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中国生理学会第24届全国会员代表大会暨生理学学术大会

作者： Xiaoyan Zhang shizheng huang Youfei Guan AstraZeneca-Shenzhen University Joint Institute of Nephrology

＜正＞Renal collecting ducts play an essential role in water and sodium homeostasis under the regulation of antidiuretic hormone and *** evidence suggests other mechanisms may also be involved in regulating collecting duct *** Farnesoid X receptor（FXR）is a ligand-activated transcription factor belonging to the nuclear receptor *** is mainly expressed in the liver and small intestine,where it plays an important role in bile acid,lipid and glucose

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研发投入、专利与经营绩效实证研究:以台湾为例

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科技进步与对策 2015年第2期32卷 53-58页

作者：黄世政 "国立中山大学"企业管理学系中国台湾80424

世界各国将研发作为可持续发展驱动力,以研发投入作为创新政策工具之一,并将专利产出作为评估指标。基于台湾新竹科学园区6大产业1989-2012年经营绩效、研发投入、专利数和投资金额数据,运用回归分析方法探讨了研发投入、专利与经营绩... 详细信息

世界各国将研发作为可持续发展驱动力,以研发投入作为创新政策工具之一,并将专利产出作为评估指标。基于台湾新竹科学园区6大产业1989-2012年经营绩效、研发投入、专利数和投资金额数据,运用回归分析方法探讨了研发投入、专利与经营绩效之间的关系与影响。结果显示,政府研发投入与企业经营绩效正相关;研发投入与专利数正相关,但专利件数与经营绩效相关性较弱;企业投资规模与园区经营绩效正相关。进一步验证了政府将研发投入作为创新政策工具的有效性,可为政府及企业制定研发创新政策提供参考。

关键词： R&D投入经营绩效企业规模科学园区

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Proteomic analysis of protein expression in lipid droplet of rat RMICs

Proteomic analysis of protein expression in lipid droplet of...

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2012国际生理学学术大会

作者： Wen Su Qifei Han shizheng huang Jialin Fu Department of Physiology ＆ Pathophysiology Peking University Health Science Center

＜正＞Basically,renomedullary interstitial cells（RMICs） are full of lipid droplets（LDs）,which have been thought to be the source of *** this study,proteomic analysis had been performed to investigate the protein profile in LDs of rat *** than 300 proteins had been identified,including some enzymes controlling arachidonic metabolism such as CYP4F6,CYP2E1 and CYP2A3,suggesting that LDs in RMICs are important places for eicosanoid *** difference in the morphology and protein profile of LDs in renal medulla of SHR（spontaneously hypertensive rat） and Wistar-Kyoto（WKY） rats were further *** microscopy revealed more LDs in renal medulla of SHR than in that of WKY *** analysis revealed 15 differently expressed proteins in renal medulla of SHR when compared with WKY *** blot further confirmed that the expression of clathrin and CYP4A3 were upregulated,whereas the expression of UBXD8 was downregulated in renal medulla LDs of *** conclusion,these preliminary results have suggested that LDs in RMICs are rich in many enzymes involving lipid metabolism and blood pressure *** further study the biological function of these proteins in LDs will shed light on the understanding of the mechanisms of high blood pressure.

关键词： lipid droplets proteomics RMICs

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Induction of Cytochrome P450 4A14 is associated with Angiotensin–induced Renal Fibrosis in Mice

Induction of Cytochrome P450 4A14 is associated with Angiote...

