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Natural product-based treatment potential for type 2 diabetes mellitus and cardiovascular disease

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World Journal of Diabetes 2024年第7期15卷 1603-1614页

作者： Dharmsheel Shrivastav Satyam Kumar Kumbhakar shivangi Srivastava Desh Deepak Singh Amity Institute of Biotechnology Amity University RajasthanJaipur 303002RajasthanIndia Department of Biotechnology Govt Veer Surendra Say P.G.CollegeGariaband 493889ChhattisgarhIndia Department of Life Science Chhatrapati Shahu ji Maharaj UniversityKanpur 208024Uttar PradeshIndia

BACKGROUND Type 2 diabetes(T2D)is a metabolic disease of impaired glucose utilization and a major cause of cardiovascular disease(CVD).The pathogenesis of both diseases shares common risk factors and mechanisms,and both are significant contributors to global morbidity and *** of natural products for T2D mellitus(T2DM)and CVD can be seen as a potential preventive and effective therapeutic *** To critically evaluate the therapeutic potential of natural products in T2D and coronary artery disease(CAD).METHODS By using specific keywords,we strategically searched the PubMed *** controlled trials(RCTs)were searched as the primary focus that examined the effect of natural products on glycemic control,oxidative stress,and antioxidant *** focused on outcomes such as low blood glucose levels,adjustment on markers of oxidative stress and *** screening fulllength papers,we included 9 RCTs in our review that met our inclusion *** In the literature search on the database,we found that various natural products like plant secondary metabolites play a diverse role in the management of *** ginseng,sesame oil and cocoa flavanols proved effective in lowering blood glucose levels and controlling blood pressure,which are key factors in managing T2DM and *** diabetic patients Melissa officinalis effectively reduce inflammation and shows diabetes *** fish oil and flaxseed oil reduced insulin levels and inflammatory markers,suggesting benefits for both *** lipid profile and endothelial function were enhanced by Nigella sativa oil and Terminalia chebula,which is significant for the management of cardiovascular risk factors in *** Bilberry extract also showed promise for improving glycemic control in patients with *** The high level of antioxidant,anti-inflammatory,and anti-angiogenic properties found in natural products makes them promising therapeutic opt

关键词： Type 2 diabetes mellitus Cardiovascular disease Natural products Antioxidants Oxidative stress Therapeutic impact Global burden

A hierarchical clustering approach for colorectal cancer molecular subtypes identification from gene expression data

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Intelligent Medicine 2024年第1期4卷 43-51页

作者： shivangi Raghav Aastha Suri Deepika Kumar Aakansha Aakansha Muskan Rathore Sudipta Roy Department of Computer Science&Engineering Bharati Vidyapeeth’s College of EngineeringNew DelhiIndia Artificial Intelligence&Data Science Jio InstituteNavi Mumbai410206India

Background Colorectal cancer(CRC)is the second leading cause of cancer fatalities and the third most common human *** molecular subgroups of CRC and treating patients accordingly could result in better therapeutic success compared with treating all CRC patients *** have highlighted the significance of CRC as a major cause of mortality worldwide and the potential benefits of identifying molecular subtypes to tailor treatment strategies and improve patient *** This study proposed an unsupervised learning approach using hierarchical clustering and feature selection to identify molecular subtypes and compares its performance with that of conventional *** proposed model contained gene expression data from CRC patients obtained from Kaggle and used dimension reduction techniques followed by Z-score-based outlier *** hierarchy clustering was used to identify molecular subtypes,with a P-value-based approach for feature *** performance of the model was evaluated using various classifiers including multilayer perceptron(MLP).Results The proposed methodology outperformed conventional methods,with the MLP classifier achieving the highest accuracy of 89%after feature *** model successfully identified molecular subtypes of CRC and differentiated between different subtypes based on their gene expression *** This method could aid in developing tailored therapeutic strategies for CRC patients,although there is a need for further validation and evaluation of its clinical significance.

关键词： Machine learning Colorectal cancer Feature selection Classification Clustering

Mobile Home Residents and Hurricane Vulnerability in South Florida:Research Gaps and Challenges

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International Journal of Disaster Risk Science 2016年第4期7卷 436-439页

作者： shivangi Prasad Justin Stoler Department of Geography and Regional Studies University of Miami Department of Public Health Sciences Miller School of MedicineUniversity of Miami Abess Center for Ecosystem Science and Policy University of Miami

In South Florida there are several social and logistical challenges to surveying and advocating for mobile home residents regarding vulnerability to natural hazards such as sea level rise and *** residents have consequently been understudied despite historically exhibiting higher vulnerability and lower *** exploratory study uses a social-ecological framework to highlight individual-,community-,and institutional-level challenges and research gaps encountered when working with mobile home *** observations represent a longer-term opportunity to further refine our understanding of natural hazard vulnerability,build increased resilience among vulnerable populations,and improve health equity in South Florida and beyond.

