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铁路计算机应用 2014年第5期23卷 45-48页

作者：刘家良毕红军杨世武杨磊鲍才让泰北京交通大学电子信息工程学院北京100044 青藏铁路公司西宁810000

根据均匀传输线和四端网络理论,建立ZPW-2000无绝缘轨道电路分路电流的计算模型,利用MATLAB软件实现相邻区段干扰电流的数值算法,对轨道电路正常情况、调谐单元故障情况下邻区段干扰电流的分布进行仿真。

关键词：轨道电路相邻区段干扰仿真

Acetylated-PPARγexpression is regulated by different P53 genotypes associated with the adipogenic differentiation of polyploid giant cancer cells with daughter cells

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Cancer Biology & Medicine 2023年第1期20卷 56-76页

作者： Kexin Zhang Xiaohui yang Minying Zheng Yidi Ning shiwu Zhang Tianjin Union Medical Center Tianjin 300122China Nankai University School of Medicine Nankai UniversityTianjin 300071China

Objective:Polyploid giant cancer cells(PGCCs)with daughter cells express epithelial–mesenchymal transition(EMT)-associated *** malignant tumor cells with EMT properties can transdifferentiate into mature tumor *** this study,we elucidated the potential for,and underlying mechanism of,adipogenic differentiation of PGCCs with daughter cells(PDCs).Methods:Cobalt chloride was used to induce PGCC formation in HEY(wild-type P53)and MDA-MB-231(mutant P53)cells;these cells were then cultured in adipogenic differentiation *** red O staining was used to confirm adipogenic differentiation,and the cell cycle was detected with flow *** expression of adipogenic differentiation-associated proteins and P300 histone acetyltransferase activity were compared before and after adipogenic *** xenograft models were used to confirm the adipogenic differentiation of ***:PDCs transdifferentiated into functional *** different cell cycle distributions were observed in PDCs after adipogenic *** expression levels of PPARγ,Ace-PPARγ,and Ace-P53 were higher in PDCs after adipogenic differentiation than in cells before adipogenic ***-PPARγand FABP4 expression increased in HEY cells and decreased in MDA-MB-231 PDCs after p53 knockdown.A485 treatment increased Ace-P53,Ace-PPARγ,and FABP4 expression in HEY PDCs by inhibiting SUMOylation of *** MDA-MB-231 PDCs,A485 treatment decreased Ace-P53,Ace-PPARγ,and FABP4 *** experiments also confirmed the adipogenic differentiation of ***:Acetylation of P53 and PPARγplays an important role in the adipogenic differentiation of PDCs.

关键词： PGCCs adipogenic differentiation PPARγ post-translational modification P53 genotype

A Three-Dimensional Kinematics Analysis of a Koi Carp Pectoral Fin by Digital Image Processing

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Journal of Bionic Engineering 2013年第2期10卷 210-221页

作者： Lei Wang Min Xu Bo Liu Kin Huat Low Jie yang shiwu Zhang Department of Precision Machinery and Precision Instrumentation University of Science and Technology of China Hefei Anhui 230026 P. R. China School of Mechanical and Aerospace Engineering Nanyang Technological University Singapore 639798 Singapore

Pectoral fins fascinate researchers for their important role in fish maneuvers. By possessing a complicated flexible structure with several fin rays made by a thin film, the fin exhibits a three-dimensional （3D） motion. The complex 3D fin kinematics makes it challenging to study the performance of pectoral fin. Nevertheless, a detailed study on the 3D motion pattern of pectoral fins is necessary to the design and control ofa bio-inspired fin rays. Therefore, a highspeed photography system is introduced in this paper to study the 3D motion ofa Koi Carp by analyzing the two views of its pectoral fin simultaneously. The key motions of the pectoral fins are first captured in both hovering and retreating. Next, the 3D configuration of the pectoral fins is recon- structed by digital image processing, in which the movement of fin rays during fish retreating and hovering is obtained. Fur- thermore, the method of Singular Value Decomposition （SVD） is adopted to extract the basic motion patterns of pectoral fins from extensive image sequences, i.e. expansion, bending, cupping, and undulation. It is believed that the movement of the fin rays and the basic patterns of the pectoral fins obtained in the present work can provide a good foundation for the development and control of bionic flexible pectoral fins for underwater propeller.

