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Differences and identification on multi-time hydrocarbon generation of carboniferous-permian coaly source rocks in the Huanghua Depression,Bohai Bay Basin

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Petroleum Science 2024年第2期21卷 765-776页

作者： Jin-Jun Xu Xian-Gang Cheng shu-Nan Peng Jun-Cai Jiang Qi-Long Wu Da lou Fu-Qi Cheng La-mei Lin National Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)Qingdao 266580ShandongChina PetroChina Dagang Oilfield Company Tianjin300280China

Coal is a solid combustible mineral,and coal-bearing strata have important hydrocarbon generation potential and contribute to more than 12%of the global hydrocarbon resources.However,the deposition and hydrocarbon evolution process of ancient coal-bearing strata is characterized by multiple geological times,leading to obvious distinctions in their hydrocarbon generation potential,geological processes,and production,which affect the evaluation and exploration of hydrocarbon resources derived from coaly source rocks worldwide.This study aimed to identify the differences on oil-generated parent macerals and the production of oil generated from different coaly source rocks and through different oil generation processes.Integrating with the analysis of previous tectonic burial history and hydrocarbon generation history,high-temperature and high-pressure thermal simulation experiments,organic geochemistry,and organic petrology were performed on the Carboniferous-Permian(C-P)coaly source rocks in the Huanghua Depression,Bohai Bay Basin.The oil-generated parent macerals of coal's secondary oil generation process(SOGP)were mainly hydrogen-rich collotelinite,collodetrinite,sporinite,and cutinite,while the oil-generated parent macerals of tertiary oil generation process(TOGP)were the remaining small amount of hydrogen-rich collotelinite,sporinite,and cutinite,as well as dispersed soluble organic matter and unexhausted residual hydrocarbons.Compared with coal,the oil-generated parent macerals of coaly shale SOGP were mostly sporinite and cutinite.And part of hydrogen-poor vitrinite,lacking hydrocarbon-rich macerals,and macerals of the TOGP,in addition to some remaining cutinite and a small amount of crude oil and bitumen from SOGP contributed to the oil yield.The results indicated that the changes in oil yield had a good junction between SOGP and TOGP,both coal and coaly shale had higher SOGP aborted oil yield than TOGP starting yield,and coaly shale TOGP peak oil yield was lower than SOGP peak oil yield.There were significa

关键词： Thermal simulation Multi-time oil generation processes Coaly source rock Carboniferous-permian Huanghua Depression

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Plastic deformation of magnesium alloy with different forming parameters during ultrasonic vibration-assisted single-point incremental forming

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Rare Metals 2022年第11期41卷 3878-3886页

作者： Chun Jian Su Ting Ting Xu Ke Zhang Ke Zhang shu mei lou Qing Wang College of Mechanical and Electronic Engineering Shandong University of Science and TechnologyQingdao266590China

The research of forming parameters on the ultrasonic vibration single-point incremental forming of magnesium alloy plastic deformation can provide a theoretical basis for the establishment of the forming parameters.According to the forming characteristics of magnesium alloy sheet,a new method of ultrasonic vibration-as sis ted single-point incremental forming was proposed.The influence of forming parameters on the plastic deformation of magnesium alloy was studied by finite element simulation and experimentation.The influence of vibration frequency,amplitude,friction coefficient,and tool head size on stress and thinning rate of magnesium alloy during ultrasonic vibration-as sis ted single-point asymptotic forming was studied.The results show that the vibration frequency of 20 kHz and forming tool radius of about 5 mm are beneficial for plastic deformation magnesium alloy in ultrasonic vibration-assisted single-point incremental forming.With vibration amplitude increasing,the maximum shear stress tends to decrease as a whole,but at the amplitude of 0.16 mm,the thinning rate is large and fracture occurs easily.With friction coefficient increasing,the maximum shear stress tends to increase,and there is a good linear relationship between the maximum thinning rate and the friction coefficient.

