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(Salen)osmium (Ⅵ) nitrides catalyzed glutathione depletion in chemotherapy

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Chinese Chemical Letters 2023年第10期34卷 185-190页

作者： Wanqiong Huang Chen Pan Yongliang Huang Tao Huang Xiaonan Dong Yunzhou Chen Huatian Shi Taichu Lau Wailun man Wenxiu Ni Department of Medicinal Chemistry Shantou University Medical CollegeShantou 515041China Department of Chemistry Hong Kong Baptist UniversityHong KongChina Department of Chemistry City University of Hong KongHong KongChina Chemistry and Chemical Engineering Guangdong Laboratory Shantou 515063China

Glutathione depletion provides a promising strategy for the design of non-platinum anticancer *** we report a series of electrophilic (salen)osmium(Ⅵ) nitrides that react with glutathione to generate (salen)osmium(Ⅲ) ammine *** vitro studies indicate that these osmium(VI) nitrides show comparable cytotoxicity to cisplatin against various *** studies with the representative compound[OsⅥ(N)(LH)(OH_(2))](Pf6)(1,LH=N,N’-bis(salicylidene)-o-cyclohexyldiamine dianion) suggest that 1 induces glutathione depletion,reactive oxygen species generation,endoplasmic reticulum stress,and in turn triggers death receptor-mediated apoptosis and autophagy in lung cancer *** vivo evaluations show that 1 can inhibit tumor xenograft growth effectively with no body weight drop.

关键词： Chemotherapy Osmium complex Glutathione depletion Apoptosis Autophagy

基于视觉与文本语义增强的多模态命名实体识别方法

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湖南工业大学学报 2025年第1期39卷 64-71页

作者：满芳滕朱艳辉张志轩应旭剑陈豪湖南工业大学计算机学院湖南株洲412007 湖南工业大学轨道交通学院湖南株洲412007

为了解决视觉特征和文本特征融合后存在部分语义缺失从而导致视觉信息对文本信息的补充有较大偏差的问题,提出了一种基于视觉与文本语义增强的多模态命名实体识别方法。融合BERT文本特征提取和CLIP(contrastive language–image pre-tra... 详细信息

为了解决视觉特征和文本特征融合后存在部分语义缺失从而导致视觉信息对文本信息的补充有较大偏差的问题,提出了一种基于视觉与文本语义增强的多模态命名实体识别方法。融合BERT文本特征提取和CLIP(contrastive language–image pre-training)视觉特征提取方法,设计了基于协同交叉注意力机制的特征交互单元,以增强视觉信息和文本信息之间的语义关系。CLIP通过对比学习框架进行预训练,优化模型以正确匹配视觉和对应的文本描述,最大化正样本(匹配的视觉-文本对)的相似性,同时最小化负样本(不匹配的视觉-文本对)的相似性。采用通用领域数据集TWITTER-2015和TWITTER-2017作为实验数据集。实验结果表明,本模型相比传统方法在多模态命名实体识别任务中的准确率、召回率、f1值均有显著提升。

关键词：多模态命名实体识别特征融合语义增强

Multifunctional self-delivery micelles targeting the invasion-metastasis cascade for enhanced chemotherapy against melanoma and the lung metastasis

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Asian Journal of Pharmaceutical Sciences 2021年第6期16卷 794-805页

作者： Shanshan Xu Chunyu Liu Shuya Zang Jiaxin Li Yashi Wang Kebai Ren man Li Zhirong Zhang Qin He West China School of Pharmacy Sichuan UniversityChengdu 610041China Pharmacy Department West China HospitalChengdu 610041China

Metastasis is closely related to the high mortality of cancer patients,which is regulated by multiple signaling ***,multiphase blocking of this biological process is beneficial for cancer ***,we establish a multifunctional self-delivering system by synthesizing D-α-tocopheryl succinates(TOS)-conjugated chondroitin sulfate(CS)(CT NPs),which both serve as nanocarrier and antimetastatic agent that affects different phases of the metastatic *** as the hydrophobic segment of CT NPs can inhibit the secretion of matrix metalloproteinase-9,while the hydrophilic segment CS targets B16f10 cells through CD44 receptors and reduces the interaction between tumor cells and *** results show that CT NPs are able to inhibit metastasis successfully both in vitro and in vivo by interfering the multiphase of the metastatic *** encapsulating chemotherapeutic drug doxorubicin(DOX),the obtained micelles CT/DOX efficiently suppress both primary-tumor growth and metastases in B16f10 bearing *** a result,the rationally designed multifunctional NPs composing of biocompatible materials provide excellent therapeutic effects on solid tumors and metastases。

