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Inverse relationship between platelet Akt activity and hippocampal atrophy:A pilot case-control study in patients with diabetes mellitus

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World Journal of Clinical Cases 2024年第2期12卷 302-313页

作者： Haruhiko Tokuda Takamitsu Hori Daisuke Mizutani Tomoyuki Hioki Kumi Kojima Takashi Onuma Yukiko Enomoto Tomoaki Doi Rie Matsushima-Nishiwaki shinji Ogura Hiroki Iida Toru Iwama Takashi Sakurai Osamu Kozawa Department of Metabolic Research Research InstituteNational Center for Geriatrics and GerontologyObu 474-8511Japan Department of Clinical Laboratory National Center for Geriatrics and GerontologyObu 474-8511Japan Department of Pharmacology Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Neurosurgery Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Dermatology Central Japan International Medical CenterMinokamo 505-8510Japan Department of Anesthesiology and Pain Medicine Gifu University Graduate School of MedicineGifu 501-1194Japan Department of Emergency Medicine Faculty of MedicineUniversity of ToyamaToyama 930-0194Japan Department of Emergency and Disaster Medicine Gifu University Graduate School of MedicineGifu 501-1194Japan Research Institute National Center for Geriatrics and GerontologyObu 474-8511Japan

BACKGROUND Akt plays diverse roles in *** is involved in the pathogenesis of type 2 diabetes mellitus(T2DM),which is caused by insulin *** also plays a vital role in human platelet ***,the hippocampus is closely associated with memory and learning,and a decrease in hippocampal volume is reportedly associated with an insulin-resistant phenotype in T2DM patients without *** To investigate the relationship between Akt phosphorylation in unstimulated platelets and the hippocampal volume in T2DM *** Platelet-rich plasma(PRP)was prepared from the venous blood of patients with T2DM or age-matched *** pellet lysate of the centrifuged PRP was subjected to western blotting to analyse the phosphorylation of Akt,p38 mitogen-activated protein(MAP)kinase and glyceraldehyde 3-phosphate dehydrogenase(GAPDH).Phosphorylation levels were quantified by densitometric *** volume was analysed using a voxel-based specific regional analysis system for Alzheimer’s disease on magnetic resonance imaging,which proposes the Z-score as a parameter that reflects hippocampal *** The levels of phosphorylated Akt corrected with phosphorylated p38 MAP kinase were inversely correlated with the Z-scores in the T2DM subjects,whereas the levels of phosphorylated Akt corrected with GAPDH were ***,this relationship was not observed in the control *** These results suggest that an inverse relationship may exist between platelet Akt activation and hippocampal atrophy in T2DM *** findings provide insight into the molecular mechanisms underlying T2DM hippocampal atrophy.

关键词： Akt Platelet Hippocampal atrophy Magnetic resonance imaging Diabetes mellitus

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Symptomatic COVID-19 in University Students: A School-Wide Web-Based Questionnaire Survey during the Omicron Variant Outbreak

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Advances in Infectious Diseases 2024年第1期14卷 133-146页

作者： Mai Kitahara Hisami Sameshima Rie Tanuma Kumi Setoyama Yuka Yamaguchi Akiyo Kamachi Satoko Nakamura Mayuko Sakuma Yoichi Kawaike Tamotsu Furuya shinji Ijichi Health Service Center Kagoshima University Kagoshima Japan Center for Management of Information Technologies Kagoshima University Kagoshima Japan

Aim: To detect risk and preventive factors associated with the Omicron variant infection in university students, a combination of a web-based survey and multivariate logistic regression analysis was introduced as the front-line initiatives by the school health practitioners. Design: Questionnaire survey. Methods: The school-wide web-based questionnaire survey was conducted among our university students as a part of the annual health check-up in April, 2023. The positive outcome was confined to the first symptomatic COVID-19 onset during the Omicron variant outbreak. Results: In this self-administered survey, risk or protective associations were merely estimated statistically in university students (n = 5406). In measured factors, karaoke and club/group activities could maintain the statistical significance in adjusted odds ratios (ORs) as relative risk factors, and science course, measles/ rubella (MR) vaccination, and COVID-19 vaccination remained as relative protective factors in adjusted OR analyses. Club/group activities with member gathering and karaoke sing-along sessions in university students may frequently have WHO’s three Cs. These risk factors are still important topics for the infection control of COVID-19 in university students. Together with some recent reports from other researchers, the significant protective role of MR vaccine in our survey warrants further clinical investigation. If the breakthrough infection continuously constitutes the majority of infection, real data in test-negative case-control or web-based questionnaire design continue to be important for statistical analysis to determine the minimal requirement of our strategies which may be equivalent to or replace COVID-19 vaccines.

