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A Novel 6G Scalable Blockchain Clustering-Based Computer Vision Character Detection for Mobile Images

Computers, Materials & Continua 2024年第3期78卷 3041-3070页

作者： Yuejie li shijun li Department of Mathematics and Computer Engineering Ordos Institute of TechnologyOrdos017000China School of Mathematics and Physics North China Electric Power UniversityBeijing102206China School of Electrical Information Hunan University of EngineeringXiangtan411104China

6G is envisioned as the next generation of wireless communication technology,promising unprecedented data speeds,ultra-low Latency,and ubiquitous Connectivity.In tandem with these advancements,blockchain technology is leveraged to enhance computer vision applications’security,trustworthiness,and transparency.With the widespread use of mobile devices equipped with cameras,the ability to capture and recognize Chinese characters in natural scenes has become increasingly important.Blockchain can facilitate privacy-preserving mechanisms in applications where privacy is paramount,such as facial recognition or personal healthcare monitoring.Users can control their visual data and grant or revoke access as needed.Recognizing Chinese characters from images can provide convenience in various aspects of people’s lives.However,traditional Chinese character text recognition methods often need higher accuracy,leading to recognition failures or incorrect character identification.In contrast,computer vision technologies have significantly improved image recognition accuracy.This paper proposed a Secure end-to-end recognition system(SE2ERS)for Chinese characters in natural scenes based on convolutional neural networks(CNN)using 6G technology.The proposed SE2ERS model uses the Weighted Hyperbolic Curve Cryptograph(WHCC)of the secure data transmission in the 6G network with the blockchain model.The data transmission within the computer vision system,with a 6G gradient directional histogram(GDH),is employed for character estimation.With the deployment of WHCC and GDH in the constructed SE2ERS model,secure communication is achieved for the data transmission with the 6G network.The proposed SE2ERS compares the performance of traditional Chinese text recognition methods and data transmission environment with 6G communication.Experimental results demonstrate that SE2ERS achieves an average recognition accuracy of 88%for simple Chinese characters,compared to 81.2%with traditional methods.For complex Chinese characters,the average recogni

关键词： 6G technology blockchain end-to-end recognition Chinese characters natural scene computer vision algorithms convolutional neural network

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A meso–molecular muscle based on copillar[5]arenes

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Chinese Chemical Letters 2024年第3期35卷 308-311页

作者： Yu Yao Peiling Zhang Dan Zhou Zhinan Lai shijun li Feihe Huang Zibin Zhang College of Material Chemistry and Chemical EngineeringKey Laboratory of Organosilicon Chemistry and Material TechnologyMinistry of EducationKey Laboratory of Organosilicon Material TechnologyHangzhou Normal UniversityHangzhou 311121China Department of Chemistry Stoddart Institute of Molecular ScienceZhejiang UniversityHangzhou 310027China Green Catalysis Center and College of Chemistry Zhengzhou UniversityZhengzhou 450001China

A meso–molecular muscle was prepared by capping the[c2]daisy chain based on a mono-functionalized copillar[5]arene with an imidazolium group in its axle.From its crystal structure,we observed that it was a cyclic dimer composed of two mirror image subcomponents,a pR-and a pS-copillar[5]arene.Their conformations were fixed by the doubly interlocked mechanical bond.By comparison of the^1H NMR and COSY spectra,we found that the length of this meso–molecular muscle could be controlled not only by the solvents,but also by the counter anions.

关键词： Pillararenes Molecular muscles [c2]daisy chains Planar chirality

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Antibody drug conjugate:the“biological missile”for targeted cancer therapy

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Signal Transduction and Targeted Therapy 2022年第4期7卷 1066-1090页

作者： Zhiwen Fu shijun li Sifei Han Chen Shi Yu Zhang Department of Pharmacy Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022People’s Republic of China Hubei Province Clinical Research Center for Precision Medicine for Critical Illness Wuhan 430022People’s Republic of China Drug Delivery Disposition and DynamicsMonash Institute of Pharmaceutical SciencesMonash University(Parkville Campus)381 Royal ParadeParkvilleVIC 3052Australia Faculty of Pharmacy China Pharmaceutical University639 Longmian AvenueJiangning DistrictNanjing 211198People’s Republic of China