关键词： Self-delivery system Chondroitin sulfate Tumor metastasis Multiphase

Empirical Analysis on Company＇s Competitiveness from financial Index

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Chinese Business Review 2007年第2期6卷 54-59页

作者： WANG man LI Qian Accountancy College Dongbei University of Finance and Economics Dalian 116025 China

Taking the enterprise survival ability and the development ability as a basis, this paper constructs the financial appraisal index system of enterprise competitiveness. Also, it draws the overall impression of the enterprise competitiveness through selecting listed f＇u＇ms＇ financial index of the equipment man.facturing industry, with the aid of factor analysis model, using the principal components analytic method, making rotation of varimax, and arranging the synthesizes enterprise competitiveness from the financial angle. After the empirical analysis, the paper completes appraisal and analysis which based on company＇s competitiveness from financial index.

关键词： financial index enterprise competitiveness empirical analysis

Genome-wide analysis of nuclear factor Y genes and functional investigation of watermelon ClNf-YB9 during seed development

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The Crop Journal 2023年第5期11卷 1469-1479页

作者： Qin feng Ling Xiao Jiafa Wang Jie Wang Chenyang Chen Jianyang Sun Xixi Wu man Liu Xian Zhang Shujuan Tian Li Yuan State Key Laboratory of Crop Stress Biology for Arid Areas College of HorticultureNorthwest A&F UniversityYangling 712100ShaanxiChina Shenzhen Research Institute Northwest A&F UniversityShenzhen 518000GuangdongChina

The nuclear factor Y(Nf-Y) gene family is a class of transcription factors that are widely distributed in eukaryotes and are involved in various biological processes. However, the Nf-Y gene family members in watermelon, a valued and nutritious fruit, remain largely unknown and their functions have not been characterized. In the present study, 22 ClNf-Y genes in watermelon, 29 CsNf-Y genes in cucumber, and 24CmNf-Y genes in melon were identified based on the whole-genome investigation and their protein properties, gene location, gene structure, motif composition, conserved domain, and evolutionary relationship were investigated. ClNf-YB9 from watermelon and its homologs in cucumber and melon were expressed specifically in seeds. Its expression remained low in the early stages of watermelon seed development,increased at 20 days after pollination(DAP), and peaked at 45–50 DAP. Moreover, the knockout mutant Clnf-yb9 exhibited abnormal leafy cotyledon phenotype, implying its critical role during seed ***, protein interaction assays showed that ClNf-YB9 interacts with all ClNf-YCs and the ClNf-YB9-YC4 heterodimer was able to recruit a ClNf-YA7 subunit to assemble a complete Nf-Y complex, which may function in seed development. This study revealed the structure and evolutionary relationships of the Nf-Y gene family in Cucurbitaceae and the novel function of ClNf-YB9 in regulating seed development in watermelon.

关键词： Watermelon Nf-Y gene family Evolution relationship ClNf-YB9 gene function Seed development

Creation of a watermelon haploid inducer line via ClDMP3-mediated single fertilization of the central cell

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Horticulture Research 2023年第6期10卷 312-321页

作者： Xiner Chen Yuxiu Li Gongli Ai Jinfan Chen Dalong Guo Zhonghou Zhu Xuejie Zhu Shujuan Tian Jiafa Wang man Liu Li Yuan State Key Laboratory of Crop Stress Biology for Arid Areas College of HorticultureNorthwest A&F UniversityYangling712100ShanxiChina College of Horticulture and Plant Protection Henan University of Science and Technology 471000LuoyangChina Luoyang Nongfa Agricultural Technology Co. LTD471100LuoyangChina Shenzhen Research Institute Northwest A&F UniversityShenzhen518000GuangdongChina

The use of doubled haploids is one of the most efficient breeding methods in modern *** of pollen grains has been shown to induce haploids in cucurbit crops,possibly because it causes preferential fertilization of the central cell over the egg *** of the DMP gene is known to induce single fertilization of the central cell,which can lead to the formation of *** the present study,a detailed method of creating a watermelon haploid inducer line via ClDMP3 mutation is *** cldmp3 mutant induced haploids in multiple watermelon genotypes at rates of up to 1.12%.These haploids were confirmed via fluorescent markers,flow cytometry,molecular markers,and *** haploid inducer created by this method has the potential to greatly advance watermelon breeding in the future.

