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Response of understory plant species richness and tree regeneration to thinning in Pinus tabuliformis plantations in northern China

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Forest Ecosystems 2023年第2期10卷 215-226页

作者： Haijiao Yang Chao Pan Yun Wu shiqi qing Zhibin Wang Dihai Wang College of Forestry Northwest A&F UniversityYanglingShaanxi712100China

Background:Chinese pine(Pinus tabuliformis Carr.)is one of the major afforestation species in northern China and plays a key role in restoring forest ecosystems and preserving soil and ***,most Chinese pine plantations are experiencing ecological problems such as the low diversity of understory plants and difficulty in natural *** has been widely used to maintain and improve a variety of forest ecosystem services from *** date,however,few studies have been conducted to systematically determine the effects of thinning on understory plant diversity and the regeneration of Chinese pine in ***:We conducted a literature search,and selected 22 publications covering a total of 83 treatments related to thinning effects on the species richness of understory plants and 15 publications covering a total of 43 treatments related to thinning effects on the regeneration of Chinese pine,in tree plantations of northern *** data from the literature were synthesized and evaluated with meta-analysis approach to determine the treatment ***:Compared with the control stands,thinning increased the species richness of shrubs and herbs by an average of 25.3%and 26.5%,*** the varying thinning intensities all had significantly positive effects on the species richness of understory plants,only moderate thinning(30%–50%)had a positive effect on the density of regenerating seedlings and saplings of Chinese pine(60.2%).The species richness of understory plants was greatest after 14 years of thinning with an increase of 36.3%,whereas the density of regenerating Chinese pine seedlings and saplings reached a maximum after≥11 years of thinning with an increase of 76.5%,compared to that of the unthinned *** in the half-mature plantations had the greatest effects on the understory shrub richness(44.1%)and the density of regenerating Chinese pine seedlings and saplings(86.5%).Both single and multiple thinn

关键词： Chinese pine plantation Forest thinning Meta-analysis Natural regeneration Understory plants

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Species composition and influencing factors of understory woody species in Robinia pseudoacacia plantations on the Loess Plateau

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Journal of Forestry Research 2023年第6期34卷 1693-1706页

作者： Haijiao Yang Jinfang Gao Chao Pan shiqi qing Yun Wu Lina Jiang Zhibin Wang Dihai Wang College of Forestry Northwest A&F UniversityYangling 712100ShaanxiPeople’s Republic of China

Black locust(Robinia pseudoacacia L.)plantations have contributed significantly to soil and water conservation and ecological reconstruction on China’s Loess *** the impact of stand and environment on species composition of understory woody plants will improve the stability of existing black locust *** stands were selected in second-generation black locust plantations in tableland and gully areas of the Loess *** number of understory tree species in the tablelands was significantly lower than in the gully *** black locust(19.76%)and Rubus corchorifolius L.f.(64.85%)were the most abundant understory tree and shrub species,respectively,in the tableland stands;Broussonetia papyrifera(L.)L’Hé*** Vent.(6.77%)and Acanthopanax senticosus(***.)Harms.(37.22%)were most abundant in the gully *** richness(S),Shannon diversity(H),and evenness index(J)of the understory plants were significantly lower in the tableland stands than in the gully *** diverse understory species and community structures occurred in the gully *** in species diversity among landform positions may be attributed to differences in soil *** addition,77.57%of the variation in understory species composition was explained,among which shrub and herb coverage,stand age,leaf area index,slope and total soil phosphorus in the 10-20 cm layer were the main *** organic carbon and total potassium significantly impacted S,H and *** the environmental conditions and the biological characteristics of the plants investigated,*** should be given priority in the development of tableland stands,while *** and Celtis sinensis *** form mixed forests with black locust in gully *** management could promote biodiversity and stability of the existing black locust plantations but also optimize regional landscape patterns.

