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Chinese Journal of Chemistry 2024年第2期42卷 157-163页

作者： Weicai Li Lu Tan Yijun Chen Rui Liu Zhongyu Qi shixuan yuan Zhanwen Huang Siping Wei Xi Du Dong Yi Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province School of PharmacySouthwest Medical UniversityLuzhouSichuan 646000China Department of Chemistry School of Basic Medical ScienceSouthwest Medical UniversityLuzhouSichuan 646000China Department of Pharmacy Affiliated HospitalSouthwest Medical UniversityLuzhouSichuan 646000China

Tetralin-1-carboxamides are frequently incorporated in myriad medicinally important ***,their existing synthetic routes not only suffer from some drawbacks such as tedious procedures,harsh reaction conditions,narrow substrate scope,low yields,and environmental problems,but are also based upon the elaboration of uneasily available non-linear tetralin ***,we describe a metal-and additive-free visible light-induced[4+2]annulation of two simple linear starting materials,namely acrylamides and 2-benzyl-2-bromocarbonyls,through a cascade C(sp^(3))-Br/C(sp^(2))-H bond cleavage,double C-C bond formation,and aromatization *** developed protocol provides a convenient,efficient,and green approach to a variety of tetralin-1-carboxamide derivatives with good functional group ***,the resulting products could also undergo the Licl-mediated mono-decarboxylative cyclization process to further furnish the architecturally novel bridged polycyclic imides with excellentcis-diastereoselectivities.

关键词： Annulation Metal-free Photoredox catalysis Tetralin-1-carboxamide Cyclic imides Synthetic methods C-C coupling Radical reactions Reaction mechanisms

Correlation of Twist upregulation and senescence bypass during the progression and metastasis of cervical cancer

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Frontiers of Medicine 2014年第1期8卷 106-112页

作者： Tian Wang Yan Li Abidan Tuerhanjiang Wenwen Wang Zhangying Wu Ming yuan shixuan Wang Department of Obstetrics and Gynecology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan430030 China

Cervical carcinoma is associated with high propensity for local invasion and lymph node metastasis. However, the molecular alterations that drive progression and metastasis of cervical cancer remain unclear. Cellular senescence has been proposed as the mechanism that protects an organism against cancer progression and metastasis. In addition, Twist, a basic helix-loop-helix transcription factor, has been suggested as an oncogene because it is overexpressed in many types of human cancer. This gene also exhibits a positive function in regulating invasion and metastasis. In this study, Twist was strongly and positively expressed in normal tissue, squamous cell carcinoma （SCC） IA-IIA, and SCC IIB-IIIB （4.3%, 44%, and 88.9%, respectively）. The strong positive expressions of the senescence marker CBX3 were 39.1%, 32%, and 15.6%, respectively. The strong positive expressions of Twist in the SCC groups with or without lymph node metastasis were 80.8% and 50%. For CBX3, such expressions were 7.7% and 29.5%, respectively. Results also showed that the expression of Twist was inversely correlated with that of CBX3. Moreover, the knockdown of Twist with target siRNA in SiHa triggered the induction of the chromatin marker of the cellular senescence CBX3 and senescence-associated p-galactosidase activity. Our results suggested that the expression of Twist increased during the progression and metastasis of cervical cancer. Furthermore, Twist-induced senescence bypass is important in this process.

关键词： cervical cancer senescence Twist CBX3 lymph node metastasis

部分ESCRT亚基通过调控STING的降解调节其活性

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Science Bulletin 2024年第8期69卷 1000-1005页

作者：赵远周晨暄田文敏陈杨赵冲冲栗妍王世宣荣岳光 School of Basic Medicine Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious DiseaseHuazhong University of Science and TechnologyWuhan 430030China Center for Precision Medicine Multi-Omics Research Peking University Health Science CenterPeking UniversityBeijing 100191China School of Basic Medical Sciences Peking University Health Science CenterPeking UniversityBeijing 100083China The State Key Laboratory of Membrane Biology Tsinghua University-Peking University Joint Center for Life SciencesSchool of Life SciencesTsinghua UniversityBeijing 100084China The HIT Center for Life Sciences Harbin Institute of TechnologyHarbin 150080China Department of Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Cell Architecture Research Center Huazhong University of Science and TechnologyWuhan 430030China

Stimulator of interferon genes(STING),also known as MITA,ERIS,MPYS or TMEM173,is a key player in innate immunity,specifically in the typeⅠinterferon response[1-3].It is also involved in a range of non-canonical biological functions,including autophagy,cellular metabolism,translation,and DNA repair,and has implications in many diseases[4-9].After activation by its ligands,STING translocates from endoplasmic reticulum(ER),via ERGIC,Golgi apparatus and endosomes,finally to lysosomes for degradation[4-9].However,the mechanisms by which STING is delivered to lysosomes and whether this delivery process regulates STING activity remain elusive.