关键词： highspeed photography Singular Value Decomposition (SVD) three-dimensional kinematics digital image proc-essing

四种非典型抗精神病药物对精神分裂症患者代谢综合征患病率的影响

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精神医学杂志 2010年第5期23卷 365-367页

作者：陶世武杨诚潘润德潘天伟李梁广西壮族自治区龙泉山医院精神科柳州545005

目的探讨4种非典型抗精神病药物对精神分裂症患者代谢综合征患病率的影响。方法符合入组标准的360例精神分裂症患者随机分成4组,于治疗前和治疗后进行相关测定和实验室检查,代谢综合征的诊断标准采用2004年中华医学会糖尿病分会代谢综... 详细信息

目的探讨4种非典型抗精神病药物对精神分裂症患者代谢综合征患病率的影响。方法符合入组标准的360例精神分裂症患者随机分成4组,于治疗前和治疗后进行相关测定和实验室检查,代谢综合征的诊断标准采用2004年中华医学会糖尿病分会代谢综合征标准。结果利培酮组、喹硫平组、阿立哌唑组和齐拉西酮组的代谢综合征患病率分别为18.9%、14.4%、10.0%和6.7%。其中利培酮组与齐拉西酮组比较差异有统计学意义(P<0.05)。女性的患病率均高于男性。结论非典型抗精神病药物中利培酮和喹硫平对代谢综合征患病率有明显影响,阿立哌唑和齐拉西酮对代谢综合征患病率影响较小。

关键词：非典型抗精神病药物精神分裂症代谢综合征患病率

Coverage Dependence of Charge Transfer Between Cs Overlayer and 5d Transition Metal Subtrates

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Chinese Physics Letters 1991年第1期8卷 25-28页

作者： GAO shiwu WANG Dingsheng Laboratory for Surface Physics Academia SinicaBeijing 100080

A recently developed embedded cluster scheme is applied to study the coverage dependence of charge transfer between Cs and the(001)surface of all 5d transition,metalsj which agrees with the jellium-slab model calculation given by the first principle band *** correlation between the initial drop of work function during cesiation caused by this charge transfer and the unfilled d band of the substrates is revealed.

关键词： method. Transition charge

Gait Study and Pattern Generation of a Starfish-Like Soft Robot with Flexible Rays Actuated by SMAs

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Journal of Bionic Engineering 2014年第3期11卷 400-411页

作者： Shixin Mao Erbao Dong Hu Jin Min Xu shiwu Zhang Jie yang Kin Huat Low Department of Precision Machinery and Precision Instrumentation University of Science and Technology of China Hefei 230026 P. R. China School of Mechanical and Aerospace Engineering Nanyang Technological University Singapore 639798 Singapore

This paper presents the design and development of a starfish-like soft robot with flexible rays and the implementation of multi-gait locomotion using Shape Memory Alloy （SMA） actuators. The design principle was inspired by the starfish, which possesses a remarkable symmetrical structure and soft internal skeleton. A soft robot body was constructed by using 3D printing technology. A kinematic model of the SMA spring was built and developed for motion control according to displacement and force requirements. The locomotion inspired from starfish was applied to the implementation of the multi-ray robot through the flexible actuation induced multi-gait movements in various environments. By virtue of the proposed ray control patterns in gait transition, the soft robot was able to cross over an obstacle approximately twice of its body height. Results also showed that the speed of the soft robot was 6.5 times faster on sand than on a clammy rough terrain. These experiments demonstrated that the bionic soft robot with flexible rays actuated by SMAs and multi-gait locomotion in proposed patterns can perform successfully and smoothly in various terrains.