关键词： breeding crops fir

Genetic associations with adverse events from anti-tumor necrosis factor therapy in inflammatory bowel disease patients

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World Journal of Gastroenterology 2017年第40期23卷 7265-7273页

作者： Daniel Lew Soon man Yoon Xiaofei Yan Lori Robbins Talin Haritunians Zhenqiu Liu Dalin Li Dermot PB McGovern Department of Medicine Cedars-Sinai Medical Center f. Widjaja foundation Inflammatory Bowel and Immunobiology Research Institute Cedars-Sinai Medical Center Department of Gastroenterology Cedars-Sinai Medical Center

AIM To study the type and frequency of adverse events associated with anti-tumor necrosis factor(TNf)therapy and evaluate for any serologic and genetic *** This study was a retrospective review of patients attending the inflammatory bowel disease(IBD) centers at Cedars-Sinai IBD Center from 2005-2016. Adverse events were identified via chart review. IBD serologies were measured by ELISA. DNA samples were genotyped at Cedars-Sinai using Illumina Infinium Immunochipv1 array per man.facturer's protocol. SNPs underwent methodological review and were evaluated using several SNP statistic parameters to ensure optimal allele-calling. Standard and rigorous QC criteria were applied to the genetic data, which was generated using immunochip. Genetic association was assessed by logistic regression after correcting for population *** Altogether we identified 1258 IBD subjects exposed to anti-TNf agents in whom Immunochip data were available. 269/1258 patients(21%) were found to have adverse events to an anti-TNf-α agent that required the therapy to be discontinued. 25% of women compared to 17% of men experienced an adverse event. All adverse events resolved after discontinuing the antiTNf agent. In total: n = 66(5%) infusion reactions; n = 49(4%) allergic/serum sickness reactions; n = 19(1.5%) lupus-like reactions, n = 52(4%) rash, n = 18(1.4%) infections. In Crohn's disease, Ig A ASCA(P = 0.04) and Ig G-ASCA(P = 0.02) levels were also lower in patients with any adverse events, and anti-I2 level in ulcerative colitis was significantly associated with infusion reactions(P = 0.008). The logistic regression/human annotation and network analyses performed on the Immunochip data implicated the following five signaling pathways: JAK-STAT(Janus Kinase-signal transducer and activator of transcription), measles, IBD, cytokine-cytokine receptor interaction, and toxoplasmosis for any adverse event. CONCLUSION Our study shows 1 in 5 IBD patients experience an

关键词： Genetic associations Inflammatory bowel disease Anti-tumor necrosis factor Adverse events

Li_(2)NiSe_(2):A new-type intrinsic two-dimensional ferromagnetic semiconductor above 200 K

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Chinese Physics B 2023年第3期32卷 502-508页

作者：肖丽蔓杨焕成卢仲毅 Department of Physics and Beijing Key Laboratory of Opto-electronic functional Materials Micro-nano Devices Renmin University of ChinaBeijing 100872China

By using first-principles electronic structure calculations,we propose a two-dimensional ferromagnetic semiconductor Li_(2)NiSe_(2)with a Curie temperature above 200 *** structure of monolayer Li_(2)NiSe_(2)is dynamically stable,which is derived from the synthesized prototype compound Li_(2)Ni O_(2)and can be denoted as Li-decorated 1T-type NiSe_(2).The Ni–Se–Ni ferromagnetic superexchange dominates the magnetic couplings between the Ni atoms,which can be understood in the frame of the Goodenough–Kanamori–Anderson(GKA)*** systematic study of monolayer Li_(2)NiSe_(2)enables its promising applications in spintronics and suggests a new choice to design two-dimensional ferromagnetic semiconductors.

关键词： two-dimensional ferromagnetic semiconductor ferromagnetic superexchange first-principles calculations

带有多个Dirichlet特征和加法特征的Menon-Sury恒等式

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数学学报（中文版） 2019年第6期62卷 949-958页

作者：陈曼华南理工大学数学学院

本文研究了同时带有多个Dirichlet特征和多个加法特征的Menon-Sury恒等式,给出了下列求和的明确表达式∑gcd(a1-1,…,as-1,b1,…,br,n)χ1(a1)…χs(as)λ1(b1)…λr(br),其中n是一个正整数,s,r为非负整数,Zn*是环Zn=Z/nZ的单位群,gcd(,)表示最大公因子,χi(1≤i≤s)是模n的导子为di的Dirichlet特征,λj(1≤j≤r)是Zn的加法特征.从有限交换群上的fourier分析的角度看,我们的结果给出了这个算术函数f(a1,…,as,b1,…,br)=gcd(a1-1,…,as-1,b1,…,br,n)在交换群(Zn*)s×(Zn)r上的fourier展开的系数的明确表达式.

关键词： Menon-Sury恒等式 Dirichlet特征加法特征中国剩余定理