关键词： Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Coronavirus Disease 2019 (COVID-19) Omicron Variant Risk Behaviors Protective Factors

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Characterization of Full-WDM-Band Photodiode Modules Using Raman Amplifiers in the U Band at 40 Gb/s

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光学学报 2003年第S1期23卷 447-448页

作者： Morio wada Toshimasa Umezawa Takahiro Kudou Takashi Mogi shinji Iio shinji Kobayashi Tsuyoshi Yakihara Akira Miura Corporate R&D Center Yokogawa Electric Co. JapanCorporate R&D Center Yokogawa Electric Co. JapanCorporate R&D Center Yokogawa Electric Co. JapanCorporate R&D Center Yokogawa Electric Co. JapanCorporate R&D Center Yokogawa Electric Co. JapanCorporate R&D Center Yokogawa Electric Co. JapanCorporate R&D Center Yokogawa Electric Co. JapanCorporate R&D Center Yokogawa Electric Co. Japan

We present the characteristics of a full-WDM-band photodiode module in 40 Gb/s U-band operation using a Raman amplifier. This module is suitable for wide-band transmission systems with the additional new channels in t... 详细信息

关键词： WDM for with Characterization of Full-WDM-Band Photodiode Modules Using Raman Amplifiers in the U Band at 40 Gb/s of in

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Effects of hydraulic oil and lubricant additives on dynamic friction properties under various reciprocating sliding conditions

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Friction 2020年第2期8卷 471-480页

作者： shinji KATO Shinya SASAKI Engineering Headquarters Automotive ComponentsKYB Corporation2548DolaKani-shiGifu 509-0298Japan Department of Mechanical Engineering Faculty of Engineering Division ITokyo University of Science6-3-1NiijukuKatsushika-kuTokyo 125-8585Japan

The friction characteristics of a shock absorber are very complex because the reciprocating motion is not always *** this study,a device was developed and used to analyze the dynamic friction characteristics under various reciprocating sliding conditions to determine the sliding materials and hydraulic oils that improve the shock absorber *** study describes the influence of hydraulic oil additive on the fine reciprocating friction characteristics of steel and copper *** oils were prepared by blending a paraffinic mineral oil with zinc dithiophosphate(ZnDTP)and polyhydric alcohol ester as *** results show that the dynamic frictional characteristics vary mainly depending on the additive concentration.A specific additive formulation induces a unique amplitude-dependent friction *** addition,the influence of different additives on the lubrication mechanism is investigated based on the instrumental analysis of the friction surface.

关键词： shock absorber dynamic friction reciprocating friction additive zinc dithiophosphate(ZnDTP)

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Frontalis suspension procedure with an upper retroauricular fascia graft:a preliminary case report

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International Journal of Ophthalmology(English edition) 2020年第12期13卷 2012-2014页

作者： Kazuki Ueno Yuji Shirakawa Yoshitaka wada Kazuhisa Uemura shinji Kumegawa Hiroki Iwanishi Shizuya Saika Shinichi Asamura Department of Plastic and Reconstructive Surgery Graduate School of Wakayama Medical UniversityWakayama CityWakayama 6410012Japan Department of Ophthalmology Graduate School of Wakayama Medical UniversityWakayama CityWakayama 6410012Japan

Dear Editor,We present the first reported case of frontalis suspension procedure with the retroauricular fascia(RF)for a patient of unilateral congenital *** suspension procedure is one of the major surgical procedures for congenital ptosis[1].This procedure connects the affected eyelid and the brow with a graft and utilizes the frontalis muscle as the power of opening the upper eyelid[2].

关键词： congenital auricular graft

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Perspective of mixed matrix membranes for carbon capture

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Frontiers of Chemical Science and Engineering 2020年第3期14卷 460-469页

作者： shinji Kanehashi Colin AScholes Graduate School of Engineering Tokyo University of Agriculture and TechnologyTokyo184-8588Japan Peter Cook Centre for Carbon Capture and Storage Research Department of Chemical EngineeringThe University of MelbourneMelbourne 3010Australia

Polymeric membrane-based gas separation has found wide applications in industry,such as carbon capture,hydrogen recovery,natural gas sweetening,as well as oxygen *** gas separation membranes are required to have high gas permeability and selectivity,while being cost-effective to *** matrix membranes(MMMs)have a composite structure that consists of polymers and fillers,therefore featuring the advantages of both *** effort has been made to improve the gas separation performance of MMMs as well as general membrane properties,such as mechanical strength and thermal *** perspective describes potential use of MMMs for carbon capture applications,explores their limitations in fabrication and methods to overcome them,and addresses their performance under industry gas conditions.