Antibody–drug conjugate(ADC)is typically composed of a monoclonal antibody(mAbs)covalently attached to a cytotoxic drug via a chemical linker.It combines both the advantages of highly specific targeting ability and highly potent killing effect to achieve accurate and efficient elimination of cancer cells,which has become one of the hotspots for the research and development of anticancer drugs.Since the first ADC,Mylotarg®(gemtuzumab ozogamicin),was approved in 2000 by the US Food and Drug Administration(FDA),there have been 14 ADCs received market approval so far worldwide.Moreover,over 100 ADC candidates have been investigated in clinical stages at present.This kind of new anti-cancer drugs,known as“biological missiles”,is leading a new era of targeted cancer therapy.Herein,we conducted a review of the history and general mechanism of action of ADCs,and then briefly discussed the molecular aspects of key components of ADCs and the mechanisms by which these key factors influence the activities of ADCs.Moreover,we also reviewed the approved ADCs and other promising candidates in phase-3 clinical trials and discuss the current challenges and future perspectives for the development of next generations,which provide insights for the research and development of novel cancer therapeutics using ADCs.

关键词： Antibody drugs conjugate

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Regulatory mechanisms of rapeseed petal color formation:Current research status and future perspectives

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Oil Crop Science 2022年第4期7卷 174-179页

作者： shijun li Tao Chang Xi li Zechuan Peng Chunyun Guan Mei Guan National Oil Crops Improvement Center in Hunan Department of AgronomyHunan Agricultural UniversityChangsha410128China

Flower color,an important rapeseed character,has great practical value and research significance.It has become an area of intensive research in recent years.This paper summarizes the latest research progress on rape flower color in terms of variety,source,pigment composition,formation mechanism,and omics.Moreover,it provides an overview of rape flower color breeding and omics.

关键词： Rape Flower color Carotenoids Flavonoids Omics

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Antitumor activity of aumolertinib, a third-generation EGFR tyrosine kinase inhibitor, in non-small-cell lung cancer harboring uncommon EGFR mutations

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药学学报:英文版 2023年第6期13卷 2613-2627页

作者： Chen Shi Cong Zhang Zhiwen Fu Jinmei liu Yuanfeng Zhou Bao Cheng Cong Wang shijun li Yu Zhang Department of Pharmacy Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Hubei Province Clinical Research Center for Precision Medicine for Critical Illness Wuhan 430022China Department of Preclinical Translational Science Shanghai Hansoh Biomedical Co.Ltd.Shanghai 201203China Department of Chemistry Shanghai Hansoh Biomedical Co.Ltd.Shanghai 201203China

Uncommon epidermal growth factor receptor(EGFR) mutations account for 10% 20% of all EGFR mutations in non-small-cell lung cancer(NSCLC). The uncommon EGFR-mutated NSCLC is associated with poor clinical outcomes and generally achieved unsatisfactory effects to the current therapies using standard EGFR-tyrosine kinase inhibitors(TKIs), including afatinib and osimertinib. Therefore, it is necessary to develop more novel EGFR-TKIs to treat uncommon EGFR-mutated NSCLC.Aumolertinib is a third-generation EGFR-TKI approved in China for treating advanced NSCLC with common EGFR mutations. However, it remains unclear whether aumolertinib is effective in uncommon EGFR-mutated NSCLC. In this work, the in vitro anticancer activity of aumolertinib was investigated in engineered Ba/F3 cells and patient-derived cells bearing diverse uncommon EGFR mutations. Aumolertinib was shown to be more potent in inhibiting the viability of various uncommon EGFR-mutated cell lines than those with wild-type EGFR. And in vivo, aumolertinib could also significantly inhibit tumor growth in two mouse allograft models(V769-D770insASV and L861Q mutations) and a patientderived xenografts model(H773-V774insNPH mutation). Importantly, aumolertinib exerts responses against tumors in advanced NSCLC patients with uncommon EGFR mutations. These results suggest that aumolertinib has the potential as a promising therapeutic candidate for the treatment of uncommon EGFR-mutated NSCLC.

关键词： Aumolertinib Non-small cell lung cancer Oncology Uncommon EGFR mutations Exon 20 insertion EGFR tyrosine kinase inhibitor Targeted therapy Anti-tumor activity

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Mechanistic investigation of zwitterionic MOF-catalyzed enyne annulation using UNLPF-14-Mn^(Ⅲ) as catalyst

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Chinese Chemical Letters 2022年第9期33卷 4281-4286页

