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Incorporating redox-sensitive nanogels into bioabsorbable nanofibrous membrane to acquire ROS-balance capacity for skin regeneration

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Bioactive Materials 2021年第10期6卷 3461-3472页

作者： shihao zhang Yamin Li Xiaofeng Qiu Anqi Jiao Wei Luo Xiajie Lin Xiaohui zhang Zeren zhang Jiachan Hong Peihao Cai Yuhong zhang Yan Wu Jie Gao Changsheng Liu Yulin Li The Key Laboratory for Ultrafine Materials of Ministry of Education State Key Laboratory of Bioreactor EngineeringEngineering Research Center for Biomedical Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai200237China Institute of Translational Medicine Shanghai UniversityShanghai200444China Heilongjiang Key Laboratory of Anti-fibrosis Biotherapy Mudanjiang Medical UniversityMudanjiang157011China Shanghai Jiaotong University Affiliated Sixth People’s Hospital Shanghai200233China Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional MoleculesCollege of Chemistry and Chemical EngineeringHubei UniversityWuhan430062China

Facing the high incidence of skin diseases,it is urgent to develop functional materials with high bioactivity for wound healing,where reactive oxygen species(ROS)play an important role in the wound healing process mainly via adjustment of immune response and *** this study,we developed a kind of bioabsorbable materials with ROS-mediation capacity for skin disease ***,redox-sensitive poly(N-isopropylacrylamide-acrylic acid)(PNA)nanogels were synthesized by radical emulsion polymerization method using a disulfide molecule as *** resulting nanogels were then incorporated into the nanofibrous membrane of poly(L-lactic acid)(PLLA)via airbrushing approach to offer bioabsorbable membrane with redox-sensitive ROS-balance *** vitro biological evaluation indicated that the PNA-contained bioabsorbable membrane improved cell adhesion and proliferation compared to the native PLLA *** vivo study using mouse wound skin model demonstrated that PNA-doped nanofibrous membranes could promote the wound healing process,where the disulfide bonds in them were able to adjust the ROS level in the wound skin for mediation of redox potential to achieve higher wound healing efficacy.

关键词： Polylactide Nanofibrous membrane Redox sensitivity ROS-Balance capacity Skin regeneration

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Injectable nanofiber-reinforced bone cement with controlled biodegradability for minimally-invasive bone regeneration

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Bioactive Materials 2023年第3期21卷 267-283页

作者： Peihao Cai Shunyi Lu Jieqin Yu Lan Xiao Jiayi Wang Haifeng Liang Lei Huang Guanjie Han Mengxuan Bian shihao zhang Jian zhang Changsheng Liu Libo Jiang Yulin Li The Key Laboratory for Ultrafine Materials of Ministry of Education Frontiers Science Center for Materiobiology and Dynamic ChemistryEngineering Research Center for Biomedical Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai200237China Department of Orthopaedic Surgery Zhongshan HospitalFudan UniversityShanghai200032China Centre for Biomedical Technologies School of MechanicalMedical and Process EngineeringQueensland University of TechnologyBrisbane4059Australia

Injectable materials show their special merits in regeneration of damaged/degenerated bones in minimally-invasive *** calcium phosphate bone cement(CPC)has attracted broad attention for its bioactivity,as compared to non-degradable polymethyl methacrylate ***,its brittleness,poor anti-washout property and uncontrollable biodegradability are the main challenges to limit its further clinical application mainly because of its stone-like dense structure and fragile inorganic-salt ***,we developed a kind of injectable CPC bone cement with porous structure and improved robustness by incorporating poly(lactide-co-glycolic acid)(PLGA)nanofiber into CPC,with carboxymethyl cellulose(CMC)to offer good injectability as well as anti-wash-out ***,the introduction of PLGA and CMC also enabled a formation of initial porous structure in the cements,where PLGA nanofiber endowed the cement with a dynamically controllable biodegradability which provided room for cell movement and bone ***-estingly,the reinforced biodegradable cement afforded a sustainable provision of Ca^(2+)bioactive components,together with its porous structure,to improve synergistically new bone formation and osteo-integration in vivo by using a rat model of femur condyle *** study on regenerative mechanisms indicated that the good minimally-invasive bone regeneration may come from the synergistic enhanced osteogenic effect of calcium ion enrichment and the improved revascularization capacity contributed from the porosity as well as the lactic acid released from PLGA *** results indicate the injectable bone cement with high strength,anti-washout property and controllable biodegradability is a promising candidate for bone regeneration in a minimally-invasive approach.