关键词： membranes polymeric mixed matrix impurities

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Fundamental study on short range measurement using RF time of flight based on Vernier effect

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仪器仪表学报 2009年第12期30卷 2461-2467页

作者： Sang-il Ko shinji Ohyama Graduate School of Science and Engineering Tokyo Institute of Technology

Recognizing the position of moving objects, facilities or important equipments has been regarded as a hot issue in the future environment which needs ubiquitous characteristics. Furthermore, it is indispensably needed to acquire location data in order to realize an infrastructure of sensor network system. Namely, distance data are the preliminary information to complete localization of a moving object in local area. Even though there have been several researches on this topic, there are however still much amount of problems in getting precisely exact distance data. Out of them, the research on using TOF (Time-of-flight) is very few as well as could be thought of as a cutting-edge technique. Moreover, it is very difficult to get minutely RF signal's TOF for getting short distance data; that is, very complicated signal processing skills are requested for realizing it. In this paper, we present a new methodology of RF short ranging technique based on vernier effect through using of heterogeneous operating clocks.

关键词：传感器信号处理技术射频技术时间飞行

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The Roles of Nuclear Energy in Hydrogen Production

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Engineering 2022年第9期16卷 16-20页

作者： shinji Kubo Japan Atomic Energy Agency Ibaraki-ken 311-1393Japan

*** energy as primary energy and hydrogen energy as secondary energy Fossil resources are unevenly distributed on the earth and are a finite source of primary energy that is widely used in industry(factories,etc.),transportation(automobiles,etc.),and energy conversion(power generation,etc.).It must be said that the mass consumption of fossil resources is *** energies that can replace fossil-fuel-based energy include renewable energy and nuclear energy,while hydrogen energy has the potential to be a secondary energy source that can be widely used in industry for various purposes,including the use of hydrogen as raw material for chemical products,a reducing agent,and *** example,the International Energy Agency(IEA)has provided a roadmap[1]for achieving net-zero emissions by 2050,stating that about 530 Mt∙a^(-1)of global hydrogen is *** is about six times the hydrogen demand in 2020(about 90 Mt∙a^(-1)).

关键词： replace industry automobile

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Synthesis and sintering of samarium rich SmS_x and its electrical property

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Journal of Rare Earths 2016年第10期34卷 1042-1047页

作者： Liang Li shinji Hirai Yohei Tasaki Department of Materials Science and Engineering Muroran Institute of Technology

Non-stoichiometric samarium monosulfide（SmS_x, 0.55≤x≤1.2） was synthesized from Sm_2S_3 and SmH_3 at 1273 K for 3 h under vacuum. The influence of reaction ratio of Sm_2S_3 to SmH_3 on the fabrication of SmS_x was investigated. The fabrication of SmS required the molar ratio of Sm_2S_3 to SmH_3 above 1. Lattice parameter of synthetic SmS_x increased firstly and then decreased to saturate following with the addition of SmH_3 content. SmS_x compact was sintered at 1373 K by spark plasma sintering. Density of synthetic SmS_x was about 99% of theory density. Seebeck coefficient of n-type semiconductor Sm Sx decreased as temperature rose. The absolute value was distributed between 170–280 μV/K. The electrical resistivity of SmS_x（0.86≤x≤1.07） decreased with temperature increasing and showed similar temperature dependence. The surplus Sm which randomly distributed in the SmS_x（0.55≤x≤0.75） matrix led to a remarked reduction of electrical resistivity. The optimized power factor for SmS_（0.6） and Sm S_（0.75） could reach 1500 μW/（K^2·m） at 600 K.

关键词： samarium monosulfide SmH_3 Seebeck coefficient electrical resistivity rare earths

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2-D localization system utilizing M-sequence encoded laser beam scanning

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仪器仪表学报 2007年第3期28卷 408-413页

作者： shinji Ohyama Kiyoshi Tanaka Junya Takayama Graduate School of Science and Engineering Tokyo Institute of Technology 2-12-1 O-okayama Meguro-ku Tokyo 152-8552 Japan

In this paper, as the active position measurement system, a novel method for a two-dimensional localization system using M-sequence signal is proposed. The feature of this system is to realize a position measurement only by scanning the encoded laser beams from fixing points to a measurement field, and by observing it. First, both the system configuration and encoding method were practically considered, and an order and an initial value of M-sequence signal were selected for encoding. This method is based on discrete angle measurement therefore the resolution has its own limitation. To overcome this limitation, analogue phase shift detecting method was introduced. System design was performed and applied to position measurement experiments. The experimental results show that the measurement error of the analogue method is 1/3 of that of the discrete method.

关键词：激光电子束扫描位置测量二维定位系统 M序列离散法

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