关键词： Magnesium alloy Ultrasonic vibration Incremental forming Forming parameters Plastic deformation

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Magnetic resonance imaging-based lymph node radiomics for predicting the metastasis of evaluable lymph nodes in rectal cancer

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1849-1860页

作者： Yong-Xia Ye Liu Yang Zheng Kang mei-Qin Wang Xiao-Dong Xie Ke-Xin lou Jun Bao mei Du Zhe-Xuan Li Department of Radiology The Affiliated Cancer Hospital of Nanjing Medical University&Jiangsu Cancer Hospital&Jiangsu Institute of Cancer ResearchNanjing 210011Jiangsu ProvinceChina Department of Colorectal Surgery Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research and The Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210000Jiangsu ProvinceChina1 Department of Pathology The Affiliated Cancer Hospital of Nanjing Medical University&Jiangsu Cancer Hospital&Jiangsu Institute of Cancer ResearchNanjing 210011Jiangsu ProvinceChina Colorectal Center The Affiliated Cancer Hospital of Nanjing Medical University&Jiangsu Cancer Hospital&Jiangsu Institute of Cancer ResearchNanjing 210011Jiangsu ProvinceChina

BACKGROUND Lymph node(LN)staging in rectal cancer(RC)affects treatment decisions and patient prognosis.For radiologists,the traditional preoperative assessment of LN metastasis(LNM)using magnetic resonance imaging(MRI)poses a challenge.AIM To explore the value of a nomogram model that combines Conventional MRI and radiomics features from the LNs of RC in assessing the preoperative metastasis of evaluable LNs.METHODS In this retrospective study,270 LNs(158 nonmetastatic,112 metastatic)were randomly split into training(n=189)and validation sets(n=81).LNs were classified based on pathology-MRI matching.Conventional MRI features[size,shape,margin,T2-weighted imaging(T2WI)appearance,and CE-T1-weighted imaging(T1WI)enhancement]were evaluated.Three radiomics models used 3D features from T1WI and T2WI images.Additionally,a nomogram model combining conventional MRI and radiomics features was developed.The model used univariate analysis and multivariable logistic regression.Evaluation employed the receiver operating characteristic curve,with DeLong test for comparing diagnostic performance.Nomogram performance was assessed using calibration and decision curve analysis.RESULTS The nomogram model outperformed conventional MRI and single radiomics models in evaluating LNM.In the training set,the nomogram model achieved an area under the curve(AUC)of 0.92,which was significantly higher than the AUCs of 0.82(P<0.001)and 0.89(P<0.001)of the conventional MRI and radiomics models,respectively.In the validation set,the nomogram model achieved an AUC of 0.91,significantly surpassing 0.80(P<0.001)and 0.86(P<0.001),respectively.CONCLUSION The nomogram model showed the best performance in predicting metastasis of evaluable LNs.

关键词： Radiomics Lymph node metastasis Rectal cancer Magnetic resonance imaging

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中国式现代化视域下畜禽养殖业规模化发展的路径研究

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饲料研究 2024年第11期47卷 189-192页

作者：娄银梅天津职业大学马克思主义学院天津300410

畜禽养殖业规模化发展是推动畜牧经济高质量发展的核心所在,也是实现中国式现代化目标的重要基础。文章从健全畜禽养殖发展格局、畜禽养殖政策持续出台方面阐述了全国畜禽养殖业规模化发展机遇。立足中国式现代化,畜禽养殖业规模化发展... 详细信息

畜禽养殖业规模化发展是推动畜牧经济高质量发展的核心所在,也是实现中国式现代化目标的重要基础。文章从健全畜禽养殖发展格局、畜禽养殖政策持续出台方面阐述了全国畜禽养殖业规模化发展机遇。立足中国式现代化,畜禽养殖业规模化发展能够推动畜牧业高质量转型,打造畜禽养殖现代化生态,增强畜禽养殖市场经济稳定性。在此基础上,文章提出完善畜禽养殖业规模化发展机制、建立畜禽养殖现代化发展模式、全面挖掘现代化畜禽养殖资源的创新路径,为推动中国式现代化发展提供助力。