关键词： Disaster preparedness Mobile homes Social-ecological model Vulnerability

EOQ model of deteriorating items for fuzzy demand and learning in fuzziness with finite horizon

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Journal of Control and Decision 2021年第2期8卷 89-97页

作者： Hardik N.Soni shivangi N.Suthar Chimanbhai Patel Post Graduate Institute of Computer Applications AhmedabadIndia Gujarat Daman&Diu Geo-spatial Data CentreSurvey of IndiaGandhinagar 382010GujaratIndia

This study investigates the effect of learning in fuzziness by considering fuzzy demand in theEOQ model for deteriorating items under a finite time *** crisp equivalent form of the fuzzy objective function is obtained by employing the centroid *** calculus,the number of replenishments which optimizes the fuzzy objective function is *** model is extended by applying learning in fuzziness and an algorithm is developed to determine the number of *** illustrations are provided for the model under a crisp,fuzzy and fuzzylearning *** results reveal that the cost is lower with learning in fuzziness than that of without learning in ***,results indicate that the learning in fuzziness is more effective whenever the parameter has higher impreciseness in the estimation of its value.

关键词： EOQ model fuzzy demand reduction of fuzziness learning effect centroid method

Escalating complexity of endoscopic retrograde cholangiopancreatography over the last decade with increasing reliance on advanced cannulation techniques

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World Journal of Gastroenterology 2020年第41期26卷 6391-6401页

作者： Monique T Barakat Mohit Girotra Nirav Thosani shivangi Kothari Subhas Banerjee Divisions of Adult and Pediatric Gastroenterology and Hepatology Stanford University Medical CenterCupertinoCA 95014United States Division of Gastroenterology and Hepatology University of Miami Miller School of MedicineMiamiFL 33136United States Department of Internal Medicine Division of GastroenterologyHepatology&NutritionUniversity of Texas Health Science Center HoustonHoustonTX 77030United States Division of Gastroenterology and Hepatology University of Rochester Medical CenterRochesterNY 14627United States Division of Gastroenterology and Hepatology Stanford University Medical CenterStanfordCA 94304United States

BACKGROUND At our academic tertiary care medical center, we have noted patients referred for endoscopic retrograde cholangiopancreatography(ERCP) who increasingly require advanced cannulation techniques. This trend is noted despite increased endoscopist experience and annual ERCP volume over the same *** To evaluate this phenomenon of perceived escalation in complexity of cannulation at ERCP and assessed potential underlying *** Demographic/clinical variables and records of ERCP patients at the beginning(2008), middle(2013) and end(2018) of the last decade were reviewed retrospectively. Cannulation approaches were classified as "standard" or "advanced" and duodenoscope position was labeled as "standard"(short position) or "non-standard"(e.g., long, semi-long).RESULTS Patients undergoing ERCP were older in 2018 compared to 2008(69.7 ± 15.2 years vs 55.1 ± 14.7, P 4 cm, pancreatic uncinate mass, and bilirubin > 10 mg/d L predicted use of advanced cannulation techniques(P < 0.03 for each).CONCLUSION Complexity of cannulation at ERCP has sharply increased over the past 5 years, with an increased proportion of elderly patients and those with malignancy requiring advanced cannulation approaches. These data suggest that complexity of cannulation at ERCP may be predicted based on patient/ampulla characteristics. This may inform selection of experienced, high-volume endoscopists to perform these complex procedures.

关键词： Endoscopic retrograde cholangiopancreatography Biliary cannulation Goff trans-pancreatic septotomy Needle knife precut sphincterotomy Endoscopy Complexity

Clinical efficacy of the over-the-scope clip device: A systematic review

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World Journal of Gastroenterology 2020年第24期26卷 3495-3516页

作者： Nicholas Bartell Krystle Bittner Vivek Kaul Truptesh H Kothari shivangi Kothari Division of Gastroenterology and Hepatology University of Rochester Medical CenterRochesterNY 14642United States

BACKGROUND The over-the-scope clip(OTSC)system has been increasingly utilized as a nonsurgical option to endoscopically manage refractory gastrointestinal(GI)hemorrhage,perforations/luminal defects and *** data exist evaluating the efficacy and safety of *** To determine the clinical success and adverse event(AE)rates of OTSC across all GI *** A PubMed search was conducted for eligible articles describing the application of the OTSC system for any indication in the GI *** article or case series reporting data for less than 5 total patients was *** primary outcome was the rate of clinical *** outcomes included:Technical success rate,OTSC-related AE rate and requirement for surgical intervention despite-OTSC *** rates(per-indication and overall)were calculated as the number of patients with the event of interest divided by the total number of *** A total of 85 articles met our inclusion criteria(n=3025 patients).OTSC was successfully deployed in 94.4%of patients(n=2856/3025).The overall rate of clinical success(all indications)was 78.4%(n=2371/3025).Per-indication clinical success rates were as follows:(1)86.0%(1120/1303)for GI hemorrhage;(2)85.3%(399/468)for perforation;(3)55.8%(347/622)for fistulae;(4)72.6%(284/391)for anastomotic leaks;(5)92.8%(205/221)for defect closure following endoscopic resection(e.g.,following endoscopic mucosal resection or endoscopic submucosal dissection);and(6)80.0%(16/20)for stent ***’s related to the deployment of OTSC were only reported in 64 of 85 studies(n=1942 patients),with an overall AE rate of 2.1%(n=40/1942).Salvage surgical intervention was required in 4.7%of patients(n=143/3025).CONCLUSION This systematic review demonstrates that the OTSC system is a safe and effective endoscopic therapy to manage GI hemorrhage,perforations,anastomotic leaks,defects created by endoscopic resections and for stent *** success in fistula

