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DIStRIBUtION OF CRYStALLItES IN AMORPHOUS SiO2 FILM ON Si WAFER AND ItS CHANGE WItH OXIDAtION PROCESS

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DISTRIBUTION OF CRYSTALLITES IN AMORPHOUS SiO2 FILM ON Si WA...

Sixteenth Congress of the International Union of Crystallography

作者： I.takahashi K.Nakano J.Harada t.shimura M.Umeno Department of Applied Physics Nagoya UniversityNagoya 464Japan Department of Precision Engineering Osaka UniversitySuita 565Japan

Electrical and mechanical properties of amorphous SiO film grown on the Si substrate have been attracted much attention because of an industrial application as an atomically thin insulator on semiconductor *** a non-d...

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液氧泵的轴向力研究

上海航天 1993年第3期10卷 53-59页

作者： J.Kurokawa K.Kamijo t.shimura 王文琦

为了解推力平衡装置中的流动特性,以改进装置,对装置中的内部流动作了详细的分析。本文所作的研究取得了令人满意的结果。应用本研究,可对具有平衡活塞、平衡孔、涡流破碎器等的各种组合下的液氧泵轴向力特性有所揭示。本研究方法适用... 详细信息

为了解推力平衡装置中的流动特性,以改进装置,对装置中的内部流动作了详细的分析。本文所作的研究取得了令人满意的结果。应用本研究,可对具有平衡活塞、平衡孔、涡流破碎器等的各种组合下的液氧泵轴向力特性有所揭示。本研究方法适用于任何类型的推力平衡装置。

关键词：液体推进剂火箭发动机液氧泵

Increase in serum levels of phosphatidylserine-specific phospholipase A_(1) in COVID-19 patients

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Cellular & Molecular Immunology 2021年第9期18卷 2275-2277页

作者： takuya shimura Makoto Kurano Koh Okamoto Daisuke Jubishi Kuniyuki Kano Koji Igarashi Satoshi Shimamoto Junken Aoki Kyoji Moriya Yutaka Yatomi Department of Clinical Laboratory The University of Tokyo HospitalTokyoJapan Department of Clinical Laboratory Medicine Graduate School of MedicineThe University of TokyoTokyoJapan Department of Infectious Diseases The University of Tokyo HospitalTokyoJapan Department of Health Chemistry Graduate School of Pharmaceutical SciencesThe University of TokyoTokyoJapan Bioscience Division TOSOH CorporationKanagawaJapan

the development of novel drugs to overcome the current global coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is an important *** antiviral agents have been investigated,one of the important goals of treatment is also to control the biological response to the infection.A series of elegant basic studies have revealed that lysophosphatidylserine(LysoPS)might play important roles in inflammation through three kinds of G protein-coupled receptors[1];LysoPS reportedly suppresses activation of t cells[2]and secretion of inflammatory cytokines from macrophages[3]and promotes phagocytosis of apoptotic cells,including apoptotic neutrophils,by macrophages[4].

关键词： drugs inflammation acute

HsfAld, a Protein Identified via FOX Hunting Using thellungiella salsuginea cDNAs Improves Heat tolerance by Regulating Heat-Stress-Responsive Gene Expression

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Molecular Plant 2013年第2期6卷 411-422页

作者： Yukari Higashi Naohiko Ohama tomoko Ishikawa taku Katori Ayaka shimura Kazuya Kusakabe Kazuko Yamaguchi-Shinozaki Junko Ishida Maho tanaka Motoaki Seki Kazuo Shinozaki Yoichi Sakata takahisa Hayashi teruaki taji Department of Bio-Science Tokyo University of Agriculture 1-1-1 Sakuragaoka Setagaya Tokyo 156-8502 Japan Graduate School of Agriculture and Life Sciences University of Tokyo Tokyo 113-8657 Japan RIKEN Yokohama Institute 1-7-22 Suehiro-cho Tsururni-ku Yokohama 230-0045 Japan