关键词： soft robot bio-inspiration multi-gait locomotion rough terrains SMA actuators

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不同术式治疗婴儿食管裂孔疝的疗效分析

中华妇幼临床医学杂志（电子版） 2024年第1期20卷 25-31页

作者：马永钰杨仕武王舒钰陈君如曹辛洪伟罗忠明温瑷菡高云鹏陈健吴骏昆明市儿童医院心胸外科昆明650103 昆明医科大学公共卫生学院昆明650500

目的探讨腹腔镜下手术与开腹手术治疗婴儿食管裂孔疝(EHH)患儿的临床疗效。方法选择2017年1月至2023年9月于昆明市儿童医院采取手术治疗的46例EHH婴儿为研究对象。按照手术方法,将其分为开腹组(n=22,采取开腹EHH修补术+Nissen胃底折叠术... 详细信息

目的探讨腹腔镜下手术与开腹手术治疗婴儿食管裂孔疝(EHH)患儿的临床疗效。方法选择2017年1月至2023年9月于昆明市儿童医院采取手术治疗的46例EHH婴儿为研究对象。按照手术方法,将其分为开腹组(n=22,采取开腹EHH修补术+Nissen胃底折叠术)与腔镜组(n=24,采取腹腔镜下EHH修补术+Nissen胃底折叠术)。采用回顾性分析方法,收集2组患儿手术治疗情况及术后并发症发生率、EHH复发率等,并采用Mann-Whitney U检验与连续性校正χ2检验,或Fisher确切概率法进行统计学分析。本研究遵循的程序符合2013年修订的《世界医学协会赫尔辛基宣言》相关要求。患儿监护人对诊疗均知情同意,并签署临床研究知情同意书。结果对46例患儿均成功完成手术,无一例患儿死亡。腔镜组患儿手术中位时间为192.0 min(112.5 min,243.8 min),显著长于开腹组的97.5 min(81.0 min,120.0 min),术后开始经口进食中位时间为2.0 d(2.0 d,4.0 d),较开腹组的4.0 d(3.0 d,4.0 d)短,并且差异均有统计学意义(Z=-3.59,P0.05)。腔镜组术后,5例(20.8%)患儿发生EHH复发,术后并发症包括腹胀为1例(4.2%),呕吐为4例(16.7%),胃食管反流(GER)为3例(12.5%),消化道出血为2例(8.3%);再次手术修复EHH为1例(4.2%)。开腹组患儿术后腹胀、GER发生率均为4.5%(1/22)。2组患儿术后复发率与腹胀、呕吐、GER、消化道出血等并发症发生率和再手术率分别比较,差异均无统计学意义(P>0.05)。对42例患儿随访的平均时间为27.6个月(1~83个月)。随访过程中,开腹组1例患儿长期存在反酸、胸痛等GER症状;腔镜组术后5例EHH复发,其中4例通过保守治疗好转,1例因保守治疗效果不佳,经再次腹腔镜下EHH修补术后治愈。结论腹腔镜下EHH修补术+Nissen胃底折叠术,以及开腹EHH修补术+Nissen胃底折叠术,均可有效治疗婴儿EHH。与开腹EHH修补术+Nissen胃底折叠术相比,腹腔镜下EHH修补术+Nissen胃底折叠术对患儿具有术后开始经口进食时间早、切口小、美观等优点。

关键词：疝,食管裂孔胃食管反流疝修补术食管裂孔疝修补术腹腔镜胃底折叠术开腹手术婴儿

Design, fabrication, and testing of a maneuverable underwater vehicle with a hybrid propulsor

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Biomimetic Intelligence & Robotics 2022年第4期2卷 21-29页

作者： Dongqi Gao Tong Wang Fenghua Qin shiwu Zhang Jun Jing Jiming yang Department of Modern Mechanics University of Science and Technology of ChinaHefei 230027China Department of Precision Machinery and Precision Instrumentation University of Science and Technology of ChinaHefei 230027China China Ship Development and Design Center Wuhan 430064China