关键词： Over-the-scope clip Hemostasis Perforation Fistula closure Endoscopic resection Anastomotic leak Ovesco Endoscopy

Effects of particle size on the triboelectrification phenomenon in pharmaceutical excipients:Experiments and multi-scale modeling

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Asian Journal of Pharmaceutical Sciences 2016年第5期11卷 603-617页

作者： Raj Mukherjee Vipul Gupta shivangi Naik Saurabh Sarkar Vinit Sharma Prasad Peri Bodhisattwa Chaudhuri Department of Pharmaceutical Sciences University of ConnecticutStorrsCT 06269USA Institute of Material Sciences University of ConnecticutStorrsCT 06269USA Merck Sharp and Dohme West PointPA 19486USA

Particle sizes play a major role to mediate charge transfer, both between identical and different material surfaces. The study probes into the probable mechanism that actuates opposite polarities between two different size fractions of the same material by analyzing the charge transfer patterns of two different sizes of microcrystalline cellulose(MCC). Quantum scale calculations confirmed alteration of charge transfer capacities due to variation of moisture content predicted by multiple surface and bulk analytical techniques. Discrete Element Method(DEM) based multi-scale computational models pertinent to predict charge transfer capacities were further implemented, and the results were in accordance to the experimental charge profiles.

关键词： Tribocharging Work function Excipient Discrete Element Modeling

Role of artificial intelligence in the diagnosis of COVID-19:A mini review

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Journal of Acute Disease 2022年第5期11卷 168-172页

作者： Rajeesh Mohammed PK Saakshi Gulati shivangi Gupta Department of Oral Pathology and Microbiology KMCT Dental CollegeKeralaIndia Department of Oral Medicine and Radiology Sathyabama Dental College and HospitalChennaiIndia Department of Periodontics and Implantology MMCDSR Deemed to be UniversityMullanaAmbalaIndia

The ongoing COVID-19 pandemic due to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has resulted in a significant public health care system *** disease has resulted in devastating damage to human lives and significant disruption in *** of“machine-learning”algorithms as tools of artificial intelligence may help identify a suspected or infected individual with an estimation of chances of *** algorithms make use of recorded observational data including medical histories,patient demographics as well as any related data on COVID-19.

关键词： COVID-19 Artificial intelligence Algorithm Analysis

Prospective evaluation of the hemorrhoid energy treatment for the management of bleeding internal hemorrhoids

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World Journal of Gastrointestinal Endoscopy 2021年第8期13卷 329-335页

作者： Truptesh H Kothari Krystle Bittner shivangi Kothari Vivek Kaul Division of Gastroenterology and Hepatology University of Rochester Medical CenterRochesterNY 14642United States

BACKGROUND The hemorrhoid energy treatment(HET)system is a non-surgical bipolar electrotherapy device,which has previously demonstrated efficacy in the management of bleeding Grade I and II internal hemorrhoids;however,data is *** To prospectively assess the safety and efficacy of the HET *** This was an IRB-approved prospective study of 73 patients with Grade I or II internal hemorrhoids who underwent HET from March 2016 to June *** factors and procedural data were obtained.A post-procedure questionnaire was administered by telephone to all patients at 1-wk and 3-mo following HET to assess for improvement and/or resolution of rectal bleeding and adherence to a stool softener regimen.A chart review was performed to observe recurrent symptoms and durability of *** analyses were performed using SPSS software(IBM;SPSS Version 25.0).RESULTS Seventy-three patients underwent HET during the study *** post-HET follow-up was 1.89 *** resolution of bleeding was reported in 65%at 1 wk(n=48),with improvement in bleeding in 97.2%(n=71)of *** 3-mo,resolution and/or improvement in bleeding was reported in 90%(n=64)of *** procedure-related pain or adverse events were *** HET is well tolerated,safe and highly effective in the majority of our patients presenting with Grade I and II symptomatic internal hemorrhoids.

关键词： Internal hemorrhoids Bleeding hemorrhoids Painless bleeding Mucus Constipation Straining