thellungiella salsuginea （formerly t. halophila）, a species closely related to Arabidopsis （Arabidopsis thali-ana）, is tolerant not only to high salt levels, but also to chilling, freezing, and ozone. Here, we report that t. salsuginea also shows greater heat tolerance than Arabidopsis. We identified t. salsuginea HsfAld （tsHsfAld） as a gene that can confer marked heat tolerance on Arabidopsis. tsHsfAld was identified via Full-length cDNA Over-eXpressing gene （FOX） hunt-ing from among a collection of heat-stress-related t. salsuginea cDNAs. transgenic Arabidopsis overexpressing tsHsfAld showed constitutive up-regulation of many genes in the Arabidopsis AtHsfA1 regulon under normal growth tempera-ture. in Arabidopsis mesophyll protoplasts, tsHsfAld was localized in both the nucleus and the cytoplasm. tsHsfAld also interacted with AtHSP90, which negatively regulates AtHsfAls by forming HsfA1-HSP90 complexes in the cytoplasm. It is likely that the partial nuclear localization of tsHsfAld induced the expression of the AtHsfAld regulon in the transgenic plants at normal temperature. We also discovered that transgenic Arabidopsis plants overexpressing AtHsfAldwere more heat-tolerant than wild-type plants and up-regulated the expression of the HsfAld regulon, as was observed in tsHsfAld-overexpressing plants. We propose that the products of both tsHsfAld and AtHsfAld function as positive regulators of Arabidopsis heat-stress response and would be useful for the improvement of heat-stress tolerance in other plants.

关键词： thellungiella salsuginea heat-stress tolerance HsfA1 FOX hunting.

视力尚好的严重糖尿病性视网膜病变患者后tenon囊下注射曲安奈德可防止全视网膜光凝引起的视功能下降

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世界核心医学期刊文摘（眼科学分册） 2006年第8期2卷 50-51页

作者： shimura M. Yasuda K. Shiono t. 张少娟 Department of Ophthalmology NTT East Japan Tohoku Hospital 2- 29- 1 Yamato Wakabayashi Sendai Miyagi 984- 8560 Japan Dr.

Purpose: to evaluate prospectively the efficacy of a single sub-tenon’ s capsule injection of triamcinolone acetonide (tA) against panretinal photocoagulation (PRP)-induced macular thickening and visual disturbance in patients with severe diabetic retinopathy and good vision. Design: Prospective, comparative, interventional case series. Participants: twenty eyes of 10 patients with severe nonproliferative diabetic retinopathy or non-high-risk proliferative diabetic retinopathy whose visual acuity was 20/40 or better (thm of the minimum angle of resolution LogMAR acuity) before the PRP, whose retinopathy was bilateral and symmetrical. the averaged parafoveal retinal thickness was more than 300 μ m, leading to a worse visual prognosis after PRP. Intervention: Sub-tenon’ s capsule injection of 20 mg tA. Main Outcome Measures: Best-corrected visual acuity (BCVA) with logMAR chart and averaged foveal thickness (Ft) using the retinal mapping program of optical coherence tomography. Methods: In all patients, PRP was performed every other week for 4 sessions on both eyes, and 1 week before PRP; 1 eye received the tA injection, and the other eye served as a control. the clinical course of BCVA and Ft was monitored for up to 24 weeks after beginning PRP. Results: Before tA injection, BCVA and Ft were 0.055± 0.072 and 235.5± 37.5 μ m in the tA-injected eye and 0.065± 0.071 and 233.7± 39.8 μ m in the control eye, respectively; there was no significant difference between eyes. After the tA injection, Ft in the tA-injected eyes was significantly decreased. During and after the PRP, Ft in the control eye increased dramatically and reached 312.0± 68.2 μ m at 24 weeks, which was significantly different from that in the tA-injected eyes (235.3± 38.6 μ m at 24weeks). Best-corrected visual acuity in the control eye decreased with time to 0.24± 0.13; in contrast, and BCVA in the tA-injected eye was good (to 0.085± 0.11) . Conclusions: As a pretreatment for PRP, a single s

关键词：全视网膜光凝 tenon 视功能黄斑中心凹视网膜病变增殖性视网膜厚度干预性预后差病例研

视力良好的重型糖尿病视网膜病变患者行全视网膜光凝后视功能障碍

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世界核心医学期刊文摘（眼科学分册） 2005年第12期1卷 4-5页

作者： shimura M Yasuda K Nakazawa t tamai M 杨秀梅 Department of Ophthalmology NTT East Japan Tohoku Hospital 2- 29- 1 Yamato Wakabayashi Sendai Miyagi 984- 8560 Japan.Dr.

