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Molecular Plant 2009年第1期2卷 43-58页

作者： Ballachanda N. Devaiah Ramaiah Madhuvanthi Athikkattuvalasu S. karthikeyan Kashchandra G. Raghothama Department of Horticulture and Landscape Architecture Purdue University West Lafayette IN 47907-116S USA

The limited availability of phosphate （Pi） in most soils results in the manifestation of Pi starvation responses in plants. To dissect the transcriptional regulation of Pi stress-response mechanisms, we have characterized the biological role of MYB62, an R2R3-type MYB transcription factor that is induced in response to Pi deficiency. The induction of MYB62 is a specific response in the leaves during Pi deprivation. The MYB62 protein localizes to the nucleus. The overexpression of MYB62 resulted in altered root architecture, Pi uptake, and acid phosphatase activity, leading to decreased total Pi content in the shoots. The expression of several Pi starvation-induced （PSI） genes was also suppressed in the MYB62 overexpressing plants. Overexpression of MYB62 resulted in a characteristic gibberellic acid （GA）-deficient phenotype that could be partially reversed by exogenous application of GA. In addition, the expression of SOC1 and SUPERMAN, molecular reg- ulators of flowering, was suppressed in the MYB62 overexpressing plants. Interestingly, the expression of these genes was also reduced during Pi deprivation in wild-type plants, suggesting a role for GA biosynthetic and floral regulatory genes in Pi starvation responses. Thus, this study highlights the role of MYB62 in the regulation of phosphate starvation responses via changes in GA metabolism and signaling. Such cross-talk between Pi homeostasis and GA might have broader implications on flowering, root development and adaptive mechanisms during nutrient stress.

关键词： Abiotic/environmental stress nutrition signal transduction.

A New Species of the Genus Tylototriton(Amphibia: Urodela: Salamandridae) from Eastern Himalaya

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Asian Herpetological Research 2015年第4期6卷 245-256页

作者： Janak Raj KHATIWADA Bin WANG Subarna GHIMIRE karthikeyan VASUDEVAN Shanta PAUDEL Jianping JIANG Chengdu Institute of Biology Chinese Academy of Sciences University of Chinese Academy of Sciences Tribhuvan University Central Department of Zoology CSIR-Centre for Cellular and Molecular Biology (CCMB) Laboratory for the Conservation of Endangered Species Himalayan Research and Conservation Nepal

A new species of the genus Tylototriton is described from eastern Himalaya based on molecular and morphological comparisons. The new species is diagnosable from the closely-related species by having light brown colouration in dorsal region in life, flat and blunt snout, greatly separated dorsolateral bony ridges on head and straightthick tailfin. In addition to head morphology, the new species is also morphologically distinguishable from its closelyrelated species Tylototriton shanorum by having 16 dorsal warts and average smaller Snout Vent Length（SVL）.

关键词： Tylototriton himalayanus sp. nov. eastern Himalaya morphology molecular phylogeny taxonomy

Silibinin induces hepatic stellate cell cycle arrest via enhancing p53/p27 and inhibiting Akt downstream signaling protein expression

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Hepatobiliary & Pancreatic Diseases International 2017年第1期16卷 80-87页

作者： Devaraj Ezhilarasan Jonathan Evraerts Brice Sid Pedro Buc Calderon Sivanesan karthikeyan Etienne Sokal Mustapha Najimi institut de recherche expérimentale et clinique (irec) laboratory of pediatric hepatology and cell therapyuniversité catholique de louvain 1200 Brussels Belgium louvain drug research institute toxicology and cancer biology research group pmnt unituniversité catholique de louvain 1200 Brussels Belgium facultad de ciencias de la salud universidad arturo prat Iquique Chil department of pharmacology and environmental toxicology food and hepatotoxicology laboratory dr. alm post graduate institute of basic medical sciences university of madrastaramani campus Chennai-600 l13 India

