检索结果-南通市图书馆

Acta Pharmaceutica Sinica B 2024年第9期14卷 3901-3915页

作者： Yumeng Wang Chengxi Li Jianping Li shu zhang Qinyu zhang Jinao Duan Jianming Guo Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization Nanjing University of Chinese MedicineNanjing 210023China Jiangsu Key Laboratory for High Technology Research of TCM Formulae Nanjing University of Chinese MedicineNanjing 210023China

The intestinal mucus barrier is an important line of defense against gut *** to this barrier brings bacteria into close contact with the epithelium,leading to intestinal ***,its restoration is a promising strategy for alleviating intestinal *** study showed that Abelmoschus manihot polysaccharide(AMP)fortifies the intestinal mucus barrier by increasing mucus production,which plays a crucial role in the AMP-mediated amelioration of ***-10-deficient mouse models demonstrated that the effect of AMP on mucus production is dependent on ***,bacterial depletion and replenishment confirmed that the effects of AMP on IL-10 secretion and mucus production were mediated by Akkermansia *** findings suggest that plant polysaccharides fortify the intestinal mucus barrier by maintaining homeostasis in the gut *** demonstrates that targeting mucus barrier is a promising strategy for treating intestinal inflammation.

关键词： Plant polysaccharide Abelmoschus manihot Intestinal inflammation Mucus barrier Interleukin 10 Gut microbiota A.muciniphila Mucin 2

Unfolding rates of 1:1 and 2:1 complex of CX-5461 and c-MYC promoter G-quadruplexes revealed by single-molecule force spectroscopy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biophysics Reports 2024年第3期10卷 180-189页

作者： Hui Peng Yashuo zhang qun Luo Xinyu Wang Huijuan You Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation School of Pharmacy Tongji Medical College Huazhong University of Science and Technology College of Physics Science and Technology Yangzhou University

CX-5461, also known as pidnarulex, is a strong G4 stabilizer and has received FDA fast-track designation for BRCA1-and BRCA2-mutated cancers. However, quantitative measurements of the unfolding rates of CX-5461-G4 complexes which are important for the regulation function of G4s, remain ***, we employ single-molecule magnetic tweezers to measure the unfolding force distributions of c-MYC G4s in the presence of different concentrations of CX-5461. The unfolding force distributions exhibit three discrete levels of unfolding force peaks, corresponding to three binding modes. In combination with a fluorescent quenching assay and molecular docking to previously reported ligand-c-MYC G4 structure, we assigned the ～69 pN peak corresponding to the 1:1（ligand:G4） complex where CX-5461binds at the G4's 5'-end. The ～84 p N peak is attributed to the 2:1 complex where CX-5461 occupies both the 5' and 3'. Furthermore, using the Bell-Arrhenius model to fit the unfolding force distributions,we determined the zero-force unfolding rates of 1:1, and 2:1 complexes to be（2.4 ± 0.9） × 10-8s-1and（1.4 ± 1.0） × 10-9s-1respectively. These findings provide valuable insights for the development of G4-targeted ligands to combat c-MYC-driven cancers.

关键词： Single-molecule G-quadruplex Magnetic tweezers Stoichiometry Force spectroscopy Pidnarulex

Combination of Nitrogen-Rich Skeleton and Coordination Group:Synthesis of a High-Energy Primary Explosive Based on 1H-Tetrazole-5-Carbohydrazide

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2024年第1期31卷 271-277页

作者： Tingwei Wang Zujia Lu shu Bu Baolong Kuang Lu zhang Zhenxin Yi Kun Wang shunguan Zhu Jianguo zhang State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China School of Chemical Engineering Nanjing University of Science and Technology200 Xiaolingwei StreetXuanwuNanjing 210094China Department of Chemistry Laboratory of Structure and Functional Regulation of Hybrid MaterialsAnhui UniversityMinistry of EducationHefei 230601China

The high energy coordination compounds Cu(TZCA)_(2)(ClO_(4))_(2)(ECCs-1) was prepared by 1H-tetrazole-5-carbohydrazide(TZCA) with a high energy skeleton and a strong coordination ability *** the same time,the reaction activity of the ligand was explored,and the single crystal structure of it and intermediate were *** structures of all substances were characterized by IR and *** the structure and composition of ECCs-1 are confirmed by ESP,AC,SEM and *** and chemical properties tests show that ECCs-1 has an acceptable thermal stability(T_(d)=177℃) and extremely sensitive mechanical stimulation(IS=1 J,FS=5 N).The comprehensive performance test results show that ECCs-1 has excellent initiation *** addition,the decomposition mechanism of ECCs-1 is explored from two aspects of experiment and theoretical calculation.