关键词： has finally immunity

2型糖尿病合并非酒精性脂肪性肝病患者肠道菌群的特征分析

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中华临床营养杂志 2024年第2期32卷 80-89页

作者：高玉婷赵天奕刘诗璇律娜袁涛高俊祥朱宝利赵维纲中国医学科学院、北京协和医学院、北京协和医院内分泌科国家卫生健康委员会内分泌重点实验室北京100730 中日友好医院体检科北京100029 中日友好医院病理科北京100029 中国医学科学院、微生物研究所北京100101

目的探讨2型糖尿病(type 2 diabetes mellitus,T2DM)合并非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)患者肠道菌群的特征。方法纳入2021年4月至2023年10月于北京协和医院内分泌科首次诊断为T2DM的患者74例,其中合并NA... 详细信息

目的探讨2型糖尿病(type 2 diabetes mellitus,T2DM)合并非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)患者肠道菌群的特征。方法纳入2021年4月至2023年10月于北京协和医院内分泌科首次诊断为T2DM的患者74例,其中合并NAFLD者28例(T2DM合并NAFLD组);未合并NAFLD者46例(T2DM组),同时匹配健康对照者51例(对照组)。收集研究对象的临床化验指标及粪便,进行16S rRNA测序,比较各组间肠道菌群的差异。结果相较于T2DM组,T2DM合并NAFLD组患者年龄更小,胰岛素抵抗指数、体重指数及甘油三酯更高。T2DM合并NAFLD组、T2DM组和对照组的α多样性差异无统计学意义(P>0.05),但β多样性差异有统计学意义(P=0.03)。产粪甾醇真杆菌属、梭状链杆菌属、副萨特氏菌属和Tyzzerella 3在T2DM合并NAFLD组富集,而解黄酮菌属水平下降。Tyzzerella 3与甘油三酯和白蛋白的水平呈正相关,与高密度脂蛋白胆固醇水平呈负相关。结论T2DM合并NAFLD的患者菌群结构及特定菌属显著改变,解黄酮菌属可能为T2DM合并NAFLD的保护因素。

关键词： 2型糖尿病非酒精性脂肪性肝病肠道菌群

Sputtered Stainless Steel on Silicon Photoanode for Stable Seawater Splitting in Photoelectrochemical Flow Cell

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Transactions of Tianjin University 2023年第6期29卷 473-481页

作者： shixuan Zhao Bin Liu Gong Zhang Qingzhen Wang yuan Cai Yuting Tong Shujie Wang Peng Zhang Tuo Wang Jinlong Gong School of Chemical Engineering and Technology Key Laboratory for Green Chemical Technology of Ministry of EducationTianjin UniversityTianjin 300072China Collaborative Innovation Center of Chemical Science and Engineering(Tianjin) Tianjin 300072China Haihe Laboratory of Sustainable Chemical Transformations Tianjin 300192China National Industry-Education Platform of Energy Storage Tianjin 300350China Joint School of National University of Singapore and Tianjin University International Campus of Tianjin UniversityBinhai New CityFuzhou 350207China

Photoelectrochemical(PEC)seawater splitting is a promising method for the direct utilization of solar energy and abundant seawater resources for hydrogen *** are susceptible to various ions in seawater and complicated competitive reactions,resulting in the failure of *** paper proposes the design and fabrication of diff erent sputtered stainless steel(SS)fi lms deposited on silicon photoanodes,completely isolating the electrolytes and semiconductor *** coupling with the PEC flow cell,the back-illuminated photoanode coated with 316 SS cocatalyst achieves stable operation for 70 h in natural seawater with a highly alkaline KOH(30 wt.%,7.64 mol/L)electrolyte due to the remarkable protection eff ect of the substrate from stainless steel,while the PEC seawater splitting system achieves a record hydrogen production rate of 600μmol/(h·cm^(2)).An appropriate Ni/Fe ratio in the SS ensures remarkable oxygen evolution activity,while chromic oxide ensures the effective anticorrosion effect by adjusting the microenvironment of the ***,fabricating PEC flow cells with photoanodes coated with SS cocatalysts are a viable strategy for PEC seawater splitting.

