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PD-1免疫抑制剂联合化疗治疗晚期NSCLC的效果及对肿瘤标志物、预后的影响

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现代生物医学进展 2024年第10期24卷 1901-1905页

作者：戴婷查名宝许林利童玫瑰娄悦芜湖市中医医院肿瘤科安徽芜湖241000

目的:探究PD-1免疫抑制剂联合化疗治疗晚期非小细胞肺癌(NSCLC)的效果及对肿瘤标志物、预后的影响。方法:回顾性选取2020.6~2023.6间收治的处于III B期~IV期NSCLC患者为研究对象,依据其治疗方案分为化疗组(n=32,培美曲塞/紫杉类+铂类化... 详细信息

目的:探究PD-1免疫抑制剂联合化疗治疗晚期非小细胞肺癌(NSCLC)的效果及对肿瘤标志物、预后的影响。方法:回顾性选取2020.6~2023.6间收治的处于III B期~IV期NSCLC患者为研究对象,依据其治疗方案分为化疗组(n=32,培美曲塞/紫杉类+铂类化疗方案)和联合组(n=36,免疫抑制剂+培美曲塞/紫杉类+铂类化疗方案),治疗至少2个周期后比较两组实体瘤治疗效果[疾病控制率(DCR)、客观缓解率(ORR)],随访预后生存情况[无进展生存期(PFS)、总生存期(OS)],比较治疗期间药物不良反应,比较两组治疗前、治疗2个周期后的血清生化指标[癌胚抗原(CEA)、细胞角蛋白19片段抗原(CY-FRA21-1)和白蛋白(ALB)]水平变化。结果:治疗2个周期后,联合组DCR(83.33%vs 59.38%)显著高于化疗组(P0.05);随访18个月,联合组PFS为(11.44±1.81)个月,死亡11例,OS为(15.17±1.42)个月;化疗组PFS为(6.87±3.05)个月,死亡16例,OS为(11.91±1.09)个月,联合组PFS显著高于化疗组(log rank x^(2)=4.377,P0.05);治疗期间,两组药物不良反应总发生率比较无显著差异(P>0.05);治疗2个周期后,两组CEA和CY-FRA21-1水平逐渐降低(P<0.05),ALB水平显著升高(P<0.05),且联合组治疗2个周期指标变化显著高于化疗组(P<0.05)。结论:PD-1免疫抑制剂联合化疗治疗晚期NSCLC效果良好,可显著抑制肿瘤发展进程,延长患者PFS,改善预后,值得推荐。

关键词：晚期NSCLC PD-1免疫抑制剂化疗肿瘤标志物预后

Associations of preterm and early-term birth with suspected developmental coordination disorder:a national retrospective cohort study in children aged 3-10 years

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World Journal of Pediatrics 2023年第3期19卷 261-272页

作者： Ming-Xia Liu Hai-Feng Li mei-Qin Wu Shan-Shan Gengg Li Ke Bi-Wen lou Wenchong Du Jing Hua The Women's and Children's Department Shanghai First Maternity and Infant HospitalSchool of MedicineTongji UniversityShanghaiChina Shanghai Key Laboratory of Maternal Fetal Medicine Shanghai First Maternity and Infant HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Rehabilitation Children's HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhouChina State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal UniversityBeijingChina Leitontech Research Institution SuzhouChina Department of Psychology NTU PsychologyNottingham Trent UniversityNottinghamUK

Background This study analyzed the motor development and suspected developmental coordination disorder of very and moderately preterm(0.05).Conclusions Our findings have important implications for understanding motor impairment in children born at different gestational *** and moderately preterm preschoolers have an increased risk of DCD,and long-term follow-up should be provided for early detection and intervention.