作者： Taotao liu Ruihong Duan Yanyan Wang shijun li lingbo Qu Jinshuai Song Qiang liu Yu Lan Green Catalysis Center and College of ChemistryZhengzhou UniversityZhengzhou 450001China Center of Basic Molecular Science(CBMS) Department of ChemistryTsinghua UniversityBeijing 100084China College of Chemistry and Chemical Engineering Henan Institute of Science and TechnologyXinxiang 453000China School of Chemistry and Chemical Engineering and Chongqing Key Laboratory of Theoretical and Computational ChemistryChongqing UniversityChongqing 400030China

Hybrid quantum mechanics/molecular mechanics calculations were performed to elucidate how[Mn^(Ⅲ)porphyrin]^(+X−)-based metal-organic frameworks(MOFs)catalyze the[2+1]cycloisomerization of enynes and why zwitterionic MOFs exhibit strong activity in Lewis acid catalysis.The calculations showed that zwitterionic MOFs have a“pure cationic active center”leading to a concerted nucleophilic attack pathway with lower barriers.In contrast,metals with coordinating anions have reduced electrophilicity,resulting in a stepwise radical-type pathway with much higher barriers.Further calculations showed the nature of catalysis was strongly depended on the charge on the anion ligand.A good linear relationship between the NPA charge and barrier was found,and verified by 73 anions with small derivations,which presents a universal adaptive character for various coordinated anions.

关键词： ONIOM QM/MM Zwitterionic MOF [Mn^(III)porphyrin]^(+X−) Enyne annulation Mechanism Anion effect

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Response and Assessment of the Effectiveness of the Countermeasures for a COVID-19 Outbreak—Guizhou Province,China,March 2022

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China CDC weekly 2022年第30期4卷 655-659页

作者： Jiao Huang liying Wang Chun Yu Zhaobing liu Guanghong Yang Ziyao Lan Zhongfa Tao Kaike Ping He Huang shijun li Yan Huang Guizhou Center for Disease Control and Prevention Guiyang CityGuizhou ProvinceChina National Institute of Parasitic Diseases Chinese Center for Tropical Diseases ResearchChinese Center for Disease Control and PreventionNHC Key Laboratory of Parasite and Vector BiologyWHO Collaborating Center for Tropical DiseasesNational Center for International Research on Tropical DiseasesShanghai MunicipalityChina Doctorate School of Chemical and Biological Sciences for Health(CBS2) University of MontpellierMontpellierFrance.

Summary What is already known about this topic?Many regions in China have recently reported outbreaks of the coronavirus disease 2019(COVID-19)caused by the Omicron variant.What is added by this report?Wuchuan County,Guizhou Province reacted quickly and implemented accurate intervention measures to effectively control the outbreak.The susceptibleexposed-infectious-asymptomatic-removed(SEIAR)model was applied to evaluate the effectiveness of intervention measures.What are the implications for public health practice?Fast response measures should be taken to prevent the spread of outbreaks caused by the Omicron variant.

关键词： Guizhou measures Countermeasures

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A low-cost and high-efficiency 10-in-1 test for the PCR-based screening of SARS-CoV-2 infection in low-risk areas

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Chinese Medical Journal 2022年第4期135卷 496-498页

作者： Xiaosong Qin Peng Gao Zhijie Zhang Zhijian Bo shijun li Mei Yang Jianhua liu lina Wu Ting li Zuowei Zhao Yan li Haodong Bian Yong liu Department of Laboratory Medicine Shengjing Hospital of China Medical UniversityShenyangLiaoning 110004China Department of Laboratory Medicine Dalian Sixth People’s HospitalDalianLiaoning 1160311China Microbiological Laboratory Dalian Municipal Center for Disease Control and PreventionDalianLiaoning 116019China Department of Laboratory Medicine First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning 116011China Committee of the Party Group Health Commission of DalianDalianLiaoning 116006China Clinical Laboratory and Medical Quality Control Center Health Service Center of Liaoning ProvinceShenyangLiaoning 110005China

To the Editor:As of August 9,2020,the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has infected 19,432,244 people and caused 721,594 deaths globally.To timely identify the infected persons,nucleic acid detection screenings have been carried out for high-infection risk groups in areas known to have coronavirus disease 19(COVID-19)cases,such as Wuhan,Beijing,and Xinjiang.The rapid identification of infected patients and the implementation of quarantine measures play an important role in preventing the transmission of SARS-CoV-2.However,there are some issues associated with large-scale screening for this virus.The consumption of equipment and reagents for specimen collection and detection is high,resulting in elevated screening costs.Moreover,with the increase in the number of samples collected,the testing capabilities of medical institutions have reached a saturation point,hindering the speed and scope of large-scale screenings.For this reason,the mixed detection after RNA extraction(detection in a mixture of nucleic acids extracted from several patients)or before RNA extraction(detection in a mixture of pharyngeal swab transfer buffer obtained from different patients before nucleic acid extraction)has been proposed in many regions.[1]However,both the pooling of swab transfer buffer before nucleic acid extraction and pooling of RNA after nucleic acid extraction inevitably cause dilution of samples and decrease of detection sensitivity.However,there is still a lack of research on how to effectively improve the screening efficiency and control the decrease of sensitivity caused by dilution in an appropriate range.In this study,we designed a novel 10-in-1 test(ten pharyngeal swab samples from ten individuals were placed in one custom-made virus collection tube[CMT]for nucleic acid extraction and testing)by optimizing the current mixed acquisition technique,and after a promising pilot test.