关键词：中国式现代化畜禽养殖业规模化发展供应链体系创新模式

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基于BP神经网络和Arrhenius本构模型的石墨烯/7075复合材料热变形行为

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吉林大学学报（工学版） 2024年第5期54卷 1237-1245页

作者：娄淑梅李一明李鑫陈鹏白雪峰程宝嘉山东科技大学智能装备学院山东泰安271019

在653~713 K温度范围和0.01~10 s^(-1)应变速率下,进行了w(GNP/7075Al)=0.5%增强7075铝基复合材料的热压缩试验,建立了BP神经网络和应变补偿Arrhenius模型,同时建立了复合材料的热加工图和动态再结晶体积分数预测模型,研究了复合材料的... 详细信息

在653~713 K温度范围和0.01~10 s^(-1)应变速率下,进行了w(GNP/7075Al)=0.5%增强7075铝基复合材料的热压缩试验,建立了BP神经网络和应变补偿Arrhenius模型,同时建立了复合材料的热加工图和动态再结晶体积分数预测模型,研究了复合材料的热变形行为,并确定了复合材料的热加工工艺参数。结果表明:BP神经网络模型得到的流变应力预测值与试验结果吻合较好,其相关系数最高为99.9983%,平均相对误差绝对值最小为0.5%,表明神经网络对w(GNP/7075Al)=0.5%复合材料的热变形行为具有较高的预测精度。w(GNP/7075Al)=0.5%复合材料最佳变形温度和应变速率分别为685~705 K和0.01~0.1 s~(-1)。动态再结晶(DRX)倾向于在低应变速率和高变形温度下发生。数值模拟和热挤压试验表明,在挤压温度693 K、挤压速度1 mm/min的工艺参数下可以挤出表面质量良好的型材。

关键词：材料加工工程石墨烯/铝复合材料热变形本构方程热加工图再结晶模型数值模拟

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Epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China:a hospital-based retrospective study

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Neural Regeneration Research 2024年第5期19卷 1126-1132页

作者： Hengxing Zhou Yongfu lou Lingxiao Chen Yi Kang Lu Liu Zhiwei Cai David BAnderson Wei Wang Chi Zhang Jinghua Wang Guangzhi Ning Yanzheng Gao Baorong He Wenyuan Ding Yisheng Wang Wei mei Yueming Song Yue Zhou Maosheng Xia Huan Wang Jie Zhao Guoyong Yin Tao Zhang Feng Jing Rusen Zhu Bin Meng Li Duan Zhongmin Zhang Desheng Wu Zhengdong Cai Lin Huang Zhanhai Yin Kainan Li Shibao Lu Shiqing Feng Department of Orthopedics The Second HospitalCheeloo College of MedicineShandong UniversityShandongChina Department of Orthopedics Shandong University Center for OrthopedicsQilu HospitalCheeloo College of MedicineShandong UniversityShandongChina Department of Orthopedics Tianjin Medical University General HospitalInternational Science and Technology Cooperation Base of Spinal Cord InjuryTianjin Key Laboratory of Spine and Spinal CordTianjinChina Faculty of Medicine and Health The Back Pain Research TeamSydney Musculoskeletal HealthThe Kolling InstituteUniversity of SydneySydneyNSWAustralia Department of Spine Surgery Honghui HospitalXi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Burns and Plastic Surgery The Fourth Medical Center of Chinese PLA General HospitalBeijingChina Faculty of Medicine and Health School of Health SciencesUniversity of SydneyNSWAustralia Sydney Spine Institute BurwoodSydneyNSWAustralia Laboratory of Epidemiology Tianjin Neurological InstituteDepartment of NeurologyTianjin Medical University General Hospital&Tianjin Neurological InstituteKey Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in Central Nervous SystemMinistry of Education and Tianjin CityTianjinChina Department of Orthopedics Henan Provincial People’s HospitalZhengzhouHenan ProvinceChina Department of Spinal Surgery The Third Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Orthopedics The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Spine Surgery Zhengzhou Orthopedics HospitalZhengzhouHenan ProvinceChina Department of Orthopedic Surgery and Orthopedic Research Institute West China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Orthopedics Xinqiao HospitalArmy Medical UniversityChongqingChina Department of Orthopedics The First Affiliated Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Department of Spinal Surgery Shengj