关键词： China Early-term and preterm birth Late motor impairment Movement Assessment Battery-2 for Children

Genetic diversity and temporal dynamics of phytoplankton viruses in East Lake, China

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Virologica Sinica 2015年第4期30卷 290-300页

作者： mei-Niang Wang Xing-Yi Ge Yong-Quan Wu Xing-lou Yang Bing Tan Yu-Ji Zhang Zheng-Li Shi Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of Virology Chinese Academy of Sciences

Phytoplankton viruses are important components of aquatic ecosystems. However, their prevalence and genetic diversity in marine and freshwater systems are largely under estimated owing to the immense size of water bodies and limitations in virus discovery techniques. In this study, we conducted a 1-year survey of phytoplankton virus communities by collecting surface water monthly from an inland lake(East Lake) in China between May 2012 and April 2013. We examined four phytoplankton viruses, i.e., myoviruses, podoviruses, siphoviruses, and phycodnaviruses, and seven sets of primers were used to target conserved genes within these four species. In this year-long investigation, a total of 358 different virus-related sequences from four virus families were obtained. All virus families were detected in all months, except for cyanopodoviruses, which were only identified during eight of the 12 months surveyed. Moreover, virus abundance and diversity changed dynamically over time. Phylogenetic analysis revealed that the majority of viral sequences from East Lake, China displayed distinct clustering patterns compared with published sequences. These results supported the existence of a highly diverse and unique phytoplankton virus community in East Lake, China.

关键词： cyanophage phycodnavirus genetic diversity dynamic

孕康口服液对缺铁性贫血孕鼠产后恢复及子代质量的影响

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中成药 2024年第4期46卷 1151-1161页

作者：李婷颜美秋苏洁郭静妍汪晨兴韩丽萍俞静静陈素红吕圭源楼招欢浙江中医药大学药学院浙江杭州310053

目的探究孕康口服液对缺铁性贫血(IDA)孕鼠产后恢复及子代质量的影响。方法采用饲喂缺铁饲料联合放血法建立缺铁性贫血孕鼠模型,造模成功后,在妊娠第7天同期灌胃给予琥珀酸亚铁片(52 mg/kg)及孕康口服液(9、6、4 mL/kg),每天1次,直至... 详细信息

目的探究孕康口服液对缺铁性贫血(IDA)孕鼠产后恢复及子代质量的影响。方法采用饲喂缺铁饲料联合放血法建立缺铁性贫血孕鼠模型,造模成功后,在妊娠第7天同期灌胃给予琥珀酸亚铁片(52 mg/kg)及孕康口服液(9、6、4 mL/kg),每天1次,直至产后6周。结束后,检测小鼠相关体征指标(自主活动、抓力、背温、爪色)、脏器系数(心脏、脾、胸腺系数)、外周血指标(RBC、HGB、HCT、MCH、MCHC)、铁代谢相关血清因子指标(EPO、FEP、SF、sTfR、TFR1),免疫组化法检测肝组织FPN、Tf蛋白表达,免疫荧光法检测肝组织TFR1、Hepcidin蛋白表达,RT-qPCR检测肝组织Hepcidin、FPN、Tf、TFR1 mRNA表达,测定子代相关情况(存活率、自主活动、抓力、爪色、心脏系数、脾脏系数、体长、外周血象指标)。结果孕康口服液可提高IDA孕鼠产后的自主活动次数、抓力、背温、爪色(P<0.05,P<0.01),降低心脏和脾脏系数(P<0.01),提高全血RBC、HGB、HCT、MCH、MCHC水平(P<0.05,P<0.01),降低血清EPO、FEP、TFR1、sTfR水平(P<0.05,P<0.01),升高SF水平(P<0.05,P<0.01),提高肝组织Hepcidin、FPN mRNA及蛋白表达(P<0.05,P<0.01),降低Tf、TFR1 mRNA及蛋白表达(P<0.05,P<0.01)。与模型组比较,孕康口服液各剂量组子代存活率、自主活动次数、抓力提高(P<0.05,P<0.01),心脏系数、脾脏系数降低(P<0.05,P<0.01),体长增加(P<0.05,P<0.01),全血RBC、HGB、HCT水平升高(P<0.01)。结论孕康口服液可改善IDA孕鼠的贫血状况,促进其产后恢复,并提高子代质量。

关键词：孕康口服液缺铁性贫血铁调素-膜铁转运铁蛋白轴子代质量

Relation between eardrum flap area and healing outcome of traumatic eardrum perforation

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Chinese Journal of Traumatology 2011年第5期14卷 264-268页

作者： lou Zheng-cai TANG Yong-mei WU Xiao-hong CHEN Jia-hai Department of Otorhinolaryngology Yiwu Central Hospital Yiwu 322000 Zhejiang Province China