关键词： Injectable calcium phosphate cement Biodegradable PLGA nanofiber Angiogenesis Osseointegration Minimally-invasive bone regeneration

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Gold nanoparticle-directed autophagy intervention for antitumor immunotherapy via inhibiting tumor-associated macrophage M2 polarization

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Acta Pharmaceutica Sinica B 2022年第7期12卷 3124-3138页

作者： Siyue zhang Fangyuan Xie Kaichun Li He zhang You Yin Yuan Yu Guangzhao Lu shihao zhang Yan Wei Ke Xu Yan Wu Hong Jin Lan Xiao Leilei Bao Can Xu Yulin Li Ying Lu Jie Gao Department of Pharmacy Naval Medical UniversityShanghai 200433China Changhai Clinical Research Unit Shanghai Changhai HospitalNaval Medical UniversityShanghai 200433China Institute of Translational Medicine Shanghai UniversityShanghai 200444China Department of Pharmacy Shanghai Eastern Hepatobiliary Surgery HospitalNaval Medical UniversityShanghai 200433China Department of Oncology Shanghai Fourth People’s HospitalSchool of MedicineTongji UniversityShanghai 200434China Unit for Drug and Instrument Supervision and Inspection of Wuxi Joint Logistic Support Center Nanjing 210000China Key Laboratory for Ultrafine Materials of Ministry of Education Engineering Research Center for Biomedical Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China Department of Gastroenterology Shanghai Changhai HospitalNaval Medical UniversityShanghai 200433China Department of Neurology Changzheng HospitalNaval Medical UniversityShanghai 200003China Department of Biomaterial College of Life SciencesMudanjiang Medical UniversityMudanjiang 157011China Department of Laboratory Medicine Hongqi HospitalMudanjiang Medical CollegeMudanjiang 157011China Centre for Biomedical Technologies Queensland University of TechnologyBrisbane QLD 4000Australia mWenzhou Institute of Shanghai UniversityWenzhou 325000China

Tumor-associated macrophages(TAMs),one of the dominating constituents of tumor microenvironment,are important contributors to cancer progression and treatment ***,regulation of TAMs polarization from M2 phenotype towards M1 phenotype has emerged as a new strategy for tumor ***,we successfully initiated antitumor immunotherapy by inhibiting TAMs M2 polarization via autophagy intervention with polyethylene glycol-conjugated gold nanoparticles(PEG-Au NPs).PEG-Au NPs suppressed TAMs M2 polarization in both in vitro and in vivo models,elicited antitumor immunotherapy and inhibited subcutaneous tumor growth in *** demonstrated by the m RFP-GFP-LC3 assay and analyzing the autophagy-related proteins(LC3,beclin1 and P62),PEGAu NPs induced autophagic flux inhibition in TAMs,which is attributed to the PEG-Au NPs induced lysosome alkalization and membrane ***,TAMs were prone to polarize towards M2phenotype following autophagy activation,whereas inhibition of autophagic flux could reduce the M2polarization of *** results revealed a mechanism underlying PEG-Au NPs induced antitumor immunotherapy,where PEG-Au NPs reduce TAMs M2 polarization via induction of lysosome dysfunction and autophagic flux *** study elucidated the biological effects of nanomaterials on TAMs polarization and provided insight into harnessing the intrinsic immunomodulation capacity of nanomaterials for effective cancer treatment.

关键词： Macrophage polarization Tumor-associated macrophages Nanomaterials Autophagy flux Lysosomal damage Gold nanoparticles M2 macrophage Cancer therapy

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有源配电网安全域的体积:定义、算法与分析

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电网技术 2023年第3期47卷 1196-1205页

作者：肖峻张诗豪智能电网教育部重点实验室(天津大学) 天津市南开区300072

安全域体积描述了配电网安全运行范围大小,是配电网安全域(distribution system security region,DSSR)的一个重要指标。该文提出了有源配电网N-0(DSSR0)和N-1下安全域体积的定义和新算法。首先,将有源网安全域体积定义为状态空间中的n... 详细信息

