO)(p<0.05,or p<0.01);BrdU/NeuN cell numbers in GTS group also were significantly higher than those in NS group in the ipsilateral infarct area a

关键词： Focal cerebral ischemia Neurogenesis Neurological function Ginseng total saponins

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Traditional Medicine Research 2025年第1期10卷 73-81页

作者： Xiao-Long zhou Wei-Jin Jiang Ji Yu Mao-Jun Yao yun-Tong Li Hunan Provincial Key Laboratory of Research Resource Mining and High-valued Utilization on Edible&Medicinal PlantCollege of Chemistry and Chemical EngineeringJishou UniversityJishou 416000China Hunan Gaoge Dairy Co. Ltd.Changsha 410000China

Background:Ampelopsis grossedentata,vine tea,which is the tea alternative beverages in *** vine tea processing,a large amount of broken tea is produced,which has low commercial ***:This study investigates the influence of different extraction methods(room temperature water extraction,boiling water extraction,ultrasonic-assisted room temperature water extraction,and ultrasonic-assisted boiling water extraction,referred to as room temperature water extraction(RE),boiling water extraction(BE),ultrasonic assistance at room temperature water extraction(URE),and ultrasonic assistance in boiling water extraction(UBE))on the yield,dihydromyricetin(DMY)content,free amino acid composition,volatile aroma components,and antioxidant properties of vine tea ***:A notable influence of extraction temperature on the yield of vine tea extracts(P<0.05),with BE yielding the highest at 43.13±0.26%,higher than that of RE(34.29±0.81%).Ultrasound-assisted extraction significantly increased the DMY content of the extracts(P<0.05),whereas DMY content in the RE extracts was 59.94±1.70%,that of URE reached 66.14±2.78%.Analysis revealed 17 amino acids,with L-serine and aspartic acid being the most abundant in the extracts,nevertheless ultrasound-assisted extraction reduced total free amino acid *** chromatography-mass spectrometry analysis demonstrated an increase in the diversity and quantity of compounds in the vine tea water extracts obtained through ultrasonic-assisted ***,69 and 68 volatile compounds were found in URE and UBE extracts,which were higher than the number found in RE and BE *** vitro,antioxidant activity assessments revealed varying antioxidant capacities among different extraction methods,with RE exhibiting the highest DPPH scavenging rate,URE leading in ABTS•+free radical scavenging,and BE demonstrating superior ferric ion reducing antioxidant ***:The findings suggest that extraction methods signi

关键词： vine tea dihydromyricetin ultrasonic-assisted extraction volatile aroma components

Sex-dependent alterations in extracellular vesicles linking chronic spinal cord injury to brain neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第2期20卷 483-484页

作者： yun Li Junfang Wu Department of Anesthesiology&Shock Trauma and Anesthesiology Research(STAR)CenterUniversity of Maryland School of MedicineBaltimoreMDUSA

Traumatic spinal cord injury(SCI)is a devastating exogenous injury with long-lasting consequences and a leading cause of death and disability *** in assistive technology,rehabilitative interventions,and the ability to identify and intervene in secondary conditions have significantly increased the long-term survival rate of SCI patients,with some people even living well into their seventh or eighth *** survival changes have led neurotrauma researchers to examine how SCI interacts with brain *** health and epidemiological data showed that patients with long-term SCI can have a lower life expectancy and quality of life,along with a higher risk of comorbidities and complications.

关键词： alterations inflammation injury

线粒体分裂抑制剂Mdivi-1对星形胶质细胞NLRP3炎症小体及A1活化的影响

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中国药理学通报 2025年第1期41卷 43-49页

作者：刘书芬陈旭青张亚运姚敏周龙云上海中医药大学附属龙华医院上海200032 南京中医药大学附属医院江苏南京210029 扬州大学附属医院江苏扬州225000 南京医科大学第一附属医院江苏南京210029

目的观察线粒体分裂抑制剂1(Mdivi-1)对星形胶质细胞A1型活化及其相关信号分子的影响。方法根据CCK-8法筛选浓度,将CTX-TNA2星形胶质细胞分为对照组、ACM组、Mdivi-1低、中、高剂量组。ACM为含预设浓度IL-1α、TNF-α及补体C1q的DMEM高... 详细信息

目的观察线粒体分裂抑制剂1(Mdivi-1)对星形胶质细胞A1型活化及其相关信号分子的影响。方法根据CCK-8法筛选浓度,将CTX-TNA2星形胶质细胞分为对照组、ACM组、Mdivi-1低、中、高剂量组。ACM为含预设浓度IL-1α、TNF-α及补体C1q的DMEM高糖培养基。ACM组以ACM刺激24 h,诱导A1型活化。Mdivi-1组分别以相应浓度Mdivi-1预处理2 h,而后以ACM刺激24 h。采用实时荧光定量PCR及免疫印迹检测各组细胞A1型活化相关指标IL-1β、C3及iNOSmRNA水平与蛋白表达;联合免疫荧光及免疫印迹测定各组细胞NLRP3、caspase-1、凋亡相关斑点样蛋白ASC等信号分子表达;以二氢乙锭染色流式细胞分析检测各组干预后细胞ROS水平。结果CCK-8结果示,5、10、25μmol·L^(-1)为Mdivi-1干预CTX-TNA2细胞的适宜浓度。实时荧光定量PCR及免疫印迹结果表明,与对照组比较,ACM组IL^(-1)β、C3及iNOS mRNA水平与蛋白表达均明显升高,差异有统计学意义(P<0.05);与ACM组比较,10、25μmol·L^(-1) Mdivi-1组上述指标基因及蛋白表达水平均有所降低,差异有统计学意义(P<0.05)。免疫荧光及免疫印迹结果均证实,ACM刺激下,星形胶质细胞NLRP3炎症小体明显激活;而Mdivi-1干预则能有效逆转ACM刺激下NLRP3、caspase-1、ASC等表达的升高。DHE染色结果表明,5、10、25μmol·L^(-1) Mdivi-1干预均能一定程度上逆转ACM刺激下细胞ROS水平的升高,且该效应与药物剂量呈正相关。结论线粒体分裂抑制剂Mdivi-1可有效抑制星形胶质细胞A1型活化,该效应可能与其对ROS及NLRP3炎症小体的调节作用相关。