关键词： Black locust plantation Understory woody plants Species composition Species diversity pattern Loess plateau

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Co-delivery of TRAIL and paclitaxel by fibronectin-targeting liposomal nanodisk for effective lung melanoma metastasis treatment

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Nano Research 2022年第1期15卷 728-737页

作者： shiqi Huang Lang Deng Hanming Zhang Luyao Wang Yicong Zhang qing Lin Tao Gong Xun Sun Zhirong Zhang Ling Zhang Key Laboratory of Drug Targeting and Drug Delivery Systems Ministry of EducationWest China School of PharmacyCollege of Polymer Science and EngineeringSichuan UniversityChengdu 610041China

Melanoma is a highly aggressive cancer which often forms metastatic tumors in the lung,leading to sharply reduced patients'survival *** treating these tumors thus could improve late stage melanoma with lung *** this study,we fabricated a Cys-Arg-Glu-Lys-Ala with N-methylated Glu(CR(NMe)EKA)decorated disk shaped nano vehicle to co-deliver tumor necrosis factor-related apoptosis-inducing ligand(TRAIL)and paclitaxel(PTX)to lung melanoma tumor sites(TRAIL-[ND-PTX]^(CR(NMe)EKA)).These nanodisks displayed better tumor-targeting and penetration capability than spherical nanoparticles,while the fibronectin-targeting CR(NMe)EKA motif also increased the tumor accumulation of loaded *** combined usage of TRAIL and PTX both killed tumor cells and reduced local nutrition supply,leading to stronger overall anti-tumor *** TRAIL-[ND-PTX]^(CR(NMe)EKA)system performed remarkably better than free paclitaxel and also significantly elongated survival rate of melanoma lung metastasis bearing mice,without displaying significant ***,this designing strategy and the fabricated nanoplatform possess potential for further development.

关键词： nanodisks Cys-Arg-Glu-Lys-Ala with N-methylated Glu(CR(NMe)EKA) tumor necrosis factor-related apoptosis-inducing ligand(TRAIL) lung melanoma metastasis tumor-targeting

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Enzyme-activatable disk-shaped nanocarriers augment tumor permeability for breast cancer combination therapy

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Nano Research 2024年第7期17卷 6400-6410页

作者： Hanming Zhang Honglin Gao Yicong Zhang Yikun Han qing Lin Tao Gong Xun Sun Zhirong Zhang Ling Zhang shiqi Huang Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry West China School of PharmacySichuan UniversityChengdu 610041China Med-X Center for Materials College of Polymer Science and EngineeringSichuan UniversityChengdu 610065China

Unique physiopathological characteristics of tumor tissues impose obstacles to the sufficient penetration of traditional nanomedicines,resulting in undesirable drug delivery efficacy and therapeutic ***,we constructed TRAIL-[NDHCPT]^(GAC),a synergistic hydroxycamptothecin(HCPT)and tumor necrosis factor-related apoptosis-inducing ligand(TRAIL)protein co-loaded disk-shaped nanocarrier withγ-glutamyl transpeptidase *** the novel nanodisks extravasated into the tumor interstitium,theγ-glutamyl transpeptidase overexpressed on the tumor cell membranes cleaved theγ-glutamyl portions of the nanodisk surface to produce positively charged amino *** a result,the cationic nanodisks possessed stronger tumor infiltration ability through transcytosis than anionic *** and TRAIL exerted synergistic antitumor effects with better overall therapeutic *** TRAIL-[ND-HCPT]^(GAC)system performed significantly better than free HCPT and remarkably prolonged the survival of breast tumor-bearing mice with no significant toxicity.

关键词： tumor penetration combination therapy charge reversal γ-glutamyl transpeptidase nanodisk

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Fabrication of oxygen-doped MoSe2 hierarchical nanosheets for highly sensitive and selective detection of trace trimethylamine at room temperature in air

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Nano Research 2020年第6期13卷 1704-1712页

作者： Nannan Hou Qianqian Sun Jing Yang Su You Yun Cheng Qian Xu Wei Li shiqi Xing Li Zhang Junfa Zhu qing Yang Hefei National Laboratory of Physical Sciences at the Microscale(HFNL) Department of ChemistryLaboratory of Nanomaterials for Energy Conversion(LNEC)University of Science and Technology of ChinaHefei230026China National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei230029China