安全域体积描述了配电网安全运行范围大小,是配电网安全域(distribution system security region,DSSR)的一个重要指标。该文提出了有源配电网N-0(DSSR0)和N-1下安全域体积的定义和新算法。首先,将有源网安全域体积定义为状态空间中的n重积分,与现有无源网安全域体积定义的区别有:1)积分变量不同。无源网采用馈线负荷,有源网采用节点净功率。2)状态空间所在象限不同。无源网安全域位于第一象限,有源网安全域位于全象限。其次,提出了基于拟蒙特卡罗的新算法,适用于有源网和无源网安全域体积计算。相比于现有算法,有更好的精度和速度,且适用于直流潮流和交流潮流的安全域模型。最后,采用算例验证了该文定义和算法。深入分析得到了分布式电源接入位置与渗透率对N-0和N-1下安全域体积的影响规律和原因。

关键词：有源配电网安全域体积渗透率

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Fabrication of magnesium-doped porous polylactic acid microsphere for bone regeneration

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Biomaterials Translational 2023年第4期4卷 280-290页

作者： Ziwei Tao Ziyang Yuan Dong Zhou Lang Qin Lan Xiao shihao zhang Changsheng Liu Jinzhong Zhao Yulin Li Engineering Research Centre for Biomedical Materials of Ministry of Education Key Laboratory for Ultrafine Materials of Ministry of EducationSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghaiChina Department of Sports Medicine Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina School of Chemistry and Chemical Engineering Nanchang UniversityNanchangJiangxi ProvinceChina School of Mechanical Medical and Process EngineeringCenter of Biomedical TechnologyQueensland University of TechnologyBrisbaneAustralia Wenzhou Institute of Shanghai University WenzhouZhejiang ProvinceChina

Biodegradable polymer microspheres that can be used as drug carriers are of great importance in biomedical applications,however,there are still challenges in controllable preparation of microsphere surface morphology and improvement of *** this paper,firstly,poly(L-lactic acid)(PLLA)was synthesised by ring-opening polymerisation under anhydrous anaerobic conditions and further combined with the emulsion method,biodegradable PLLA microspheres(PM)with sizes ranging from 60-100μm and with good sphericity were *** addition,to further improve the surface morphology of PLLA microspheres and enhance their bioactivity,functionalised porous PLLA microspheres loaded with magnesium oxide(MgO)/magnesium carbonate(MgCO_(3))(PMg)were also prepared by the emulsion *** results showed that the loading of MgO/MgCO_(3)resulted in the formation of a porous structure on the surface of the microspheres(PMg)and the dissolved Mg^(2+)could be released slowly during the degradation of *** vitro cellular experiments demonstrated the good biocompatibility of PM and PMg,while the released Mg^(2+)further enhanced the anti-inflammatory effect and osteogenic activity of *** PMg not only show promise for controlled preparation of drug carriers,but also have translational potential for bone regeneration.

关键词： magnesium ion osteogenesis polylactic acid porous microspheres

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High-performance GaSb planar PN junction detector

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Journal of Semiconductors 2024年第9期45卷 48-52页

作者： Yuanzhi Cui Hongyue Hao shihao zhang Shuo Wang Jing zhang Yifan Shan Ruoyu Xie Xiaoyu Wang Chuang Wang Mengchen Liu Dongwei Jiang Yingqiang Xu Guowei Wang Donghai Wu Zhichuan Niu Derang Cao College of Physics National Demonstration Center for Experimental Applied Physics EducationQingdao UniversityQingdao 266071China Key Laboratory of Optoelectronic Materials and Devices Chinese Academy of SciencesBeijing 100083China College of Materials Science and Opto-Electronic Technology University of Chinese Academy of SciencesBeijing 100049China

This paper examines GaSb short-wavelength infrared detectors employing planar PN junctions. The fabrication was based on the Zn diffusion process and the diffusion temperature was optimized. Characterization revealed a 50% cut-off wavelength of 1.73 μm, a maximum detectivity of 8.73 × 10^(10) cm·Hz^(1/2)/W, and a minimum dark current density of 1.02 × 10^(-5) A/cm^(2).Additionally, a maximum quantum efficiency of 60.3% was achieved. Subsequent optimization of fabrication enabled the realization of a 320 × 256 focal plane array that exhibited satisfactory imaging results. Remarkably, the GaSb planar detectors demonstrated potential in low-cost short wavelength infrared imaging, without requiring material epitaxy or deposition.