关键词： Flow cell Seawater splitting Stainless steel Chloridion Photoelectrochemical

2021-2022年浙江省义乌市和河南省永城市健康人群百日咳抗体水平调查

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中国预防医学杂志 2024年第3期25卷 279-282页

作者：蔡世轩李杰代函鹰朱瑶姬艳芳周倩倩骆淑英邵祝军高源南京医科大学公共卫生学院江苏南京210000 中国疾病预防控制中心传染病预防控制所浙江省疾病预防控制中心河南省疾病预防控制中心永城市疾病预防控制中心义乌市疾病预防控制中心

目的调查2021-2022年浙江省义乌市和河南省永城市≥3岁健康人群百日咳抗体水平,评价人群百日咳免疫状况。方法采用多阶段分层随机抽样法采集两地社区≥3岁的健康人血液样本,采用酶联免疫吸附试验(enzyme linked immunosorbent assay,E... 详细信息

目的调查2021-2022年浙江省义乌市和河南省永城市≥3岁健康人群百日咳抗体水平,评价人群百日咳免疫状况。方法采用多阶段分层随机抽样法采集两地社区≥3岁的健康人血液样本,采用酶联免疫吸附试验(enzyme linked immunosorbent assay,ELISA)方法检测血清百日咳毒素IgG抗体(pertussis toxin IgG,PTIgG)。研究不同年龄组、地区、性别之间抗体浓度的差异。结果浙江省义乌市和河南省永城市抗体几何平均浓度(geometricmean concentration,GMC)分别为3.79和12.48 IU/ml,两地抗体水平差异有统计学意义(U=907 430,P<0.01)。两地既往及近期感染率(4.88%、4.01%)差异无统计学意义(χ^(2)=0.832,P=0.362)。义乌市≥20岁成人和3~<20岁人群之间的既往及近期感染率(5.87%vs. 4.18%)差异无统计学意义(χ^(2)=2.506,P=0.113),永城市≥20岁成人的既往及近期感染率高于3~<20岁人群(9.76%vs. 1.50%),差异有统计学意义(χ^(2)=25.259, P<0.01)。义乌市既往感染率和近期感染率最高的年龄组分别为≥65岁组(8.33%)、7~<15岁(2.04%),永城市既往感染率和近期感染率最高的年龄组均为≥65岁组(12.50%、12.50%)。义乌市和永城市估计百日咳感染率分别为6.67%和6.48%。结论浙江省义乌市和河南省永城市健康人群百日咳感染率较高,永城市成年人抗体水平既往及近期感染率高于儿童及青少年组,可能存在接受疫苗免疫的人群仍然感染百日咳的现象,需进一步加强监测,优化免疫策略。

关键词：百日咳百日咳毒素IgG抗体健康人群血清学流行病学调查

Impurity-induced formation of bilayered graphene on copper by chemical vapor deposition

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Nano Research 2016年第9期9卷 2803-2810页

作者： Jun Li Jianing Zhuang Chengmin Shen yuan Tian Yande Que Ruisong Ma Jinbo Pan Yanfang Zhang Yeliang Wang shixuan Du Feng Ding Hong-Jun Gao Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Institute of Textiles and Clothing Hong Kong Polytechnic UniversityKowloonHong KongChina Beijing Key Laboratory for Nanomaterials and Nanodevices Beijing 100190China

High-quality single-layered and bilayered graphene (SLG and BLG) was synthesized on copper foil surfaces by controllable chemical vapor deposition (CVD). Impurity nanoparticles formed on the copper foil surface by hightemperature annealing were found to play a crucial role in the growth of BLG. Analysis of energy-dispersive spectrometry (EDS) data indicated that these nanoparticles consisted of silicon and aluminum. According to the inverted wedding cake model, these nanoparticles served as nucleation centers for BLG growth and the free space between a nanoparticle and graphene served as the center of C injection for the continuous growth of the adlayer beneath the top layer. By combining phase-field theory simulations, we confirmed the mechanism of BLG growth and revealed more details about it in comparison with SLG growth. For the first time, this study led to a complete understanding of the BLG growth mechanism from nucleation to continuous growth in the CVD process, and it has opened a door to the thickness-controllable synthesis of graphene. [Figure not available: see fulltext.] © 2016, Tsinghua University Press and Springer-Verlag Berlin Heidelberg.

关键词： graphene chemical vapor deposition (CVD) bilayer growth mechanism

The composite phenotype analysis identifies potential concerted responses of physiological systems to high altitude exposure

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National Science Review 2023年第5期10卷 109-111页