Traumatic spinal cord injury is potentially catastrophic and can lead to permanent disability or even death.China has the largest population of patients with traumatic spinal cord injury.Previous studies of traumatic spinal cord injury in China have mostly been regional in scope;national-level studies have been rare.To the best of our knowledge,no national-level study of treatment status and economic burden has been performed.This retrospective study aimed to examine the epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China at the national level.We included 13,465 traumatic spinal cord injury patients who were injured between January 2013 and December 2018 and treated in 30 hospitals in 11 provinces/municipalities representing all geographical divisions of China.Patient epidemiological and clinical features,treatment status,and total and daily costs were recorded.Trends in the percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department and cost of care were assessed by annual percentage change using the Joinpoint Regression Program.The percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department did not significantly change overall(annual percentage change,-0.5%and 2.1%,respectively).A total of 10,053(74.7%)patients underwent surgery.Only 2.8%of patients who underwent surgery did so within 24 hours of injury.A total of 2005(14.9%)patients were treated with high-dose(≥500 mg)methylprednisolone sodium succinate/methylprednisolone(MPSS/MP);615(4.6%)received it within 8 hours.The total cost for acute traumatic spinal cord injury decreased over the study period(-4.7%),while daily cost did not significantly change(1.0%increase).Our findings indicate that public health initiatives should aim at improving hospitals’ability to complete early surgery within 24 hours,which is associated with improved sensorimot

关键词： China clinical features costs epidemiology methylprednisolone sodium succinate methylprednisolone retrospective study traumatic spinal cord injury treatment

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清毒栓提取物对人子宫颈鳞癌细胞免疫逃逸的影响

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环球中医药 2024年第2期17卷 232-237页

作者：李美楼姣英北京中医药大学第二临床医学院 100029 北京中医药大学东方医院生殖中心

目的研究清毒栓提取物对人子宫颈鳞癌细胞(SiHa细胞)免疫逃逸的影响,探讨清毒栓提取物治疗宫颈人乳头瘤病毒感染的免疫机制。方法选择均匀成团生长的jurkat细胞,使用SiHa上清液培养jurkat细胞48小时,采用染色质免疫沉淀技术检测SiHa... 详细信息

目的研究清毒栓提取物对人子宫颈鳞癌细胞(SiHa细胞)免疫逃逸的影响,探讨清毒栓提取物治疗宫颈人乳头瘤病毒感染的免疫机制。方法选择均匀成团生长的jurkat细胞,使用SiHa上清液培养jurkat细胞48小时,采用染色质免疫沉淀技术检测SiHa细胞上清液处理后jurkat细胞中叉状头/翅膀状螺旋转录因子(Forkhead boxP3,Foxp3)含量。取Foxp3高表达的T细胞模型,用血清药理学方法制备的清毒栓含药血清和对照血清进行干预,采用染色质免疫沉淀技术、实时荧光定量PCR法、流式细胞术分别检测jurkat细胞中Foxp3蛋白表达水平、Foxp3转录水平,以及Foxp3阳性细胞比例。结果 SiHa上清液可以显著增加jurkat细胞中Foxp3含量(P0.05);清毒栓含药血清可以显著降低jurkat细胞模型中Foxp3转录和蛋白水平以及Foxp3阳性细胞数(P<0.05)。结论清毒栓含药血清通过抑制jurkat T细胞中的Foxp3转录和蛋白表达,降低Foxp3阳性细胞数及Treg细胞比例,从而抑制宫颈SiHa细胞的免疫逃逸,增加机体对宫颈SiHa细胞的免疫反应性。