关键词： antimonide short-wave infrared planar junction zinc diffusion

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GRK2 mediated degradation of SAV1 initiates hyperplasia of fibroblast-like synoviocytes in rheumatoid arthritis

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1222-1240页

作者： Paipai Guo Ji Jiang Rui Chu Feng He Mingli Ge Ruhong Fang Qiuyun Guan Huijuan Cheng Chunru Jiang Tiantian Su Zhenduo Zhu Hao Liu Wei Wei shihao zhang Qingtong Wang Institute of Clinical Pharmacology Anhui Medical UniversityKey Laboratory of Anti-inflammatory and Immune MedicineMinistry of EducationCollaborative Innovation Center of Anti-inflammatory and Immune MedicinesHefei 230032China School of Pharmacy Bengbu Medical CollegeBengbu 233030China The Third Affiliated Hospital of Anhui Medical University(the First People’s Hospital of Hefei) Hefei 230061China

Hyperplasia and migration of fibroblast-like synoviocytes(FLSs)are the key drivers in the pathogenesis of rheumatoid arthritis(RA)and joint *** Yes-associated protein(YAP),which is a powerful transcription co-activator for proliferative genes,was observed in the nucleus of inflammatory FLSs with unknown upstream *** Gene Expression Omnibus database analysis,it was found that Salvador homolog-1(SAV1),the pivotal negative regulator of the Hippo-YAP pathway,was slightly downregulated in RA ***,SAV1 protein expression is extremely ***,it was revealed that SAV1 is phosphorylated,ubiquitinated,and degraded by interacting with an important serine-threonine kinase,G protein-coupled receptor(GPCR)kinase 2(GRK2),which was predominately upregulated by GPCR activation induced by ligands such as prostaglandin E2(PGE2)in *** process further contributes to the decreased phosphorylation,nuclear translocation,and transcriptional potency of YAP,and leads to aberrant FLSs *** depletion of GRK2 or inhibition of GRK2 by paroxetine rescued SAV1 expression and restored YAP phosphorylation and finally inhibited RA FLSs proliferation and ***,paroxetine treatment effectively reduced the abnormal proliferation of FLSs in a rat model of collagen-induced arthritis which was accompanied by a significant improvement in clinical ***,these results elucidate the significance of GRK2 regulation of Hippo-YAP signaling in FLSs proliferation and migration and the potential application of GRK2 inhibition in the treatment of FLSs-driven joint destruction in RA.

关键词： Rheumatoid arthritis Fibroblast-like synoviocytes G protein-coupled receptor kinase 2 Salvador homolog-1 Yes-associated protein

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Yap methylation-induced FGL1 expression suppresses anti-tumor immunity and promotes tumor progression in KRAS-driven lung adenocarcinoma

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Cancer Communications 2024年第11期44卷 1350-1373页

作者： Ji Jiang Pengfei Ye Ningning Sun Weihua Zhu Mei Yang Manman Yu Jingjing Yu Hui zhang Zijie Gao Ningjie zhang Shijie Guo Yuru Ji Siqi Li Cuncun zhang Sainan Miao Mengqi Chai Wenmin Liu Yue An Jian Hong Wei Wei shihao zhang Huan Qiu Institute of Clinical Pharmacology Anhui Medical University Key Laboratory of Anti-Inflammatory and Immune Medicine Ministry of EducationAnhui Collaborative Innovation Centre of Anti-Inflammatory and Immune MedicineHefeiAnhuiP.R.China School of Nursing Anhui Medical UniversityHefeiAnhuiP.R.China 3Department of HematologyThe First Affiliated Hospital of Anhui Medical UniversityHefeiAnhuiP.R.China