BACKGROUND： Proliferation of hepatic stellate cells （HSCs） plays a pivotal role in the progression of liver fibrosis conse- quent to chronic liver injury. Silibinin, a flavonoid compound, has been shown to possess anti-fibrogenic effects in animal models of liver fibrosis. This was attributed to an inhibition of cell proliferation of activated HSCs. The present study was to gain insight into the molecular pathways involved in silibinin anti-fibrogenic effect. METHODS： The study was conducted on LX-2 human stellate cells treated with three concentrations of silibinin （10, 50 and 100 μmol/L） for 24 and 96 hours. At the end of the treatment cell viability and proliferation were evaluated. Protein expression of p27, p21, p53, Akt and phosphorylated-Akt was evaluated by Western blotting analysis and Ki-67 protein expression was by immunocytochemistry. Sirtuin activity was evaluated by chemiluminescence based assay. RESULTS： Silibinin inhibits LX-2 cell proliferation in doseand time-dependent manner; we showed that silibinin upregulated the protein expressions of p27 and p53. Such regulation was correlated to an inhibition of both downstream Akt and phosphorylated-Akt protein signaling and Ki-67 protein expression. Sirtuin activity also was correlated to silibinin- inhibited proliferation of LX-2 cells. CONCLUSION： The anti-proliferative effect of silibinin on LX-2 human steUate cells is via the inhibition of the expres- sions of various cell cycle targets including p27, Akt and sir- tuin signaling.

关键词： silibinin hepatic stellate cells in vitro cell cycle arrest proliferation

Synthesis and anticholinesterase activity of a novel series of acetazolamide condensed 1,4-dihydropyridines

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Carbon Resources Conversion 2019年第3期2卷 191-197页

作者： Mudduluru Niranjan Babu karthikeyan Elumalai Sivaneswari Srinivasan Kalpana Eluri Manogaran Elumalai Srinivasan Sivannan Department of Phytochemistry Seven Hills College of PharmacyTirupati 517561India Department of Medicinal Chemistry Seven Hills College of PharmacyTirupati 517561India Department of Pharmaceutics K.K.College of PharmacyChennai 600122India Faculty of Pharmaceutical Sciences UCSI UniversityCherasKuala Lumpur 56000Malaysia Department of Pharmacy Practice Togari Veeramallappa Memorial College of PharmacyBallariIndia

A novel Acetazolamide condensed 1,4-dihydropyridines was set up by treating of N-(5-acetamido-1,3,4-thiadiazol-2-ylsulfonyl)-3-oxobutanamide with an aryl aldehyde and 25-30%alkali with sight amount of barium nitrate as a *** of the synthetic structure of the titled compounds(4-16)was substantiated by thin-layer chromatography(TLC),IR,^(1)H NMR,^(13)C NMR,Mass spectra(MS)and elemental analysis(C,H,and N)were *** titled compounds were assessed for anticholinesterase activity against acetylcholinesterase and butyl cholinesterase *** titled compound produced weak,moderate,or high anticholinesterase ***,compound 8 demonstrated the best anticholinesterase activity of all the 1,4-dihydropyridines,with an IC_(50) estimation of 0.08μM and 2.9μM.

关键词： Acetazolamide Anticholinesterase 1,4-Dihydropyridines Acetylcholinesterase Butyl cholinesterase

Comparison and Performance Analysis of FACTs Controller in System Stability

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Circuits and Systems 2016年第10期7卷 2948-2958页

作者： karthikeyan Ramasamy Department of Electrical and Electronics Engineering M. Kumarasamy College of Engineering Karur India

In large inter connected power systems, inter-area oscillations are turned to be a severe problem. Hence inter-area oscillations cause severe problems like damage to generators, reduce the power transfer capability of transmission lines, increase wear and tear on network components, increase line losses etc. This paper is to maintain the stability of system by damping inter-area oscillations. Implementation of new equipment consists of high power electronics based technologies such as FACTs and proper controller design has become an essential to provide better damping performance than Power System Stabilizer (PSS). With development of Wide Area Measurement System (WAMS), remote signals have become as feedback signals to design Wide Area Damping Controller (WADC) for FACTs devices. In this work, POD is applied to both SVC and SSSC. Simulation studies are carried out in Power System Analysis Toolbox (PSAT) environment to evaluate the effectiveness of the FACTs controller in a large area power system. Results show that extensive analysis of FACTs controller for improving stability of system.

