Effects of particle size on the triboelectrification phenomenon in pharmaceutical excipients:Experiments and multi-scale modeling

作     者：Raj Mukherjee Vipul Gupta Shivangi Naik Saurabh Sarkar Vinit Sharma Prasad Peri Bodhisattwa Chaudhuri 

作者机构：Department of Pharmaceutical SciencesUniversity of ConnecticutStorrsCT 06269USA Institute of Material SciencesUniversity of ConnecticutStorrsCT 06269USA Merck Sharp and DohmeWest PointPA 19486USA 

出 版 物：《Asian Journal of Pharmaceutical Sciences》 (亚洲药物制剂科学（英文）)

年 卷 期：2016年第11卷第5期

页      面：603-617页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

基　　金：U.S. Food and Drug Administration  (5U01FD004275) 

主　　题：Tribocharging Work function Excipient Discrete Element Modeling 

摘      要：Particle sizes play a major role to mediate charge transfer, both between identical and different material surfaces. The study probes into the probable mechanism that actuates opposite polarities between two different size fractions of the same material by analyzing the charge transfer patterns of two different sizes of microcrystalline cellulose(MCC). Quantum scale calculations confirmed alteration of charge transfer capacities due to variation of moisture content predicted by multiple surface and bulk analytical techniques. Discrete Element Method(DEM) based multi-scale computational models pertinent to predict charge transfer capacities were further implemented, and the results were in accordance to the experimental charge profiles.