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中国生理学会第24届全国会员代表大会暨生理学学术大会

作者：周云枫 Min Gao shizheng huang Shiqi Ye Youfei Guan 深圳大学生理系

Angiotensin Ⅱ(Ang Ⅱ)plays an important role in the pathogenesis of hypertension and its associated cardiovascular and renal *** elucidate the molecular mechanism by which Ang Ⅱ induces renal damage,we determined expression profile of genes involved in arachidonic acid metabolism in the kidneys of mice receiving chronic Ang Ⅱ infusion for 14 *** P450 4A14(CYP4A14)was found to be significantly induced by Ang Ⅱ,which was associated with a marked increase in systolic blood pressure and ***-time PCR,Western blot and immunohistochemistry assays demonstrated that CYP4A14 expression was predominantly upregulated in the proximal tubules of Ang Ⅱ-infused *** production of the major CYP4A14 metabolite,20-hydroxyeicosatetraenoic acid(20-HETE),was also significantly increased in the Ang Ⅱ-treated *** to wild-type(WT)mice,CYP4A14-/-mice exhibited significantly lower levels of blood pressure and proteinuria following Ang Ⅱ *** Ⅱ infusion resulted in renal glomeruloscelerosis and tubulointerstitial fibrosis in WT mice,which was significantly attenuated in CYP4A14-/-***,renal collagen I levels were significantly lower in CYP4A14-/-mice than in WT mice following Ang Ⅱ ***,Ang Ⅱ-induced renal fibrosis was associated with elevated expression of renal proinflammatory genes including MCP-1,TNF-α,IL-1,IL-6 and F4/80,whose expression was significantly decreased in CYP4A14-/-***,treatment of proximal tubule cells(PTCs)with Ang Ⅱ significantly induced CYP4A14 expression and20-HETE *** Ang Ⅱ and 20-HETE treatment resulted in a marked increase in TGF-βand collagen *** addition,elevated CYP4A14 expression in Ang Ⅱ-treated PTCs was blocked by ERK,JNK and p38 ***,these findings suggest that Ang Ⅱ-mediated renal fibrosis may result from increased CYP4A14 expression and 20-HETE ***4A14 could represent a useful target for the treatment of Ang Ⅱ-elici

关键词： CYP4A14 renal fibrosis angiotensin Ⅱ

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Induction of Cytochrome P450 4A14 is associated with Angiotensin Ⅱ-induced Renal Fibrosis in Mice

Induction of Cytochrome P450 4A14 is associated with Angiote...

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脂质组学与脂蛋白的新功能——第十二届全国脂质与脂蛋白学术会议

作者： Yunfeng Zhou Min Gao shizheng huang Shiqi Ye Youfei Guan Department of Physiology ShenzhenUniversity Health Science Center

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Cytochrome P450 4A14 is Responsible for Renal Fibrosis Caused by Angiotensin Ⅱ in Mice

Cytochrome P450 4A14 is Responsible for Renal Fibrosis Cause...

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中国生理学会肾脏生理专业委员会第二届学术年会

作者：周云枫 Sha Li Min Gao shizheng huang Zhenwei Yu Youfei Guan Department of Physiology and Pathophysiology Peking University Health Science Center

＜正＞Angiotensin II（Ang II）plays an important role in the pathogenesis of hypertension and its associated cardiovascular and renal *** elucidate the molecular mechanism by which Ang II induces renal damage,we determined expression profile of genes involved in arachidonic acid metabolism in the kidneys of mice receiving chronic Ang II infusion for 14 days.

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Disruption of PGE2 receptor EP4 gene impairs urinary concentration via decreasing aquaporin-2 abundance and membrane targeting in the renal collecting duct

Disruption of PGE2 receptor EP4 gene impairs urinary concent...

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中国生理学会肾脏生理专业委员会第二届学术年会

作者： Xiao Jia Senfeng Zheng Shengnan Du Qifei Han shizheng huang Jihong Kang Youfei Guan Department of Physiology and Pathophysiology Peking University Health Science Center

＜正＞The antidiuretic hormone arginine vasopressin（AVP）is a primary regulator in urinary concentration by regulating aquaporin-2（AQP2）abundance and membrane targeting in the renal collecting *** addition to AVP,other factors may also play a role in water reabsorption in this renal tubule ***,evidence has been emerged suggesting that

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PGE2 receptor 3 subtype（EP3）regulates adipose metabolism in mice

PGE2 receptor 3 subtype（EP3）regulates adipose metabolism i...

