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药学与临床研究 2022年第2期30卷 127-130页

作者：俞平文诗雨赵杨房秋晨陈相龙曾女金李悦陆超孙鲁宁王永庆南京市溧水人民医院南京211200 南京医科大学第一附属医院临床药理研究室南京210029 南京医科大学药学院南京211166 江苏省妇幼保健院儿科南京210036

目的:建立HILIC-MS/MS法测定对使用咖啡因治疗呼吸暂停的早产儿血浆中的咖啡因浓度。方法:以13C3-咖啡因为内标;色谱柱:Atlantis^(■)HILIC Silica(2.1 mm×150 mm,3μm);流动相:5 mmol·L^(-1)甲酸铵水溶液(含0.1%甲酸)和乙腈(梯度洗... 详细信息

目的:建立HILIC-MS/MS法测定对使用咖啡因治疗呼吸暂停的早产儿血浆中的咖啡因浓度。方法:以13C3-咖啡因为内标;色谱柱:Atlantis^(■)HILIC Silica(2.1 mm×150 mm,3μm);流动相:5 mmol·L^(-1)甲酸铵水溶液(含0.1%甲酸)和乙腈(梯度洗脱);流速:0.3 mL·min^(-1);进样量:1.0μL。采用电喷雾离子化,正离子模式,多反应监测扫描测定。结果:本法测定咖啡因在0.0500~50.0μg·mL^(-1)范围线性关系良好;批内、批间准确度和精密度均<15.0%;提取回收率为89.7%~92.1%;无明显基质效应和残留效应。结论:本方法快速、灵敏,可准确测定早产儿微量血样中的咖啡因浓度。

关键词： HILIC-MS/MS 早产儿呼吸暂停咖啡因

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基于TGF-β-Smad通路探讨壮骨止痛方对绝经后骨质疏松症的治疗

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湖南中医药大学学报 2016年第7期36卷 31-34页

作者：刘平安戴瑜娉孟小莎柳诗雨高凡张国民湖南中医药大学湖南长沙410208

目的探究壮骨止痛方能否通过TGF-β-Smad通路治疗绝经后骨质疏松症,并探索其作用机制。方法60只雌性大鼠随机分为空白对照组、假手术组、模型组和壮骨止痛方组并提取相应含药血清,提取培养原代成骨细胞并添加相应的含药血清继续培养,先... 详细信息

目的探究壮骨止痛方能否通过TGF-β-Smad通路治疗绝经后骨质疏松症,并探索其作用机制。方法60只雌性大鼠随机分为空白对照组、假手术组、模型组和壮骨止痛方组并提取相应含药血清,提取培养原代成骨细胞并添加相应的含药血清继续培养,先后进行碱性磷酸酶、茜素红染色、免疫组化等一系列的指标检测。结果见大量被染成了蓝紫色的成骨细胞以及橘红色钙化结节;TGF-β、Smad蛋白在壮骨止痛方组中表达水平明显高于空白对照组和假手术组,模型组中的蛋白表达水平最低,具有统计学意义(P<0.05)。结论壮骨止痛方可以通过TGF-β-Smad信号转导通路治疗绝经后骨质疏松症并可大量提高该通路的表达水平。

关键词：绝经后骨质疏松症 TGF-β-Smad 壮骨止痛方

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A novel evaluation method for the synchronicity of drug release based on the mathematics set for preparation of a TCM drug delivery system

A novel evaluation method for the synchronicity of drug rele...

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2012年中国药学大会暨第十二届中国药师周

作者： Lan SHEN 1,2,Yu ZHAI 1,Wenjuan CONG 2,Xiao LIN 1,2,shiyu MA 1,Yi FENG 2,Kefeng RUAN 2 1 School of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,P.R.China 2 Engineering Research Center of Modern Preparation Technology of Traditional Chinese medicine of Ministry of Education,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,P.R. China.

The quantitative characterization and evaluation of the synchronization of multi component release behavior are urgently needed to solve bottlenecks in multicomponent release kinetics and the quality control of traditional Chinese medicine （TCM）.Existing research of TCM drug delivery systems （TCMDDS） has been confined to studying the release characteristics of a single or a few components,but the correlation of active ingredients and efficacy is not ***,the reported evaluation method is too macroscopic,and unable to specifically identify the components which caused the integral *** a result,this evaluation method cannot provide a valid foundation for the design of *** this paper,a novel evaluation method for the synchronicity of drug release based on the mathematics set for TCMDDS has been *** fang was selected as the model drug and this new evaluation method utilized to guide the optimization of the release unit types and the dose ratio of Fuzhenghuayu *** method was shown to be highly sensitive,stable and reproducible,providing a quantitative assessment of drug release characteristics of multicomponent ***,it may guide the optimal combination of release units,thus providing a basis for the construction of a scientific TCMDDS.

关键词： mathematics set evaluation method of the synchronicity fingerprint chromatography traditional Chinese medicine drug delivery system

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi Ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH University of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui University HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu University Institute of ScienceVaranasi Bandirma Onyedi Eylul University Bandirma Beihang University Beijing Beijing Computational Science Research Center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal University Beijing Brown University ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad University Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo University Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central China Normal University WuhanHubei Central South University ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan China academy of engineering physics MianyangSichuan China building materials academy Beijing China Center of Advanced Science and Technology Beijing China Institute of Atomic Energy Beijing China Jiliang University HangzhouZhejiang China Nuclear Instrument CO. LTDBeijing China University of Geosciences Beijing China University of Geosciences WuhanHubei China University of Mining and Technology XuzhouJiangsu China West Normal University NanchongSichuan Chongqing University Department of PhysicsChongqing Chulalongkorn University Bangkok City University of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell University IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu University DalianLiaoning Dalian University of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East China University Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by China,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV Linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The Linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2)s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2015)and the Conceptual Design Report(CDR,2018),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

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