Nano Research volume 13,pages1704–1712(2020)Cite this article 191 Accesses Metrics details Abstract Intelligent gas sensors based on the layered transition metal dichalcogenides(TMDs)have attracted great interest in the field of gas sensing due to their multiple active sites,fast electron,mass transfer capability and large surface-to-volume ***,conventional TMDs-based sensors typically work at elevated temperature in inert atmosphere,which would largely limit the corresponding practical ***,novel oxygen-doped MoSe2 hierarchical nanostructures composed of ultrathin nanosheets with large specific surface area have been designed and generated typically at 200°C in air for fast and facile gas sensing of trimethylamine(TMA),*** from the gas-accessible hierarchical morphology and high surface area with abundant nanochannels,highly sensitive and selective detection of trace TMA has been achieved under ambient condition,and as detected the theoretical limit of detection(LOD)is 8 ppb,which is the lowest for TMA detection under ambient condition among the reported *** mechanism of oxygen doping on the improved gas-sensing performance has been investigated,revealing that the oxygen doping could greatly optimize the electronic structure,thus regulate the Fermi level of MoSe2 as well as the affinity between TMA molecule and sensor *** is expected that the oxygen doping strategy developed for the highly efficient gas sensors based on TMDs in present work may also be applicable to other types of gas-sensing semiconductors,which could open up a new direction for the rational design of high-performance gas sensors working under ambient condition.

关键词： oxygen-doped MoSe2 nanosheet ambient gas sensing trimethylamine detection highly selective trace detection limit

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Novel fibronectin-targeted nanodisk drug delivery system displayed superior efficacy against prostate cancer compared with nanospheres

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Nano Research 2019年第10期12卷 2451-2459页

作者： Luyao Wang Bingjie Zhou shiqi Huang Mengke Qu qing Lin Tao Gong Yuan Huang Xun Sun Qin He Zhirong Zhang Ling Zhang Key Laboratory of Drug Targeting and Drug Delivery Systems Ministry of EducationWest China School of PharmacyCollege of Polymer Science and EngineeringSichuan UniversityChengdu 610041China

Currently,prostate cancer is the most frequently diagnosed cancer in males and chemotherapy is often essential for treating advaneed prostate ***,common chemotherapies for prostate cancer suffer from serious adverse effects due to poor drug targeting ability and tissue penetration,even with the help of conventional drug delivery ***,encouraged by recent studies showing possible drug retention and tissue pen etration advan tages of unconventional non-spherical nan oparticles over conventional spherical nan oparticles,we design and construct a novel non-spherical nano disk drug delivery system for treating prostate *** to enhance tumor-targeting capability,these nanodisks are further modified with targeting peptide,Cys-Arg-Glu丄ys?Ala peptide with N-methylated Glu(CR(NMe)EKA),which recognizes extracellular matrix fibronectin and its complexes specifically expressed on the walls of tumor vessels and in tumor *** with conventional nano spheres,the nano disks achieve much higher drug accumulati on at prostate tumor *** loaded with paclitaxel,the CR(NMe)EKA-modified nan odisks display superior an titumor efficacy to free paclitaxel,unmodified nan odisks and nano *** summary,our study provides an attractive therapeutic strategy for targeted therapy against prostate cancer with simple preparation,high efficiency and low toxicity,and supplements a theoretical support for treatments realized by different shaped nano *** study also offers valuable data for understa nding biological effects of non-spherical nano disks and highlights the great pote ntial of unconventional nan oparticles in biomedical applicati ons.

关键词： Cys-Arg-Glu-Lys-Ala peptide with N-methylated Glu(CR(NMe)EKA) fibronectin nanodisks prostate cancer tumor-targeting

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Mechanical regulation of lipid and sugar absorption by Piezo1 in enterocytes

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3576-3590页

作者： Tian Tao qing Shu Yawen Zhao Wenying Guo Jinting Wang Yuhao Shi shiqi Jia Hening Zhai Hui Chen Cunchuan Wang Geyang Xu Department of Physiology School of MedicineJinan UniversityGuangzhou 510632China Department of Metabolic and Bariatric Surgery the First Affiliated Hospital of Jinan UniversityGuangzhou 510630China Endoscopy Center the First Affiliated Hospital of Jinan UniversityGuangzhou 510630China Biotherapy Center Cell-gene Therapy Translational Medicine Research Centerthe Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630China Key Laboratory of Viral Pathogenesis&Infection Prevention and Control(Jinan University) Ministry of EducationGuangzhou 510632China