Objective： To retrospectively study the clinical effects of eardrum flap area on the healing outcome following traumatic ***： Totally 291 traumatic eardrum perforations with in-/everted edges were included in this study. They were randomly divided into three groups and received conservative treatment, epidermal growth factor （EGF） via Gelfoam patching, or edge-approximation plus Gelfoam patching respectively. Patients in each group were further divided into two subgroups according to the eardrum flap area ≤ 1/2 or 〉1/2 of the perforation size. The healing rate and mean closure time after tympanic membrane perforation were evaluated at three ***： Of the total 291 participants, 281 were included in the final statistical analysis. The area of curled edge did not affect the healing outcome significantly in any groups （P〉0.05）. The healing rate varied slightly： 90.7% vs 92.3% in spontaneous healing group, 98.2% vs 97.4% in EGF via Gelfoam patching group, and 96.5% vs 100% in edge-approximation plus Gelfoam patching group. In addition, in all groups the area of curled edge did not affect the mean closure time significantly （P〉0.05）. The closure time was （32.3±2.4） d vs （30.6±3.1） d in sponaneous healing group, （13.4±2.5） d vs （13.1± 1.9） d in EGF via Gelfoam patching group, and （11.9±3.1） d vs （12.2±2.1） d in edge-approximation plus Gelfoam patching ***： The eardrum flap area of traumatic eardrum perforation does not significantly affect the clinical outcomes.

关键词： Tympanic membraneperforation Wounds and injuries Surgical flaps Gelatin sponge, absorbable

Aberrant methylation of SPARC in human hepatocellular carcinoma and its clinical implication

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World Journal of Gastroenterology 2012年第17期18卷 2043-2052页

作者： Ye Zhang Zhi Du Tong Bai Ying-Tang Gao Yi-Jun Wang Cheng lou Feng-mei Wang Yu Bai Bin Yang Third Central Clinical College of TianjinMedical University Tianjin 300170 China The Third Central Hospital of Tian-jin Tianjin 300170 China Tianjin Key Laboratory of Artificial Cell Tianjin 300170 China

AIM:To investigate the methylation status of secreted protein acidic and rich in cysteine(SPARC) in human hepatocellular carcinoma(HCC) and evaluate its clinical ***:The methylation status of SPARC was analyzed in one HCC cell line(SMMC-7721) and 60 pairs of HCC and corresponding nontumorous tissues by methylation-specific polymerase chain reaction and bisulfite *** expression of SPARC mRNA and protein were examined by reverse transcription polymerase chain reaction and immunohistochemistry,*** correlations between the methylation status and the gene expression,the clinicopathological parameters,as well as the prognosis after surgery were ***:In the SMMC-7721 cell line,the loss of SPARC expression was correlated with the aberrant methylation and could be reactivated by the demethylating agent 5-aza-2'-*** frequency of SPARC in HCC was significantly higher than that in the corresponding nontumorous tissues(45/60 vs 7/60,P < 0.001),and it was correlated with the pathological classification(P = 0.019).The downregulation of the SPARC mRNA expression in HCC was correlated with the SPARC methylation(P = 0.040).The patients with methylated SPARC had a poorer overall survival than those without methylated SPARC(28.0 mo vs 41.0 mo,P = 0.043).CONCLUSION:Aberrant methylation is an important mechanism for SPARC inactivation in HCC and SPARC methylation may be a promising biomarker for the diagnosis and prognosis of HCC.

关键词： Biomarker Diagnosis Hepatocellular carcinoma Methylation Prognosis Tumor suppressor gene

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圆柱体骰子最终面朝向概率的研究

大学物理 2024年第2期43卷 55-59页

作者：姜素馨邵芳娜许泽林楼慈波段香梅王霁宁波大学物理科学与技术学院浙江宁波315211

下落物体的最终静止状态取决于物体的几何特征、运动状态、材料特性等多种因素.本文以圆柱体骰子为研究对象,基于动力学模型,探究了圆柱体骰子初始速度、角速度、高度、质量以及恢复系数等因素对骰子落地后最终面朝向的影响,并探讨了使... 详细信息

下落物体的最终静止状态取决于物体的几何特征、运动状态、材料特性等多种因素.本文以圆柱体骰子为研究对象,基于动力学模型,探究了圆柱体骰子初始速度、角速度、高度、质量以及恢复系数等因素对骰子落地后最终面朝向的影响,并探讨了使圆柱体骰子每一面最终朝向概率相等时应具有的几何特征和物理条件.本文结果可为此类研究提供思路和借鉴.