Rapidity and agility are equally important to unmanned underwater vehicles(UUVs).In this study we developed a UUV equipped with a hybrid propulsor which consists of a screw propeller and four bio-inspired *** bionic flippers rely on their flapping motion to generate both thrust and lateral forces,and the screw propeller provides additional thrust for fast *** maneuverability is greatly improved while the capability of sailing fast is *** the typical sailing requests,the flapping motions of the flippers were designed meticulously,and a control algorithm based on central pattern generators(CPGs)was built to produce rhythmic locomotor signals considering the motion ***,a feedback control method was merged to correct the deviation of the course.A compact concentric-shafts transmission mechanism was employed to overcome the inadequacy of the inside space,and the vehicle was ***,the sailing and maneuvering performance were *** was demonstrated that,the UUV’s overall sailing performance was enhanced significantly due to the combination of the flapping flippers and the screw *** hybrid-propulsor vehicle is capable of sailing in multiplicate environments.

关键词： UUV Hybrid propulsor Bio-inspired Flapping flippers Bionic

Initial Development of a Novel Amphibious Robot with Transformable Fin-Leg Composite Propulsion Mechanisms

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Journal of Bionic Engineering 2013年第4期10卷 434-445页

作者： shiwu Zhang Xu Liang Lichao Xu Min Xu Department of Precision Machinery and Precision Instrumentation University of Science and Technology of China Hefei 230026 P. R. China

Amphibious robots are very attractive for their broad applications in resource exploration, disaster rescue, and recon- naissance. However, it is very challenging to develop the robots for their complex, amphibious working environments. In the complex amphibious environment, amphibious robots should possess multi-capabilities to walk on rough ground, maneuver underwater, and pass through transitional zones such as sandy and muddy terrain. These capabilities require a high-performance propulsion mechanism for the robots. To tackle a complex task, a novel amphibious robot （AmphiHex-I） with,transformable fin-leg composite propulsion mechanisms is developed. With the fin-leg composite propulsions, AmphiHex-I can walk on rough and soft substrates and swim in water with many maneuvers. This paper presents the structural design of the transformable fin-leg propulsion mechanism and its driving module. A hybrid model is used to explore the dynamics between the trans- formable legs and transitional environment such as granular medium. The locomotion performances of legs with various ellip- tical shapes are analyzed, which is verified by the coincidence between the model predictions and the simulation results. Further, an orthogonal experiment is conducted to study the locomotion performance of a two-legged platform walking with an asyn- chronous gait in the sandy and muddy terrain. Finally, initial experiments of AmphiHex-I walking on various lands and swimming in water are implemented. These results verify that the transformable fin-leg mechanisms enable the amphibious robot to pass through a complex, amphibious working environment.

关键词： amphibious robot transformable fin-leg composite propulsion mechanism amphibious environment

Properties of strangelets in a new quark mass confinement model with one-gluon-exchange interaction

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Science China(Physics,Mechanics & Astronomy) 2014年第7期57卷 1304-1310页

作者： XIA ChengJun CHEN shiwu PENG GuangXiong School of Physics University of Chinese Academy of Sciences China Information Technology Security Evaluation Center Theoretical Physics Center for Science Facilities Institute of High Energy Physics

The properties of strangelets at zero temperature with a new quark model that includes both the confinement and one-gluonexchange interactions is studied in a fully self-consistent *** charge and parameter dependence of the stability of strangelets are *** is found that the one-gluon-exchange interaction lowers the energy of a strangelet,and consequently allows the strangelet to be absolutely *** stable strangelet radius in the present model is smaller in comparison with the absence of one-gluon-exchange interaction,and can thus be much less than that of a normal nucleus with the same baryon number,according to the strength of the confinement and one-gluon-exchange interactions.

关键词： strangelets quark confinement model one-gluon-exchange effect