作者： Yi Li Meng Hao Zixin Hu Yanyun Ma Kun Wang Xiaoyu Liu Xianhong Yin Menghan Zhang Yi Wang Meng Liang yuan Guo Lei Bao shixuan Zhang Shiguan Le Chenyuan Wu Dayan Sun Yang Wei Fei Wu Rui Zhang Lingxian Zhu Hui Zhang Shuai Jiang Xingdong Chen Xiaofeng Wang Yao Zhang Longli Kang Wenyuan Duan Bin Qiao Jiucun Wang Li Jin State Key Laboratory of Genetic Engineering Collaborative Innovation Center for Genetics and DevelopmentSchool of Life Sciences and Human Phenome InstituteFudan University Institute for Six-sector Economy Fudan University International Human Phenome Institutes Ministry of Education Key Laboratory of Contemporary Anthropology Department of Anthropology and Human GeneticsSchool of Life SciencesFudan University Greater Bay Area Institute of Precision Medicine(Guangzhou) School of Life SciencesFudan University Artificial Intelligence Innovation and Incubation Institute Fudan University Shanghai Pudong Hospital Fudan University Pudong Medical Center Fudan-Taizhou Institute of Health Sciences Key Laboratory of High-Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region School of MedicineXizang Minzu University Institute of Cardiovascular Disease Shandong Provincial Western Hospital Research Unit of Dissecting the Population Genetics and Developing New Technologies for Treatment and Prevention of Skin Phenotypes and Dermatological Diseases (2019RU058) Chinese Academy of Medical Sciences

Environmental stresses,such as temperature,disease and altitude could induce systematic changes of biological systems which manifests as concerted responses across multiple systems within a certain period of time[1].High altitude acclimatization (HAA) refers to a series of adaptive physiological responses to hypoxic *** these processes,

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基于吸引子SVD降噪的改进EMD法

振动．测试与诊断 2010年第3期30卷 325-329页

作者：苑宇李宝良姚世选大连交通大学机械工程学院大连116028

基于经验模式分解(empirical mode decomposition,简称EMD)分解出的基本模式分量往往会因为原始数据中的一些异常数据和高频噪声而丧失明确的物理意义。因此,提出了一种基于系统重构吸引子奇异值分解(singular value decomposition,简称... 详细信息

基于经验模式分解(empirical mode decomposition,简称EMD)分解出的基本模式分量往往会因为原始数据中的一些异常数据和高频噪声而丧失明确的物理意义。因此,提出了一种基于系统重构吸引子奇异值分解(singular value decomposition,简称SVD)降噪的EMD分解方法。在改进方法中,原始信号经SVD降噪后分解出了原信号中的有用成分和冗余成分,对有用成分进行EMD分解可以减少原信号中冗余成分对EMD分解能力的干扰,提高EMD分解能力,使得分解出的基本模式分量更加具有实际意义,更加有利于特征的提取。

关键词：吸引子奇异值分解基于经验的模式分解基本模式分量

Real- and momentum-indirect neutral and charged excitons in a multi-valley semiconductor

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National Science Open 2023年第4期2卷 76-85页

作者： Zhiheng Huang Yuhui Li Tao Bo Yanchong Zhao Fanfan Wu Lu Li Yalong yuan Yiru Ji Le Liu Jinpeng Tian Yanbang Chu Xiaozhou Zan Yalin Peng Xiuzhen Li Yangkun Zhang Kenji Watanabe Takashi Taniguchi Zhipei Sun Wei Yang Dongxia Shi shixuan Du Luojun Du Guangyu Zhang Beijing National Laboratory for Condensed Matter Physics Key Laboratory for Nanoscale Physics and DevicesInstitute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100190China Ningbo Institute of Materials Technology&Engineering Chinese Academy of SciencesNingbo 315201China Research Center for Functional Materials National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan International Center for Materials Nanoarchitectonics National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan Department of Electronics and Nanoengineering Aalto UniversityTietotie 3Espoo FI-02150Finland Quantum Technology Finland(QTF)Centre of Excellence Department of Applied PhysicsAalto UniversityAalto FI-00076Finland Beijing Key Laboratory for Nanomaterials and Nanodevices Beijing 100190China Songshan Lake Materials Laboratory Dongguan 523808China

Excitons dominate the photonic and optoelectronic properties of a *** significant advancements exist in understanding various types of excitons,progress on excitons that are indirect in both real-and momentum-spaces is still ***,we demonstrate the real-and momentum-indirect neutral and charged excitons(including their phonon replicas)in a multi-valley semiconductor of bilayer MoS_(2),by performing electric-field/doping-density dependent *** with first-principles calculations,we uncover that the observed real-and momentum-indirect exciton involves electron/hole from K/Γvalley,solving the longstanding controversy of its momentum ***,the binding energy of real-and momentum-indirect charged exciton is extremely large(i.e.,~59 meV),more than twice that of real-and momentum-direct charged exciton(i.e.,~24 meV).The giant binding energy,along with the electrical tunability and long lifetime,endows real-and momentum-indirect excitons an emerging platform to study many-body physics and to illuminate developments in photonics and optoelectronics.

关键词： excitons real-and momentum-indirect exciton giant binding energy electrical tunability multi-valley semiconductor