关键词：圆柱体骰子动力学概率

系统性红斑狼疮患者血清NGAL、HMGB1、Gal-3与疾病活动度和颈动脉粥样硬化的关系分析

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现代生物医学进展 2024年第9期24卷 1731-1735页

作者：马倩倩祖蓓蓓殷松楼刘琳饶咏梅徐州医科大学第一临床医学院江苏徐州221000 徐州市中心医院风湿免疫科江苏徐州221000 徐州医科大学附属医院风湿免疫科江苏徐州221000

目的:分析系统性红斑狼疮(SLE)患者血清中性粒细胞明胶酶相关载脂蛋白(NGAL)、高迁移率族蛋白B1(HMGB1)、半乳糖凝集素-3(Gal-3)与疾病活动度和颈动脉粥样硬化(CAS)的关系。方法:选取2020年1月到2023年3月在徐州市中心医院收治的160例SL... 详细信息

目的:分析系统性红斑狼疮(SLE)患者血清中性粒细胞明胶酶相关载脂蛋白(NGAL)、高迁移率族蛋白B1(HMGB1)、半乳糖凝集素-3(Gal-3)与疾病活动度和颈动脉粥样硬化(CAS)的关系。方法:选取2020年1月到2023年3月在徐州市中心医院收治的160例SLE患者。采用酶联免疫吸附法检测血清NGAL、HMGB1、Gal-3水平。根据SLE疾病活动度指数(SLEDAI)评分将患者分为无活动组(n=48)、重度活动组(n=32)中度活动组(n=39)、轻度活动组(n=41)。同时根据颈动脉彩色多普勒超声检查结果将患者分为CAS组(n=56)和无CAS组(n=104)。对比各组血清NGAL、HMGB1、Gal-3水平的差异。SLE发生CAS的影响因素采用多因素logistic回归分析。结果:无活动组、轻度活动组、中度活动组、重度活动组的血清NGAL、HMGB1、Gal-3的水平依次升高,整体对比差异有统计学意义(P<0.05)。CAS组的血清NGAL、HMGB1、Gal-3的水平高于无CAS组(P<0.05)。多因素logistic回归分析结果显示,高NGAL、高HMGB1、高Gal-3高、高年龄、SLE病程长是SLE患者发生CAS的危险因素,而规范应用羟氯喹药物治疗是保护因素(P<0.05)。结论:SLE患者血清NGAL、HMGB1、Gal-3水平升高,且随着疾病严重程度的增加而增加。同时,高NGAL、HMGB1、Gal-3、年龄以及SLE病程长是SLE患者发生CAS的危险因素。

关键词：系统性红斑狼疮 NGAL HMGB1 Gal-3 疾病活动度颈动脉粥样硬化

Seasonal Variation,Microscopic and Chromatographic Analysis of Leaves in Malus hupehensis:A Protocol for Its Quality Control

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Chinese Herbal Medicines 2013年第2期5卷 145-150页

作者： SHEN Tao XIANG Lan REN Dong-mei WANG shu-qi YANG Ming-ren lou Hong-xiang School of Pharmaceutical Sciences Shandong University Linyi Shansong Pharmaceutical Company

Objective To establish a quality control protocol based on microscopic, TLC, and HPLC methods, and to verify the optimal harvesting time for the leaves of Malus hupehensis(LMH). Methods The LMH were pulverized into powder for microscopic identification or TLC and HPLC analysis after ultrasonic extraction with methanol. Seasonal variations of the phlorizin content and average leaf weight were determined by HPLC analysis and weighing up the leaves collected from May to October. Results Microscopic and macromorphologic characteristics have been described for the leaf identification. A qualitative TLC assay and a quantitative HPLC method have been established for the quality control of LMH. Phlorizin was selected as a reference marker, which resolved at Rf 0.53 in TLC assay and at 14.0 min in HPLC assay. The content of phlorizin decreased gradually from 17.0% in leaves collected in May to 7.5% in October. The average leaf weight reached the level of 0.6 g in August and maintained until its *** These methods are simple, selective, accurate, and reliable for the quality control of LMH. The period from late August to early September is suggested as the optimal harvesting time of the LMH.

关键词： HPLC Malus hupehensis optimal harvesting time phlorizin quality control TLC