Obesity is primarily caused by excessive intake as well as absorption of sugar and *** surge in distention pressure and intestinal motility accelerates the absorption of *** response of intestinal epithelial cells to mechanical stimulation is not fully ***1,a mechanosensitive ion channel,is widely expressed throughout the digestive ***,its function in intestinal nutrient absorption is not yet *** our study,excessive lipid deposition was observed in the duodenum of obese patients,while duodenal Piezo1-CaMKK2-AMPKa was decreased when compared to normal-weight *** high-fat diet condition,the Piezo1iKO mice exhibited abnormally elevated sugar and lipid absorption as well as severe lipid deposition in the duodenum and *** phenotypes were mainly caused by the inhibition of duodenal CaMKK2-AMPKa and the upregulation of SGLT1 and *** contrast,Yoda1,a Piezo1 agonist,was found to reduce intestinal lipid absorption in diet induced obese *** of Piezo1,stretch and Yoda1 inhibited lipid accumulation and the expression of DGAT2 and SGLT1,whereas knockdown of Piezo1 stimulated lipid accumulation and DGAT2 in Caco-2 *** study reveals a previously unexplored mechanical regulation of nutrient absorption in intestinal epithelial cells,which may shed new light on the therapy of obesity.

关键词： Piezo1 DGAT2 SGLT1 Lipid metabolism Obesity Mechanical sensing Intestinal lipid absorption Intestinal glucose absorption

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Signaling pathways and targeted therapy for myocardial infarction

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Signal Transduction and Targeted Therapy 2022年第4期7卷 1009-1046页

作者： qing Zhang Lu Wang shiqi Wang Hongxin Cheng Lin Xu Gaiqin Pei Yang Wang Chenying Fu Yangfu Jiang Chengqi He Quan Wei Rehabilitation Medicine Center and Institute of Rehabilitation Medicine West China HospitalSichuan UniversityChengduSichuanPR China Key Laboratory of Rehabilitation Medicine in Sichuan Province ChengduSichuanPR China National Clinical Research Center for Geriatrics West China HospitalSichuan UniversityChengduSichuanPR China Aging and Geriatric Mechanism Laboratory West China HospitalSichuan UniversityChengduSichuanPR China State Key Laboratory of Biotherapy West China HospitalSichuan UniversityChengduSichuanPR China

Although the treatment of myocardial infarction(MI)has improved considerably,it is still a worldwide disease with high morbidity and high *** there is still a long way to go for discovering ideal treatments,therapeutic strategies committed to cardioprotection and cardiac repair following cardiac ischemia are *** of pathological characteristics in MI illustrates cell signaling pathways that participate in the survival,proliferation,apoptosis,autophagy of cardiomyocytes,endothelial cells,fibroblasts,monocytes,and stem *** signaling pathways include the key players in inflammation response,e.g.,NLRP3/caspase-1 and TLR4/MyD88/NF-κB;the crucial mediators in oxidative stress and apoptosis,for instance,Notch,Hippo/YAP,RhoA/ROCK,Nrf2/HO-1,and Sonic hedgehog;the controller of myocardial fibrosis such as TGF-β/SMADs and Wnt/β-catenin;and the main regulator of angiogenesis,PI3K/Akt,MAPK,JAK/STAT,Sonic hedgehog,*** signaling pathways play an important role in administering the process of MI,aiming at targeting these aberrant signaling pathways and improving the pathological manifestations in MI is indispensable and ***,drug therapy,gene therapy,protein therapy,cell therapy,and exosome therapy have been emerging and are known as novel *** this review,we summarize the therapeutic strategies for MI by regulating these associated pathways,which contribute to inhibiting cardiomyocytes death,attenuating inflammation,enhancing angiogenesis,*** as to repair and re-functionalize damaged hearts.