Background:Despite significant strides in lung cancer immunotherapy,the response rates for Kirsten rat sarcoma viral oncogene homolog(KRAS)-driven lung adenocarcinoma(LUAD)patients remain ***-like protein 1(FGL1)is a newly identified immune checkpoint target,and the study of related resistance mechanisms is crucial for improving the treatment outcomes of LUAD *** study aimed to elucidate the potential mechanism by which FGL1 regulates the tumor microenvironment in KRAS-mutated ***:The expression levels of FGL1 and SET1 histone methyltransferase(SET1A)in lung cancer were assessed using public databases and clinical *** were constructed for transduction to overexpress or silence FGL1 in lung cancer cells and mouse *** effects of FGL1 and Yes-associated protein(Yap)on the immunoreactivity of cytotoxic T cells in tumor tissues were evaluated using immunofluorescence staining and flow *** immunoprecipitation and dual luciferase reporter assays were used to study the SET1A-directed transcriptional ***:Upregulation of FGL1 expression in KRAS-mutated cancer was inversely correlated with the infiltration of CD8^(+)T ***,KRAS activated extracellular signal-regulated kinase 1/2(ERK1/2),which subsequently phosphorylated SET1A and increased its stability and nuclear ***1A-mediated methylation of Yap led to Yap sequestration in the nucleus,thereby promoting Yap-induced transcription of FGL1 and immune evasion in KRAS-driven ***,dual blockade of programmed cell death-1(PD-1)and FGL1 further increased the therapeutic efficacy of anti-PD-1 immunotherapy in LUAD ***:FGL1 could be used as a diagnostic biomarker of KRAS-mutated lung cancer,and targeting the Yap-FGL1 axis could increase the efficacy of anti-PD-1 immunotherapy.

关键词： KRAS immunity Yap

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聚苯偶酰的合成及在水系电解液中的循环伏安性能

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高分子材料科学与工程 2022年第11期38卷 154-159,168页

作者：张世豪丁菡黎明湖北大学化学化工学院湖北武汉430062

发展新型电化学活性分子对各种电化学器件的开发具有重要意义。文中通过电化学工作站测试,发现苯偶酰小分子在乙醇和水的混合溶液中具有良好的循环伏安可逆性,并以对苯二甲醛为单体,利用安息香缩合串联氧化脱氢反应首次制备了聚苯偶酰... 详细信息

发展新型电化学活性分子对各种电化学器件的开发具有重要意义。文中通过电化学工作站测试,发现苯偶酰小分子在乙醇和水的混合溶液中具有良好的循环伏安可逆性,并以对苯二甲醛为单体,利用安息香缩合串联氧化脱氢反应首次制备了聚苯偶酰高聚物(DB-YHH)。傅里叶变换红外光谱、核磁共振光谱及渗透凝胶色谱测试结果证明,DB-YHH是一类含有邻双羰基的共轭聚合物。该合成方法简单易行、原料简单易得、经济性高。电化学工作站测试结果表明,聚苯偶酰在1 mol/L的KOH水系电解液中具有良好的电化学可逆性,其还原电势为0.206 V vsRHE、氧化电势为0.082 V vsRHE、可逆电势差为124 mV。文中开辟了一种安息香缩合串联氧化脱氢反应制备聚苯偶酰的新方法,为新型聚苯偶酰类聚合物的制备提供了参考。此外,聚苯偶酰在水系电解液中良好的电化学活性有望在各类电化学电池中得到应用。

关键词：苯偶酰聚苯偶酰安息香缩合氧化脱氢循环伏安

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关键参数对CFB颗粒体积分数与温度的综合效应分析

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洁净煤技术 2024年第S1期30卷 298-309页

作者：张世豪张进春河南理工大学工商管理学院能源经济研究中心河南焦作454000 河南理工大学工商管理学院工业工程系河南焦作454000

关键参数的科学设定对循环流化床反应器的稳定、高效运行至关重要,是反应器性能优化的重要基础。本文应用数值模拟技术对循环流化床反应器进行了三维全回路仿真,并将仿真结果与试验数据进行了对比分析。在此基础上,针对关键参数(粉煤粒... 详细信息

关键参数的科学设定对循环流化床反应器的稳定、高效运行至关重要,是反应器性能优化的重要基础。本文应用数值模拟技术对循环流化床反应器进行了三维全回路仿真,并将仿真结果与试验数据进行了对比分析。在此基础上,针对关键参数(粉煤粒径、氧气速率和床料藏量)对循环流化床反应器内颗粒体积分数与温度的综合效应进行了分析。应用响应面分析法,总结了各因素间的交互作用与目标变量间的相关性。结果表明:氧气速率对反应器内颗粒体积分数和温度均有显著影响;粉煤粒径仅对颗粒体积分数有显著影响;床料藏量对颗粒体积分数有显著影响,对温度影响较弱;粉煤粒径与氧气速率的交互作用对反应器颗粒体积分数影响较为显著。在实际的工程应用中,可考虑调整氧气速率和改变粉煤粒径以提高循环流化床反应器物料循环效率。此外,可通过调整氧气速率来控制循环流化床反应器内的温度变化。

关键词：关键参数循环流化床全回路仿真颗粒体积分数温度效应响应面分析

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