关键词： Power System Stabilizer Wide-Area Measurement System Wide-Area Damping Controller Static VAR Compensator Flexible AC Transmission System Power Oscillation Damper Static Synchronous Series Compensator

Fournier’s gangrene complicating severe acute pancreatitis: a case report and literature review

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Journal of Pancreatology 2021年第3期4卷 130-133页

作者： Gautham Krishnamurthy Patta Radhakrishna Aswin Khanna karthikeyan Damodaran SIMS Institute of Gastroenterology Hepatology and Transplantation Department of Imaging Sciences SIMS HospitalSRM Institute for Medical SciencesChennaiIndia SIMS Hospital SRM Institute for Medical SciencesNo.1Jawaharlal Nehru SalaiVadapalaniChennai 600026India

Severe acute pancreatitis is commonly associated with pancreatic and extrapancreatic necrosis(EPN).Progressive EPN leading to necrotizing fasciitis of the retroperitoneum and abdominal wall has been ***,extension of retroperitoneal necrosis to the scrotum causing Fournier’s gangrene is *** present a case of 39-year-old male admitted with severe acute pancreatitis requiring prolonged mechanical *** was managed with percutaneous drainage and culture specific antibiotics during the 1st month of hospital *** the 3rd month of hospital stay,the patient started developing pain and ulceration over the *** was diagnosed with Fournier’s gangrene based on clinical examination and was planned for *** surgery,the track extending up to the deep inguinal ring was widened and drain was placed into the right lateral pelvic wall through the deep ring via a separate stab incision to reduce further scrotal wound *** case highlights a rare but potentially fatal complication of Fournier’s gangrene following severe acute necrotizing pancreatitis and the importance of measures to prevent further contamination of scrotum after surgical *** management of two potentially fatal conditions poses numerous challenges.

关键词： Case report Debridement Extrapancreatic necrosis Fournier’s gangrene Necrotizing fasciitis Severe acute pancreatitis

“Triple Trouble”in A Case of Mass Lesion

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中国肺癌杂志 2020年第12期23卷 1113-1116页

作者： K.KOWSHIKREDDY Ranganadin PAJANIVEL Ramalingam BASKARAN Selvaraj karthikeyan C.S.PRABHU Department of Pulmonary Medicine Mahatma Gandhi Medical College and Research InstituteSri Balaji Vidyapeeth UniversityPondicherry 607402India Department of Cardiology Mahatma Gandhi Medical College and Research InstituteSri Balaji Vidyapeeth UniversityPondicherry 607402India Department of Radiology Mahatma Gandhi Medical College and Research InstituteSri Balaji Vidyapeeth UniversityPondicherry 607402India

Bronchogenic carcinoma,the commonest lung tumor occurs more frequently in the elderly with typical symptoms of cough,haemoptysis,weight loss,dyspnoea or chest *** symptoms mimic common respiratory infections in en-demic areas like pulmonary ***,metastasis at presentation itself is common,the favoured sites being liver,contra-lateral lungs,bones,brain,etc.,although unusual and rare sites like heart also are *** herein report a rare association of both carcinoma with active pulmonary tuberculosis in the same lobe associated with intracardiac *** few cases have been published describing lung carcinoma with intracardiac *** hope the documentation of this rare case will shed further light into the subject area and improve clinical education.