关键词： 1H-tetrazole-5-carbohydrazide Primary explosive Decomposition mechanism Coordination polymers Laser

Rapid Phase Ambiguity Elimination Methods for DOA Estimator via Hybrid Massive MIMO Receive Array

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Electronics 2024年第1期33卷 175-184页

作者： Xichao ZHAN Zhongwen SUN Feng shu Yiwen CHEN Xin CHENG Yuanyuan WU Qi zhang Yifan LI Peng zhang School of Information and Communication Engineering Hainan University School of Electronic and Optical Engineering Nanjing University of Science and Technology

For a sub-connected hybrid multiple-input multiple-output(MIMO) receiver with K subarrays and N antennas, there exists a challenging problem of how to rapidly remove phase ambiguity in only single time-slot. A direction of arrival(DOA) estimator of maximizing received power(Max-RP) is proposed to find the maximum value of K-subarray output powers, where each subarray is in charge of one sector, and the center angle of the sector corresponding to the maximum output is the estimated true DOA. To make an enhancement on precision, Max-RP plus quadratic interpolation(Max-RP-QI) method is designed. In the proposed Max-RP-QI, a quadratic interpolation scheme is adopted to interpolate the three DOA values corresponding to the largest three receive powers of *** achieve the Cramer Rao lower bound, a Root-MUSIC plus Max-RP-QI scheme is developed. Simulation results show that the proposed three methods eliminate the phase ambiguity during one time-slot and also show low computational complexities. The proposed Root-MUSIC plus Max-RP-QI scheme can reach the Cramer Rao lower bound,and the proposed Max-RP and Max-RP-QI are still some performance losses 2–4 d B compared to the Cramer Rao lower bound.

关键词： Phased arrays Interpolation Wireless sensor networks Direction-of-arrival estimation Simulation Receiving antennas Massive MIMO

Metallurgy and Solidification Microstructure Control of Fusion-Based Additive Manufacturing Fabricated Metallic Alloys:A Review

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Metallurgica Sinica(English Letters) 2024年第1期37卷 29-53页

作者： Qiang Li Xing-Ran Li Bai-Xin Dong Xiao-Long zhang Shi-Li shu Feng Qiu Lai-Chang zhang Zhi-Hui zhang Key Laboratory of Bionic Engineering(Ministry of Education) and College of Bionic Science and EngineeringJilin UniversityChangchun130022China Institute of Structured and Architected Materials Liaoning Academy of MaterialsShenyang110167China Key Laboratory of Automobile Materials Ministry of Education and Department of Materials Science and EngineeringJilin UniversityChangchun130025China School of Mechanical and Aerospace Engineering Jilin UniversityChangchun130025China School of Engineering Edith Cowan University270 Joondalup DriveJoondalupPerthWA6027Australia

The metal-based additive manufacturing(AM),also referred to as metal 3D printing,has drawn particular interest because it enables direct creation,aided by computationally-directed path design,of intricate components with site-specific compositions and geometrical requirements as well as low buy-to-fly *** the last two decades,the objective of this revolutionary technology has been shifting from only“rapid prototyping”to advanced manufacturing of special high-end products or devices,which,in many aspects,outperform conventional manufacturing *** fusion-based AM,significant progress has been achieved in understanding the processing window of macroscopic scales,non-equilibrium metallurgy of mesoscale scales,and grain evolution of microscopic *** the versatile capacity of AM facilitates new avenues for discovering advanced materials and structures,their potential has still not been fully *** the unique non-equilibrium solidification during the AM process,coarse columnar grains with strong textures are usually developed along the build direction,which downgrades the mechanical *** push the limits of this digital manufacturing,this review attempts to provide in-depth and comprehensive overviews of the recent progress in understanding the evolution and control of the as-built microstructure that has been made recently and the challenges encountered during the AM process.

