The composite phenotype analysis identifies potential concerted responses of physiological systems to high altitude exposure

作     者：Yi Li Meng Hao Zixin Hu Yanyun Ma Kun Wang Xiaoyu Liu Xianhong Yin Menghan Zhang Yi Wang Meng Liang Yuan Guo Lei Bao Shixuan Zhang Shiguan Le Chenyuan Wu Dayan Sun Yang Wei Fei Wu Rui Zhang Lingxian Zhu Hui Zhang Shuai Jiang Xingdong Chen Xiaofeng Wang Yao Zhang Longli Kang Wenyuan Duan Bin Qiao Jiucun Wang Li Jin Yi Li;Meng Hao;Zixin Hu;Yanyun Ma;Kun Wang;Xiaoyu Liu;Xianhong Yin;Menghan Zhang;Yi Wang;Meng Liang;Yuan Guo;Lei Bao;Shixuan Zhang;Shiguan Le;Chenyuan Wu;Dayan Sun;Yang Wei;Fei Wu;Rui Zhang;Lingxian Zhu;Hui Zhang;Shuai Jiang;Xingdong Chen;Xiaofeng Wang;Yao Zhang;Longli Kang;Wenyuan Duan;Bin Qiao;Jiucun Wang;Li Jin

作者机构：State Key Laboratory of Genetic EngineeringCollaborative Innovation Center for Genetics and DevelopmentSchool of Life Sciences and Human Phenome InstituteFudan University Institute for Six-sector EconomyFudan University International Human Phenome Institutes Ministry of Education Key Laboratory of Contemporary AnthropologyDepartment of Anthropology and Human GeneticsSchool of Life SciencesFudan University Greater Bay Area Institute of Precision Medicine(Guangzhou)School of Life SciencesFudan University Artificial Intelligence Innovation and Incubation InstituteFudan University Shanghai Pudong HospitalFudan University Pudong Medical Center Fudan-Taizhou Institute of Health Sciences Key Laboratory of High-Altitude Environment and Genes Related to Diseases of Tibet Autonomous RegionSchool of MedicineXizang Minzu University Institute of Cardiovascular DiseaseShandong Provincial Western Hospital Research Unit of Dissecting the Population Genetics and Developing New Technologies for Treatment and Prevention of Skin Phenotypes and Dermatological Diseases (2019RU058)Chinese Academy of Medical Sciences 

出 版 物：《National Science Review》 (国家科学评论(英文版))

年 卷 期：2023年第10卷第5期

页      面：109-111页

核心收录：

学科分类：07[理学] 0713[理学-生态学] 

基　　金：supported by the National Natural Science Foundation of China (32288101,32200536 and 31521003) the Shanghai Municipal Science and Technology Major Project(2017SHZDZX01) the CAMS Innovation Fund for Medical Sciences (2019-I2M-5-066) the Major Project of Special Development Funds of Zhangjiang National Independent Innovation Demonstration Zone (ZJ2019-ZD-004) the Shanghai Sailing Program (23YF1430500) the111 Project (B13016) 

摘      要：Environmental stresses,such as temperature,disease and altitude could induce systematic changes of biological systems which manifests as concerted responses across multiple systems within a certain period of time[1].High altitude acclimatization (HAA) refers to a series of adaptive physiological responses to hypoxic *** these processes,