关键词： Lung neoplasms Intra-cardiac metastasis Pulmonary tuberculosis

Studies on the seasonal variations in the proximate composition of ascidians from the Palk Bay,Southeast coast of India

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Asian Pacific Journal of Tropical Biomedicine 2012年第10期2卷 793-797页

作者： Ananthan G karthikeyan MM Selva Prabhu A Raghunathan C Centre of Advanced Study in Marine Biology Faculty of Marine SciencesAnnamalai University Zoological Survey of India Andaman and NicobarRegional Station.1Horticulture RoadHaddoPort Blair744102

Objective:To investigate the seasonal fluctuations of the proximate composition of the ascidians ***:The moisture content was estimated by drying 1 g of fresh tissue at a constant temperature at 105(?)for 24 *** loss of weight was taken as moisture *** total protein was estimated using the Biuret *** total carbohydrate in dried sample was estimated spectrophotometrically following the phenol-sulphuric acid *** lipid in the dried sample tissue was gravimetrically estimated following the chloroform-methanol mixture *** content was determined gravimetrically by incinerating 1 g dried sample in muffle furnace at about 550℃for 6 h and results are expressed in ***:It was found very difficult to compare the monthly variations,as all the ten species,exhibited wide fluctuations in their proximate *** the sake of convenience,average seasonal values were calculated by summing the monthly ***:The proximate composition of the 10 commonly available ascidians showed high nutritive value and hence these groups especially solitary ascidians can be recommended for human consumption in terms of pickles,soup,curry and others after ensuring the safety of consumers.

关键词： Ascidians Biochemical composition Seasonal variations proximate composition

Design,synthesis and in vitro antibacterial activities of methyl-4-((substituted phenyl)[6H-indolo(2,3-b)quinoxalin-6-yl]methyl-amino)benzoate derivatives

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Chinese Chemical Letters 2011年第5期22卷 567-570页

作者： Yellajyosula Lakshmi Narasimha Murthy Nagalakshmi karthikeyan Govindh Boddeti Bhagavathula S.Diwakar E.Rajendra Singh Department of Organic Chemistry Andhra UniversityVisakhapatnam 530003India DRDO - HQ New Delhi 110011India

A series of new methyl-4-（（substituted phenyl）[6H-indolo（2,3-b）quinoxalin-6yl]methylamino）benzoate derivatives have been synthesized and assayed for their antibacterial activity on 9 different bacterial *** the screened compounds 2e-2g exhibited potent inhibitory activity compared to standard drug employed,worth further investigation.

关键词： Isatin Schiff base Mannich base Antibacterial activity

喷雾热解法在硅衬底上生长定向碳纳米管阵列(英文)

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新型炭材料 2013年第4期28卷 284-288页

作者： V S Angulakshmi K Rajasekar C Sathiskumar S karthikeyan Department of Chemistry Kathir college of EngineeringCoimbatoreTNIndia Department of Nanotechnology Anna University of TechnologyCoimbatoreTNIndia Department of Chemistry Chikkanna Govt.Arts CollegeTirupurTNIndia

以向日葵油的甲基酯为碳源,二茂铁为催化剂前驱体,Ar为载气,通过喷雾热解法在硅衬底上合成定向碳纳米管阵列。结果表明,在硅衬底上原位形成Fe催化剂纳米颗粒。由拉曼光谱、透射电镜图和X-射线衍射谱图显示所制定向碳纳米管阵列具有较好... 详细信息

以向日葵油的甲基酯为碳源,二茂铁为催化剂前驱体,Ar为载气,通过喷雾热解法在硅衬底上合成定向碳纳米管阵列。结果表明,在硅衬底上原位形成Fe催化剂纳米颗粒。由拉曼光谱、透射电镜图和X-射线衍射谱图显示所制定向碳纳米管阵列具有较好的石墨化程度,其直径为1 0～3 0 nm,管壁约为1 0 nm。所制定向碳纳米管阵列中残留的催化剂含量可以忽略。

关键词：喷雾热解法定向碳纳米官阵列二茂铁硅衬底化学气相沉积