关键词： Additive manufacturing Temperature field Microstructure control Nanoparticles Functionally graded materials

Simulation of fire emergency evacuation in a large-passenger-flow subway station based on the on-site measured data of Shenzhen Metro

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transportation Safety and Environment 2024年第1期6卷 47-55页

作者： Hua Chen Chenyang zhang Jieyu zhang Ya shu Xinjian Qi Chaozhe Jiang Sichuan FAST Fire Safety Assessment Co. LTD.Chengdu 610036SichuanChina School of Transportation and Logistics Southwest Jiaotong UniversityChengdu 611756SichuanChina Sichuan Fire Research Institute of MEM Chengdu 610036SichuanChina Shenzhen Metro Group Co. LTD.Shenzhen 518026GuangdongChina

Because of its large capacity,high efficiency and energy savings,the subway has gradually become the primary mode of transportation for citizens.A high density of passengers exists within a large-passenger-flow subway station,and the number of casualties and injuries during a fire emergency is *** this paper,Pathfinder software and on-site measured data of Pingzhou station in Shenzhen(China)were utilized to simulate a fire emergency evacuation in a large-passenger-flow subway *** Required Safe Egress Time(RSET),number of passengers and flow rates of stairs and escalators were analysed for three fire evacuation scenarios:train fire,platform fire and hall *** evacuation time of the train fire,which was 1173 s,was the longest,and 3621 occupants needed to evacuate when the train was fully *** could not complete the evacuation within 6 mins in all three fire evacuation scenarios,which does not meet the current standard requirements and *** changing the number of passengers and the number of stairs for evacuation,the flow rate capacity and evacuation time were explored,which have reference values for safety management and emergency evacuation plan optimization during peak hours of subway operation.

关键词： fire emergency evacuation large-passenger-flow subway station on-site measured data Pathfinder

Both host and diet shape bacterial communities of predatory mites

在线全文

学校读者我要写书评

暂无评论

Insect Science 2024年第2期31卷 551-561页

作者： Hong Yan Endong Wang Guo-shu Wei Bo zhang Xuenong Xu Institute of Plant Protection Chinese Academy of Agricultural SciencesBejingChina College of Plant Protection Hebei Agricultural UniversityBaodingHebei ProvinceChina Key Laboratory of Natural Enemies Insects Ministry of Agriculture and Rural AffairsBeijingChina

Microbial communities,derived from food,ambient,and inner,can affect host ecological adaption and *** with most phytophagous arthropods,predators may have more opportunities to develop specific microbiota depending on the level of prey *** explore how diet sources affect host microbial communities and vary across predator species,we considered 3 types of predators from Phytoseiidae(Acari:Mesostigmata):polyphagous(Amblyseius orientalis Ehara,Neoseiulus barkeri Hughes,and Amblyseius swirski Athias-Henrio),oligophagous(Neoseiulus californicus McGregor),and monophagous(Phytoseiulus persimilis Athias-Henriot)predatory *** polyphagous species were fed on 2 types of diets,natural prey and alternative *** using 16S rRNA sequencing,we found that diet was the main source of microbiota in predatory mites,while there was no clear pattern affected by prey *** 3 polyphagous predators,host species had a larger impact than prey on microbial *** *** or *** which showed consistency in their microbiota,prey switching significantly affectedβ-diversity of bacterial composition in ***,with 56%of the microbial *** short,our results confirmed the substantial influence of diet on host microbial construction in predatory species,and highlighted species differences in shaping the microbiota which are not necessarily related to prey specialization.

关键词： diet switching feeding habits host-microbial interactions invertebrate microbiota 16S rRNA

Highly Red Emissive Conjugated Homopolymers Based on Double B←N Bridged Bipyridine Unit

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2024年第8期42卷 1029-1037页

作者： Yu-Yue Gao Kai-Yuan zhang shu-Meng Wang Hui Tong Jun Liu State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei 230026China

Conjugated homopolymers based on six-member rings,e.g.,polyfluorene,always exhibit blue emission and conjugated homopolymers based on five-member rings,e.g.,polythiophene,can give red emission with low *** this work,we report a series of new conjugated homopolymers based on six-member rings with high-efficiency deep-red *** repeating units of the red light emitting homopolymers are double B←N bridged bipyridine(BNBP)with the boron atoms functionalized with diphenyl,borafluorene,and 2,7-di-tert-butyl-borafluorene groups,*** relationship between the chemical structures and the opto-electronic properties of the monomers and the homopolymers has been systematically *** three polymers emit pure red light(λ_(max)=656 nm)or deep red light(λ_(max)=693 nm)with fluorescence quantum efficiency in solution higher than 60%.The polymers can be used as the emitters in solution-processed organic light-emitting diodes with red emission and decent device *** work indicates a new strategy to design highly efficient light emitting conjugated polymers.