PURPOSE: to compare macular thickness and best-corre-cted visual acuity (BcVA) before and after panretinal photocoagulation (PRP) in patients with severe diabetic retinopathy and good visual acuity (VA) to identify factors that predict post-operative visual function. DESIGN: Prospective, non-comparative, interventional case series. MEtHODS: Sixty-four consecutive patients with severe non-proliferative diabetic retinopathy or with non-high-risk proliferative diabetic retinopathy whose VA was 20/20 or better before PRP were studied. Sixty-four eyes of 64 patients underwent scatter PRP in four sessions every other week. Macular thickness was measured by optical coherence tomography (OCt), and VA was measured before and periodically after PRP. RESULtS: During the 24- week observation period, patients were classified into three groups according to changes in VAduring the post-operative period. In groupA, VA was maintained at pre-operative levels in 54 (84% ) eyes during the 24 weeks after PRP. In group B, VA initially decreased in three eyes but subsequently recovered to baseline during the observation period; in group C, VA did not recover during follow-up in seven eyes. there was no significant difference in pre-operative foveal thicknesses among the three groups, but parafoveal thickness was to 280 μ m in group B, and was > 300 μ m in group C. CONCLUSION: For eyes with severe diabetic retinopathy and good VA, PRP did not affect post-operative VA in more than 80% of patients. Patients whose pre-operative parafoveal thickness was > 300 μ m had a worse visual prognosis.

关键词：全视网膜光凝视功能障碍中心凹干预性定期测量预测术病例研究预后差基线水平

2例干扰素相关性视网膜病变患者OCt检查所示黄斑水肿的临床病程

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世界核心医学期刊文摘（眼科学分册） 2005年第10期1卷 53-53页

作者： shimura M. Saito t. Yasuda K. tamai M. 宋虎平 Departments ofOphthalmolog y andMedical Sciences Tohoku UniversityGraduate School of Medicine 1-1 Seiry o Aoba Sendai 980-8574 Japan

Background: Interferon (IFN)-associated retinopathy is typically characterize d by retinal hemorrhages and cotton wool spots at the posterior fundus, but visu al function is usually maintained. With the use of optical coherence tomography (OCt), two patients with IFN-associated retinopathy who had developed macular e dema and reduced visual acuity during the clinical course of IFN therapy were ob served. Cases: A 37-year-old man with chronic hepatitis C and a 59-year-old man with chronic myeloid leukemia, both of whom had received IFN therapy, were r eferred to our outpatient clinic. the former patient had complained once that hi s visual acuity had decreased after the termination of IFN therapy, and the latt er patient complained twice during IFN therapy that his visual acuity had decrea sed. Observations: In both patients, at the time of the visual disturbances, mac ular edema was clearly observed by OCt. Hypoalbuminemia and thrombocytopenia wer e observed at this time also. After the remission of the hypoalbuminemia and thr ombocytopenia, the macular edema observed by OCt disappeared and visual acuity r eturned to normal. Conclusion: During and after IFN therapy, OCt is a useful exa mination technique for revealing macular edema in patients who have decreased vi sion. Ophthalmologists should be aware of the ocular side effects of IFN therapy and carefully monitor patients for the possible occurrence of hypoalbuminemia a nd thrombocytopenia.

关键词：黄斑水肿 OCt检查视网膜病变临床病程眼底视网膜后极部慢性丙型肝炎髓细胞视功能眼科医生