关键词：清毒栓含药血清宫颈人乳头瘤病毒感染人子宫颈鳞癌细胞 jurkat细胞叉状头/翅膀状螺旋转录因子

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鸡蛋花中2个新的苯甲酸苄基酯类酚苷化合物

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中国中药杂志 2024年第5期49卷 1255-1259页

作者：陈正吴美珠郑婷陈雅林孙晨楼永浩周学明海南师范大学、热带药用资源化学教育部重点实验室、海南省热带药用植物化学重点实验室海南海口571158

综合运用多种柱色谱技术采用活性追踪法对鸡蛋花中具有降血糖活性的成分进行了分离纯化,对所有纯化的单体化合物的理化性质进行表征及分析鉴定,共分离鉴定了6个化合物,分别为6-羟基-6″-乙酰基苯甲酸苄基酯-2-O-β-D-葡萄糖苷(1)、6-羟... 详细信息

综合运用多种柱色谱技术采用活性追踪法对鸡蛋花中具有降血糖活性的成分进行了分离纯化,对所有纯化的单体化合物的理化性质进行表征及分析鉴定,共分离鉴定了6个化合物,分别为6-羟基-6″-乙酰基苯甲酸苄基酯-2-O-β-D-葡萄糖苷(1)、6-羟基-6‴-乙酰基苯甲酸苄基酯-2-O-β-D-葡萄糖苷-(1‴→6″)-β-D-葡萄糖苷(2)、2-羟基-6-甲氧基苯甲酸苄基酯-2-O-β-D-葡萄糖苷(3)、6-羟基苯甲酸苄基酯-2-O-β-D-葡萄糖苷(4)、6-羟基苯甲酸苄基酯-2-O-β-D-葡萄糖苷-(1‴→6″)-β-D-葡萄糖苷(5)、6-羟基苯甲酸苄基酯-2-O-β-D-葡萄糖苷-(1‴→6″)-β-D-木糖苷(6)。其中化合物1和2为新化合物,化合物3~6为首次从鸡蛋花属植物中分离得到。对鉴定的6个化合物进行了α-葡萄糖苷酶抑制活性测试,结果表明化合物1~6显示出一定的抑制活性,其IC50为8.2~33.5μmol·L^(-1)。

关键词：鸡蛋花苯甲酸苄基酯糖苷 α-葡萄糖苷酶抑制活性

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实体恶性肿瘤相关性静脉血栓患者的临床特征及实验室指标分析

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中国实验血液学杂志 2024年第3期32卷 847-851页

作者：周永梅张海燕郭青青娄方方周湘红冉飞贵州省人民医院检验科贵州贵阳550002

目的:分析实体恶性肿瘤相关静脉血栓栓塞症(Ta-VTE)患者的临床特征和实验室指标,研究其危险因素。方法:收集2020年1月至12月在本院住院的静脉血栓患者,根据是否患有实体恶性肿瘤,分为Ta-VET组和单纯VTE组,分析两组患者间的临床资料和实... 详细信息