关键词： Conjugated homopolymers Double B←N bridged bipyridine(BNBP) Deep-red emission High fluorescent efficiency

Anti-aging performance improvement and enhanced combustion efficiency of boron via the coating of PDA

在线全文

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2024年第3期33卷 399-410页

作者： shuai Ma Qinghai shu Mengyang zhang Hongyu Huang Yansong Shi Xijuan Lv shuai Zhao School of Materials Science and Engineering Beijing Institute of TechnologyBeijing100081China Key Lab of Advanced Optoelectronic Quantum Architecture and Measurement(MOE) Beijing Key Lab of Nanophotonics&Ultrafine Optoelectronic SystemsSchool of PhysicsBeijing Institute of TechnologyBeijing100081China Tangshan Research Institute of Beijing Institute of Technology Tangshan063000HebeiChina

Boron is an ambitious fuel in energetic materials since its high heat release values,but its application is prohibited by low combustion efficiency and oxidization during *** polydopamine(PDA)was introduced into boron particles,investigating the impact of PDA content on the energetic behavior of *** results indicated that the PDA coating formed a fishing net structure on the surface of boron *** heat release results showed that the combustion calorific value of B@PDA was higher than that of the raw ***,the actual combustion heat of boron powder in B@10%PDA increased by 38.08%.Meanwhile,the DSC peak temperature decreased by 100.65℃under similar oxidation rate compared to raw ***,the B@PDA@AP and B@AP composites were prepared,and their combustion properties were *** was demonstrated that B@10%PDA@AP exhibited superior performance in terms of peak pressure and burning time,*** peak pressure is 12.43 kPa more than B@AP and burning time is 2.22 times higher than B@***,the coating of PDA effectively inhibits the oxidization of boron during storage and enhances the energetic behavior of boron and corresponding composites.

关键词： Boron particles Polydopamine Anti-aging performance improvement Heat release

Elaborative collection of condensed combustion products of solid propellants:Towards a real Solid Rocket Motor(SRM)operational environment

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2024年第1期37卷 77-88页

作者： Wenchao zhang Zhimin FAN Dongliang GOU Yao shu Peijin LIU Aimin PANG Wen AO National Key Laboratory of Solid Rocket Propulsion Northwestern Polytechnical UniversityXi’an 710072China Science and Technology on Aerospace Chemical Power Laboratory Xiangyang 441003China

A novel constant-pressure and constant-quenching distance Condensed Combustion Products(CCPs)collection system was developed,coupled with a timing control system,to collect the CCPs formed in the course of burning of aluminum-based composite *** effects of adiabatic graphite plating,collection zone,quenching distance,time series of collection,and propellant burning rate on the microscopic morphology,particle size distribution and unburned aluminum content of CCPs were *** was verified that the graphite plating can provide a high-fidelity high-temperature environment for propellant *** combustion efficiency is improved by 2.44% compared to the bare propellant *** time series of collection has a significant effect on the combustion efficiency of aluminum,and the combustion efficiency of aluminum in the thermal state(1.2-2.4 s)is 2.75% higher than that in the cold state(0-1.2 s).Similarly,the characteristics of the CCPs in different collection zones are *** the quenching distance of 5 mm,the combustion efficiency of aluminum in the core zone(85.39%)is much lower than that in the outer zone(92.07%),while the particle size of the CCPs in the core zone(172μm)is larger than that in the outer zone(41μm).This indicates that the core zone is more likely to produce large-sized and incompletely burned agglomerates during the propellant combustion *** burning rates also lead to a significant difference in particle size distribution and combustion *** burning rates result in higher combustion efficiency.A detailed sequence of the elaborative collection process of CCPs is proposed,mainly including the setting of ignition delay time,burning rate,working pressure,plating length and time series of *** findings of this study are expected to provide a reliable tool for the evaluation of the combustion efficiency of solid propellants.

关键词： Composite propellants Condensed combustion products Aluminum Combustion efficiency Particle size distribution