关键词： inflammation infarction instance

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Metabolic reprogramming of proinflammatory macrophages by target delivered roburic acid effectively ameliorates rheumatoid arthritis symptoms

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Signal Transduction and Targeted Therapy 2023年第8期8卷 3862-3876页

作者： Na Jia Yunzhen Gao Min Li Yi Liang Yuwen Li Yunzhu Lin shiqi Huang qing Lin Xun Sun Qin He Yuqin Yao Ben Zhang Zhirong Zhang Ling Zhang Key Laboratory of Drug Targeting and Drug Delivery Systems Ministry of EducationWest China School of PharmacyCollege of Polymer Science and EngineeringState key Laboratory of Polymer Materials EngineeringWest China School of Public Health and West China Fourth HospitalSichuan UniversityChengdu 610041P.R.China Department of Pharmacy West China HospitalSichuan UniversityChengdu 610041China

Rheumatoid arthritis(RA)is a common chronic inflammatory disorder that usually affects *** was found that roburic acid(RBA),an ingredient from anti-RA herb Gentiana macrophylla Pall.,displayed strong anti-inflammatory ***,its medical application is limited by its hydrophobicity,lack of targeting capability and unclear functional ***,we constructed a pH responsive dual-target drug delivery system hitchhiking RBA(RBA-NPs)that targeted both CD44 and folate receptors,and investigated its pharmacological *** rat RA model,the nanocarriers effectively delivered RBA to inflammatory sites and significantly enhanced the therapeutic outcomes compared with free RBA,as well as strongly reducing inflammatory cytokine levels and promoting tissue *** analysis revealed that M1 macrophages in the joints were reprogrammed to M2 phenotype by *** the balance of pro-and anti-inflammatory macrophages play important roles in maintaining immune homeostasis and preventing excessive inflammation in RA,this reprogramming is likely responsible for the anti-RA ***,we revealed that RBA-NPs drove M1-to-M2 phenotypic switch by down-regulating the glycolysis level via blocking ERK/HIF-1α/GLUT1 ***,our work not only developed a targeting delivery system that remarkably improved the anti-RA efficiency of RBA,but also identified a potential molecular target to reversely reprogram macrophages though energy metabolism regulation.

关键词： inflammatory metabolism programming

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Stretchable polymer composites with ultrahigh piezoelectric performance

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National Science Review 2023年第8期10卷 203-210页

作者： Tongxiang Tang Zhonghui Shen Jian Wang shiqi Xu Jiaxi Jiang Jiahui Chang Mengfan Guo Youjun Fan Yao Xiao Zhihao Dong Houbing Huang Xiaoyan Li Yihui Zhang Danyang Wang Long-qing Chen Ke Wang Shujun Zhang Ce-Wen Nan Yang Shen State Key Lab of New Ceramics and Fine Processing School of Materials Science and Engineering Tsinghua University State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Center of Smart Materials and Devices Wuhan University of Technology Advanced Research Institute of Multidisciplinary Science Beijing Institute of Technology Applied Mechanics Laboratory Department of Engineering Mechanics Tsinghua University Center for Flexible Electronics Technology Tsinghua University School of Materials Science and Engineering University of New South Wales Department of Materials Science and Engineering The Pennsylvania State University State College Institute for Superconducting and Electronic Materials Australian Institute for Innovative MaterialsUniversity of Wollongong

Flexible piezoelectric materials capable of withstanding large deformation play key roles in flexible electronics. Ferroelectric ceramics with a high piezoelectric coefficient are inherently brittle, whereas polar polymers exhibit a low piezoelectric coefficient. Here we report a highly stretchable/compressible piezoelectric composite composed of ferroelectric ceramic skeleton, elastomer matrix and relaxor ferroelectric-based hybrid at the ceramic/matrix interface as dielectric transition layers, exhibiting a giant piezoelectric coefficient of 250 picometers per volt, high electromechanical coupling factor keff of 65%,ultralow acoustic impedance of 3MRyl and high cyclic stability under 50% compression strain. The superior flexibility and piezoelectric properties are attributed to the electric polarization and mechanical load transfer paths formed by the ceramic skeleton, and dielectric mismatch mitigation between ceramic fillers and elastomer matrix by the dielectric transition layer. The synergistic fusion of ultrahigh piezoelectric properties and superior flexibility in these polymer composites is expected to drive emerging applications in flexible smart electronics.

关键词： polymer composites piezoelectric materials structure design flexible electronics

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