目的:分析实体恶性肿瘤相关静脉血栓栓塞症(Ta-VTE)患者的临床特征和实验室指标,研究其危险因素。方法:收集2020年1月至12月在本院住院的静脉血栓患者,根据是否患有实体恶性肿瘤,分为Ta-VET组和单纯VTE组,分析两组患者间的临床资料和实验室指标的差异,将有显著差异的指标纳入logistic回归,分析Ta-VTE的危险因素。结果:本研究共纳入288例静脉血栓患者,其中Ta-VTE组64例,单纯VTE组224例。两组患者间住院时长(14.20±15.29 d vs 10.05±6.90 d,t=3.112,P=0.002)、疼痛患者比例(35.94%vs 65.18%,χ^(2)=17.554,P=0.000)、近期手术史患者比例(75.00%vs 37.50%,χ^(2)=28.196,P=0.000)、D-D[2.8(0.92,7.55)μg/ml vs 5.69(2.25,13.91)μg/ml,Z=-2.710,P=0.007]、PLR[198.59(139.54,312.16)vs 149.76(114.08,233.66),Z=-2.924,P=0.003]、TBIL[10.90(7.63,15.68)μmol/L vs 12.90(9.33,18.28)μmol/L,Z=-2.066,P=0.039]具有显著统计学差异,其余各指标均无明显差异(P>0.05)。多因素logistic回归分析结果显示,PLR水平升高(OR=1.003,95%CI:1.000-1.006,P=0.027)、近期手术史(OR=4.312,95%CI:2.093-8.885,P=0.000)和住院时间延长(OR=1.037,95%CI:1.002-1.074,P=0.038)是恶性实体肿瘤相关静脉血栓栓塞症的独立危险因素;而疼痛(OR=0.274,95%CI:0.133-0.564,P=0.000)是一项保护性因素。结论:PLR水平升高、近期手术史和住院时间延长是Ta-VTE患者的独立危险因素,合理利用这些指标有助于Ta-VTE患者的临床诊疗。

关键词：肿瘤相关静脉血栓临床特征实验室指标危险因素

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Diagnosis,treatment,and prevention of severe acute hepatitis of unknown etiology in children

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World Journal of Pediatrics 2022年第8期18卷 538-544页

作者： Ying‑Hu Chen Jin‑Gan lou Zi‑Hao Yang Qing‑Jiang Chen Chun‑Zhen Hua Sheng Ye Chen‑mei Zhang Jie Chen Zong‑Wei Huang Jin‑Dan Yu Zhi‑Gang Gao Qiang shu Infectious Disease Department National Clinical Research Center for Child HealthChildren’s HospitalZhejiang University School of MedicineHangzhou 310052China Gastroenterology Department National Clinical Research Center for Child HealthChildren’s HospitalZhejiang University School of MedicineHangzhou 310052China PICU National Clinical Research Center for Child HealthChildren’s HospitalZhejiang University School of MedicineHangzhou 310052China General Surgery Department National Clinical Research Center for Child HealthChildren’s HospitalZhejiang University School of MedicineBinsheng Road 3333Hangzhou 310052China

Background Severe acute hepatitis of unknown etiology in children has recently exhibited a global trend of concentrated occurrence.This review aimed to summarize the current available information regarding the outbreak of severe acute hepatitis and introduce our hospital’s previous experiences with the diagnosis and treatment of severe acute hepatitis for reference.Data sources Websites including the UK Health Security Agency,European Centre for Disease Prevention and Control,CDC,WHO,and databases including PubMed/Medline,Cochrane Library,Embase and Web of Science were searched for articles on severe acute hepatitis in children.Results As of May 26,2022,a total of 650 cases have been reported in 33 countries;at least 38(6%)children required liver transplantation,and nine(1%)died.Cases are predominantly aged between 3 and 5 years old,and there are no epidemiological links among them.The common manifestations are jaundice,vomiting and pale stools.Adenovirus tested positive in most cases,and SARS-CoV-2 and other viruses were detected in a few cases,but virus particles were not found in liver tissue.Adenovirus immunohistochemistry showed immunoreactivity in the intrasinusoidal lumen from some liver samples.The hierarchical treatment includes symptomatic and supportive therapy,management of coagulation disorders and hepatic encephalopathy,artifcial liver support,and liver transplantation(approximately 6%–10%of cases require liver transplant).Conclusions The etiology of this severe acute hepatitis in children is not clear.The clinical features are severe acute hepatitis with signifcantly elevated liver enzymes.Clinicians need to be alert to children with hepatitis.

关键词： Acute Hepatitis Diagnosis Epidemiology Pediatrics Treatment

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