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中国生理学会第24届全国会员代表大会暨生理学学术大会

作者：徐虎 Yifei Miao Sha Li Jialin Fu shizheng huang Shengnan Du Jia Liu Xiaoyan Zhang Youfei Guan 北京大学 Department of Physiology and Pathophysiology Peking University Health Science Center Astra Zeneca-Shenzhen University Joint Institute of Nephrology Shenzhen University Health Science Center

Preadipocyte and adipocyte are two major cell types that exist in white adipose tissue（WAT）.The differentiation of preadipocyte increases the number of mature adipocyte and governs fat ***（TG）in adipose tissue is the main energy storage form in *** breakdown of TG,termed lipolysis,in adipocyte produces glycerol and free fatty acid（FFA）,which is released to circulatory system to supply energy for various *** imbalance of adipogenesis and adipocyte lipolysis and hypertrophy in WAT account for the development of obesity under over-nutrition *** development of obesity also depends on the function of brown adipose tissue（BAT）.Prostaglandin E2（PGE2）is the predominant prostaglandin produced in adipose tissue and plays an important role in the regulation of adipose tissue functions through its four receptors,i.e.,EP1,EP2,EP3,and *** study showed that the EP3 receptor deficient mice exhibited increased night eating frequency and developed obesity and insulin ***,the underlying mechanism remains *** aimed to investigate the impact of EP3 receptor on both WAT and BAT functions and its contribution to the development of *** demonstrated that global EP3 receptor gene deficiency in mice（EP3-/-）resulted in reduced locomotion,increased food intake and spontaneous obesity,with an enhanced ***3-/-mice also exhibited increased adipocyte size,WAT mass and body weight,mainly due to enhanced preadipocyte ***,the lipolysis process was also activated in the WAT of EP3-/-mice via the stimulation of the c AMP/protein kinase A（PKA）/hormone sensitive lipase（HSL）pathway,which promoted excessive lipid ectopic deposition in liver and mild insulin *** the condition of 24h fasting,EP3-/-mice displayed higher serum glycerol level but less lipid deposition in liver than that in EP3+/+*** also found that EP3-/-mice exhibited more BAT content and lower respiratory quotient（R

关键词： PGE2 receptor 3 subtype adipose lipogenesis lipolysis

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基于外部绿色压力的农业碳减排行为研究

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华东经济管理 2024年第3期38卷 74-83页

作者：柯春媛黄世政澳门城市大学商学院中国澳门999078 南宁师范大学经济与管理学院广西南宁530001

农业“双碳”目标的实现需要新型农业经营主体参与碳减排。文章基于PSR模型,探讨农业碳减排行为的前因后果、交互作用、生成机理,并验证高层环境认知的调节效果。研究以问卷调查方式收集广东省新型农业经营主体的284份数据样本,采用结... 详细信息

农业“双碳”目标的实现需要新型农业经营主体参与碳减排。文章基于PSR模型,探讨农业碳减排行为的前因后果、交互作用、生成机理,并验证高层环境认知的调节效果。研究以问卷调查方式收集广东省新型农业经营主体的284份数据样本,采用结构方程式进行分析验证。研究发现:政府压力、市场压力、社会压力对新型农业经营主体的碳减排行为和意愿均具有显著正向影响,且对其碳减排意愿具有中介作用;高层环境认知在市场压力、社会压力与碳减排意愿间的调节作用显著,但对政府压力与碳减排意愿间的调节效果不显著。新型农业经营主体应借助于市场压力、社会压力和政府压力推进碳减排行为,实现可持续发展。

关键词：低碳生产行为新型农业经营主体政府压力市场压力社会压力高层环境认知

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深基坑支护设计探究及实例分析

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江西建材 2023年第6期 160-161,164页

作者：黄世政甘肃省水利水电勘测设计研究院有限责任公司甘肃兰州730000

文中从支护设计的角度出发,详细介绍了深基坑支护的设计思路和方法,并对实际支护情况进行了分析,阐述了大型深基坑的特点,并结合实例,总结了该基坑支护设计的创新之处,以供参考。

关键词：深基坑支护设计项目创新

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