关键词：线粒体分裂抑制剂 Mdivi-1 星形胶质细胞 A1 活性氧 NLRP3炎症小体

FISH与RQ-PCR监测慢性髓系白血病患者造血干细胞移植后微小残留病

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癌症 2010年第2期29卷 207-211页

作者：朱红倩刘晓力宋兰林刘启发孟凡义周淑芸南方医科大学南方医院血液科广东广州510515

背景与目的:监测慢性髓系白血病(chronic myeloid leukemia,CML)的微小残留病(minimal residual disease,MRD)的常用方法有间期荧光原位杂交(interphase fluorescence in situ hybridization,FISH)和实时定量逆转录-聚合酶链反应(real-time quantitative reverse transcription PCR,RQ-PCR)。本研究分析用FISH和RQ-PCR两种方法在CML造血干细胞移植后不同时间点监测MRD的意义。方法:采用间期FISH和RQ-PCR技术,对31例异基因造血干细胞移植前后的CML患者骨髓细胞进行BCR-ABL融合基因定期监测,随访时间3～48个月。结果:31例患者移植后,前30个月各时间点FISH检测的阳性细胞数及RQ-PCR检测的BCR-ABL/ABL比值均较移植前明显下降,下降>2个对数值(P3个对数值(P<0.05)。结论:FISH和RQ-PCR方法检测BCR-ABL融合基因有较好的一致性。RQ-PCR连续监测MRD的敏感性更高,MDR的定量分析有利于评估疗效和指导个体化治疗。

关键词：慢性髓系白血病 BCR—ABL FISH PCR 移植

Role of nutrition in diabetes mellitus and infections

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World Journal of Clinical Cases 2025年第3期13卷 1-8页

作者： Xue-Lu Yu Li-yun zhou Xiao Huang Xin-Yue Li Ming-Ke Wang Ji-shun Yang Naval Medical Center of PLA Naval Medical UniversityShanghai 200052China

In this editorial,we have commented on the article that has been published in the recent issue of World Journal of Clinical *** authors have described a case of unilateral thyroid cyst and have opined that the acute onset of infection may be linked to diabetes mellitus(DM).We have focused on the role of nutrition in the association between DM and *** with DM are at a high risk of infection,which could also be attributed to nutrition-related *** interventions for patients with diabetes are mainly based on a low-calorie diet,which can be achieved by adhering to a low-carbohydrate ***,dietary fiber supplementation is recommended to maintain the diversity of the gut ***,high-quality protein can prevent the increased risk of infection due to *** of vitamins C,vitamins A,vitamins D,and folic acid improves blood sugar control and facilitates immune *** deficiencies augment the risk of infection,but the relationship with diabetes is mostly U-shaped and a good intake should be maintained.

关键词： Diabetes mellitus Infection Macronutrients Vitamins Minerals

Interfacial Zn2+-solvation regulator towards reversible and stable Zn anode

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Journal of Energy Chemistry 2025年第1期100卷 684-692页

作者： Miao zhou Xiongbin Luo Hang Li Shan Guo Zhuang Tong Xiaotao zhou Xu Li Zhaohui Hou shuquan Liang Guozhao Fang College of Mechanical Engineering Key Laboratory of Hunan Province for Advanced Carbon-based Functional Materials Hunan Institute of Science and Technology School of Materials Science and Engineering Key Laboratory of Electronic Packaging and Advanced Functional Materials of Hunan Province Central South University College of Materials and Metallurgy Guizhou University National Energy Metal Resources and New Materials Key Laboratory Central South University

Aqueous zinc-ion batteries （AZIBs） are fundamentally challenged by the instability of the electrode/electrolyte interface,predominantly due to irreversible zinc （Zn） deposition and hydrogen ***,the intricate mechanisms behind the electrochemical discrepancies induced by interfacial Zn2+-solvation and deposition behavior demand comprehensive *** molecules endowed with special functional groups （such as hydroxyl,carboxyl,etc.） have the potential to significantly optimize the solvation structure of Zn2+and regulate the interfacial electric double layer （EDL）.By increasing nucleation overpotential and decreasing interfacial free energy,these functional groups facilitate a lower critical nucleation radius,thereby forming an asymptotic nucleation model to promote uniform Zn ***,this study presents a pioneering approach by introducing trace amounts of n-butanol as solvation regulators to engineer the homogenized Zn （H-Zn） anode with a uniform and dense *** interfacial reaction and structure evolution are explored by in/ex-situ experimental techniques,indicating that the H-Zn anode exhibits dendrite-free growth,no by-products,and weak hydrogen evolution,in sharp contrast to the bare ***,the H-Zn anode achieves a remarkable Zn utilization rate of approximately 20% and simultaneously sustains a prolonged cycle life exceeding 500 ***,the H-Zn//NH4V4O10（NVO） full battery showcases exceptional cycle stability,retaining 95.04%capacity retention after 400 cycles at a large current density of 5 A *** study enlightens solvation-regulated additives to develop Zn anode with superior utilization efficiency and extended operational lifespan.

关键词： Aqueous zinc-ion batteries Interfacial reaction Asymptotic nucleation model Reversible and stable Zn anode