关键词： screening cost globally

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BnGLO4 gene cloning and bioinformatics analysis in Brassica napus L

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Oil Crop Science 2023年第3期8卷 133-142页

作者： Xi li Xiaodan Wang shijun li Zechuan Peng Dongfang Zhao Bingqian Zhou Chunyun Guan Mei Guan College of Agriculture Hunan Agricultural UniversityHunan Branch of National Oilseed Crops Improvement CenterSouthern Regional Collaborative Innovation Center for Grain and Oil Crops in ChinaChangsha410128China

High oleic acid rapeseed oil offers superior nutritional and health benefits,but its mass production is limited due to poor resistance and slightly lower yield.Photosynthesis serves as the foundation of biological survival and closely correlates with crop resistance to stresses,yield,and quality.To identify photosynthesis-related genes,transcriptome sequencing was conducted on high oleic acid rapeseed Gaoyousuan No.1 and low oleic acid rapeseed Xiangyou 15 resulting in the identification of a total of 9396 differentially expressed genes(4669 upregulated and 4727 down-regulated).From these genes nine candidate genes were screened using GO and KEGG analysis with BnGLO4 being selected for cloning purposes.The BnGLO4 gene fragment has a length of 1161 bp with an ORF sequence of 1092 bp encoding a theoretical isoelectric point of pI 7.60;it encodes an unstable lipid-soluble protein localized in peroxisomes without transmembrane structural domains or signal peptides.Its amino acid sequence homology was highest with that of BnaA01G0355200ZS,BnaA01G0355600ZS,BnaA05G0410400ZS,BnaC01G0441800ZS,and Brassica rapa(XP_009117145.1),Brassica napus(CDY39100.1),Brassica cretica(KAF3533604.1)and Brassica oleracea var.oleracea(XP_013610644.1)belonging to the same cruciferous family.The BnGLO4 gene may be associated with responses to abiotic stresses such as salt,drought,and temperature extremes along with photosynthesis and growth in rapeseed plants.The expression levels of the GLO4 gene(BnaA01G0355200 ZS)were highest in filaments while being higher at each stage in seeds and siliques with the highest expression level at day 14 in seeds.Expression was significantly upregulated after 3 h of salt stress treatment,reaching a maximum at 12 h before slightly decreasing at 24 h.The findings of this study lay a foundation for further investigation on photosynthesis and stress response in high oleic rapeseed.

关键词： High oleic acid Transcriptome Glycolate oxidase GLO4

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Coordination-driven self-assembly of dibenzo-18-crown-6 functionalized Pt(Ⅱ) metallacycles

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Chinese Chemical Letters 2023年第2期34卷 158-160页

作者： Zibin Zhang Yu Yao Lang He Tao Hong shijun li Feihe Huang Peter J.Stang College of Material Chemistry and Chemical EngineeringHangzhou Normal UniversityHangzhou 311121China State Key Laboratory of Chemical Engineering Stoddart Institute of Molecular ScienceDepartment of ChemistryZhejiang UniversityHangzhou 310027China Green Catalysis Center and College of Chemistry Zhengzhou UniversityZhengzhou 450001China Department of Chemistry University of UtahSalt Lake CityUT 84112United States

Coordination-driven self-assembly was used to construct two metallacycles of a dicarboxylatefunctionalized dibenzo-18-crown-6 in combination with either a 0° anthracene-based clip-type acceptor or a 60° phenanthrene-based acceptor. The angularities of these moieties make them suitable for the formation of a [2 + 2] rectangle and a [3 + 3] triangle, respectively. The synthesis, characterization and host-guest chemistry of two metallacycles were described and supported by31P{1H},1H NMR spectra and electrospray mass spectrometry.

关键词： Crown ethers Metallacycles Cation receptors Self-assembly

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